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individualized complement inhibition and enrollment in a PNH clinical trial at Beijing GoBroad Boren Hospital gradually improved his blood counts and quality of life.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F99b0dba67a2747faf8fda7ab656ed380.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","Aplastic Anemia","Clinical Trials Related to PNH","Adult","2026-05-08","\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Summary: Mr. Liu, 65, was found to have pancytopenia after seeking care for a fever and was diagnosed with very severe aplastic anemia (VSAA). His condition initially stabilized after immunosuppressive therapy, but about a year later his PNH clone began to expand, and he developed VSAA-PNH overlap syndrome with hemolysis, anemia, and a large gallstone that complicated treatment. Persistently low platelet counts made surgery high risk, leaving him with limited options. In 2025, he came to the Anemia Diagnosis & Treatment Center at Beijing GoBroad Boren Hospital, where the team developed an individualized plan that included complement inhibition to control hemolysis and enrollment in a PNH-related clinical trial. With treatment, he gradually became transfusion independent, his hemoglobin and platelet counts continued to improve, and his quality of life improved markedly. After years of difficult treatment, he could finally see hope again.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Very severe aplastic anemia with paroxysmal nocturnal hemoglobinuria (VSAA-PNH overlap syndrome) is a high-risk hematologic overlap condition characterized by severe bone marrow failure together with persistent intravascular hemolysis. When gallstones and obstructive jaundice are also present, very low platelet counts can make surgery especially risky, creating a major treatment challenge and an unfavorable prognosis. In this case, the Anemia Diagnosis & Treatment Center at Beijing GoBroad Boren Hospital shares the management of a critically ill patient with VSAA-PNH overlap syndrome complicated by obstructive jaundice. The team's experience with individualized comprehensive treatment and a clinical trial offers a practical reference for similarly complex patients with severe hematologic disease and surgical complications.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Mr. Liu (pseudonym), a 65-year-old from Tianjin, had been living a quiet, ordinary life. Then in 2023, he went to a local hospital because of a fever, and the blood test results immediately alarmed his family: all three blood cell lines were low. His white blood cell count was only 1.53 × 10^9\u002FL, hemoglobin was 74 g\u002FL, platelets were as low as 9 × 10^9\u002FL, and neutrophils were just 0.18 × 10^9\u002FL. The local hospital promptly treated him for infection, but his blood counts failed to recover. His family then took him to the hematology department of a tertiary hospital, where bone marrow aspiration and other detailed tests finally revealed the cause: very severe aplastic anemia (VSAA). He was started on intensive immunosuppressive therapy (IST), and fortunately his blood counts gradually returned to normal.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">But the disease was not finished with him. About a year after IST, follow-up testing detected a PNH clone—a population of abnormal blood cells associated with paroxysmal nocturnal hemoglobinuria—and the clone continued to expand. By July 2025, it had reached 91.1%. Taken together, the findings led to a diagnosis of VSAA-PNH overlap syndrome. At that point, Mr. Liu also had markedly elevated direct bilirubin, and imaging showed a gallstone about 3 cm in size that was already causing partial obstructive jaundice. Doctors advised stopping his medication that was supporting blood cell production, but once it was stopped, the aplastic anemia relapsed, his blood counts fell sharply, and he again required frequent transfusions. With platelets persistently below 20 × 10^9\u002FL and no acute abdominal emergency, outside hospitals considered surgery too risky. His family felt desperate and unsure where to turn.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002F7be4f72eda750d81a349771532711544_20260913000234.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"7be4f72eda750d81a349771532711544_20260913000234.png\" alt=\"9109f9e9-0d78-4ec6-9740-0f70a77502eb.png\"\u002F>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">Progression of Mr. Liu's PNH clone\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">With few options left, Mr. Liu came to Beijing GoBroad Boren Hospital. On admission, repeat blood counts showed a white blood cell count of 5.18 × 10^9\u002FL, hemoglobin 65 g\u002FL, mean corpuscular volume 118.6 fL, platelets 14 × 10^9\u002FL, neutrophils 3.38 × 10^9\u002FL, and a reticulocyte count of 48.30 × 10^9\u002FL. Lactate dehydrogenase (LDH) was markedly elevated at 871.6 U\u002FL. Because he also had underlying bone marrow failure, the Anemia Diagnosis & Treatment Center developed an individualized plan that combined treatment to support hematopoiesis with complement inhibition to control hemolysis.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">On July 29, 2025, Mr. Liu began treatment with eculizumab, a C5 complement inhibitor. His platelet count improved, reaching 48 × 10^9\u002FL by November 11, 2025, but when his hemoglobin dropped to its lowest levels, he still needed transfusions. Years of medical care had consumed nearly all of this ordinary family's savings. Mr. Liu's son worked away from home and used his modest income to help support the family. With limited finances and little room left in the treatment budget, Mr. Liu felt anxious and helpless. More than anything, he hoped there might be an option that was both more effective and financially manageable.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002F74ff45035885ae1910e2162a05a566ef_20260913000252.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"74ff45035885ae1910e2162a05a566ef_20260913000252.png\" alt=\"c63e2e52-9a4b-46d5-8be2-95c2d4a2f29f.png\"\u002F>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px; text-align: center;\">Specialists from the Anemia Diagnosis & Treatment Center during rounds with Mr. Liu\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At this difficult point, a new possibility emerged. The Anemia Diagnosis & Treatment Center at Beijing GoBroad Boren Hospital had a PNH-related clinical trial underway. When Mr. Liu heard about it, he immediately expressed strong interest in participating.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After rigorous eligibility screening, he qualified and enrolled in the clinical trial on November 11, 2025, starting treatment with a new complement inhibitor. From that point, his course began to change again: he gradually became transfusion independent, his LDH level fell substantially, and hemolysis came under effective control. His hemoglobin has now risen to 94 g\u002FL and his platelet count to 84 × 10^9\u002FL. The fatigue and dizziness caused by anemia have resolved, his quality of life has improved significantly, and his risk of thrombosis has also been markedly reduced.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002F86000cff296409da303cdf9d06372d30_20260913000308.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"86000cff296409da303cdf9d06372d30_20260913000308.png\" alt=\"1d3436e6-ab4d-42cb-a9d1-e2850e9466bb.png\"\u002F>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px; text-align: center;\">Changes in Mr. Liu's blood counts at first admission and before and after the clinical trial\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">"I will never forget it. The doctors and the clinical trial pulled me back when I felt I had run out of options." Whenever Mr. Liu talks about his experience, his gratitude is clear. At a recent follow-up visit, he brought two commemorative banners to thank the people who had supported him. One was for the blood bank staff, who repeatedly helped him through the difficult period when transfusions were essential. The other was for the entire Anemia Diagnosis & Treatment Center team, whose attention to every detail made him feel genuinely cared for throughout treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Mr. Liu speaks with deep appreciation for the Anemia Diagnosis & Treatment Center. In his words, the doctors and nurses did more than treat his illness—they gave him back the confidence and dignity to keep living. That bond between patient and care team means more to him than any words that could be written on a banner.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002Fa82a4f698f0021835bc2db52d40c3fc3_20260913000327.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"a82a4f698f0021835bc2db52d40c3fc3_20260913000327.png\" alt=\"c38bb24d-0ce9-4974-9108-7597bcd207e8.png\"\u002F>\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002Ffacca5b2e72ea9464f40577f8c52a972_20260913000336.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"facca5b2e72ea9464f40577f8c52a972_20260913000336.png\" alt=\"711fadd8-02d8-4c4b-9026-007f66afaff0.png\"\u002F>\u003C\u002Fspan>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px; text-align: center;\">Mr. Liu personally presents commemorative banners to express his thanks\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">This kind of warmth and hope is not unique to one patient. Prof. Liping Jing's team keeps each patient's individual circumstances at the center of care, carefully assessing the disease and tailoring treatment to find the best possible balance between safety and effectiveness. That commitment to individualized, precision care is helping more patients like Mr. Liu find a way forward even when treatment options seem limited—and feel supported along the way.\u003C\u002Fspan>\u003C\u002Fp>","This content is published with the authorization of the patient and their family, intended solely to share real experiences and health knowledge. It does not constitute a recommendation of any treatment plan or medical diagnostic advice. For specific treatment, please follow the guidance of a professional physician.",false,"2026-09-13",[74,84,93,102,110,118,127,136,144,152,160,168,176,185,193,201,210,216,224,232,242,250,259,260,268,276,284,293,301,311,321,330,340,348,356,363,371,380,388,397],{"slug":75,"title":76,"summary":77,"cover":78,"disease":79,"treatment":80,"patientType":67,"publishedAt":81,"contentHtml":82,"expertView":83,"disclaimer":70,"hasAlternate":71,"updatedAt":72},"relapsed-refractory-follicular-lymphoma-car-t-treatment","After Multiple Lines of Treatment and Four CAR-T Therapies, Her Disease Still Progressed - She and Her Doctors Are Still Looking for What Comes Next","From multiple lines of treatment to repeated CAR-T therapies, Ms. Wang has seen her disease change again and again. With every new set of test results, she and her medical team continue to look for the next treatment possibility.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F1761d4b78468d162a0230fe17eb52175.jpg?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","Follicular Lymphoma","CAR-T","2026-08-21","\u003Cp>\u003Cspan style=\"font-size: 15px;\">Summary: In 2020, 41-year-old Ms. Wang (pseudonym) was diagnosed with Grade 3A, Stage IV follicular lymphoma with bone marrow involvement. Over the years that followed, she received chemotherapy, targeted and immunotherapy combinations, clinical-trial treatment, antibody-based therapy, radiotherapy, and multiple CAR-T cell therapies, yet the disease continued to relapse and progress. After she came to Beijing GoBroad Boren Hospital in 2025, Dr. Yajing Zhang and her team reviewed her entire treatment history and repeatedly adjusted the strategy according to tumor burden, target expression, blood counts, and her overall condition. Along the way, autologous CAR-T cells failed to expand effectively, universal CAR-T responses were not durable, and massive splenomegaly and thrombocytopenia became new barriers to treatment. Through splenectomy, CD22 CAR-T, and subsequent sequential treatment, the team kept creating conditions for the next step. Ms. Wang is still receiving treatment and being monitored closely today. Her story is a real account of long-term treatment, repeated reassessment, and the continuing search for another possibility.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>Rapid Progression After First-Line Treatment Made Her Realize This Would Be a Long Journey\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">In the summer of 2020, 41-year-old Ms. Wang sought medical care for persistent abdominal pain and fever.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">After ultrasound, CT, PET-CT, and a pathology biopsy, she was diagnosed with Grade 3A, Stage IV follicular lymphoma with bone marrow involvement.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">After diagnosis, she received six cycles of R-CHOP followed by two courses of rituximab maintenance. Early follow-up showed a marked reduction in disease, and for a while Ms. Wang thought that once treatment was over, life might finally return to normal.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">But not long after completing treatment, new lymph nodes appeared and abnormal findings returned in the bone marrow. The disease was progressing again.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Over the next several years, she enrolled in clinical trials and received therapies with different mechanisms, including targeted and immunotherapy combinations, chemotherapy, antibody-drug conjugate therapy, and splenic radiotherapy.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Some treatments brought a short period of remission. Others showed progression again after only one or two cycles.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">For Ms. Wang, the hardest part was not any single piece of bad news. It was the repeated cycle of "just starting to see hope, then having to change course again."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cstrong>\u003Cspan style=\"text-align: center;\">After Three Universal CAR-T Treatments, the Disease Still Could Not Be Controlled for Long\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">In 2023, Ms. Wang's disease progressed significantly again. On the advice of other patients, she began learning about CAR-T cell therapy.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">During evaluation, her own T cells were found to be in poor condition, so autologous CAR-T could not be manufactured as originally planned. She therefore received universal CD19 CAR-T therapy.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">After the first infusion, she developed persistent high fever and shortness of breath. One month later, however, follow-up showed a complete metabolic response. Unfortunately, the remission did not last long. Abnormal findings soon returned in both bone marrow and imaging studies.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">In 2024, Ms. Wang received a second and then a third universal CD19 CAR-T treatment. Each brought a period of response, but the disease never achieved stable, long-term control.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">By early 2025, fever, fatigue, and enlarged lymph nodes had returned. Tests showed involvement of multiple lymph nodes, the spleen, and bone marrow, with abnormal cells also appearing in peripheral blood.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">At the same time, years of treatment had reduced both the number and function of her lymphocytes, while her platelet count remained low. Treatment options were narrowing, and her body had less reserve to tolerate further therapy. At that point, her previous attending doctor recommended that she travel to Beijing GoBroad Boren Hospital for further evaluation by Dr. Yajing Zhang and her team.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cstrong>\u003Cspan style=\"font-size: 16px;\">At Beijing GoBroad Boren Hospital, the Team First Reconstructed Her Entire Treatment History\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Ms. Wang first met Dr. Yajing Zhang at the end of February 2025. Rather than focusing only on the latest test report, the team began by reviewing her pathology, every previous treatment, and the pattern of each response and progression since diagnosis.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">At this stage, the question was no longer simply, "What drug is left to try?" The team needed to address several issues at the same time:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cul class=\" list-paddingleft-2\" style=\"list-style-type: disc;\">\u003Cli>\u003Cp>\u003Cspan style=\"font-size: 15px;\">How high is the current tumor burden?\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Fli>\u003Cli>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Which treatment targets are the tumor cells still expressing?\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Fli>\u003Cli>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Are the patient's own lymphocytes still suitable for another attempt at cellular therapy?\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Fli>\u003Cli>\u003Cp>\u003Cspan style=\"font-size: 15px;\">What level of treatment can her blood counts and overall condition still tolerate?\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Fli>\u003Cli>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Could the treatment chosen now limit options later?\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Fli>\u003C\u002Ful>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">After a comprehensive assessment, the team initially aimed to reduce the tumor burden and create the conditions for another attempt at autologous CD19 CAR-T therapy.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">After lymphocyte collection, tumor-reduction treatment, and lymphodepleting conditioning, Ms. Wang received an autologous CD19 CAR-T cell infusion on April 7, 2025.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cstrong>\u003Cspan style=\"font-size: 16px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cstrong>\u003Cspan style=\"font-size: 16px;\">Autologous CAR-T Cells Failed to Expand, So the Team Quickly Looked for a New Treatment Window\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">After the CAR-T infusion, repeated monitoring showed no effective cellular expansion. Even after pomalidomide was used in an attempt to stimulate expansion, the expected response did not occur.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">For Ms. Wang, this was another heavy blow. But the team did not stop at the conclusion that the treatment had "failed." Based on her disease status and the narrow treatment window at the time, they moved promptly to universal CD19 CAR-T on day 12 after the autologous infusion.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">The new CAR-T cells did expand in her body. Ms. Wang developed high fever, capillary leak syndrome, diarrhea, and low blood pressure, but with close monitoring and supportive care, these problems gradually stabilized. Her spleen shrank substantially, and her blood counts also improved.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Even so, the effect of this CAR-T treatment did not last. Subsequent monitoring again showed no sustained cellular expansion, further attempts at stimulation did not produce the hoped-for response, and her platelet count continued to fall.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Treatment had reached another crossroads.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cstrong>\u003Cspan style=\"font-size: 16px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cstrong>\u003Cspan style=\"font-size: 16px;\">Massive Splenomegaly and Low Platelets Became the Next Bottleneck - Splenectomy Reopened the Path to Treatment\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">As treatment continued, Ms. Wang's massive splenomegaly and thrombocytopenia increasingly became major barriers to the next stage of care.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">The spleen continued to enlarge. This reflected the tumor burden, while also interfering with recovery of her blood cells.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">With platelets too low, many treatments could not be given safely.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">After repeated assessment, Dr. Yajing Zhang's team concluded that treating the spleen was not simply about solving a local problem. More importantly, it could create new room for subsequent treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">The team actively coordinated with a partner hospital in the medical network to move the surgical plan forward.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">On May 26, 2025, Ms. Wang successfully underwent total splenectomy. After surgery, her blood counts and overall condition gradually improved. Fever and night sweats eased, her weight began to recover, and most importantly, she became physically able to continue treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">For Ms. Wang, the surgery also helped her understand something important: long-term treatment is not about continuously adding more drugs. At each stage, the team first has to identify the problem that most limits the next step - and address that problem first.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cstrong>\u003Cspan style=\"font-size: 16px;\">As Tumor Targets Changed, the Treatment Strategy Changed with Them\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">After splenectomy, follow-up still found a small number of abnormal B cells in the bone marrow and peripheral blood. Because the tumor cells were still expressing CD22, the team decided to try CD22 CAR-T therapy.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">After the July 2025 infusion, the CAR-T cells initially expanded but soon became undetectable again. Drug-based stimulation and reinfusion of the remaining cells also failed to produce a durable effect.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Over the following months, the disease continued to fluctuate. The team repeatedly adjusted targeted therapy, antibody therapy, and cellular immunotherapy based on peripheral blood tests, bone marrow examinations, PET-CT, and reassessment of tumor targets.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Sometimes the abnormal cells fell and then rose again. Sometimes a new combination worked briefly but could not maintain the response.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Ongoing treatment was also changing the tumor itself. CD19 expression had shifted, which meant that approaches that had worked before - or had once seemed theoretically possible - could not simply be repeated.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Ms. Wang gradually came to understand why the doctors kept repeating bone marrow tests, blood tests, and target-expression testing.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">They were not treating an unchanging disease called "follicular lymphoma." They were treating a disease that could evolve under treatment pressure.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cstrong>\u003Cspan style=\"font-size: 16px;\">Every Time the Disease Progresses, Four Questions Need to Be Asked Again\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">For a patient with relapsed or refractory disease like Ms. Wang, every progression requires the team to reassess four questions:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Where is the disease mainly active now?\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Is it in the bone marrow, spleen, lymph nodes, or several sites at the same time?\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Which targets are the tumor cells expressing now?\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Are targets such as CD19 and CD22 that were previously usable still present?\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">What treatment can the patient tolerate at this point?\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Platelet count, immune function, organ status, and damage from previous therapies can all change what is feasible next.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Could this step affect the options that come after it?\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Treatment needs to control the disease as much as possible while also preserving the patient's ability to move on to the next stage of care.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">In May 2026, testing again showed disease progression, with a higher proportion of abnormal cells in the bone marrow and new lesions on PET-CT. Instead of repeating approaches that had already stopped working, the team used the latest target-testing results to switch to inotuzumab ozogamicin combined with targeted therapy.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">After the first cycle, abnormal cells in peripheral blood fell markedly. At the June follow-up, peripheral blood immunophenotyping temporarily showed no abnormal population.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">The treatment also caused a further drop in platelets, so the team adjusted the treatment schedule again and replanned the next steps. This was still not the endpoint, but it showed that even as the disease changed, there were still directions worth exploring.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>\u003Cbr\u002F>\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>In Long-Term Treatment, It Is Not Only About the Tumor - It Is Also About Whether the Patient Can Keep Going\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Over the years, Ms. Wang has already gone through many different treatments. In addition to the disease itself, she has had to deal with repeated testing, treatment side effects, financial pressure, and the psychological impact of one progression after another.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">One thing she values about working with the team is that the doctors do not look only at tumor markers on a report. They also ask whether she can still eat, sleep, and move normally; whether her blood counts can support the next treatment; and whether the financial and physical burden of the current plan is manageable. Dr. Yajing Zhang once even gave her a small duck mascot nicknamed "Turn Negative" - a lighthearted good-luck charm for better test results.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Whenever a test result is disappointing, the team explains why the plan needs to change and what options may still remain, rather than simply saying, "We will try another regimen." That kind of understanding and communication has helped Ms. Wang keep moving forward after repeated setbacks.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cstrong>\u003Cspan style=\"font-size: 16px;\">She Is Still in Treatment, but She No Longer Treats Every Test Report as a Final Verdict\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Ms. Wang's weight has now recovered from a low of about 45 kg to more than 55 kg. Her energy, stamina, and appetite have also improved compared with when she first arrived at the hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">She is still receiving treatment and undergoing dynamic follow-up. The disease has not ended, and there is still considerable uncertainty. But unlike before, she no longer sees the next test report as a "verdict" that decides everything.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Looking back over the past six years, there are three things she most wants to share with other patients:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q: If one treatment does not work as expected, does that mean there are no other options?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Not necessarily.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">In relapsed or refractory lymphoma, disease status, target expression, and the patient's physical condition can all change after each treatment. The next step needs to be based on a new assessment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Ms. Wang has experienced multiple treatment challenges: failure of autologous CAR-T cells to expand, a universal CAR-T response that was not durable, and only brief expansion after CD22 CAR-T. Each time, the team returned to the latest test results to look for another potentially usable treatment direction.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q: Why does relapsed or refractory lymphoma require repeated target testing?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Because the tumor does not stay the same.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Ongoing treatment can create selective pressure on the tumor, changing target expression and clonal composition. A target that was present before may later decrease or change, so after progression the treatment direction needs to be reconsidered using updated test results.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q: During long-term treatment, what matters besides controlling the tumor?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Blood counts, infection, organ function, nutrition, physical strength, and whether the patient can tolerate the next stage of treatment all matter.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">For patients with complex relapsed disease, keeping the patient well enough to remain eligible for treatment - and creating an opportunity for the next effective intervention - is itself an important long-term goal.\u003C\u002Fspan>\u003C\u002Fp>","Case Commentary by Dr. Fangfang Cheng, Attending Physician: \nMs. Wang has a typical case of relapsed or refractory follicular lymphoma, but the difficulty of her treatment is substantially greater than in many other patients who have relapsed after multiple lines of therapy.\nShe has had a long disease course and many prior lines of treatment, with recurrent involvement of the bone marrow and spleen. By the time she transferred to our hospital, she had a high tumor burden together with significant thrombocytopenia, impaired immune function, and poor lymphocyte quantity and function.\nThese factors not only affect drug efficacy; they also directly limit cell collection, manufacturing, expansion in the body, and the range of subsequent treatment options.\nThe team first reduced the tumor burden to create better conditions for cellular therapy. When the autologous CD19 CAR-T cells failed to expand effectively, we used the treatment window available at the time to transition promptly to universal CD19 CAR-T, which temporarily improved both splenomegaly and blood counts.\nLater, massive splenomegaly and thrombocytopenia became the main barriers to continuing treatment, so the team facilitated total splenectomy. After surgery, her fever, night sweats, blood counts, weight, and quality of life all improved, and she became physically able to proceed with CD22 CAR-T and subsequent sequential therapy.\nSince then, we have continued adjusting treatment according to peripheral blood, bone marrow, imaging, and target-expression results rather than mechanically repeating previous regimens. A recent new treatment led to a marked drop in abnormal cells in peripheral blood, but close dynamic follow-up is still needed.\nThis case shows that the goal in complex relapsed disease cannot be reduced to any one drug or any one cell infusion. The more important task is to identify the key problem at each stage, control the tumor while managing infection, blood counts, and organ function, and preserve the patient's treatment fitness as much as possible so there is still an opportunity for the next effective intervention.\nThe long-standing trust, understanding, and cooperation of the patient and her family have also been essential in allowing this journey to keep moving forward.\n\nCommentary by Dr. Yajing Zhang: Do Not Predetermine the Endpoint - Keep Looking for Better Options as the Disease Changes\nFollicular lymphoma is generally considered an indolent lymphoma with a relatively slow course and multiple treatment options. But having \"many options\" does not mean that every patient will achieve a long and stable remission.\nMs. Wang had Stage IV disease with bone marrow involvement at diagnosis and progressed soon after first-line immunochemotherapy. Her responses to several subsequent treatments with different mechanisms were short-lived, showing that her lymphoma had strongly refractory features.\nAs the number of prior treatments increased, she gradually developed a high tumor burden, massive splenomegaly, bone marrow involvement, thrombocytopenia, immunoglobulin deficiency, reduced lymphocyte number and function, and changes in tumor targets and phenotype.\nThe team was therefore not facing a single question of \"which drug should we choose?\" We were dealing with a system in which disease biology, damage from previous treatment, and the patient's overall ability to tolerate therapy were all intertwined.\nFor a patient like this, treatment cannot be understood as a series of isolated regimens, and hope cannot be placed entirely on any single cell infusion.\nThe core approach is full-course sequential management: first identify the most important problem at the current stage, then consider how tumor reduction, targeted therapy, antibody therapy, cellular therapy, surgery, and supportive care can work together to create the conditions for the next step.\nWhen Ms. Wang's autologous CD19 CAR-T cells failed to expand effectively, we used the treatment window at that time to transition promptly to universal CAR-T, which still produced meaningful splenic shrinkage and improved blood counts.\nThe subsequent splenectomy was not simply a replacement for drug therapy. It was intended to relieve the bottleneck created by massive splenomegaly and blood-cell consumption, improve her overall condition, and reopen treatment options.\nAnother defining feature of relapsed or refractory lymphoma is that the tumor is not static.\nTreatment creates selective pressure. Target expression, clonal composition, and the tumor microenvironment can all change as a result. That is why every progression requires a new assessment rather than a plan based only on the original pathology label or previous target results.\nThe team must keep asking four questions:\n·Where is the disease mainly active now?\n·What are the tumor cells expressing now?\n·What can the patient tolerate now?\n·Could this treatment step affect what can be done next?\nCellular therapy also cannot be judged only by whether a target is present.\nCell source and quality, the effect of prior treatment on T cells, whether the cells can expand and persist in the body, tumor burden, the immune microenvironment, and infection risk can all influence the outcome.\nFailure of one cell product to expand does not mean that every cellular therapy will fail. Likewise, one remission does not mean that monitoring can stop.\nTrue individualized care means putting all of these variables on the same treatment map and reprioritizing them as the patient's condition changes, rather than simply stacking one therapy on top of another.\nThe team also pays close attention to the patient's overall condition.\nBeyond disease control, the ability to eat, sleep, and remain active; whether blood counts can support the next treatment; whether infections can be prevented; whether the patient understands the plan; and whether the financial and psychological burden is manageable all influence how far long-term treatment can go.\n\"Not giving up\" does not mean promising that every treatment will work, and it does not mean adding more therapy when there is no evidence to support it.\nAs long as the patient still wishes to continue and there remains a medically reasonable opportunity to intervene, the team will keep looking for a more appropriate next step through scientific assessment, risk control, and full communication. Even when treatment needs to slow down, we try to preserve the patient's ability to keep living - and to keep having choices.\nFor relapsed or refractory lymphoma, the most meaningful kind of persistence is to keep identifying problems as they change, create the conditions for the next step, and continue walking this long road together with the patient.",{"slug":85,"title":86,"summary":87,"cover":88,"disease":89,"treatment":90,"patientType":91,"publishedAt":81,"contentHtml":92,"disclaimer":70,"hasAlternate":71,"updatedAt":72},"childhood-b-all-car-t-five-year-recovery","Five Years After CAR-T for Relapsed Leukemia, He's Now the Fastest Runner in His Class","Keke (pseudonym) was diagnosed with leukemia before the age of two. After relapse in the bone marrow and both testes, he received CAR-T ","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F5bdd781f2c320daaa52809289ccd4685.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","B-Cell Acute Lymphoblastic Leukemia"," CAR-T","Child","\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">Summary: Keke was diagnosed with B-cell acute lymphoblastic leukemia (B-ALL) before he turned two. After nearly three and a half years of treatment, he stopped therapy, only to develop a bone marrow relapse with leukemic involvement of both testes a little over six months later. After the relapse, his family began actively exploring new treatment options. Following medical evaluation, Keke received sequential CD19 and CD22 CAR-T cell therapy, followed by consolidation treatment. He also faced infectious complications after CAR-T, including Pneumocystis jirovecii pneumonia (PJP), but gradually recovered with appropriate treatment and long-term follow-up. Now, five years after CAR-T therapy, Keke is back at school. He loves PE, running, and badminton, and has begun imagining what he wants to be when he grows up.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-bottom: 13px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Ch2 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);text-align: center\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>\u003Cspan style=\"font-size: 16px; color: rgb(0, 0, 0);\">Leukemia Relapsed Just Over Six Months After Treatment Ended\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fh2>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Keke was diagnosed with B-cell acute lymphoblastic leukemia before he was two years old.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">For nearly three and a half years, he received chemotherapy according to his treatment plan. Overall, the course went relatively smoothly. After treatment ended, Keke was eating well, running around, and full of energy. To anyone looking at him, he seemed just like any other child.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">The family thought the long treatment journey was finally behind them. But a little over six months later, before Keke's mother returned to work, she decided to take him for a comprehensive follow-up. The results brought news no one had expected: the leukemia had relapsed.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong> \u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">The relapse involved not only the bone marrow, but also leukemic infiltration of both testes.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">"When he was first diagnosed, we knew childhood leukemia could often be treated successfully. We were scared, of course, but we still felt that if we followed the treatment plan, things would work out. We never imagined the leukemia would come back only a little over six months after he stopped treatment." This time, the situation was more complex than at initial diagnosis.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cstrong style=\"font-size: 15px; color: rgb(15, 71, 97); text-align: center;\">\u003Cspan style=\"font-size: 16px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Ch2 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);text-align: center\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>\u003Cspan style=\"font-size: 16px; color: rgb(0, 0, 0);\">Why Did the Family Start Looking Into CAR-T After Relapse?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fh2>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">During Keke's initial treatment, his mother mostly followed the medical team's plan step by step and did not actively research many other treatment options.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">Once the leukemia relapsed, she gradually realized that the decisions ahead would be very different from those they had faced during first-line treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">She began looking for information on her own, speaking with other parents, and learning more about treatment options that might be considered for children with relapsed leukemia.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">"At the time, we had very limited access to information. We didn't know which children had been through relapse, or even who we should ask. Eventually, we found two families with similar experiences. Both had gone to Beijing, and that was when we started looking there too."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">Through conversations with other families, consultations with different doctors, and formal medical evaluation, the family gradually learned about CAR-T cell therapy.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">Keke's mother asked very practical questions: "How many children have you treated? Have you seen cases similar to ours? What were the outcomes?"\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">Other families' experiences helped broaden what they knew, but she also came to understand an important point: every child's disease biology, site of relapse, previous treatment, and overall condition are different. Another patient's treatment journey can be useful for learning, but it cannot simply be copied.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong> \u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">After gathering more information and completing further evaluation, the family decided to seek treatment from Dr. Jing PAN's team.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-bottom: 13px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Ch2 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);text-align: center\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>\u003Cspan style=\"font-size: 16px; color: rgb(0, 0, 0);\">With Relapse in Both the Bone Marrow and Testes, Where Did CAR-T Fit Into the Treatment Plan?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fh2>\u003Cp>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">After arriving in Beijing, the medical team carried out a comprehensive assessment, taking into account Keke's bone marrow relapse, bilateral testicular leukemic involvement, and previous treatment history.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">The team first used treatment to bring the disease under control. Once remission was achieved, Keke moved on to CAR-T therapy.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">He subsequently received CD19 CAR-T followed by CD22 CAR-T, and then completed additional consolidation treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">After CAR-T cell infusion, Keke developed lower blood counts and a mild fever. Before treatment began, however, the doctors had already explained the reactions that might occur, which symptoms the family should watch for, and what would happen if a problem arose. So when these issues did appear, the family was still anxious, but no longer felt completely unprepared.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">Every day, Keke's mother recorded his temperature, energy level, and any physical changes. She followed the team's guidance on diet, medications, and daily care, and reported anything unusual promptly.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">She later reflected: "Parents don't have to force themselves to understand every piece of medical knowledge. What really matters is knowing what stage of treatment your child is in, what the doctors want you to watch for, and which changes need to be reported right away. Doing those things well is already very important."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-bottom: 13px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Ch2 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);text-align: center\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>\u003Cspan style=\"font-size: 16px; color: rgb(0, 0, 0);\">Why Does Infection Prevention Still Matter After CAR-T?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fh2>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">About five months after his first CAR-T infusion, Keke suddenly developed a high fever.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">He had seemed completely well that morning, but by the afternoon he was running a high fever, without obvious respiratory symptoms such as cough or a runny nose.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">For the first two days, the cause was unclear. Considering Keke's stage of treatment and medical history, Dr. Jing PAN's team carried out further evaluation for infection. He was ultimately diagnosed with Pneumocystis jirovecii pneumonia (PJP).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">The infection kept Keke in the hospital for 23 days. Looking back, his mother feels the family may have relaxed their precautions a little too soon.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">"He looked no different from a healthy child, so we thought he had probably recovered quite well. We even took him to the park to play in the sand."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">The experience made the family understand more clearly that looking well and feeling energetic after CAR-T does not necessarily mean the immune system has fully recovered.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">During the recovery period recommended by the medical team, infection precautions, food hygiene, and a clean environment may still be important. If a child develops an unexpected fever or other concerning symptoms, the family should contact the treating team or seek medical care promptly. When normal activities can gradually resume should be decided according to follow-up results and the treating physician's assessment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Ch2 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);text-align: center\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>\u003Cspan style=\"font-size: 16px; color: rgb(0, 0, 0);\">Five Years After CAR-T, He's Back on the Playground\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fh2>\u003Cp>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">After treatment ended, Keke's mother did not rush to send him straight back to school. Instead, she let him rest at home for another year. "I wanted him to recover as fully as possible first. One more year didn't matter."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">When Keke first returned to school, he still wore a mask. At first, his mother was also hesitant to let him join PE classes, although Keke himself loved being active.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">As his health became more stable, he gradually returned to normal physical activity. His mother also spoke with his teacher and said, "Just treat him like any other child. He doesn't need to be singled out."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">Now, five years after CAR-T therapy, PE is Keke's favorite class, and he also loves badminton. What makes his mother especially happy is that the little boy who once spent so much of his childhood in treatment is now one of the fastest runners in his class.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">When asked what he wants to be when he grows up, he answers seriously, "A soldier." He says he was impressed by how strong and proud the soldiers looked when he watched a military parade on television.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">Chemotherapy, follow-up visits, infections, and treatment once dominated the family's conversations. Today, they talk much more about school, PE, badminton, and what Keke might want to do in the future.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">It is the ordinary family life they once hoped so deeply to have again.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-bottom: 13px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Ch2 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);text-align: center\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>\u003Cspan style=\"font-size: 16px; color: rgb(0, 0, 0);\">Five Lessons Keke's Mother Would Like to Share with Other Families\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fh2>\u003Ch2 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>\u003Cspan style=\"font-size: 16px; color: rgb(0, 0, 0);\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fh2>\u003Ch2 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>\u003Cspan style=\"color: rgb(0, 0, 0);\">Q: After a child's leukemia relapses, how can parents look for reliable information about new treatment options?\u003C\u002Fspan>\u003C\u002Fstrong>\u003Cstrong>\u003Cspan style=\"color: rgb(0, 0, 0);\">\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fh2>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Relapsed disease may be very different from newly diagnosed leukemia, and treatment decisions can become more complex. Keke's mother suggests staying in close communication with the treating physician while also learning about the disease, experienced medical teams, and newer treatment developments, so that families are not left feeling powerless simply because they lack information.\u003C\u002Fspan>\u003C\u002Fp>\u003Ch2 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>\u003Cspan style=\"font-size: 16px; color: rgb(0, 0, 0);\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fh2>\u003Ch2 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>\u003Cspan style=\"font-size: 16px; color: rgb(0, 0, 0);\">Q: Can another family's treatment experience be used as a direct guide for your own child?\u003C\u002Fspan>\u003C\u002Fstrong>\u003Cstrong>\u003Cspan style=\"font-size: 16px; color: rgb(0, 0, 0);\">\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fh2>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Other families' experiences can help parents discover treatment options they may not have known about, but they should not be treated as a ready-made plan for another child.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">Children can differ in disease subtype, site of relapse, target antigen expression, previous treatment, and overall health. The treatment plan still needs to be individualized by an experienced medical team.\u003C\u002Fspan>\u003C\u002Fp>\u003Ch2 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>\u003Cspan style=\"font-size: 16px; color: rgb(0, 0, 0);\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fh2>\u003Ch2 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>\u003Cspan style=\"font-size: 16px; color: rgb(0, 0, 0);\">Q: If leukemia relapses outside the bone marrow, such as in the testes, does that automatically mean CAR-T is needed?\u003C\u002Fspan>\u003C\u002Fstrong>\u003Cstrong>\u003Cspan style=\"font-size: 16px; color: rgb(0, 0, 0);\">\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fh2>\u003Cp>\u003Cspan style=\"font-size: 15px;\">No. Not every child with relapsed leukemia needs CAR-T therapy.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">For children with relapse involving both the bone marrow and an extramedullary site such as the testes, the medical team needs to consider the location of relapse, disease burden, previous treatment, target antigen expression, and other clinical factors.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">CAR-T became an important part of Keke's treatment, but whether CAR-T is appropriate for a particular child should be decided individually by a team with relevant experience.\u003C\u002Fspan>\u003C\u002Fp>\u003Ch2 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>\u003Cspan style=\"font-size: 16px; color: rgb(0, 0, 0);\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fh2>\u003Ch2 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>\u003Cspan style=\"font-size: 16px; color: rgb(0, 0, 0);\">Q: If a child looks back to normal after CAR-T, do infection precautions still need to continue?\u003C\u002Fspan>\u003C\u002Fstrong>\u003Cstrong>\u003Cspan style=\"font-size: 16px; color: rgb(0, 0, 0);\">\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fh2>\u003Cp>\u003Cspan style=\"font-size: 15px;\">Yes, precautions may still be needed depending on the child's immune recovery.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">Keke developed Pneumocystis jirovecii pneumonia about five months after CAR-T. A child may look and feel much better before the immune system has fully recovered. During the period advised by the medical team, families may still need to pay attention to masking, environmental hygiene, food safety, and unexpected fever or other signs of infection.\u003C\u002Fspan>\u003C\u002Fp>\u003Ch2 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>\u003Cspan style=\"font-size: 16px; color: rgb(0, 0, 0);\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fh2>\u003Ch2 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>\u003Cspan style=\"font-size: 16px; color: rgb(0, 0, 0);\">Q: Do parents need to understand every medical detail about CAR-T?\u003C\u002Fspan>\u003C\u002Fstrong>\u003Cstrong>\u003Cspan style=\"font-size: 16px; color: rgb(0, 0, 0);\">\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fh2>\u003Cp>\u003Cspan style=\"font-size: 15px;\">No. Parents do not need to put that kind of pressure on themselves.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">More important than mastering every technical detail is understanding what stage of treatment the child is in, what symptoms need to be watched, when the medical team should be contacted immediately, and how to maintain clear communication with the child's doctors.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-bottom: 13px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Ch2 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);text-align: center\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>\u003Cspan style=\"color: rgb(0, 0, 0);\">From the Hospital Ward to the Playground: A Child's Life Is About More Than Treatment\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fspan>\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>\u003Cspan style=\"font-size: 16px; color: rgb(0, 0, 0);\">\u003C\u002Fspan>\u003C\u002Fstrong>\u003Cstrong>\u003Cspan style=\"font-size: 16px; color: rgb(0, 0, 0);\">\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fh2>\u003Cp>\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px;\">From being diagnosed with B-cell acute lymphoblastic leukemia before the age of two, to relapsing after treatment, receiving CAR-T therapy, facing a serious infection, and going through a long recovery, Keke and his family have traveled a very long road.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">Today, treatment is no longer the center of this child's life.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">He is back in the classroom and out on the playground, joining PE with his classmates, playing badminton, and seriously imagining what he might want to become when he grows up.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">For children and parents who are still in treatment, there may still be procedures, tests, and long periods of waiting ahead. But illness is only one part of a child's story. It does not mean they have lost the chance to have a future.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px;\">They can still return to school, make new friends, discover new interests, and gradually build a life that belongs to them.\u003C\u002Fspan>\u003C\u002Fp>",{"slug":94,"title":95,"summary":96,"cover":97,"disease":98,"treatment":99,"patientType":67,"publishedAt":81,"contentHtml":100,"expertView":101,"disclaimer":70,"hasAlternate":71,"updatedAt":72},"mds-haploidentical-transplant-one-year-recovery","Diagnosed with High-Risk MDS at 53, She Marks One Year of Recovery After a Haploidentical Transplant","After being diagnosed with high-risk MDS, Ms. Jiang underwent a haploidentical allogeneic stem cell transplant using her son as the donor. One year later, she remains in remission and is gradually returning to everyday life.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F261bb11b36a5f535ae679f4c43154296.jpg?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","Myelodysplastic Syndrome","Hematopoietic Stem Cell Transplantation","\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">Summary: In 2025, 53-year-old Ms. Jiang (pseudonym) sought medical care after developing difficulty walking and a persistent roaring sensation in her head. She was ultimately diagnosed with myelodysplastic syndrome (MDS), subtype MDS-IB2, and was assessed as high risk. After a comprehensive evaluation, she underwent a related haploidentical allogeneic hematopoietic stem cell transplant in July, with her son as the donor. Her blood production recovered successfully after transplant. At the one-month follow-up, she was in complete remission with 99.49% donor chimerism. Recovery was not completely smooth, and she experienced an infection after leaving the transplant unit. Now one year post-transplant, her immune system has reconstituted well, she is off immunosuppressive therapy, and she has shown no signs of graft-versus-host disease (GVHD). Looking back, her message to other patients is simple: trust an experienced medical team, follow the treatment plan, and do not relax infection precautions too early just because you start feeling better.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">In June 2025, 53-year-old Ms. Jiang went to the hospital after developing difficulty walking and a persistent roaring sensation in her head.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">After a routine blood test showed abnormalities, she underwent a bone marrow examination and was ultimately diagnosed with myelodysplastic syndrome (MDS).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">The diagnosis came without warning. At first, she even asked her doctor, "How long would I have if I did not get treated?" But when the doctor told her that the disease could be treated, her fear gradually gave way to a clearer thought: if there was a treatment option, she would give it her best. Based on her age, disease subtype, and risk assessment, the medical team recommended proceeding with allogeneic hematopoietic stem cell transplantation as soon as possible.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">In July 2025, Ms. Jiang underwent a related haploidentical allogeneic hematopoietic stem cell transplant at GoBroad Shanghai Liquan Hospital, with her son as the donor.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">Neutrophil engraftment was achieved on day +20. At the one-month follow-up, her disease was in complete remission, with donor chimerism of 99.49%. She is now one year post-transplant.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">Ms. Jiang has achieved good immune reconstitution, has discontinued immunosuppressive therapy, and has shown no signs of graft-versus-host disease (GVHD). She has returned to a familiar rhythm of life and is willing to share what she has learned over the past year with other patients preparing for transplant.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Ch2 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);text-align: center\">\u003Cspan style=\"color: rgb(0, 0, 0); font-size: 16px;\">\u003Cstrong>Why Did She Choose Hematopoietic Stem Cell Transplantation After an MDS Diagnosis?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fh2>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Ch3 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">\u003Cstrong>Q: How did you first realize something was wrong?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fh3>\u003Cp>\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">\u003Cstrong> \u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">\u003Cstrong>A: In June 2025, it started with difficulty walking. Then I developed this constant roaring sensation in my head, so I went to the hospital. My blood test was abnormal, and the doctor asked me to have a bone marrow examination. That was when I was diagnosed with myelodysplastic syndrome.\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">I had always been healthy, so it came completely out of the blue. I felt lost when I was first diagnosed. I even asked the doctor how long I might live if I chose not to be treated.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">The doctor told me the disease could progress quickly without treatment. My younger sister was so frightened that her legs went weak. In the end, I was the one helping her walk out of the consultation room.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">Later, my son started looking up information online and learned that hematopoietic stem cell transplantation could offer better treatment outcomes for some people with MDS. He told me, "Mom, this can be treated. Let us go for the transplant."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">After we came to the hospital, the doctors looked at my age and the details of my disease and recommended that I have the transplant as soon as possible. Hearing the words "it can be treated" actually made me feel calmer. My thinking was very simple: if the doctors said there was a way forward, then I would take it.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Ch2 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);text-align: center\">\u003Cspan style=\"color: rgb(0, 0, 0); font-size: 16px;\">\u003Cstrong>Before Transplant, the Most Important Thing Was Understanding the Risks\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fh2>\u003Ch3 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fh3>\u003Ch3 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">Q: The doctors explained many risks and precautions before transplant. Were you frightened?\u003C\u002Fspan>\u003C\u002Fh3>\u003Cp>\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">\u003Cstrong> \u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">\u003Cstrong>A: We came to GoBroad Shanghai Liquan Hospital in July 2025. Before the transplant, Dr. Su Li sat down with me and explained the entire allogeneic hematopoietic stem cell transplant process in detail, including what might happen at different stages.\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">The informed consent documents were a thick stack.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">To be honest, I may not have understood every medical detail. But what mattered most to me was that the doctors explained in advance what could happen. That way, when something did happen, I was less likely to panic.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">For example, Dr. Li told me that I might develop a fever while my blood counts were recovering. And sure enough, I had a low-grade fever for several days when my cells started to come back.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">Because the doctors had already explained it, I paid attention to the fever, but I was not especially scared.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">For me, having a general understanding of the transplant process and knowing how the doctors would respond was much more reassuring than staring at every test report and worrying about what each number might mean.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Ch2 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);text-align: center\">\u003Cspan style=\"color: rgb(0, 0, 0); font-size: 16px;\">\u003Cstrong>In the Transplant Unit, What Reassured Me Most Was Knowing the Doctors Knew What to Expect Next\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fh2>\u003Ch3 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fh3>\u003Ch3 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">Q: What stands out most from your time in the transplant unit?\u003C\u002Fspan>\u003C\u002Fh3>\u003Cp>\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">\u003Cstrong> \u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">\u003Cstrong>A: I spent about a month in the transplant unit. After the stem cell infusion, I got anxious when my white blood cell count still had not risen by day 12. I asked Dr. Jun Zhu, "Why is it still not going up?"\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">Dr. Zhu told me to wait another two days. If it still had not risen, they would consider medication to stimulate white blood cell recovery. Then on day 14, my white blood cell count really did start to rise.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">I was amazed and asked him, "How did you predict that so accurately?" He joked, "I wrote this script - I am the director." I still remember that line today.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">For patients, so much of this is happening for the first time, and every change in a blood count can be stressful. But experienced doctors recognize the patterns. They know when it is appropriate to watch and wait and when it is time to intervene.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">That kind of clinical judgment gives patients a real sense of security. Over time, I came to feel that I did not need to understand every line of every report myself. It was more reassuring to follow the treatment plan, cooperate with the team, and ask my doctors whenever I had questions.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Ch2 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);text-align: center\">\u003Cspan style=\"color: rgb(0, 0, 0); font-size: 16px;\">\u003Cstrong>Feeling Better After Leaving the Transplant Unit Does Not Mean Infection Precautions Can Stop\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fh2>\u003Ch3 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fh3>\u003Ch3 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">Q: During recovery after transplant, what do you think patients need to pay the most attention to?\u003C\u002Fspan>\u003C\u002Fh3>\u003Cp>\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">\u003Cstrong> \u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">\u003Cstrong>A: At first, things went quite smoothly when I moved from the transplant unit to the general ward. I felt so well that day that I thought I could walk there myself, but the care staff still insisted on taking me in a wheelchair.\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">Looking back, I was a little too relaxed. I felt well, I had plenty of energy to talk, and wearing a mask was uncomfortable, so I took it off. I also walked around the hallway and used the elevator by myself.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">I developed an infection soon afterward. It took more than ten days to get through it, and for at least a week I could barely even drink water. So if I could give one piece of advice to patients who have just left the transplant unit, it would be this: feeling physically well does not mean your immune system has recovered.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">\u003Cstrong> \u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">Especially early after leaving the transplant unit, do not relax precautions such as masking, environmental hygiene, and food safety simply because you feel better. Around day 100 after transplant, I wanted to return to my hometown in Jiangxi.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">Dr. Li agreed that I could go home, but asked me to come back for follow-up every two weeks. He also recommended having a family member drive me to reduce infection exposure during the journey. I really appreciated that approach.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">The doctors did not simply tell me, "You cannot do this" or "You cannot do that." Instead, they tried to help me live as normally as possible while still keeping safety first.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Ch2 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);text-align: center\">\u003Cspan style=\"color: rgb(0, 0, 0); font-size: 16px;\">\u003Cstrong>After Returning Home, Food Safety, Hygiene, and Regular Follow-Up All Matter\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fh2>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Ch3 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">Q: What do you pay the most attention to in everyday life at home?\u003C\u002Fspan>\u003C\u002Fh3>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">\u003Cstrong>A: For me, the two most important things are keeping food clean and keeping the living environment hygienic. We have a little child at home who is just over one year old.\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">At first I was so weak that I could not even pick the child up. Around nine or ten months after transplant, I gradually became strong enough to hold him again. He likes to run into my room at night, so I ask him to bathe and get clean before coming in.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">I am just as careful with food. After all, it goes directly into my body, so I do not take chances.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">Of course, exactly how strict you need to be and when precautions can gradually be relaxed should always be discussed with your treating doctor. Everyone recovers at a different pace, so you cannot simply copy another patient's experience.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Ch2 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);text-align: center\">\u003Cspan style=\"color: rgb(0, 0, 0); font-size: 16px;\">\u003Cstrong>One Year After Transplant, She Feels Life Is Gradually Coming Back\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fh2>\u003Ch3 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fh3>\u003Ch3 style=\"margin-top: 11px;margin-bottom: 5px;break-after: avoid;color: rgb(15, 71, 97);\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">Q: After going through a serious illness, do you feel different from the person you were before?\u003C\u002Fspan>\u003C\u002Fh3>\u003Cp>\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">\u003Cstrong> \u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">\u003Cstrong>A: People often say that a serious illness changes you completely. But I still feel like myself. Sometimes I even feel as though I was never sick.\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">I also chat with other patients in support groups now. If someone asks about my experience, I share what I know. The main thing I want to tell them is very simple: there will be frightening moments and setbacks during treatment, but do not let one difficult stage convince you that there are no possibilities ahead.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">From diagnosis through transplant, I never cried because I was afraid. Now, when I do tear up sometimes, it is more often because I am moved by the people I met and the help I received along the way.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">Illness is a difficult chapter in life, but it is not the whole story. Once you get through that chapter, life still moves forward.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">\u003Cstrong>Q: Does every patient with MDS need a hematopoietic stem cell transplant?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">No. Not every patient with MDS needs hematopoietic stem cell transplantation.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">The decision depends on multiple factors, including the MDS subtype, risk category, age, overall health, and whether a suitable donor is available.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">Ms. Jiang had MDS-IB2 and was assessed as high risk, so her medical team recommended allogeneic hematopoietic stem cell transplantation.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">\u003Cstrong>Q: Can a haploidentical family donor be used for an allogeneic hematopoietic stem cell transplant?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">For some patients, a related haploidentical donor can be used for allogeneic hematopoietic stem cell transplantation after a comprehensive evaluation.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">Ms. Jiang's son served as her donor, and she successfully achieved hematopoietic reconstitution after transplant.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">\u003Cstrong>Q: Why is infection prevention still so important after leaving the transplant unit?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">Leaving the transplant unit means that blood cell production has begun to recover, but immune recovery usually takes much longer.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">So even if a patient already feels much stronger and more energetic, masking, food safety, environmental hygiene, and scheduled follow-up remain important during the recovery period recommended by the medical team.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">\u003Cstrong>Q: If a patient reaches complete remission after transplant, does that mean no further treatment is needed?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">Not necessarily.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">For some high-risk patients, doctors may recommend maintenance therapy and long-term follow-up based on the risk of the underlying disease and the patient's recovery after transplant.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top: 12px;margin-bottom: 12px;\">\u003Cspan style=\"font-size: 15px; color: rgb(0, 0, 0);\">Ms. Jiang started decitabine maintenance therapy three months after transplant and continues to receive long-term follow-up as planned.\u003C\u002Fspan>\u003C\u002Fp>","Dr. Su Li (Associate Chief Physician, MD; Director, Department of Hematology, GoBroad Shanghai Liquan Hospital; Director, Myeloma Center): \nWhy Should Allogeneic Hematopoietic Stem Cell Transplantation Be Considered for High-Risk MDS?\nMs. Jiang came to GoBroad Shanghai Liquan Hospital in June 2025 with fatigue and dizziness. Laboratory testing showed severe anemia and leukopenia. To identify the cause, she underwent a bone marrow examination. Bone marrow smear morphology showed that blasts and immature monocyte-like cells accounted for 18.5%.\n\nBased on her clinical presentation and laboratory findings, she was diagnosed with myelodysplastic syndrome (MDS), subtype MDS-IB2.\n\nRisk assessment placed her in the very-high-risk category under IPSS-R and the high-risk category under IPSS, providing a clear indication for allogeneic hematopoietic stem cell transplantation.\n\nHer son was selected as the donor and successfully completed the pre-transplant evaluation.\n\nOn July 18, 2025, Ms. Jiang began conditioning in the transplant unit. On July 24, her son's allogeneic hematopoietic stem cells were infused.\n\nDuring transplant, she experienced gastrointestinal reactions and manifestations related to bone marrow suppression. Neutrophil engraftment was achieved on day +20, marking successful hematopoietic reconstitution.\n\nA bone marrow examination one month after transplant confirmed complete remission, with donor chimerism of 99.49%.\n\nAfter completing the initial transplant phase, Ms. Jiang was discharged and continued regular outpatient follow-up. As instructed, she took immunosuppressive therapy together with antiviral and antifungal prophylaxis.\n\nBecause her MDS was high risk, decitabine maintenance therapy was started three months after transplant to reduce the risk of relapse.\n\nMs. Jiang is now one year post-transplant. Her immune system has reconstituted well, she has discontinued immunosuppressive therapy, and she has shown no signs of graft-versus-host disease (GVHD).\n\nShe will continue to be monitored and managed according to her post-transplant follow-up plan.",{"slug":103,"title":104,"summary":105,"cover":106,"disease":89,"treatment":107,"patientType":91,"publishedAt":108,"contentHtml":109,"disclaimer":70,"hasAlternate":71,"updatedAt":72},"childhood-all-blood-leukemia-survivor-story","Five Years On: From Childhood Leukemia to Moyamoya Disease - A Mother's Practical Lessons from the Journey","Diagnosed with B-cell acute lymphoblastic leukemia at age three and a half, Xiaojin completed nearly three years of treatment and achieved long-term remission. During recovery, he was also diagnosed with moyamoya disease, underwent surgery, and has now returned to school.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002Fd30fb548a8783028b45a2127a78cc178.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","Chemotherapy","2026-08-07","\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Summary: \u003C\u002Fspan>\u003Cspan style=\"font-size: 15px;\">A routine preschool health check first revealed an abnormal blood count in three-and-a-half-year-old Xiaojin (pseudonym), leading to a diagnosis of B-cell acute lymphoblastic leukemia. He went through chemotherapy, serious infection, and other treatment-related challenges, ultimately completing standard therapy and entering long-term remission. During recovery, a new set of symptoms led to another unexpected diagnosis: moyamoya disease, a rare cerebrovascular condition, for which he underwent surgery. Five years later, Xiaojin is growing well and back at school. Along the way, his mother has gone from an ordinary parent suddenly facing a frightening diagnosis to someone who has learned how to understand disease, manage treatment, ask questions, and support other families on the same road.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>One Blood Test Changed Everything\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Xiaojin is my only child. Before he was three and a half, he had hardly ever been sick. I never imagined that a routine preschool health check would change the course of our entire family's life.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">On August 7, 2021, I took him for his preschool health check. When I saw the complete blood count, my heart sank: his hemoglobin was only 86 g\u002FL, showing moderate anemia. The doctor simply told us that his blood results did not meet the requirement and that they could not issue the health certificate he needed to start preschool.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The next day was my birthday. All seven members of our family went away to a hot-spring resort. It was the last trip we would ever take together as a complete family. Even sitting in the warm water, I couldn't stop thinking about that test report with all the abnormal arrows.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">On Monday, I immediately took my husband and Xiaojin to a tertiary hospital for repeat testing. The results were worse. After examining his abdomen, the doctor told us, "He needs to be admitted. There is a very high chance this is leukemia."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The moment I heard the word leukemia, everything started ringing in my ears. Earlier that year, my mother-in-law had been diagnosed with advanced stomach cancer. Within a single year, two serious illnesses had hit our ordinary family.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">We didn't dare tell my mother-in-law. She had waited so many years for this grandson. At that point, I didn't even have time to cry. I had only one thought: we needed to transfer him somewhere with the right expertise.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>Our First Decision After Diagnosis: Find the Right Pediatric Leukemia Team\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In fact, blood disorders had crossed my path once before. In 2019, when Xiaojin was just over a year old, I saw a post on Weibo about a child three months younger than him who had juvenile myelomonocytic leukemia (JMML), a particularly aggressive childhood blood cancer. I started making a small donation every month and continued for two years.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">That child was treated at what is now GoBroad Chunfu Institute of Hematology & Oncology in Dongguan and recovered well. At the time, I simply thought I was helping another family and quietly remembered the hospital's reputation. I never imagined that two years later, that small connection would help point the way for my own son.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Before all of the bone marrow, genetic, and MRD results were even back, we had already decided to transfer. After five days at the local hospital, we discharged him and went straight to Dongguan. My mother thought I would be crying so hard I couldn't stand, but I didn't. Crying wasn't going to help. My first job was to get my child to a team that knew how to treat him.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Xiaojin was ultimately diagnosed with B-cell acute lymphoblastic leukemia. Dr. Huaying LIU developed a detailed treatment plan for him, beginning what would become a nearly three-year journey.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002Fb5a1bdc30718d301a55c37ced16486e6_20260913164821.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"b5a1bdc30718d301a55c37ced16486e6_20260913164821.png\" alt=\"131925eb-63a0-4e79-9491-20d14bb273e0.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">Photo courtesy of Lin Wan\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>A Serious Viral Infection: Why Infection Prevention Became Non-Negotiable\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The first days after we arrived were the hardest. Xiaojin was only three and a half. After having a PICC line placed under general anesthesia, he woke up groggy and clung tightly to me, refusing to let go. My husband had to return home to care for his mother, who was receiving chemotherapy, so I was alone with Xiaojin. Even buying food or going to the bathroom became difficult because I couldn't leave him.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Once chemotherapy began, the steroids made him cry for three days and nights. Fortunately, his leukemia responded well to treatment. At the day-19 bone marrow assessment, MRD was negative and the genetic markers being monitored had also become negative. For the first time since the diagnosis, I felt I could breathe a little easier.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Then, near the end of his first treatment phase, he suddenly developed adenovirus pneumonia. In a healthy person, adenovirus may cause little more than a respiratory infection, but Xiaojin's white blood cell count was nearly zero and his immune defenses were profoundly suppressed. The infection went straight to his lungs, and his oxygen saturation dropped into the low 80% range. A ventilator was brought to the ward, and transfer to the ICU seemed imminent.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">None of us slept that night. His oxygen saturation was checked and reported every 30 minutes. At around three or four in the morning, the number finally began to rise little by little. He made it through.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The infection delayed chemotherapy for more than a month. His weight dropped from about 15 kg to 12 kg, the muscles in his legs became weak, and when he left the hospital he needed someone to support him while he walked.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After that experience, I became extremely cautious about infection prevention. During high-dose chemotherapy, his white blood cell count stayed near zero for about 20 days. I arranged for him to stay alone in a private room, disinfected anything that visitors touched, and made my husband change clothes after coming back from grocery shopping before he went near Xiaojin. He got through those 20-plus days without another infection, and to me, every precaution was worth it.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">We also ran into an unusual reaction to one of his chemotherapy drugs: whenever he lay down, his oxygen saturation would drop. Even the doctor said it was uncommon. With an increased steroid dose, the reaction was brought under control, and he ultimately completed the full course of treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002F2d30dbc3c756964ee1742d29c72cca28_20260913164852.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"2d30dbc3c756964ee1742d29c72cca28_20260913164852.png\" alt=\"de6c191b-755e-4b52-98df-ca23238bdfc1.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">Photo courtesy of Lin Wan\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>One Challenge After Another, but We Kept Moving Forward\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">During the first ten months of Xiaojin's treatment, our family went through loss after loss. My mother-in-law died of stomach cancer, and my father died of multiple myeloma. I was caring for a child who needed me every day while being unable to stay close to other family members who were also seriously ill. Unless you have lived through something like that, it is hard to explain. But life leaves you no choice sometimes. You grit your teeth and keep moving.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In June 2022, Xiaojin completed intensive treatment and came home to begin maintenance therapy. I also went back to work. Life slowly settled into a rhythm again: weekly blood tests and monthly hospital visits for treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In July 2024, Xiaojin officially stopped treatment after a total course lasting nearly three years. That September, he put on his backpack and started primary school. Watching him run and bounce along, I thought, "Maybe those three difficult years are finally behind us."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002F955246acce673d1e047741346523e5bd_20260913164920.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"955246acce673d1e047741346523e5bd_20260913164920.png\" alt=\"5df60ecc-38bb-4a96-b81c-5c4b55988b10.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">Photo courtesy of Lin Wan\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>After Leukemia Treatment, Another Rare Diagnosis: Moyamoya Disease\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I thought finishing leukemia treatment meant we had finally reached the end of the road. Then life gave us another problem to solve.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In early 2025, my son's mouth suddenly drooped to one side and he began drooling, almost like a stroke. My first fear was that the leukemia had relapsed and involved the central nervous system. Lumbar puncture and MRI evaluation ruled out CNS leukemia. We then went from hospital to hospital looking for an explanation. One doctor thought it might be epilepsy and recommended long-term medication. But after everything I had learned during his leukemia treatment, something did not feel right to me: his symptoms did not fit the typical pattern of epilepsy.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I started researching, reading patient-group discussions, and comparing cases, until I finally took my questions to a hospital specializing in neurological disease. That was when we learned that Xiaojin had moyamoya disease, a rare cerebrovascular disorder. The doctors explained that the "white spots" seen on an MRI three years earlier were not signs of CNS leukemia; they were traces left by repeated small cerebral infarctions. In other words, this condition had been quietly present even while we were focused on leukemia.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After the diagnosis, Xiaojin underwent two cranial surgeries to improve blood flow to the brain. During the first operation, severe bleeding occurred unexpectedly and his condition became critical for a time. The second surgery went smoothly, and he was discharged active and energetic again.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Looking back, I have learned that facing illness takes more than courage. It also takes calm judgment, a willingness to keep learning, and the confidence to think independently and ask questions. Every time we actively searched for an answer, we may have gained precious time for our child.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>I Could Never Repay What His Doctors Have Done for Us\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">When I look back on these five years, one of the things I feel most fortunate about is the doctors we met. They genuinely cared about helping my child get better.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Dr. Huaying LIU from the hematology team was rigorous and professional, but also warm and approachable. Whether I had questions about chemotherapy adjustments or everyday care, she would respond - even when I messaged late at night. During ward rounds, she always remembered how Xiaojin was doing and regularly checked in on him. Later, when he had severe bleeding during brain surgery and I was completely overwhelmed, Dr. Liu was the first person I thought of. Every reply from her helped me steady myself again.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The neurosurgeon who operated on him was the same way. He was down-to-earth and gave me a direct way to stay in touch. If something unusual happened after surgery, he would respond with guidance even late at night. We lived more than a thousand kilometers away, but those messages made me feel as though the doctor was still nearby.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Meeting doctors like these has been an enormous blessing for our family. I don't think a lifetime would be enough to express how grateful I am.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>Staying in the Light - and Becoming a Light for Someone Else\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Xiaojin is now in second grade. He is a little more prone to colds than some other children, but overall he is doing well. In July 2026, he reached five years from his leukemia diagnosis, and his follow-up results were all reassuring.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">People often ask me: if your child is doing well now, why do you still stay involved in patient groups? My answer is that you cannot erase what happened simply by leaving the community or pretending to forget it. If I stay, keep learning, and help newly diagnosed families understand where to start, maybe they can avoid some of the detours we had to take.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Years ago, I happened to help a child I had never met. I never imagined that the kindness I put into the world would eventually circle back and help guide my own son. There is something remarkable about the way people support one another.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>Practical Lessons I Would Share with Other Families\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">1. Don't make major decisions in a rush immediately after diagnosis - first find a team with the right expertise. Learn about experienced pediatric hematology centers, their treatment approaches, and their clinical experience. The right team can help your child avoid unnecessary detours and risks.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">2. Take infection prevention seriously. The period when blood counts are at their lowest during chemotherapy is a high-risk time for infection. Careful disinfection, changing clothes before entering the child's room, and limiting visitors may feel excessive, but prevention can spare a child the additional suffering and treatment burden that a serious infection can bring. Follow the infection-control advice of your child's medical team.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">3. If unexplained symptoms appear, keep asking questions and seek appropriate evaluation. After treatment or after stopping therapy, symptoms such as unexplained weakness in an arm or leg, facial weakness, or dizziness should prompt medical assessment. In addition to checking for hematologic relapse, neurological or vascular causes may also need to be considered.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">4. A basic understanding of the disease can help families participate more confidently in decisions. You do not need to become a medical expert, but it helps to understand the basic disease subtype, commonly used treatments, and major assessment milestones. That background can make conversations with the medical team clearer and help you ask the questions that matter for your child.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">5. When you have the capacity, share what you have learned. Patient communities have a remarkable way of coming full circle. A piece of information or encouragement you offer another family today may one day return in a form you never expected. Helping one another can make a difficult road a little easier.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">There is still a long road ahead. As long as my child can run and laugh, and we can still eat meals and take walks together, I don't consider us defeated. For the days ahead, we will simply live well. One step forward is one step won.\u003C\u002Fspan>\u003C\u002Fp>",{"slug":111,"title":112,"summary":113,"cover":114,"disease":115,"treatment":80,"patientType":67,"publishedAt":116,"contentHtml":117,"disclaimer":70,"hasAlternate":71,"updatedAt":72},"burkitt-lymphoma-car-t-survivor-story","After His Lymphoma Mass Grew Beyond 10 cm, He Chose CAR-T. Now He Is Back to Fishing, Hiking, and Watching His Children Grow","After being diagnosed with Burkitt lymphoma and facing major treatment challenges, Mr. Wei received CAR-T therapy and achieved remission. Today, he is back to everyday family life.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F4e78708923e7a3ab4eab2881ad11c7b8.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","Burkitt Lymphoma","2026-07-24","\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Summary: At the end of 2023, Mr. Wei was diagnosed with Burkitt lymphoma after developing a lump beneath his jaw. His treatment journey included a revised pathology diagnosis, chemotherapy resistance, and a severe infection, while the disease at one point progressed rapidly. After evaluation by Dr. Yajing Zhang and her team at Beijing GoBroad Boren Hospital, he received CAR-T cell therapy followed by a second CAR-T treatment targeting a different antigen, and ultimately achieved complete remission (CR). Now, two years after treatment, Mr. Wei has returned to daily life and is once again able to spend time with his family and watch his children grow.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At the 3rd CAR-T Cell Immunotherapy Survivorship Conference, we met many people who had made their way back to everyday life after difficult illnesses. Mr. Wei was one of them. At the event, he shared his experience of facing lymphoma in the hope that his story might help other patients.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At the end of 2023, Mr. Wei, the main breadwinner in his family, was diagnosed with Burkitt lymphoma. His wife was two months pregnant at the time, and the diagnosis placed enormous pressure on the whole family. Today, two years after CAR-T therapy, he has returned to a normal routine - fishing and hiking with friends, spending time with his family, and watching his two children grow. Looking back, he says, "It really feels like I've been given a second chance at life."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002Fcd5628fe3dc92ee0ddb8b07f4aa11b69_20260913170327.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"cd5628fe3dc92ee0ddb8b07f4aa11b69_20260913170327.png\" alt=\"f4bbced0-d1c7-4f7a-8d49-34e53f0efcbe.png\"\u002F>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>A Small Lump Led to a Lymphoma Diagnosis\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">It started with a small lump beneath his jaw. At first, everyone assumed it was an enlarged lymph node. He took medication and watched it for a while, but instead of going away, the lump kept getting bigger. In December 2023, his doctor recommended surgical removal and a pathology examination. The result confirmed lymphoma. "I was terrified," Mr. Wei recalls. His wife was two months pregnant when he received the diagnosis.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">"I can barely remember how I drove home that day, or what I said to my wife on the way." For many families, a diagnosis of lymphoma brings an overwhelming mix of fear and uncertainty. For Mr. Wei, this was only the beginning.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>From Diffuse Large B-Cell Lymphoma to Burkitt Lymphoma: Getting the Diagnosis Right\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After diagnosis, Mr. Wei began treatment. Initially, he was treated for diffuse large B-cell lymphoma (DLBCL), and the tumor shrank for a time. But only one week after discharge, the mass began growing rapidly again. On the advice of another patient, he went to a larger hospital for an expert pathology review. This time, the diagnosis was confirmed as Burkitt lymphoma.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">With the diagnosis clarified, he restarted chemotherapy. Then another major problem emerged: he developed severe pneumonia and treatment had to be interrupted. For a long period, he needed supplemental oxygen and was too weak to get out of bed. "The treatment had started to work, but the infection delayed everything that was supposed to come next."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The disease did not wait. The tumor continued to grow rapidly, while his overall condition became weaker and weaker.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>Tumor Over 10 cm and Chemotherapy Resistance: He Decides to Go to Beijing for CAR-T\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Mr. Wei had heard about CAR-T soon after he was first diagnosed, but at the time it seemed far removed from his own situation. As he learned more about Burkitt lymphoma, he came to understand how aggressive the disease can be, and that once treatment stops working or resistance develops, the number of remaining options can narrow quickly. By then, he no longer felt he had time to keep waiting.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">"I didn't want to keep switching from one chemotherapy regimen to another just to see what might work. At that point, I was very clear in my mind - I wanted to pursue CAR-T." Through another patient, he learned about Dr. Yajing Zhang and her team at Beijing GoBroad Boren Hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">As soon as his pneumonia improved, he traveled to Beijing. He was admitted on the day he arrived, and preparations for the next stage of treatment began the following day.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>Twenty-Eight Days Later, He Achieved Complete Remission\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After admission, the medical team carried out a comprehensive assessment. Mr. Wei had a high tumor burden, and his recent history of severe infection and interrupted treatment made the situation particularly challenging. Taking into account the biology of Burkitt lymphoma and his previous treatment course, the team developed a comprehensive treatment strategy.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After cell collection, Mr. Wei successfully received his first CAR-T infusion. During treatment, the tumor in his neck temporarily became much more swollen as part of the treatment response. Seeing the mass enlarge again made him understandably anxious. "During chemotherapy, whenever it got bigger, it was always bad news, so I was really nervous." The medical team closely monitored the changes and explained the types of treatment-related reactions that could occur. Over the next several days, the mass began to shrink. A tumor that had grown to more than 10 cm decreased markedly within just over ten days.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A subsequent PET-CT showed complete remission (CR). On the team's recommendation, Mr. Wei returned two months later for a sequential second CAR-T treatment targeting a different antigen to further consolidate the response. Looking back on his treatment in Beijing, he says the doctors spent a great deal of time discussing his condition, the next steps, and the overall treatment plan with him. "That made me feel much more reassured. As a patient, I understood what might happen and what we could do to prevent or manage it."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>Getting Back to Ordinary Life Is the Greatest Happiness\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">It has now been two years since Mr. Wei received CAR-T therapy. Although his stamina has not yet fully returned to what it was before he became ill, he has resumed a normal daily life.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In his spare time, he goes fishing and hiking with friends, spends time with his family, and watches his children grow little by little. Asked what matters most to him now, he smiles and says, "I'm already very content. It feels like I've been given another life."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002F1187d02a7c28fb8487dd6f43cff55bb0_20260913170411.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"1187d02a7c28fb8487dd6f43cff55bb0_20260913170411.png\" alt=\"b5aab977-68ad-453c-88ea-a69339e3437a.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">Mr. Wei with his two children (photo provided by Mr. Wei)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>What Mr. Wei Would Like to Share with Other Patients and Families\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>1. When lymphoma is diagnosed, consider expert pathology review. Accurate classification is essential to choosing the right treatment.\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Pathology subtype directly affects treatment decisions and outcomes. Talk openly with your doctors, and when appropriate, seek an additional pathology opinion. Experiences shared by well-informed patients can also help families know what questions to ask.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>2. If treatment is not working, do not simply wait.\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">If the disease changes or the response is not what you and your doctors hoped for, discuss the next step proactively. Acting in time may open up more treatment opportunities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>3. Learn about new research and emerging treatment options for your disease.\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I learned a great deal from talking with other patients. In hematologic cancers, and lymphoma in particular, new drugs and treatment approaches are developing quickly. Understanding the available options can help you and your medical team think ahead if the situation changes later.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>4. Keep going, even when treatment becomes difficult.\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">If you encounter drug resistance, tumor growth, or a serious infection during treatment, do not give up on yourself. Follow your medical team's guidance, keep treating the problems in front of you, and hold on to the belief that you can make it through. For many patients, mindset can also be an important source of strength during a difficult treatment journey.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Behind every recovery story is a difficult road. More people with lymphoma, like Mr. Wei, are gaining opportunities for long-term survival and a return to everyday life through appropriate, standardized treatment. We hope every patient still in treatment can make it through the challenges ahead, one step at a time, and eventually receive the good news they have been waiting for.\u003C\u002Fspan>\u003C\u002Fp>",{"slug":119,"title":120,"summary":121,"cover":122,"disease":123,"treatment":80,"patientType":91,"publishedAt":124,"contentHtml":125,"disclaimer":70,"hasAlternate":71,"updatedAt":126},"b-all-car-t-recovery","After Two CAR-T Infusions, She Is Finally Ready to Put on Her Backpack and Start School","After relapse, central nervous system involvement, and sequential CD19\u002FCD22 CAR-T therapy, she completed all planned treatment and is ready for a new chapter in life.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002Fd727fe2e6147a170f603ade38602b969.webp?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","B-cell Acute Lymphoblastic Leukemia","2026-07-19","\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Summary: Jiajia was 6 years old when she was diagnosed with B-cell acute lymphoblastic leukemia (B-ALL) in 2022. Despite prolonged chemotherapy, she later developed bone marrow relapse with central nervous system involvement. In 2024, her family brought her to the Department of Hemato-Oncology & Immunotherapy at Beijing GoBroad Hospital, where Dr. Jing Pan and her team developed a sequential CD19\u002FCD22 CAR-T treatment strategy, followed by consolidation and maintenance therapy. Her leukemia has remained in remission. In July 2026, Jiajia completed all planned treatment and officially stopped therapy. Her story follows a child with relapsed, difficult-to-treat B-ALL from CAR-T treatment back to school, and highlights the importance of standardized treatment, continued follow-up, and multidisciplinary care in complex hematologic cancers.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">On July 7, 2026, in the Department of Hemato-Oncology & Immunotherapy at Beijing GoBroad Hospital, 6-year-old Jiajia underwent her final bone marrow aspiration and lumbar puncture assessment. The results showed that her leukemia remained in remission.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">That day, she officially completed treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">More than four years had passed since Jiajia first became ill in May 2022. At last, this long course of treatment had reached an important milestone. It had also been exactly two years since her first CAR-T infusion.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">But for Jiajia and her family, the journey was never as simple as receiving a single CAR-T infusion.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>From Diagnosis to Relapse: Falling Back, Then Finding the Strength to Keep Going\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">On May 7, 2022, Jiajia became unusually listless and developed fever and retching. Her family took her to a local hospital, where a bone marrow MICM assessment led to a diagnosis of B-cell acute lymphoblastic leukemia (B-ALL).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">For this young child, it was the beginning of a long and difficult course of treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After induction chemotherapy, measurable residual disease (MRD) remained positive. She went through multiple additional rounds of chemotherapy, but the MRD did not turn negative. Her family faced one cycle of hope and disappointment after another. It was only after nearly a year of chemotherapy that MRD finally became negative, giving the family a brief sense of relief after such a long wait.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The relief did not last. In March 2024, follow-up testing showed bone marrow MRD relapse, while cerebrospinal fluid testing was also positive, indicating central nervous system involvement by leukemia. Urgent chemotherapy was given at the local hospital, but this time the disease did not go into remission.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The news was devastating for Jiajia's family.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Watching such a young child endure repeated punctures, infusions, and treatment side effects was heartbreaking. Still, her family held on to hope, waiting for the next treatment to bring a turning point.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>A Turning Point: From the Darkest Moment to a Clinic Visit That Changed the Course\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">When treatment had reached an impasse, Jiajia's parents refused to give up. They read extensively, sought advice wherever they could, and eventually turned to Dr. Jing Pan in the Department of Hemato-Oncology & Immunotherapy at Beijing GoBroad Hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In June 2024, Jiajia's parents brought her to see Dr. Pan for the first time. Dr. Pan carefully reviewed her previous medical records - including the fact that it had taken nearly a year of chemotherapy for MRD to turn negative, and that chemotherapy after relapse had failed to achieve remission - and assessed her current condition. After detailed discussions with the family, the team developed a sequential CD19\u002FCD22 CAR-T strategy tailored to Jiajia's disease characteristics and treatment history.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Cell Therapy Is Not a Single Procedure - It Is an Entire Treatment Journey\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">CAR-T therapy is sometimes understood as simply receiving a one-time cell infusion. In clinical practice, however, the infusion is only one part of a much longer process.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">It begins with a comprehensive assessment. The medical team evaluates the patient's current condition, disease status, progression, and previous treatments to determine whether CAR-T is an appropriate option. From there, the treatment plan is developed and adjusted over time, followed by key steps such as cell preparation and infusion.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After infusion, patients may experience fever, inflammatory reactions such as cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), infections, and challenges related to immune recovery. Ongoing follow-up is then needed to monitor treatment response and recovery.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">These stages are closely connected and rarely stand alone. From a patient's perspective, CAR-T is better understood as a treatment journey that unfolds over time, rather than a single procedure. The outcome depends not only on what happens on infusion day, but on the care delivered before and after it.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">So what is a patient really choosing in this process? Once the full treatment pathway is laid out, the answer becomes clearer: it is not only a particular technology, but the broader clinical capabilities needed to carry that treatment safely and consistently from one stage to the next.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Those capabilities include systematic risk assessment and stratification, reliable execution of the treatment pathway at each stage, experience in managing complex complications, and the ability to adjust the pace and direction of care through multidisciplinary collaboration.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">These strengths may not be obvious at any single point, but they run through the entire treatment process. For complex diseases such as hematologic cancers, the choice is therefore not simply about selecting a technology. It is also about choosing a clinical team that can deliver that technology consistently and take responsibility for the full course of care.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>What Is a Patient Really Choosing in This Process?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Once the full treatment pathway is laid out, the answer becomes clearer: the patient is choosing not only a particular technology, but the broader clinical capabilities needed to support treatment from beginning to end. These include systematic risk assessment and stratification, reliable execution at each stage, experience in managing complex complications, and the ability to continually adjust treatment through multidisciplinary collaboration. These strengths may not be obvious at a single point, but they run through the entire process. For complex diseases such as hematologic cancers, the choice is therefore not simply about a technology. It is also about choosing a clinical team that can deliver it consistently and take responsibility for the full course of care.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Sequential Dual-Target Therapy: Two CAR-T Infusions, One Integrated Strategy\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After Jiajia transferred to Beijing GoBroad Hospital, her treatment pathway was re-evaluated and redesigned.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">On June 20, 2024, she received a CD19 CAR-T cell infusion. Fourteen days later, bone marrow and cerebrospinal fluid assessments showed complete remission. As planned, the team then proceeded with CD22 CAR-T therapy to consolidate the response and reduce the risk of relapse.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">This sequential CD19\u002FCD22 CAR-T strategy is an area of expertise for Dr. Pan's team. It uses two separate infusions targeting two different antigens, with the aim of reducing relapse associated with antigen loss or downregulation after single-target therapy. The approach requires careful timing of the CD22 CAR-T infusion while keeping patient safety at the forefront, so that there is as little opportunity as possible for immune escape of the target antigen.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After sequential CAR-T therapy, Jiajia's leukemia remained in sustained remission.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Treatment did not end there. Jiajia subsequently received monthly decitabine as consolidation therapy. Based on her previous treatment and individual condition, the team also developed a maintenance chemotherapy plan for her.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>July 7, 2026: Two Years After CAR-T, Treatment Officially Ends\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">On July 7, 2026, Jiajia completed all planned treatment. Bone marrow aspiration and lumbar puncture assessments showed that her leukemia remained in remission. It had been exactly two years since her first CAR-T infusion, and four years and two months since she first became ill.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Over those four-plus years, Jiajia went through repeated punctures, rounds of chemotherapy, and cycles of hope and disappointment. Her family also changed along the way - from feeling lost and overwhelmed, to searching everywhere for answers, and finally finding a team they felt they could trust. What they chose was not simply CAR-T technology, but a clinical team and care system capable of delivering it consistently and supporting the entire treatment journey.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F6b26df8c134972cea2111b3580c191f1_20260912211204.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"6b26df8c134972cea2111b3580c191f1_20260912211204.png\" alt=\"269ef5a3-fb3e-4d1b-ac98-2af2e35bece9.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Later this year, Jiajia will start school. Like any other 6-year-old, she will put on her backpack, walk into a classroom, and begin a new chapter of childhood.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The days of punctures, infusions, chemotherapy, and CAR-T can now begin to recede into the past, marked by July 7, 2026 - the day she officially completed treatment, two years after CAR-T. On the Department of Hemato-Oncology & Immunotherapy's CAR-T "Cure Summit" display at Beijing GoBroad Hospital, Jiajia placed her photo at the two-year milestone. The climb begins from the day of infusion: two years marks an important stage of victory, while five years is the milestone they call being truly "free of leukemia." Her family and doctors believe that one day, her photo will make it all the way to the summit.\u003C\u002Fspan>\u003C\u002Fp>","2026-09-12",{"slug":128,"title":129,"summary":130,"cover":131,"disease":132,"treatment":99,"patientType":67,"publishedAt":133,"contentHtml":134,"expertView":135,"disclaimer":70,"hasAlternate":71,"updatedAt":72},"nkt-cell-lymphoma-allogeneic-transplant-survivor-story","Diagnosed with NK\u002FT-Cell Lymphoma in His Sophomore Year; Three and a Half Years After Transplant, He Has Graduated, Found Love, and Embraced Life Again","Diagnosed with extranodal NK\u002FT-cell lymphoma during his sophomore year, Xiao Hao endured multiple treatment challenges before undergoing an allogeneic hematopoietic stem cell transplant. Three and a half years later, he has returned to campus and begun a new chapter of life.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002Fd60da009eb56aa6f0d6bdac0f958c794.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","Extranodal NK\u002FT-Cell Lymphoma","2026-07-17","\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Summary: Xiao Hao (pseudonym) was diagnosed with high-risk stage IVB extranodal NK\u002FT-cell lymphoma during his sophomore year after experiencing recurrent fevers and persistent nasal symptoms. His treatment journey was complicated by pneumonia and hemophagocytic lymphohistiocytosis (HLH), and he traveled across China in search of further treatment. In late 2022, he underwent an allogeneic hematopoietic stem cell transplant from an unrelated donor at Beijing GoBroad Boren Hospital, and his condition gradually stabilized. Now, three and a half years after transplant, Xiao Hao has not only completed his university degree but also found love and returned to the everyday life of a young adult. Looking back, he hopes his experience can remind other patients that as long as they keep going, life can still open up new possibilities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">It is graduation season again. Across campuses, young graduates pose for photos, hug their friends goodbye, and look ahead to whatever comes next. For 24-year-old university student Xiao Hao (pseudonym), however, this summer arrived two years later than expected.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In December 2021, while still a sophomore, Xiao Hao was diagnosed with high-risk stage IVB extranodal NK\u002FT-cell lymphoma. During treatment, he also developed pneumonia and an episode of hemophagocytic lymphohistiocytosis (HLH). From Yunnan to Beijing, he moved between several hospitals and underwent chemotherapy, radiotherapy, immunotherapy, and targeted treatment. In late 2022, he received an allogeneic hematopoietic stem cell transplant from a 10\u002F10 HLA-matched unrelated donor at Beijing GoBroad Boren Hospital. Now, three and a half years after transplant, his follow-up results remain normal. In the summer of 2026, he stood on campus in his graduation gown, with warm sunshine overhead, his partner of more than three years beside him, and a future full of possibilities ahead.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002F839e5f6a34f9957f02fd0dd74b870519_20260913080711.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"839e5f6a34f9957f02fd0dd74b870519_20260913080711.png\" alt=\"85ab0572-7b0b-4cba-9ad7-57cae6a96485.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>An Overlooked Warning Sign: From “Rhinitis” to Advanced Lymphoma\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In December 2021, I was a sophomore studying in Tianjin. My nose had been blocked for a while, and I assumed it was the same old rhinitis I had dealt with before. I thought I could just wait it out. But then I started losing weight, and a large ulcer developed on the roof of my mouth and throat. Medication did nothing. My throat hurt so badly that I could barely swallow, I woke up at night with my clothes soaked in sweat, and eventually I developed a persistent high fever.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">It was during a period of strict campus restrictions, so I stayed in my dorm for four or five days, alternating cold medicine and fever reducers. Nothing worked. When I finally couldn't take it anymore and decided I needed to go to the hospital, I called my family.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Because I had a fever, I was isolated in a quiet hospital room. Almost the entire floor was empty, and someone brought me two simple meals each day. At first I still thought it was just a bad cold. I even bought some fruit, thinking a few extra vitamins might help me recover faster. Then I had a laryngoscopy and nasal endoscopy. The doctors contacted my university, and the university contacted my parents. They traveled overnight from Yunnan to Tianjin. I was still confused at the time and thought everyone was making too much of it.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002Fa34411f99323c7dc74d5d9fe4542ad4c_20260913080734.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"a34411f99323c7dc74d5d9fe4542ad4c_20260913080734.png\" alt=\"60a77fa4-83df-4305-a442-2d6bfd01da2e.png\"\u002F> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The hospital then arranged a biopsy. A week later, the results came back. My parents didn't tell me anything; they simply completed the discharge paperwork and took me back to Kunming. I still didn't know exactly what I had. It wasn't until I was being treated at a hospital in Kunming and happened to see the word “tumor” that I suddenly understood.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">“Lymphoma.” When I finally learned the truth, I didn't fall apart. I felt down for a little while, but I've always handled pressure fairly well. And after my first round of chemotherapy, my throat stopped hurting and I could swallow again. Part of me even thought, “Maybe I'm getting better.”\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The first time I truly felt how close death could be, it came quietly. Medical resources in Kunming were limited and beds were tight. After one round of chemotherapy, I developed pneumonia. Because I was already very weak, it quickly triggered hemophagocytic lymphohistiocytosis. The illness progressed fast. The doctors told us I needed to get to Beijing immediately and warned that if we delayed, I might have only a month left.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>Heading North as the Disease Worsened: Hitting Rock Bottom\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">As soon as the plane landed, my fever came back. I was taken to an observation room in the fever clinic. I still remember that night clearly—the sound of patients moaning around me went on hour after hour without stopping.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I was admitted the next day, but not long afterward I had a seizure and fell into a coma for a week. By the time I woke up, Chinese New Year was approaching. My mom later told me that while I was unconscious, the doctors had told my family to prepare for the worst. I'm their only child, and hearing that nearly broke her.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">When I woke up, I was overwhelmed by a kind of weakness I had never experienced before. Once the HLH was under control, we decided to transfer again because the hospital I was in did not specialize in lymphoma. By then I was so weak that I could only get around in a wheelchair, and emotionally I had hit rock bottom.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At the next hospital, the doctor was very straightforward: if the disease could not be controlled, I might have only about three months to live.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">When I walked out of the consultation room, I broke down completely for the first time. I told my parents I didn't want any more treatment. I didn't want to put them through more, and I didn't want them spending so much money on me. My dad said just one thing: “Whatever happens, we keep trying. We do everything we can.”\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">That night, I called my closest friend back home and talked as if I were saying goodbye. I told him that if one day I really wasn't there anymore, I wanted him to help look after my parents. That was the darkest point of my entire treatment journey.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Fortunately, I met two attending physicians who took my case extremely seriously. They went back through all of my medical records and developed a new plan. I first received two cycles of the GPED regimen. When a follow-up PET\u002FCT showed that the lymphoma was still progressing, they switched me to a DEP-L regimen.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">My parents and I rented an apartment near the hospital. Those days felt like a blur, but one thing was always clear to me: wherever my parents were, that was home.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Three months passed, and I was still here. My numbers didn't improve overnight, but little by little, the disease began to stabilize.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The next step was preparing for transplant, which meant going to another hospital for radiotherapy. We moved again. Slowly, I began to come out of the mindset of “I don't want treatment anymore.” I followed the treatment plan each day and went for radiotherapy every evening without fail.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At first, I barely noticed anything. Then one day, everything I ate felt like chewing paper—I had lost my sense of taste. Soon after, the lining of my mouth and nasal passages became badly damaged, and the tissue on the roof of my mouth ulcerated. Even taking a sip of water felt like swallowing a knife. I couldn't eat at all and had to rely on intravenous nutrition. The treatment came at a very real cost.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Thankfully, a follow-up PET\u002FCT showed that the disease had gone into remission. My doctors adjusted the plan again and treated me with the targeted and immunotherapy combination of brentuximab vedotin plus tislelizumab.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After everything I had already been through, transplant was finally the next step. But then I hit another wall: because my case was so complex and the risks were so high, finding a transplant center willing to take me on was difficult. Some centers had never successfully transplanted a patient with a case like mine. It felt as though the hardship would never end, and the hope I had worked so hard to rebuild was crushed all over again.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">So when Boren finally confirmed that they could take my case, my first reaction wasn't excitement. It was relief: finally, someone was willing to take me through the next step.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>The Transplant Unit, a New Beginning, and a Bowl of Salty Pumpkin Porridge\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">When I arrived at Beijing GoBroad Boren Hospital, the transplant team led by Dr. Tong Wu carried out another comprehensive evaluation. The night before my PET\u002FCT results were due, two pieces of necrotic tissue from the ulcerated area on the roof of my mouth came away on their own. I told my dad that maybe it was a good sign—the damaged tissue had fallen away so something new could grow.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The next day, the results came back: the disease was in remission. Looking at that report, for the first time in a long while, I felt as if I could finally see the end of this road.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After entering the transplant unit, I received BU\u002FFLU conditioning. On October 11, 2022, I received stem cells from an unrelated donor who was a 10\u002F10 HLA match. My blood type was B positive and the donor's was O positive. Neutrophil engraftment occurred on day +17 and platelet engraftment on day +15.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px; text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002F09d50a5ccee2a89b640abdfbbb10db24_20260913080834.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"09d50a5ccee2a89b640abdfbbb10db24_20260913080834.png\" alt=\"c52d99f5-303f-45fb-8518-1ab5f044ad5e.png\"\u002F> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At one point in the transplant unit, I had abdominal pain so severe that it felt as if something inside me was twisting hard. The doctors and nurses responded immediately, gave me medication, and brought it under control quickly. My mom later told me, “If you hadn't had this transplant at Boren, you might not even have made it out of the transplant unit. And even if you had, you probably wouldn't be doing as well as you are now.” I knew what she meant.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After I left the transplant unit, we rented an apartment near the hospital and stayed for another six months so I could return regularly for follow-up. One day, my mom made pumpkin porridge for me. She knew my sodium was low, so she added a little salt, hoping it might help. I took one spoonful—and it tasted salty. Suddenly every emotion I had been holding in came rushing out: hurt, exhaustion, anxiety. I had a huge argument with my mom and, like a child, finally let out everything I had kept bottled up for so long.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In June 2023, my follow-up results were stable. With my doctors' approval, my parents took me back home to Yunnan to continue recovering.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002F41d4b09dd5a7d7430537a99c663149b3_20260913080933.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"41d4b09dd5a7d7430537a99c663149b3_20260913080933.png\" alt=\"1ad8cad0-1354-4c24-93aa-bdf5003cd83d.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003Cspan style=\"font-size: 15px; text-align: justify;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>Telling Her How I Felt Beneath the Tianjin Eye—and a Graduation Photo Two Years Late\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">While I was recovering, I also found love. My girlfriend and I had known each other since freshman year, and we stayed in touch after I became ill. Once, when she was feeling down and wanted to go to the seaside, I happened to be in Beijing for a follow-up appointment, so I went to Tianjin to see her. We talked for a long time, and beneath the Tianjin Eye, I finally told her how I felt.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Day by day, my health improved. But after transplant, I still had to be extremely careful about food hygiene, and I couldn't eat food prepared outside. So on our early dates, she would eat while I sat beside her and talked with her. Then I would go home and eat whatever my mom had cooked. It was simple, but it made me feel safe and happy.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">We've now been together for three years, and this year I finally graduated from university. My classmates are looking for jobs and making plans for the future, and I'm thinking about those things too—but differently than I did before I got sick. Back then, I wanted to achieve something huge. Now what I want is much simpler: to live well, build a steady life, stay close to my parents, and take care of the people I love. That sense of stability means more to me than anything.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">People tell me I'm lucky, but I think my greatest blessing is having my mom and dad. In a novel I love, the main character tells his parents, “In my next life, I still want to be your son.” Every time I think of that line, it hits me deeply. It's not about feeling that I owe them something. I just know that being alive, healthy, and living my life well is the greatest reassurance I can give them.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>Never Give Up on Life—Believe in the Power of Believing\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I am still deeply grateful to the specialists and medical team at Boren. They are the reason I can live the life I have today.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In patient support groups, when someone asks a question, I often share what I went through, especially when it comes to transplantation. I recommend Boren because, from my own experience, I believe its transplant program is highly experienced—and I am living proof of what that care made possible for me.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The last thing I want to say to patients going through something similar is this: never give up on life. We are not fighting only for ourselves. There are people supporting us, and even if it is only a handful of people, they are reason enough to keep going. Believe in the power of believing. You have to believe something is possible before you can have a chance to reach it.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">It has now been three and a half years since my transplant, and all of my follow-up results are normal. Looking back, being healthy, being alive, and moving forward one day at a time—that is probably the best answer I can give.\u003C\u002Fspan>\u003C\u002Fp>","Case Commentary (Dr. Zhanxiang Liu, from the team led by Dr. Tong Wu and Dr. Yanzhi Song): \n\nMalignant tumors are often described as ruthless because when serious illness strikes, it does not take a person's age, plans, or circumstances into account. This case involves extranodal NK\u002FT-cell lymphoma, an aggressive disease for which ideal chemotherapy options remain limited. Patients diagnosed at an earlier stage may have a better chance of achieving favorable outcomes with radiotherapy. Unfortunately, Xiao Hao was already at stage IV, the most advanced stage, when he was first diagnosed. His treatment course was equally difficult. At the most critical point, the lymphoma progressed together with an episode of HLH, placing his life at immediate risk. Fortunately, radiotherapy and salvage chemotherapy brought the lymphoma into remission. He was also able to find a suitably matched unrelated donor and, just as importantly, undergo allogeneic hematopoietic stem cell transplantation within the narrow therapeutic window. The transplant was successful: he developed neither severe graft-versus-host disease (GVHD) nor lymphoma relapse afterward.\n\nThe fundamental purpose of medicine is to treat disease and save lives. Hematopoietic stem cell transplantation is a highly complex procedure, but it plays an irreplaceable role in the treatment of hematologic malignancies. Xiao Hao's outcome was not simply a matter of luck; it reflects the efforts of the transplant team at Beijing GoBroad Boren Hospital. It also embodies the team's goal: to treat difficult disease, restore health, and help patients return to their families and society.",{"slug":137,"title":138,"summary":139,"cover":140,"disease":141,"treatment":99,"patientType":67,"publishedAt":133,"contentHtml":142,"expertView":143,"disclaimer":70,"hasAlternate":71,"updatedAt":126},"severe-aplastic-anemia-hsct-five-year","The Light I Received from Strangers - Now I Want to Pass It On","After being diagnosed with severe aplastic anemia, he nearly gave up on treatment. The determination of his family, encouragement from fellow patients, and support from his medical team helped him choose hematopoietic stem cell transplantation - and five years later, he is back in the classroom he loves.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F3c7048040c007b159173eb122a5e9ee9.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","Severe Aplastic Anemia","\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Summary: Mr. Liu (pseudonym) was diagnosed with severe aplastic anemia (SAA) after abnormalities were found on a routine blood test. As supportive treatment became less effective and he needed transfusions more and more frequently, he lost confidence and at one point considered giving up treatment altogether. His family refused to give up, and the transplant experiences shared by several patients he had never met helped restore his hope. In 2021, he underwent allogeneic hematopoietic stem cell transplantation at GoBroad Shanghai Zhaxin Hospital. Although his recovery was complicated by viral infections, intestinal infection, and chronic graft-versus-host disease (cGVHD), his condition gradually stabilized with treatment and long-term follow-up from Dr. Su Li, Dr. Huixia Liu, and their teams. About a year after transplant, he returned to teaching. Now, five years later, he remains relapse-free and has no ongoing GVHD. He hopes to pass on the kindness that once helped him, encouraging other patients with blood disorders to keep moving forward through treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002Fac0cae86eee59f881ff011e85f4f79b5_20260912224824.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"ac0cae86eee59f881ff011e85f4f79b5_20260912224824.png\" alt=\"10761a13-dd9c-48ff-a4e5-1cf25465401f.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Mr. Liu (pseudonym) had spent decades as a teacher and had always considered himself healthy. He rarely got sick, so he never imagined that a routine blood test before a physical therapy session would lead to an urgent referral to hematology - and a diagnosis of severe aplastic anemia (SAA). At first, he chose supportive treatment. But the disease progressed far more quickly than expected: the interval between transfusions shortened from about ten days, to one week, and eventually to just three days. Frequent trips between home and the hospital became part of his life. The teacher who had once stood confidently in front of a classroom soon found even basic daily activities exhausting.\u003Cbr\u002F>\u003Cbr\u002F>Just as he was losing hope, Mr. Liu met several fellow patients he had never known before. One was the father of a child who had had leukemia. Hearing that the child had returned to normal life five years after transplant gave Mr. Liu his first real sense of hope. Another younger patient told him that he had spent more than 20 relatively stable days in the transplant unit, easing Mr. Liu's fear of the procedure. An older man in the same ward also supported him with his optimism and encouragement. Mr. Liu often says, “I've been lucky. Somehow, I always meet kind people when things are at their hardest.” The light and hope these people offered at different points in his treatment helped him find direction again - and the courage to keep going.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In June 2021, with the full support of his family, Mr. Liu underwent an allogeneic hematopoietic stem cell transplant at GoBroad Shanghai Zhaxin Hospital. His underlying disease went into complete remission. About a year later, he returned to school and stepped back into the classroom he had missed so much.\u003Cbr\u002F>\u003Cbr\u002F>To mark five years since his transplant, Mr. Liu returned for a comprehensive follow-up evaluation, bringing his son with him so they could thank the medical teams at GoBroad Shanghai Zhaxin Hospital and GoBroad Shanghai Liquan Hospital in person. He also has a message for other people living with blood disorders: seek treatment while your body is still strong enough, make decisions promptly with an experienced medical team, and do not let delay close off treatment options. He once drew strength from the kindness of strangers. Now he hopes to pass that kindness on - and become a source of light for someone else.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F39484e6ef5233329af978c13b470d0c8_20260912224841.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"39484e6ef5233329af978c13b470d0c8_20260912224841.png\" alt=\"6cf8126c-d82d-4819-a380-d4518cfbb343.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">June 2026: Mr. Liu with Dr. Su Li\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q1: What symptoms did you have at first, and how were you eventually diagnosed with SAA?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: In September 2020, I went to a county hospital for physical therapy. As part of the routine process, they did a complete blood count first. I felt perfectly fine after the blood draw and even went out for lunch as usual. But when I returned to the hospital that afternoon, the doctor looked very serious. He told me to sit down, avoid moving around, and arranged for me to be transferred urgently to the hematology department at the local central hospital. After a series of detailed tests, I was diagnosed with severe aplastic anemia (SAA).\u003Cbr\u002F>\u003Cbr\u002F>I had a hard time accepting it at first. I had always been healthy and rarely got sick, and I knew almost nothing about blood disorders, so part of me kept hoping it could not be that serious. But the disease progressed quickly. While I was receiving supportive treatment locally, a transfusion initially lasted me about ten days. Then the interval shortened to a week, and eventually to only three days. My platelet count kept falling, my gums bled frequently, and I felt extremely weak. Everyday life became difficult, and I had to travel to the hospital several times a week for treatment.\u003Cbr\u002F>\u003Cbr\u002F>There were also a lot of discouraging conversations in the ward. Some patients felt that treatment would only prolong things while draining the family's finances. Hearing that repeatedly affected me. I became lost and hopeless. I had two children still in school, and at one point I thought it might be better to sell our property and leave the money for their education rather than spend all of our savings on treatment when I did not know what the outcome would be. I was ready to give up.\u003Cbr\u002F>\u003Cbr\u002F>But my family never wavered. They stayed by my side, encouraged me, and refused to give up on even the smallest chance. Their support helped me rebuild my confidence step by step and gave me the strength to keep going.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q2: What was the turning point that helped you and your family decide to proceed with hematopoietic stem cell transplantation?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: My family's refusal to give up helped me pull myself together and start actively looking into treatment options. Around that time, I met a fellow patient who had a huge influence on me. His son had been diagnosed with leukemia while still in primary school, and he told me how devastated he had felt at the time. But his son was already five years out from a hematopoietic stem cell transplant and had returned to a normal life. He told me that medicine had advanced tremendously, and that because supportive treatment was no longer doing much for me, transplant might offer a better chance of getting back to work and everyday life.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Hearing that from someone who had lived through it with his own family gave me enormous encouragement.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">There was another younger patient who had already undergone an allogeneic hematopoietic stem cell transplant at GoBroad Shanghai Zhaxin Hospital while I was still hesitating. He called me specifically to reassure me: “Uncle, I spent more than 20 days in the transplant unit and I was doing pretty well. It really wasn't as frightening as I had imagined.” Hearing that eased a lot of my fear.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After many conversations, my family and I agreed that transplant was the path we wanted to take, and we came to GoBroad Shanghai Zhaxin Hospital with a mixture of hope and anxiety. I was still weighed down when I first arrived and did not talk much. An older gentleman in my room noticed how worried I looked and started talking with me. He had lymphoma and had also come here because of Prof. Chun Wang's expertise in hematopoietic stem cell transplantation. He was full of confidence and always spoke positively about treatment. During that difficult period, we encouraged each other and helped one another through some of the most uncertain days.\u003Cbr\u002F>\u003Cbr\u002F>Before the transplant, my attending physician, Dr. Su Li, also gave me clear and reassuring answers. He explained that allogeneic hematopoietic stem cell transplantation is an established treatment option for severe aplastic anemia and may offer the possibility of long-term disease-free survival and a return to normal work and life. I had also worried that donating stem cells might harm my son. Dr. Li explained the process and donor safety clearly, which finally put that concern to rest.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q3: What stands out most when you look back on the transplant itself?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: In June 2021, I underwent a hematopoietic stem cell transplant at GoBroad Shanghai Zhaxin Hospital, with my younger son as the donor. His HLA match was more suitable for me, and we also happened to have the same blood type. Both of my sons cared for me in their own ways throughout treatment. In those difficult days, they were not only the people I worried about most, but also a major source of strength.\u003Cbr\u002F>\u003Cbr\u002F>The transplant itself was not as frightening as I had imagined. My vital signs were generally stable in the transplant unit, and the side effects were relatively manageable. Dr. Huixia Liu, who oversaw my transplant care, often encouraged and reassured me. With careful support from the doctors and nurses, I made it through more than 20 days in the transplant unit fairly smoothly.\u003Cbr\u002F>\u003Cbr\u002F>The setback came after I left the unit. I had planned to rent a place near the hospital to recover, but severe diarrhea forced me to return. Tests showed Clostridioides difficile-associated colitis. Dr. Liu treated me using an integrative approach combining conventional medicine and traditional Chinese medicine. The symptoms gradually came under control, and my strength slowly returned.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Apart from that intestinal complication, my overall recovery after transplant went relatively well. The doctors' expertise was essential, but so was the care my wife gave me every day. For the first six months after transplant, I barely left home, and almost all of the responsibility for my daily care fell on her. We had to be extremely careful about food, hygiene, and infection prevention. During the worst period of diarrhea, even basic cleaning required meticulous care, and my wife stayed beside me through it all without complaint.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Before I became ill, I was a teacher and loved my work. The diagnosis forced me to step away from the classroom for a while. About a year after transplant, I returned to school and gradually resumed teaching. Looking back, treatment for a serious blood disorder is never a short journey. From the first diagnosis, to seeking care in different places, to eventually traveling to Shanghai, my wife was beside me every step of the way. I remember clearly that before I got sick, she did not have a single gray hair. Over these years, many have appeared.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q4: How has this illness changed you? Has it changed the way you think about life, family, and happiness?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: Before I got sick, I had many expectations for my children and many plans for our family's future. I wanted everything to move in a particular direction. After going through this illness, I have learned to let go of a lot of those expectations. What matters most is simply having the whole family together, safe and healthy.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">My hopes for my sons are much simpler now. I just want them to find work that allows them to support themselves, build stable families of their own, and meet partners who are kind, responsible, and share their values. That is enough for me.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Since leaving the transplant unit, I have continued regular follow-up at GoBroad Shanghai Liquan Hospital. I came back specifically for my five-year evaluation, but also because I wanted to thank Dr. Su Li and his team in person. After all the tests are finished, my son and I plan to spend a little time exploring Shanghai and relaxing. For years, every trip here was for treatment. We were always rushing and never had the heart to look around. This time, I can finally walk around the city with a lighter heart before heading home.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q5: What would you most like to say to other people going through treatment for blood disorders, and to their families?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong> \u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: I want to share something from my own experience. When you are looking for treatment, choosing a specialized hospital and an experienced medical team can make a real difference. Seek appropriate treatment while your physical condition still allows it, rather than waiting until your health has deteriorated so much that options become more limited. For me, the lesson was simple: get treated early, proceed to transplant when it is the right option, and give yourself the best chance to recover sooner.\u003Cbr\u002F>\u003Cbr\u002F>Delays can mean more complications and a weaker body by the time treatment begins. Rather than waiting until you feel you have no options left, act early and seek help from a qualified, experienced team.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F99da1b107e79b75f852dce5d8dd2c8e6_20260912224909.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"99da1b107e79b75f852dce5d8dd2c8e6_20260912224909.png\" alt=\"2cf301af-7635-4217-bad7-c408919737c2.png\"\u002F>\u003C\u002Fp>","Dr. Su Li (Associate Chief Physician, MD; Director, Department of Hematology, GoBroad Shanghai Liquan Hospital; Director, Myeloma Center):\n\nHematopoietic stem cell transplantation is an important treatment option for achieving durable remission in severe aplastic anemia (SAA). Mr. Liu achieved good disease control after transplantation, although his post-transplant course included several complications.\n\nDuring the early post-transplant period (months 1-2), he developed cytomegalovirus (CMV) infection and Epstein-Barr virus-associated lymphoproliferative disorder (EBV-LPD). Both were brought under control with antiviral and related treatment. During months 3-6, he experienced recurrent Clostridioides difficile-associated colitis together with chronic cutaneous graft-versus-host disease (cGVHD). These complications improved with timely intervention. As his immune function gradually recovered, his overall condition continued to improve, and all immunosuppressive medications were discontinued approximately 2.5 years after transplant.\n\nMr. Liu has now been followed for five years. He remains relapse-free and free of ongoing GVHD, and has returned to normal work and everyday life.",{"slug":145,"title":146,"summary":147,"cover":148,"disease":149,"treatment":80,"patientType":91,"publishedAt":150,"contentHtml":151,"disclaimer":70,"hasAlternate":71,"updatedAt":72},"childhood-all-car-t-survivor-story"," Once Fighting for Her Life with Leukemia, She Is Now Five Years Post-CAR-T—and Beloved by Her Classmates","After being diagnosed with acute lymphoblastic leukemia and later experiencing relapse, Qiqi received CAR-T therapy and has remained in remission. Today, she is back at school and beginning a new chapter of growing up.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F1f4e9cbeb19b90b6f2a2ca1aa9aad857.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","Acute Lymphoblastic Leukemia","2026-07-16","\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Summary: In 2021, Qiqi, still only a young child, was diagnosed with acute lymphoblastic leukemia after developing persistent high fever. Her treatment journey included severe infections, hemophagocytic syndrome, and disease relapse. After the family traveled to Beijing, Dr. Jing Pan and her team reviewed Qiqi's previous treatment history and the features of her relapse, and developed a sequential CD19\u002FCD22 CAR-T treatment strategy. With comprehensive care throughout the process, Qiqi gradually recovered. Now, five years after CAR-T therapy, she is back at school and even dreams of becoming a doctor so she can help others one day.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cbr\u002F>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In 2021, young Qiqi was diagnosed with acute lymphoblastic leukemia after developing a persistent high fever.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Five years later, she is now a third-grade elementary school student, learning and playing with her classmates and making plans for her future. It is hard to imagine that this lively, cheerful girl once went through leukemia relapse and major turning points in treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At the 3rd CAR-T Cell Therapy Survivorship Conference, Qiqi's mother shared what it was like to accompany her daughter through leukemia treatment. From the shock of diagnosis, to repeated challenges during treatment, and finally the return to school, Qiqi's family never stopped looking for the next treatment opportunity. Step by step, they helped her find her way back to the childhood she deserved.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002Fb0dc3caf356181cc4b2de17e9b727c5e_20260913165840.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"b0dc3caf356181cc4b2de17e9b727c5e_20260913165840.png\" alt=\"779d8671-1a84-4e8b-b645-e8504664b6d3.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">Qiqi and her mother\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>One High Fever Changed an Entire Family\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In October 2021, Qiqi suddenly developed a persistent high fever. At first, her mother thought it was just a common cold. The test results, however, caught the entire family off guard: acute lymphoblastic leukemia.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">"We'd had a relative with leukemia before, but I never imagined it would one day happen to my own child."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">On the day of diagnosis, the doctor reassured the family while explaining the current outlook for childhood leukemia: "Children often have meaningful treatment opportunities. Don't let the diagnosis frighten you before treatment has even begun."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">From that day on, Qiqi and her family began a long treatment journey.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>Early Treatment Brings a Life-Threatening Infection\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Qiqi started chemotherapy soon after diagnosis, but the early phase of treatment was anything but smooth. During her second course, she developed a severe infection and had to be transferred urgently to the ICU. She later faced a pulmonary infection, hemophagocytic syndrome, and other critical complications, making the entire treatment course extraordinarily difficult.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">"At the time, we truly didn't know whether we would ever see her wake up again." People around the family began gently preparing them for the worst. But the doctors and other patient families kept encouraging them: "Hold on a little longer."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Qiqi's mother remembers the medical team talking with them again and again, asking them not to give up too soon. After more than 30 days of treatment, Qiqi's condition finally began to stabilize. But when she left the ICU, her mother was heartbroken by how much the illness had taken from her. Qiqi's weight had fallen from more than 15 kilograms to under 10 kilograms. She could not stand and no longer recognized her parents. "It was as if she had become a baby all over again." Her mother stayed beside her every day, talking to her and playing recordings of her own voice from when she was younger.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">More than 20 days later, Qiqi slowly regained awareness. "She couldn't say 'Mom,' but she kept looking at me. I knew she recognized me."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>When Leukemia Relapsed, the Family Headed to Beijing\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Around six months after completing treatment, Qiqi faced another major setback: the leukemia relapsed.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">For a child who had already survived a critical infection and had not yet fully regained her strength, relapse made the next stage of treatment even more difficult. To make matters worse, this was during the pandemic, but Qiqi's disease could not wait. "She had already relapsed. We simply didn't have time to sit around and think." With help from other patient families and healthcare professionals, Qiqi's family began looking for another treatment option. They learned about Dr. Jing Pan's team and decided to take Qiqi to Beijing.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Travel between provinces was tightly restricted at the time, making the trip far from easy. Qiqi's family completed her discharge paperwork overnight and set off for Beijing. They stayed in close contact with the receiving hospital along the way. "As long as someone in Beijing was willing to take her, we could get there." With active coordination from the hospital, Qiqi was ultimately able to reach Dr. Pan's team and begin treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>CAR-T Offers New Hope After Relapse\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">As soon as Qiqi arrived, the medical team assessed her condition and began planning the next stage of treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">"I remember it so clearly. The doctors and nurses kept reassuring us, saying, 'Now that she's here, let us take care of her.'" Qiqi's mother recalls that her daughter was in a fragile condition at the time: the leukemia had relapsed, infection remained a concern, and her body was still very weak.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Taking into account the pattern of relapse, Qiqi's previous treatment, and her current condition, Dr. Jing Pan's team developed a strategy centered on sequential CD19 and CD22 CAR-T therapy. The goal was to target and clear leukemia cells while creating the best possible opportunity for durable disease control.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Throughout treatment, the medical team managed Qiqi's complex condition as a whole. They worked to control her pulmonary infection and improve her physical condition so she could proceed with therapy, while also closely monitoring treatment response and the risk of complications and addressing problems promptly when they arose.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">This time, Qiqi did not need to return to the ICU because of infection and was able to complete treatment successfully.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>Five Years Later, She Is Back at School\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Throughout Qiqi's treatment, her parents put nearly all of their work aside so they could stay with her. Her mother even fractured her tailbone while caring for Qiqi, but still remained at the hospital. "Moms aren't superheroes. We just feel like we can't afford to fall down."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Today, five years after CAR-T therapy, Qiqi has returned to school. She studies and lives much like other children her age, and she already has a dream of her own. "I want to become a doctor and invent a needle that doesn't have to pierce the skin, so other children won't have to hurt the way I did." Her experience has also helped her understand how much her mother went through: "Mom worked so hard taking care of me. I hope she gets better and better too." From once needing help herself to now hoping she can help others in the future, Qiqi is finding her own meaning in what she has lived through.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>What Qiqi's Mother Wants to Share with Other Families\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">1. Understand Your Child's Condition and Keep Communicating with the Medical Team\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A child's condition can change throughout treatment, so parents need to actively understand their child's current health status, treatment goals, and what comes next. "Don't only wait for the doctor to tell you the result. Learn to ask questions and understand what your child is going through and what may come next." Having enough information at key decision points can help families make choices that better fit their child's situation.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">2. Find a Medical Team You Can Truly Trust\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Treating a hematologic disease is about much more than choosing a single regimen. Infection prevention, complication management, and long-term follow-up can all affect recovery. For a child facing a complex illness, finding an experienced, responsible medical team that can manage the full treatment journey is critically important.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">3. Connect with Other Patient Families and Learn from Their Experiences\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Patient and family support groups can be valuable sources of new information and different perspectives. Sometimes, simply talking with people who understand what you are going through can also make the days of treatment feel a little less difficult.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">4. Stay Committed to Treatment and Keep Believing in Your Child's Recovery\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">When disease relapses or treatment becomes difficult, a parent's emotional state can affect the child as well. Stay committed to treatment, stay present for your child, and focus on what can be done today. That is how families can accompany children, one step at a time, toward a better future.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">From the hospital ward back to the classroom, Qiqi's five-year journey shows that going through something difficult does not mean losing the future.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Every child still in treatment deserves to have a future to look forward to. We hope every family can find a treatment direction that fits their child and move forward with confidence and hope, waiting together for brighter days ahead.\u003C\u002Fspan>\u003C\u002Fp>",{"slug":153,"title":154,"summary":155,"cover":156,"disease":141,"treatment":157,"patientType":91,"publishedAt":158,"contentHtml":159,"disclaimer":70,"hasAlternate":71,"updatedAt":72},"severe-aplastic-anemia-ist-treatment-student-recovery","A 100-Day Comeback: An 18-Year-Old with Severe Aplastic Anemia Returns to School and Takes the Gaokao","After being diagnosed with severe aplastic anemia during her final year of high school, she received IST, became transfusion-independent within 16 days, achieved a complete hematologic response at three months, and returned to school in time to take the Gaokao.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F0dcaef58b64a4bb3af6ec01a49f56e4c.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","Immunosuppressive Therapy (IST)","2026-07-10","\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Summary: Xiaoyu (pseudonym) was in her final year of high school, preparing for China's national college entrance examination, when persistent dizziness, fatigue, recurrent infections, and unexplained bleeding spots led to a diagnosis of severe aplastic anemia. Faced with a choice between transplant and non-transplant treatment, the medical team considered her age, disease characteristics, and family circumstances and developed an immunosuppressive therapy (IST) plan using antithymocyte globulin (ATG), cyclosporine, and a thrombopoietin receptor agonist (TPO-RA). Just 16 days after treatment began, she no longer needed blood-product transfusions. Three months later, she achieved a complete hematologic response, returned to school, and went on to complete the Gaokao.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cbr\u002F>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cbr\u002F>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In the autumn of 2025, a worried mother hurried into the outpatient corridor of the Anemia Diagnosis and Treatment Center at Beijing GoBroad Boren Hospital. Walking behind her was a thin teenage girl. As a high school senior, she should have been focused on classes and university entrance exams, yet even standing was difficult; after only a few steps, she had to stop and rest.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">By then, mother and daughter had already been to one hospital after another looking for answers...\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cbr\u002F>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The story began just as her final year of high school was getting underway.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cbr\u002F>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Instead of throwing herself into exam preparation, Xiaoyu began experiencing frequent dizziness and lightheadedness. Climbing stairs caused uncomfortable palpitations. She developed recurrent mouth ulcers, repeated respiratory infections, progressive weight loss, and clusters of unexplained pinpoint bleeding spots on her skin. Alarmed, her mother took her from their local hospital to a major tertiary hospital in Beijing.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The blood test showed marked reductions across all three blood cell lines: white blood cells 2.98 x 10^9\u002FL, neutrophils 0.63 x 10^9\u002FL, hemoglobin 67 g\u002FL, and platelets only 20 x 10^9\u002FL. A bone marrow examination ruled out malignancy. The outside hospital initially considered infection-related pancytopenia and treated her with anti-infective therapy and androgen therapy to support blood-cell production.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002Fc5ae8f27758a952da0ab080c5f7cbfb4_20260913162348.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"c5ae8f27758a952da0ab080c5f7cbfb4_20260913162348.png\" alt=\"15ecee3e-abdb-429a-885a-93c35dbf7b50.png\"\u002F>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px; text-align: center;\">The patient's first complete blood count at a tertiary hospital in Beijing\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A month passed, but her symptoms did not improve. Instead, her condition continued to worsen.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The downward arrows on each new blood count were frightening for her mother: white blood cells 2.39 x 10^9\u002FL, neutrophils 0.41 x 10^9\u002FL, hemoglobin 63 g\u002FL, and platelets 24 x 10^9\u002FL. A local hospital gave her a red blood cell transfusion, which helped stabilize her temporarily, but everyone knew transfusions alone were not a long-term solution.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In October 2025, mother and daughter came to the Anemia Diagnosis and Treatment Center at Beijing GoBroad Boren Hospital. Xiaoyu was so weak that she could barely sit down without her mother's support. Her face showed exhaustion, helplessness, and uncertainty about the future. Her mother had only a few questions in mind: What exactly was wrong with her daughter? Could it be treated? Would she be able to go back to school?\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">We arranged admission immediately and quickly completed a comprehensive bone marrow and hematologic evaluation. The diagnosis was clear: severe aplastic anemia.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Severe aplastic anemia is a serious bone marrow failure disorder. It can progress quickly, and without timely and effective treatment, patients may face life-threatening infection or bleeding. For a student like Xiaoyu, it could also put any return to school far out of reach.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Because she was so young, we evaluated her particularly carefully and first ruled out inherited bone marrow failure. Genetic testing found no evidence of a congenital cause. Under standard treatment principles, for patients under 40 with severe aplastic anemia who have an HLA-matched sibling donor, allogeneic hematopoietic stem cell transplantation is generally the preferred first-line option.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">But the family was facing several very real concerns:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">HLA typing had not yet been completed for her younger siblings. Her parents were deeply worried about transplant-related risks. The possibility of impaired fertility weighed heavily on the family, and treatment costs were another major concern. On top of all this, Xiaoyu was in the most critical year of high school, preparing for the Gaokao.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Every concern carried weight, and every decision felt difficult.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After repeated discussions and careful consideration, Xiaoyu's mother made a difficult but firm decision to proceed with intensive immunosuppressive therapy (IST). The regimen combined ATG, cyclosporine, and a TPO receptor agonist - a contemporary three-drug non-transplant strategy for severe aplastic anemia.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Treatment began.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Xiaoyu handled the treatment remarkably well and experienced few significant side effects. Even more encouraging, just 16 days after starting therapy, she became independent of blood-product transfusions.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In the hospital, the once-exhausted teenager picked up her textbooks again. She memorized vocabulary between infusions and worked through practice questions whenever she had a quiet moment. The nurses cheered her on: "Keep going - the exam room and your future are waiting for you."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After discharge, she continued oral medications to support hematopoietic recovery and returned for weekly monitoring of her blood counts, liver function, and kidney function. Her mother stayed in close contact with the medical team through WeChat, and each change in her blood counts or medication plan was managed through close communication between the family and clinicians.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Three months later, spring brought the news everyone had been hoping for.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At the three-month IST evaluation, Xiaoyu had achieved a complete hematologic response.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Her white blood cell count was 4.29 x 10^9\u002FL, neutrophils 3.29 x 10^9\u002FL, hemoglobin 116 g\u002FL, and platelets 206 x 10^9\u002FL. Her bone marrow function had recovered rapidly.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002F5b8fd71ed1d86bb03289151354df7e75_20260913164158.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"5b8fd71ed1d86bb03289151354df7e75_20260913164158.png\" alt=\"be7e94c3-0615-4d66-a8bc-7e3f58ac4aad.png\"\u002F>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px; text-align: center;\">Complete blood count at the three-month follow-up after intensive IST\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The girl who had once struggled even to stand was back on her feet. She returned to school and to the goal she had been working toward. Her final-year coursework was demanding, and she had months of material to catch up on, but she kept taking her medication while working steadily through the missed lessons. Few of the students around her knew that only months earlier, she had been hospitalized with a life-threatening bone marrow failure disorder.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Then came the day of the Gaokao.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">She walked calmly into the examination room, just like millions of other students who had spent years working toward this moment, and began writing the next chapter of her future.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The wait for the results felt long. Then the good news finally arrived.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Her score was well above the undergraduate admission cutoff in her province.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002Feeb59f0ff63486419c06a384840c95d8_20260913164245.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"eeb59f0ff63486419c06a384840c95d8_20260913164245.png\" alt=\"53de9f40-6808-4765-8c1d-1c9726356439.png\"\u002F>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002Ff2cfe4db309e9f9c8d4e52f925a90ad2_20260913164310.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"f2cfe4db309e9f9c8d4e52f925a90ad2_20260913164310.png\" alt=\"4ff475ca-1683-400b-9f79-f357275434b4.png\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">The patient's exam results (only the total score is shown to protect privacy)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The whole family cried with joy. Her mother immediately sent us a screenshot of the result, her messages filled with excitement and gratitude.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cbr\u002F>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">We still remember something Xiaoyu once told us in the ward: "I want to study education and become a teacher someday."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Now that dream is within reach. She is preparing to enter the university she hoped for and move closer to the classroom she has imagined herself standing in so many times.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">What makes us proudest is not the number on the score report. It is that while recovering from a serious illness and racing against time, she still made it through one of the most demanding years in a Chinese student's education.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Looking back, what is a doctor's role?\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Often, it is simply to do everything possible to keep a patient's unfinished dreams within reach.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">From diagnosis and treatment decisions, to becoming transfusion-independent in 16 days and reaching a complete hematologic response in three months, from memorizing vocabulary in the hospital to answering questions in the Gaokao examination room - this was more than a medical success. It was a story of determination and courage shared by one young woman, her family, and the people caring for her.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Xiaoyu is now preparing for a new chapter. We still have one more goal together: to help her gradually reduce and eventually come off medication when medically appropriate, so she can move into adulthood healthy and free to pursue the life she wants.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">This summer, we wish her a safe and joyful journey ahead, with many more possibilities waiting to unfold.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002Fcdfa0d6afd6a86703c0ad0b19c2876a1_20260913164334.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"cdfa0d6afd6a86703c0ad0b19c2876a1_20260913164334.png\" alt=\"461a617f-f461-4712-8cb2-ff6fff62c979.png\"\u002F>\u003Cspan style=\"font-size: 15px; text-align: center; color: rgb(136, 136, 136);\">The patient presented a banner of thanks to the medical team upon discharge\u003C\u002Fspan>\u003C\u002Fp>",{"slug":161,"title":162,"summary":163,"cover":164,"disease":141,"treatment":99,"patientType":67,"publishedAt":165,"contentHtml":166,"expertView":167,"disclaimer":70,"hasAlternate":71,"updatedAt":126},"severe-aplastic-anemia-gvhd-recovery","Six Years After Transplant, She Never Let Chronic GVHD Hold Her Back","Diagnosed with severe aplastic anemia at 19, she underwent a stem cell transplant and then faced years of chronic GVHD. With long-term medical follow-up and her own persistence, she returned to university, graduated, and began a new chapter in life.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002Fa0a33bedc4d03a0c7a1bc4b1a692e21d.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","2026-07-09","\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Summary: At 19, Xiaoling (pseudonym) underwent a related-donor haploidentical hematopoietic stem cell transplant for severe aplastic anemia and achieved remission. But chronic graft-versus-host disease (GVHD) after transplant affected multiple systems, including her lungs, skin, and joints, leading to a long and difficult recovery. With ongoing follow-up and care from Dr. Chuxian ZHAO's team at GoBroad Shanghai Zhaxin Hospital, she stayed on treatment, attended regular checkups, committed to rehabilitation, and also received supportive care combining conventional medicine and traditional Chinese medicine. Her chronic GVHD symptoms gradually improved. In 2021, she returned to university and successfully completed her studies. Now, nearly six years after transplant, she has started a job she wanted and is gradually returning to everyday life. Her experience traces the full journey from transplantation and chronic GVHD management to long-term recovery, offering encouragement to others navigating life after transplant: consistent treatment, rehabilitation, and a positive approach to life can open the door to a new beginning.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003C\u002Fp>\u003Cp style=\";\">\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002Fcc0d0f98333d9c50f16e9646adf40063_20260912224323.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"cc0d0f98333d9c50f16e9646adf40063_20260912224323.png\" alt=\"0ce2f4fe-3cca-4b39-99fb-ff5de08e69a0.png\"\u002F> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At 19, life should have been just beginning, full of possibilities. But in the year Xiaoling (pseudonym) entered university, everything changed: she was diagnosed with severe aplastic anemia, and her college life was abruptly put on hold. Yet there was still a path forward. In July 2020, she underwent a related-donor haploidentical hematopoietic stem cell transplant at GoBroad Shanghai Zhaxin Hospital, giving her the chance to begin again.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The road after transplant, however, was far from easy. Chronic graft-versus-host disease (GVHD) followed, bringing both physical and emotional challenges. Lung involvement left her short of breath with even light activity. Stiffness in the muscles and joints of her hands made simple everyday movements difficult. Changes caused by skin GVHD made it hard for her, for a time, even to recognize herself in the mirror. With professional care and steady support from the team at GoBroad Shanghai Zhaxin Hospital, Xiaoling kept going. She returned for regular follow-ups, adjusted her medications as instructed, and worked through rehabilitation under medical guidance, gradually regaining function step by step.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In September 2021, she returned to university and went on to graduate with excellent results. Chronic GVHD remained a long-term challenge, but she refused to let it stop her. With determination beyond her years, she kept working through each setback and slowly found her rhythm in life again.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">There were still emotional ups and downs during treatment and recovery, and her body continued to adjust. But today, her chronic GVHD symptoms have improved substantially. She has also continued supportive care with Dr. Huixia LIU through a hematology clinic integrating traditional Chinese medicine, with the goal of supporting her longer-term recovery. Late last year, she also landed a job she had hoped for.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In her sixth year after transplant, the hospital prepared a special "graduation ceremony" for her. That day, Xiaoling received the first bouquet of flowers she had ever been given. Smiling, she said, "I can't believe this is the first bouquet I've ever received." Looking back, she does not avoid the what-ifs. "If I had never gotten sick, maybe my life would have been easier." Then she paused and added firmly, "But I don't think the version of me who never got sick would necessarily be stronger than the person standing here today."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In that moment, she had moved beyond more than illness - she had also grown beyond the person she once was. She chose to share her story not to dwell on hardship, but to offer a little light and courage to others still making their way through recovery.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>Patient Conversation\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q1: When did you first realize that something might be wrong with your health?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: When I started university, I moved alone to a city I didn't know. I wasn't used to the new environment or the pace of life. At first, I noticed purpura and a few small bleeding spots on my skin, but I didn't think much of them and assumed it was just a skin issue. Gradually, though, I became more and more tired. Climbing the stairs to my dorm would leave me completely out of breath.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">One weekend, I stayed with my aunt in Shanghai. On Sunday morning, I got out of bed and suddenly everything went dark in front of me. My heart was racing, and I felt so weak that I could barely stand. My family rushed me to a nearby hospital. After a series of tests, I was diagnosed with severe aplastic anemia in October 2019.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">When I first heard the diagnosis, I couldn't accept it at all. But I was already so physically weak that I hardly had time to process the sadness or fear. I just had to focus on the treatment in front of me.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q2: Hematopoietic stem cell transplantation is a major decision. How did you and your family decide to go ahead with it?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: My parents were extremely worried and took me from place to place looking for treatment. At first, I chose non-transplant treatment, but I remained very weak. We had heard that allogeneic hematopoietic stem cell transplantation could be an effective treatment for aplastic anemia, but the risks of transplant and the uncertainty around GVHD made us hesitant.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">During that time, I met another patient around my age who had exactly the same type of disease. I chose non-transplant treatment, while he decided to go ahead with a transplant.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Two or three years later, I was still dealing with blood counts that kept fluctuating, while he had recovered and returned to normal life. That had a huge impact on me. I realized that transplant wasn't necessarily as frightening as I had imagined. What scared me more was the possibility of hesitating for too long and missing the best treatment window.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">My non-transplant treatment also wasn't working very well. My blood counts stayed low and my quality of life was poor. In the end, my family and I made up our minds to proceed with transplantation.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In July 2020, I successfully underwent a related-donor haploidentical hematopoietic stem cell transplant at GoBroad Shanghai Zhaxin Hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q3: You dealt with chronic GVHD for a long time after transplant. What was that period like for you, and how did you get through it?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: A successful transplant was only the first step. The GVHD afterward was the real test.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The first problem was pulmonary GVHD. For a while, even walking a few steps left me badly short of breath. Climbing stairs felt almost impossible. For someone who had once been energetic and active, that change was very hard to accept.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Then came stiffness in the muscles and joints of my hands. At its worst, I could barely make a fist, and even simple everyday tasks took a lot of effort.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I also developed skin GVHD. My skin became rough and uneven in color, and sometimes when I looked in the mirror, I barely recognized myself.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">There were times when I felt completely overwhelmed. I kept asking myself, "Why me? Why do I still have to go through all of this after the disease itself has been treated?"\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">But every time I returned to the hospital for follow-up, the doctors and nurses encouraged me. They told me that recovery could take time, and that if I stayed with the treatment and rehabilitation, things could gradually improve.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">With my family beside me, I began rehabilitation with the simplest movements and built up little by little. Progress was slow, but every small improvement gave me a little more courage to keep going.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q4: You mentioned receiving ongoing care from Dr. Huixia LIU through a hematology clinic integrating traditional Chinese medicine. How did that support your recovery?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: Recovery after transplant is a long process. Conventional medicine was very important for controlling GVHD, while I felt that traditional Chinese medicine also helped support my overall recovery.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Dr. Huixia LIU developed an individualized supportive care plan based on how I was doing. It included approaches such as Chinese herbal medicine and acupuncture, aimed at supporting my energy and overall physical condition.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After staying with the plan for a while, I could feel my condition gradually improving. I had more energy, I was sleeping better, and even the symptoms affecting my skin became much less noticeable.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">For me, conventional medicine and traditional Chinese medicine were not an either-or choice; they could complement each other. During rehabilitation after transplant, this integrated approach helped make my recovery feel steadier.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002Fb23be6c1870d11cce775690a5a646dd3_20260912224407.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"b23be6c1870d11cce775690a5a646dd3_20260912224407.png\" alt=\"6883a848-c883-4bbc-a84b-254f9672f4b8.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">Photo of Xiaoling taken in spring 2023\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q5: Returning to university, graduating, and finding a job have all been major milestones. Looking back, how do you think illness changed you?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: Before I got sick, I was very driven. I wanted to do everything as well as possible and set very high standards for myself.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After getting sick, I learned to accept that I don't have to be perfect. I used to think life had to follow a fixed path - university, graduation, a job, marriage - and that I couldn't fall behind at any step. Illness taught me that life isn't a race. Everyone has their own journey.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">During the years I was away from school, I watched my classmates graduate and start working. I definitely felt anxious and left behind at times. Eventually, I came to understand that everyone moves at their own pace, and I didn't need to measure my life against someone else's timeline.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">When I finally returned to university, I appreciated the experience far more than I had before. Things I once took for granted became precious once I had lost them and then gotten them back.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Now that I'm working, I still take each day seriously, but I don't push myself as harshly as I used to. I allow myself to go a little slower, and I allow myself to have days when I don't feel my best. That's one of the most important things illness taught me.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q6: You said, "The version of me who never got sick wouldn't necessarily be stronger than the person I am today." What does that mean to you?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: That's genuinely how I feel.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">If I had never gotten sick, I probably would have finished university on schedule, found a job, and lived a fairly ordinary, steady life. Things might have gone more smoothly, but I might never have developed the resilience or perspective I have now.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Illness made me face life and death, the limits of my body, and a long recovery while I was still very young. Those experiences were painful, but they also helped me understand earlier than many people my age what really matters and what I can let go of.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Now I value my health, my family, and every ordinary day much more. I also have a deeper sense of empathy. Because I know what it's like to be caught in the rain, I want to hold an umbrella for someone else.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">That's why I say the version of me who never got sick wouldn't necessarily be stronger than the person I am today. It's not that I'm grateful for being ill. It's that the strength I had to build through illness is something an easy life could never have taught me.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: left;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Xiaoling also asked us to include this personal message:\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I especially want to thank Dr. Chuxian ZHAO. Over the six years since my transplant, whenever anything has gone wrong with my health, she has been the first person I turn to. She always responds promptly, helps me understand what's happening, and points me toward the next step in treatment. Whether I'm dealing with another flare of chronic GVHD, an ordinary viral infection, or even moments when I'm anxious and emotionally overwhelmed, she always knows how to steady me. She is professional, calm, and incredibly patient. She gives me an enormous sense of security.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Another thing I really admire is Dr. Zhao's amazing memory. She knows my entire medical history and remembers the medications I've taken and so many details from every stage of treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Dr. Zhao, you're my absolute hero. I love you!\u003C\u002Fspan>\u003C\u002Fp>","Dr. Chuxian ZHAO (Associate Chief Physician, MD; Director, Hematopoietic Stem Cell Transplantation Center, GoBroad Shanghai Zhaxin Hospital):\n\nAplastic anemia is a bone marrow failure disorder in which the marrow cannot produce adequate blood cells. Allogeneic hematopoietic stem cell transplantation is an effective treatment for aplastic anemia. Xiaoling underwent a haploidentical hematopoietic stem cell transplant and achieved complete remission.\n\nXiaoling is cheerful, resilient, and optimistic. She encountered many setbacks at different stages of treatment, but she consistently faced each challenge with a positive attitude and actively worked with the medical team. Her inner strength inspired everyone around her. At one point, we were very concerned that tendon contractures in her fingers caused by chronic GVHD might affect her studies and daily life. Rehabilitation required difficult stretching exercises, but Xiaoling kept at them and gradually regained function, little by little.\n\nXiaoling's recovery has deeply moved us as well. The resilience of life is often greater than we imagine. Medicine is essential in the face of disease, but a patient's hope and persistence are also powerful sources of strength throughout recovery. Illness may put life on pause, but it does not define an entire life. We hope Xiaoling receives many more flowers and rounds of applause in the years ahead, and embraces all the possibilities that belong to her.",{"slug":169,"title":170,"summary":171,"cover":172,"disease":173,"treatment":80,"patientType":91,"publishedAt":174,"contentHtml":175,"disclaimer":70,"hasAlternate":71,"updatedAt":72},"primary-mediastinal-b-cell-lymphoma-car-t-survivor-story","Diagnosed with Primary Mediastinal Large B-Cell Lymphoma at 15, He Finally Achieves CMR After Multiple Treatment Setbacks","After multiple lines of treatment and two rounds of CAR-T therapy, 15-year-old Xiao Chen finally achieved a complete metabolic response (CMR) after his treatment strategy was precisely reassessed and adjusted.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F41a2d3609eff452a9f58159483a7ae35.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","Primary Mediastinal Large B-Cell Lymphoma","2026-07-06","\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Summary: \u003C\u002Fspan>\u003Cspan style=\"font-size: 15px;\">Xiao Chen (pseudonym) was diagnosed with stage IV primary mediastinal large B-cell lymphoma (PMBCL) at age 15. He went through chemotherapy resistance, multiple courses of immunotherapy, and two rounds of CAR-T therapy, with the disease progressing more than once. Through repeated multidisciplinary review and ongoing refinement of his treatment plan, he ultimately received immunotherapy followed by dual-target CD19\u002FCD22 CAR-T cell therapy. On June 2, 2026, his PET\u002FCT showed a complete metabolic response (CMR) for the first time. His story captures not only a teenager’s difficult journey through cancer treatment, but also the importance of precise reassessment, timely treatment adjustments, and long-term management in relapsed or refractory lymphoma.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003Cstrong style=\"font-size: 15px;\"> \u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong> \u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>01\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Hello, I’m Xiao Chen’s mother. My son is 16 now, 175 cm tall, and has always been a bright, outgoing boy.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Before he became ill, he had just started high school and was placed in an advanced class. He loved programming. He won first prize in a provincial robotics competition and a gold medal in the middle-school division of the VEX EDR Asia Championship.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Before last October, I worked at a public-sector institution in Chengdu. We had a son and a daughter, and our life followed a steady routine. Then my son suddenly became ill, and I had to become the person holding the family together.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Xiao Chen was diagnosed with stage IV primary mediastinal large B-cell lymphoma from the start. Over the next year and a half, we went to 16 hospitals. He underwent 9 biopsies, 16 courses of chemotherapy, 7 courses of immunotherapy, 2 rounds of CAR-T therapy, 10 bone marrow aspirations, and 15 lumbar punctures.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I learned to search medical literature using Haodf.com, DeepSeek, and Yuanbao. I got used to traveling with my son between hospitals in different cities, and we went through several moments when his life was in immediate danger.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">It was not until he was treated by Dr. Kai Hu at Beijing GoBroad Hospital that we finally saw a major turning point. On June 2, 2026, his PET\u002FCT showed a complete metabolic response (CMR) for the first time.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I cried many times along the way. This was the first time I cried because I was happy.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002F6c67a74e617c715eccf3d0557d012a06_20260913165525.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"6c67a74e617c715eccf3d0557d012a06_20260913165525.png\" alt=\"dce49903-88c8-4a4d-bb0d-5f160cbd1146.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">Xiao Chen recovering at home after achieving CMR\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>02\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In October 2024, Xiao Chen began having recurrent fevers of around 38°C, along with fatigue, night sweats, and weight loss.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">When we went to the hospital, the doctor called me into the office alone. Imaging showed a large 13.6 × 9.1 cm mass in the anterior mediastinum, enlarged lymph nodes in both hilar regions, the supraclavicular fossae, the retroperitoneum, and the abdomen, as well as multiple lesions in the liver, spleen, and both kidneys. A needle biopsy of a left cervical lymph node then confirmed primary mediastinal large B-cell lymphoma.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">There was no time to process it. He was so young, and we knew treatment had to start as soon as possible.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">He received his first treatment at a local hospital with DA-EPOCH-R, an intensive dose-adjusted regimen.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After chemotherapy, Xiao Chen had black stools for about two weeks, but the regimen was not adjusted. Then one day, he suddenly vomited a large amount of blood and his blood pressure dropped. He was rushed to the ICU. Standing outside the ICU, my legs were shaking.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After he left the ICU, we transferred to the hematology department of another hospital. Because he had recently experienced major bleeding, the doctors did not want to use another intensive regimen and changed treatment to R-CHOP.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">But at that hospital, every cycle of chemotherapy required a new admission appointment, and a bed was not guaranteed. For a critically ill patient, that made continuity of treatment difficult. His primary doctor also changed frequently, and I was extremely anxious.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">To keep his treatment on schedule, we found a way to transfer him to another department within the same hospital. For cycles 3 and 4, he received an adult CR-CHOP regimen. After four cycles, PET\u002FCT showed disease progression.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The specialists told us chemotherapy was no longer working and suggested that we explore commercial CAR-T therapy. At the same time, they acknowledged that their department had limited experience using CAR-T in adolescents. Hearing even the specialist say that, I stood in the corridor feeling as though we had reached a dead end.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>03\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I did not have time to fall apart. I urgently asked for advice in patient support groups, took Xiao Chen’s PET\u002FCT report, and flew to Beijing the next day. With help from a friend, I visited five hospitals in Beijing in a single day.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Every specialist recommended an adult treatment approach. But Xiao Chen was only 15.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">People in the patient groups strongly urged us to try a children’s hospital and pursue a pediatric approach. I went to a pediatric specialty hospital and met with the head of its lymphoma program. The answer was clear: they could not take him. His condition was too severe and too complex, and it had moved beyond the usual scope of pediatric lymphoma treatment. We were told that by the fourth cycle of chemotherapy, the best treatment window had already been missed. Adult programs had limited experience with younger patients, while the pediatric hospital felt his disease was already too advanced. Both paths seemed closed.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">On the third day, I decided to go to Guangzhou because I knew there were hospitals there with pediatric oncology departments.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>04\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The doctors at the hospital in Guangzhou took good care of Xiao Chen. But after every cycle of chemotherapy, he developed a severe infection. His immune system was extremely weak, and the crowded inpatient environment of a large public hospital, with so many patients around, was simply too much for him.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After the seventh cycle, treatment had to be interrupted for two weeks.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After the eighth cycle, the assessment showed a partial response but also new lesions. The hospital organized a multidisciplinary consultation. The conclusion was clear: the lymphoma had become resistant to chemotherapy. The team suggested considering a bispecific antibody or CAR-T therapy.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">During the MDT meeting, a pathologist asked me, “Do you have any other children?” I froze.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">It felt as though everyone else had given up. But I would not.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>05\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The tumor was still progressing. We could not stop.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A friend of a distant relative had received compassionate-use CAR-T therapy at a hematology hospital in Beijing. I went there looking for another chance.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The Beijing specialists developed a plan to first reduce the tumor burden with blinatumomab.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">During treatment, Xiao Chen suddenly developed generalized body stiffening at around 3 a.m. It lasted about a minute. I was the only person with him, and I was terrified.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The doctors said the medication could potentially be continued, but they had not encountered this kind of reaction before and could only proceed cautiously. We had already paid RMB 50,000–60,000 out of pocket for the blinatumomab. It could not be returned or transferred to another patient.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">My family said we could try again. I said no. I could not gamble with my son’s life.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>06\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After leaving that hospital, I went to two more hospitals in Guangzhou to look for a CAR-T option. At one cancer hospital, patients aged 15 and older who wanted commercial CAR-T therapy had to go through the hospital’s ethics review process. We did not have time to wait.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At another hospital, the treatment was not controlling the tumor well, and Xiao Chen developed side effects including a rash and hypoglycemia. His attending doctor told us directly that they had not seen a similar situation and could only try to manage it step by step. I could not let Xiao Chen keep feeling like a test case.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>07\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">We returned to Beijing, where I found a leading pediatric lymphoma specialist. By then, Xiao Chen could no longer lie flat because he was short of breath. Even for an MRI, he had to be positioned on his side.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After a detailed assessment, the specialist developed a new plan. After several courses of treatment, the tumor was finally brought under control and began to shrink. For the first time, I saw hope.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">He then received three sessions of radiotherapy, with a plan to infuse CD19 CAR-T cells afterward. But he developed a fever after radiotherapy. The CAR-T infusion was given a week later, but the cells did not expand well, and the disease progressed again.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Xiao Chen did not know. He happily told me, “Mom, once I’m discharged, I’ll take online classes at home, and on weekends I want to go out with my classmates and just hang out and talk.” I could not hold it together. I hid in the bathroom and cried, then went outside and let the winter wind in Beijing dry my tears.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">He was at an age when life should have been opening up, yet he had already been through so much.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">He did not know that after so many rounds of chemotherapy, radiotherapy, and CAR-T therapy, the disease had progressed again. I could not imagine how hopeless he would have felt if he had known.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Three children with lymphoma in the room next door passed away one after another. I did not even have time to break down.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>08\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">So I started searching for a way forward again.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I went to other major general hospitals in Beijing to seek expert opinions, doing everything I could to get appointments with top national specialists, including academicians. Online, I read other patients’ experiences on Haodf.com and used DeepSeek and Yuanbao to search and analyze medical literature.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I gradually began to suspect that Xiao Chen’s disease might need to be treated specifically as primary mediastinal large B-cell lymphoma, and that adult and pediatric treatment strategies could be very different. I raised this with his specialist twice. She also consulted a pathologist, who felt the diagnosis was not primary mediastinal lymphoma and continued to favor a diffuse large B-cell lymphoma treatment approach.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">To her credit, the specialist was very open to discussion and quickly organized a multidisciplinary consultation. During the meeting, I heard Dr. Kai Hu from Beijing GoBroad Hospital propose a new pola-based regimen. It was exactly in line with the direction I had found in the cases I had been reading.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Dr. Hu’s comments at the meeting stayed with me. He was not the kind of doctor who simply gave a conclusion. He explained the reasoning—why the previous direction might not have been right, and why a pola-based approach might be more suitable for Xiao Chen. His logic was very clear.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The hospital adopted Dr. Hu’s recommendation and gave two cycles of the new pola-based regimen. The tumor came under control and shrank.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">It felt like sunlight finally breaking through a crack. But by then, Xiao Chen’s body was exhausted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After so much chemotherapy, he was in very poor physical condition. Drug side effects had accumulated, infections kept recurring, and for more than ten days he was unable to pass gas on his own.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I learned that Dr. Hu had managed more than 2,000 complex lymphoma cases and had extensive experience. I decided to transfer Xiao Chen to Beijing GoBroad Hospital to be treated by Dr. Hu.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>09\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Dr. Hu’s team developed a clear strategy: four cycles of immunotherapy followed by dual-target CD19\u002FCD22 CAR-T cell therapy. Each step was carefully paced. Xiao Chen did not develop severe cytokine release syndrome (CRS), there were no uncontrollable complications, and his infections were brought under control.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Little by little, Xiao Chen began to recover. On June 2, 2026, a follow-up PET\u002FCT showed a complete metabolic response (CMR), and circulating tumor DNA (ctDNA) was negative.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Looking back, achieving CMR depended on making the right decisions at key points and continuing to refine the treatment strategy. Dr. Hu played a critical role in the timing and sequencing of therapy—knowing when immunotherapy was needed to reduce tumor burden, when it was time to move into CAR-T therapy, and when to select the treatment targets. Every step was based on ongoing reassessment of Xiao Chen’s condition.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The entire team also worked with strong coordination and execution. From physicians and nurses to the inpatient environment and infection control, every part of the care mattered. With a complex, difficult-to-treat lymphoma, you need more than one experienced specialist—you need an entire team that can work together under pressure.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>10\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">My son has changed a lot over the past year and a half.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Before he became ill, he was cheerful and outgoing. He smiled a lot, loved basketball, and had many friends. Now he talks less and is often quiet. I understand. Anyone who has spent so long in a hospital bed and gone through so many rounds of chemotherapy, bone marrow aspirations, and lumbar punctures would have difficult days.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">But he finds his own way to make peace with what he has been through.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I told him, “What you’ve experienced is something most of your classmates may never face in their entire lives. It is a different kind of life experience. In the future, you might even consider studying integrative medicine or biomedical science. What you’ve lived through has already given you a very personal understanding of healthcare.” I wanted him to know that this year and a half had not simply been lost time.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">His younger sister often sends me messages on her smartwatch: “Mom, how is my brother? When is he coming home?” Every time, all I could say was, “Soon.”\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Now, finally, he can go home.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">If Xiao Chen continues to recover, I want to do something for other patients with blood diseases when we get home. So many people helped us along the way—strangers in patient support groups, doctors who replied to my messages late at night, relatives and friends who helped us contact hospitals. I want to pay that kindness forward.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>11\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Finally, I want to share a few words with patients and families who are still in the middle of treatment:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">First, hold on to hope. Refractory disease, relapse, infection, or blood counts hitting their lowest point—none of it is easy. As long as you do not give up, there may still be choices and possibilities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Second, find a medical team you trust and work closely with them. Trust can make a real difference in how treatment moves forward. At the same time, stay informed: look for relevant treatment experiences and published cases, and share useful information with your care team.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Third, take infection prevention and supportive care seriously. When the immune system is weak, infection can be one of the greatest dangers. Every mask, every careful hand wash, and every clean, nutritious meal is part of the defense.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">And remember: you are not fighting alone. Family support gives strength, encouragement from other patients can be a light in the dark, and the medical team is there to protect and support you. Most importantly, be kind to yourself and take care of yourself too.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">One more lesson I learned the hard way: make sure your family has adequate critical illness insurance. A relatively small premium can make a major difference when serious illness strikes.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I wish every patient a smooth recovery.\u003C\u002Fspan>\u003C\u002Fp>",{"slug":177,"title":178,"summary":179,"cover":180,"disease":89,"treatment":181,"patientType":91,"publishedAt":182,"contentHtml":183,"expertView":184,"disclaimer":70,"hasAlternate":71,"updatedAt":72},"childhood-b-all-second-transplant-cart-survival-story","Diagnosed with Leukemia at Age 3, He Finds a New Beginning After a Second Transplant Following a 10-Year Journey","Diagnosed with B-cell acute lymphoblastic leukemia at age 3, Lele went through relapse, CAR-T therapy, and two stem cell transplants. Ten years after his leukemia journey began, he is gradually returning to everyday life.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F7d827d40a5c7be3bd410d88b5f6c130b.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","CAR-T, Hematopoietic Stem Cell Transplantation","2026-06-30","\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Summary: \u003C\u002Fspan>\u003Cspan style=\"font-size: 15px;\">In 2016, 3-year-old Lele (pseudonym) was diagnosed with B-cell acute lymphoblastic leukemia (B-ALL). After achieving remission with chemotherapy, he later relapsed and received CAR-T therapy followed by a first related haploidentical hematopoietic stem cell transplant. The leukemia nevertheless returned again in 2022. After Lele came to Beijing GoBroad Boren Hospital, the specialist team developed an individualized treatment pathway based on his disease characteristics: chemotherapy to reduce tumor burden, CD22 CAR-T therapy, total body irradiation (TBI), and an unrelated-donor allogeneic hematopoietic stem cell transplant. The strategy brought him back into complete remission. Now, more than three years after his second transplant, Lele continues to regain his strength. The little boy who endured years of treatment is growing into an upbeat, cheerful teenager.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Lele was diagnosed with B-cell acute lymphoblastic leukemia (B-ALL) in 2016, when he was only 3 years old. After three years of chemotherapy, he was able to return to school, but the disease relapsed at the end of 2020. He subsequently received CAR-T therapy and a related haploidentical stem cell transplant, yet the leukemia returned again in September 2022. At one of the family's most difficult moments, they came to Beijing GoBroad Boren Hospital. The specialist team developed a combined strategy of chemotherapy, CAR-T therapy, total body irradiation, and a second transplant. In February 2023, Lele successfully received an unrelated-donor allogeneic hematopoietic stem cell transplant and again achieved complete remission.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">More than three years after the second transplant, the little boy who once faced one challenge after another has grown into a bright, cheerful teenager. Watching his son smile on stage, Lele's father quietly felt his eyes fill with tears.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002Fc00a344cd7b5ff98e7976190d6835587_20260913160501.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"c00a344cd7b5ff98e7976190d6835587_20260913160501.png\" alt=\"b4184dfb-ff7e-4451-b7e9-b58a1e628212.png\"\u002F>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px; text-align: center;\">Lele Meets His Donor for the First Time\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>One Diagnosis Ended All the Joy of That Lunar New Year\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">My family is originally from Anhui, and my wife and I later settled in Wuhan. Lele was born in 2013. He was a child who loved to smile and run around, and he brought us so much joy. During the 2016 Lunar New Year holiday, we went back to my wife's parents' home. Over those few days, I noticed that Lele looked pale and yellowish, had little appetite, and kept saying his legs hurt. At first, we thought he was simply tired from all the holiday activity. But his energy kept getting worse, so we quickly took him to a local children's hospital. When the blood test results came back, the pediatrician looked very concerned, strongly suspected a hematologic disorder, and told us to transfer him immediately.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">That same night, we traveled overnight to a major hospital in Wuhan. After a bone marrow aspiration, immunophenotyping, fusion-gene testing, and a series of other evaluations, Lele was diagnosed in March 2016 with B-cell acute lymphoblastic leukemia, with a positive TEL-AML1 fusion. His initial risk assessment placed him in the intermediate-risk group. He had not yet turned 3.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>Chemotherapy, CAR-T, Transplant - Hope and Setbacks, Again and Again\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After diagnosis, Lele began treatment on the low-risk arm of the CCCG-ALL-2015 protocol. On day 33 of induction, bone marrow flow cytometry showed MRD negativity. We thought we had finally crossed the hardest hurdle. But less than two weeks later, the day-46 assessment showed residual MRD of 0.01%. His treatment was therefore adjusted to the intermediate-risk arm, and chemotherapy continued.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In May 2019, Lele finally completed treatment and stopped medication. He returned to school, made friends, and life slowly began to feel normal again. We almost believed the darkest part was behind us. Then, without warning, the disease returned. In December 2020, a routine bone marrow assessment showed relapse together with central nervous system leukemia. Lymphoblasts accounted for 2% of the bone marrow, with flow MRD at 1.5%. Even worse, MRI showed extramedullary leukemic infiltration. The news of relapse felt like being knocked all the way back to the beginning.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At the local hospital, Lele received re-induction chemotherapy and multiple lumbar punctures with intrathecal therapy until the cerebrospinal fluid became negative. In January 2021, he received CD19 CAR-T cell therapy, and his bone marrow again reached complete remission. But the doctors told us that this remission might not last and that he needed hematopoietic stem cell transplantation as soon as possible. In May 2021, Lele underwent a related haploidentical transplant, with me as his donor. After transplant, severe pulmonary infection and skin graft-versus-host disease (GVHD) followed one after another. His weight dropped from more than 50 kilograms to just over 30 kilograms, and he became painfully thin. Somehow, despite how young he was, he fought his way through. I thought that must surely be the last major test. But a little over a year later, at the end of September 2022, another bone marrow assessment showed relapse, and the extramedullary disease had returned as well. I sat on a bench in the hospital corridor with the report in my hands and could not speak for a long time. I had never felt so powerless.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002F5bd7eaf73cf3ffaeff2d634ad4b512ff_20260913160547.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"5bd7eaf73cf3ffaeff2d634ad4b512ff_20260913160547.png\" alt=\"4f592df8-98b5-4b88-8a2f-81521ff0aebe.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>With Few Options Left, We Came to Beijing: CAR-T as a Bridge to a Second Transplant\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The local hospital recommended a second transplant, but by then we no longer knew what to think. Then several parents in a patient group pointed us toward another possibility: a number of children had undergone successful second transplants at Beijing GoBroad Boren Hospital. They told us that the Boren team had extensive experience with relapsed and refractory leukemia, highly individualized treatment planning, and post-transplant complication management.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">We decided to try. Through a video consultation, we gave Dr. Tong Wu from the Boren transplant team a detailed account of Lele's history: poor CD19 target expression, previous CAR-T treatment and transplant, and another relapse. Dr. Wu gave us a clear recommendation, and for the first time in a long while, we could see a small path forward. Once we decided to transfer, getting to Beijing became the next challenge because travel restrictions were still very strict at the time. We were fortunate to receive help from a parent volunteer known as 'Hao's dad' from the Xiaobai Chuntian patient community. In October 2022, Lele was discharged from the Wuhan hospital. We took a train north that same afternoon and, with Hao's dad helping us through the arrangements, completed admission procedures late that night. In the early hours of the morning, Lele was admitted to Ward 12 at Beijing GoBroad Boren Hospital under Dr. Shuangyou Liu's team.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After admission, the Boren specialists carried out a comprehensive reassessment. The transplant team led by Dr. Tong Wu and Dr. Yongqiang Zhao repeatedly discussed the case with the immunotherapy team led by Dr. Shuangyou Liu and Dr. Ruifeng Hou. Taking into account Lele's poor CD19 target expression, his prior therapies, and the complexity of planning a second transplant, they developed an individualized strategy: chemotherapy to reduce disease burden, followed by CD22 CAR-T, then total body irradiation (TBI), and finally a second hematopoietic stem cell transplant.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In November 2022, Lele successfully received a CD22 CAR-T cell infusion. Follow-up assessment showed molecular remission in the bone marrow, with the residual TEL-AML1 fusion level falling to 0.020%. That created a more favorable window for the second transplant. What followed was a long, difficult wait for donor matching and the call to enter the transplant unit.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002F49c308d944705b4586f2208bca61d07b_20260913160654.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"49c308d944705b4586f2208bca61d07b_20260913160654.png\" alt=\"5e733a72-5657-4d7c-b5e3-ff69a6e51114.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">On January 29, 2023, the news finally came: Dr. Yongqiang Zhao told me that Lele could enter the transplant unit and begin preparing for transplant. The next day, Lele entered the unit and started TBI-based conditioning. Then an infection was detected. The myeloablative conditioning had already been completed, so the transplant could not simply be postponed. We were so worried that we barely slept that night. Fortunately, after antiviral treatment, the infection test turned negative the day before stem cell infusion.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">On February 9, Lele successfully received allogeneic hematopoietic stem cells from an unrelated donor - a life-giving gift from someone he had never met.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">His time in the transplant unit went more smoothly than we had expected. Lele had mild diarrhea but no severe infection or high fever. Platelet engraftment occurred on day 10 after infusion, and white blood cell engraftment on day 13.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002F1bd06ab0b64f822a8ee156e14bd42f30_20260913160722.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"1bd06ab0b64f822a8ee156e14bd42f30_20260913160722.png\" alt=\"5c50945f-a2a1-48f2-848d-c1be3466b1fd.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>GVHD, Viral Infection, and One Hurdle After Another\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">We knew that leaving the transplant unit was only the first step. Controlling infection and preventing and treating graft-versus-host disease (GVHD) after transplant would bring their own challenges. Fortunately, the Boren transplant team had extensive experience, and each time a problem arose, they responded quickly and precisely.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The first major complication was severe skin GVHD, with widespread peeling and redness across Lele's face and trunk. In late 2024, the GVHD worsened again, with extensive skin lesions. Dr. Tong Wu, Dr. Yongqiang Zhao, and their team promptly adjusted treatment, and the GVHD was brought under control.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At the same time, the cause of Lele's longstanding proteinuria was finally clarified. In April 2024, he was admitted again because of elevated urinary protein. The Boren team arranged a kidney biopsy and genetic testing, which confirmed X-linked Alport syndrome, an inherited kidney disorder passed through the maternal line. Once the diagnosis was clear, the transplant and nephrology teams developed a lifelong kidney-protection plan, with regular monitoring and carefully selected medication to preserve his kidney function as much as possible.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The challenges did not end there. Beginning in May 2025, Lele developed recurrent high fevers. At our local hospital, three days of anti-infective treatment would bring the fever down, but after three days at home it would return. This cycle continued for nearly a month. In June, we returned to Boren. Rather than simply treating the fever symptomatically, Dr. Yongqiang Zhao's team carried out an extensive pathogen work-up and eventually identified the cause: reactivation of human herpesvirus 6 (HHV-6). After reviewing the available evidence, Dr. Zhao recommended trying a newer antiviral medication. It was not until November 2025 that the HHV-6 testing finally became negative, bringing the six-month infection episode to an end.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Lele himself was much stronger than we had ever imagined. As he grew older, he sometimes spoke with the dry calm of a teenager who had already been through far too much. Half joking, he once said, 'Every day I get is a bonus.' Hearing a teenager say that after everything he had endured left us, as his parents, both heartbroken and incredibly proud.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002F252763b0af009ba01573dffafd64ccbe_20260913160747.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"252763b0af009ba01573dffafd64ccbe_20260913160747.png\" alt=\"f1ae61cb-9b7d-4cd5-8b59-2c12f2a710e8.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003Cspan style=\"font-size: 15px; text-align: justify;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>After a Ten-Year Leukemia Journey, the Rainbow Finally Appears\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">One challenge followed another, and each time, the Boren team was there to catch us. People often ask me what left the deepest impression on us. For me, it was two things: expertise and compassion.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">From a medical perspective, the transplant team led by Dr. Tong Wu and Dr. Yongqiang Zhao designed Lele's entire pathway from CAR-T to a second transplant, making each decision carefully and decisively. With such a complex case, they never dismissed a concern. They repeatedly brought the case to full-department discussions and personally reviewed the critical details. The nursing team was equally dedicated - technically skilled, but also consistently warm and caring toward Lele.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Over the years of treatment, we had nearly exhausted our family's savings and at one point faced serious financial strain. After we came to Boren, the Patient Services team learned about our situation and helped us apply for financial assistance through an Angel Fund and a transplant support program. Ms. Qiao Li also came to the ward specifically to check on us, asking what we still needed and what difficulties we were facing. When it came time to search for an unrelated donor for Lele, the team went out of their way to help. I can say without hesitation that Boren played an essential role in helping Lele reach where he is today.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">By October 2024, Lele's condition had become more stable. After detailed discussions with the specialists, we were finally able to return to our home in Wuhan after a long time away.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Lele has now lived with leukemia for more than ten years. After his second transplant, the GVHD has eased to a mild level and his overall condition has improved well. We are planning for him to return to school this September.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">This time, Lele was invited to take part in the 'Rainbow Project,' where he finally met the donor he had been hoping to see for so long. On stage, Lele hugged him tightly and said through tears, 'Thank you for giving me a second life. I've been waiting for so long to meet you.' His donor gently patted him on the back and answered softly. I stood beside them with a thousand things I wanted to say, but in that moment, I could not find the words.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Ten years of leukemia treatment took us from Wuhan to Beijing, from relapse after the first transplant to a second transplant at Boren that brought a new beginning. Our family lived through more dark moments than I can count. We are deeply grateful to the transplant and multidisciplinary teams at Beijing GoBroad Boren Hospital for their precise care, and for the compassion that stayed with us throughout. You helped make it possible for Lele to stand in the sunlight today.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Today, there is something I also want to say to my son: Lele, you didn't just make it through - you did better than any of us could have imagined. For the years ahead, I hope you can finally put down some of the strength and weight you have had to carry for so long, and simply grow up happy, like any other child.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002Fa0f585dfaad295626a0e6a0729b41450_20260913160857.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"a0f585dfaad295626a0e6a0729b41450_20260913160857.png\" alt=\"b625c5c6-dfa4-4719-a317-b9dc5265b07f.png\"\u002F>\u003C\u002Fp>","Clinical Commentary (Dr. Feifei Li, on behalf of the team led by Dr. Tong Wu and Dr. Yongqiang Zhao): \n\n1. Treatment Standardization: \n\nLele was initially diagnosed with B-ALL (TEL-AML1 positive) and treated according to the CCCG-ALL-2015 protocol. MRD became negative early during induction but later reappeared. After his first relapse, the strategy of re-induction chemotherapy followed by CAR-T and haploidentical transplantation was clinically reasonable. However, relapse again 15 months after the first transplant underscored the complexity of his disease.\n\n2. Strategy for the Second Transplant: \n\nThe second treatment course had to address three major challenges: loss of the CD19 target, extramedullary involvement, and the need for a second transplant. Our team used a sequential strategy of chemotherapy -> CD22 CAR-T -> total body irradiation (TBI) -> a second allogeneic transplant from an unrelated donor. CD22 CAR-T provided precise antigen targeting, TBI offered particular value for extramedullary disease, and changing the donor reflected a highly individualized treatment decision.\n\n3. Management of Complications: \n\nPost-transplant skin GVHD was brought under control promptly. Recurrent fever was investigated systematically and ultimately traced to HHV-6 reactivation, which was successfully cleared with a newer antiviral medication. Kidney biopsy together with genetic testing confirmed X-linked Alport syndrome, allowing the team to establish a lifelong kidney-protection plan. Multidisciplinary collaboration across transplantation, immunotherapy, and nephrology remained central throughout and has been an important part of supporting long-term survival.\n\n4. Overall Assessment: \n\nThis case illustrates an individualized approach built around precise risk assessment, immune targeting, transplant consolidation, and full-course management. Across a ten-year journey with repeated setbacks, treatment decisions were made systematically and complications were managed in detail. It is an important example of how children with relapsed or refractory leukemia can still achieve a meaningful long-term outcome through carefully coordinated care. What Lele has achieved is hard-won. We hope he continues to grow strong, run freely in the sunshine, and move forward into the life ahead.",{"slug":186,"title":187,"summary":188,"cover":189,"disease":190,"treatment":99,"patientType":67,"publishedAt":182,"contentHtml":191,"expertView":192,"disclaimer":70,"hasAlternate":71,"updatedAt":126},"aml-hsct-five-year-recovery","After Two Rounds of Chemotherapy Failed to Achieve Remission, She Marks Five Years of Recovery After Transplant","After two rounds of chemotherapy failed to achieve remission, an adjusted treatment strategy finally brought her into complete remission. She then underwent allogeneic hematopoietic stem cell transplantation and has now reached her five-year recovery milestone.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F98b9f0929d1d6ab4a754c9f4cffc54ac.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","Acute Myeloid Leukemia","\u003Cp style=\"margin: 7px 0;\">\u003Cspan style=\"font-size: 15px;\">Summary: Ms. Zhang was diagnosed with acute myeloid leukemia (AML) after what initially seemed like a routine case of tonsillitis. When the first two rounds of chemotherapy failed to achieve remission, she was diagnosed with primary refractory AML. After transferring to GoBroad Shanghai Zhaxin Hospital, Dr. Shan Shao and her team tailored the treatment strategy to the features of her disease, using a non-cross-resistant regimen combined with targeted therapy. For the first time, Ms. Zhang achieved hematologic complete remission and went on to successfully receive a related haploidentical allogeneic hematopoietic stem cell transplant. Nearly five years after transplant, her leukemia remains in complete remission and she has largely returned to everyday life. Today, she is back with her family, enjoying a normal routine, and often shares her experience in patient support groups to encourage others still going through treatment. Her journey traces the full course of refractory AML - from treatment setbacks to remission and long-term recovery - and highlights the value of individualized treatment, well-managed transplantation, and long-term follow-up in improving outcomes.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F6c7a151954bd912c5740e0aedcebd351_20260912223719.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"6c7a151954bd912c5740e0aedcebd351_20260912223719.png\" alt=\"b6c775e9-bf0d-4ecb-ace5-8f53bda29c3d.png\"\u002F> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Ms. Zhang (pseudonym) has an upbeat, cheerful personality. Wherever she goes, she is like a ray of sunshine, bringing warmth and energy to the people around her. It is hard for anyone meeting her today to imagine that behind her bright smile is a story that once took her through some of life's darkest moments, when despair set in and her life hung in the balance.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In March 2021, Ms. Zhang went to the hospital thinking she simply had tonsillitis, only to be unexpectedly diagnosed with leukemia. After two rounds of chemotherapy, the disease still had not gone into remission. Even someone as strong and optimistic as she was broke down in tears, fearing that her life might be coming to an end. But a turning point came that May, when she arrived at GoBroad Shanghai Zhaxin Hospital. The medical team switched her to a new, non-cross-resistant chemotherapy regimen, and follow-up testing showed that she had achieved hematologic complete remission. Because she had primary refractory AML and had failed to respond to her first two rounds of chemotherapy, the team recommended transplant to give her the best chance of long-term survival. In September 2021, she underwent a related haploidentical allogeneic hematopoietic stem cell transplant. Her leukemia remained in complete remission, and she recovered well.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Nearly five years after transplant, Ms. Zhang returned to GoBroad Shanghai Zhaxin Hospital for follow-up and successfully reached what patients affectionately call their "graduation" milestone. She says the shadow of illness has long since faded, and in daily life she can almost forget that she was ever a leukemia patient. Coming back at this special five-year point was both a way to close an important chapter of treatment and to mark a life experience she will never forget. As an old friend of the Zhaxin team and something of a veteran among fellow patients, Ms. Zhang often encourages people in patient groups who are still confused, frightened, or struggling. She remains a warm ray of sunshine, quietly passing that light on to others.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F169cb04ef5d30be7be6563c859cbea81_20260912223737.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"169cb04ef5d30be7be6563c859cbea81_20260912223737.png\" alt=\"a21aba5d-4934-4bd4-87f6-3e26b1efdded.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">August 2023\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F7971239245d746eae13671e6f98f0e9e_20260912223747.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"7971239245d746eae13671e6f98f0e9e_20260912223747.png\" alt=\"78cd0219-359b-4fca-aaf2-89ffc44024dd.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">June 2026\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>- Patient Q&A -\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q1: How were you first diagnosed?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: In the spring of 2021, I went to the hospital because of a sore throat. I thought it was just a common cold and that a little medication would take care of it. But a routine blood test unexpectedly showed that my white blood cell count was abnormally high. The doctor immediately suspected a hematologic condition and recommended that I be admitted for further evaluation.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">It felt like a bolt from the blue. I had always been healthy, and apart from the sore throat I had no other symptoms, so I found it very hard to accept. I went to another hospital for a second opinion, but the repeat test still showed a persistently high white blood cell count. It was only after I was admitted and underwent a full work-up that I was finally diagnosed with acute myeloid leukemia. When I heard the diagnosis, my mind went completely blank.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q2: What was the major turning point in your treatment, and how did you make the key decisions along the way?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: Once the diagnosis was in front of me, I knew I had no choice but to face it. What truly pulled me into despair, though, was not the word "leukemia" itself - it was going through treatment after treatment without seeing a response. The first-line regimen failed, and then the second-line regimen failed too. I was told that if the disease still could not be brought into remission, the only remaining option might be to proceed directly to transplant despite active disease, just to fight for a chance. I had never felt so lost. The thought that I might not be able to stay with my family made me cry uncontrollably.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After finishing chemotherapy at another hospital, I came to GoBroad Shanghai Zhaxin Hospital. I had already heard from other patients about the care here, but once I arrived, I experienced the team's professionalism and warmth for myself. Their attentive care helped ease not only the physical pain of treatment, but also much of the fear and anxiety I was carrying. A younger woman in the same room, Ms. Yu, also had refractory leukemia. She had three gene mutations, and one of mine was the same as one of hers. Seeing how well she responded to treatment at Zhaxin gave me enormous encouragement (Read Ms. Yu's story). That sense of warmth and hope helped me make up my mind: I would have my stem cell transplant here. Even if things did not turn out exactly as I hoped, I felt I could accept that choice because I felt safe and cared for here.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Before transplant, the team developed a new chemotherapy plan for me - and this time, the response was better than I ever expected. I will always remember Dr. Shan Shao telling me, "Your results are back. Most of the leukemia cells are gone." In that moment, it felt as though a light had appeared in the middle of complete darkness. Reaching complete remission before transplant meant my chances with transplant were much better. I was so overwhelmed that I burst into tears.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q3: What helped you keep going through the transplant?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: My family's support was the biggest reason I kept moving forward, especially my daughter. At the time, she was preparing for the gaokao, China's national college entrance examination. As a mother, my first instinct was to put her first. I worried that donating stem cells might affect her health or interfere with her exams. While I was hesitating, she looked at me and said firmly, "Mom, you're going to get better." I immediately started crying. I wanted to live. I wanted to be there to watch her grow up. With the understanding and support of her teachers, she took a few days away from school to come to the hospital and donate stem cells for me. Whenever I think about it, I am still deeply moved. I gave her life, and in turn, she helped save mine.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Once I entered the transplant unit, my body went through an extremely difficult period. I had forceful vomiting and severe mouth ulcers that made it impossible to eat. But I did not give up on myself. I kept working with the medical team and following treatment. I kept telling myself: if I can still feel this pain, at least I am alive, and I still have a chance to see tomorrow's sun. Whenever I thought about the love and encouragement from my family and friends, I knew I had to keep going, no matter how hard it was. Day by day, my daughter's cells began to engraft and grow inside me, and I gradually started feeling better. Finally, the day came when I could leave the transplant unit. When that door opened, I felt as if I had been given my life back.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q4: How did you gradually return to everyday life after transplant? What would you say to other patients who are recovering?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: During the first year after transplant, I barely went out because I was worried about infection. Most of my activity was limited to walking around my residential community or a nearby park, and occasionally using some simple outdoor fitness equipment. After the first year, as my strength gradually returned, I started meeting friends for small get-togethers and traveling with my family. I have always been someone who enjoys good food, going out, and being around people. Staying home with nothing to do actually made me feel worse emotionally. So whenever my health allowed, I tried a little exercise or a short trip and slowly found my way back into the rhythm of life.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">What I want to say is that, within your own limits, it is important to find things that make you happy. Illness does not mean you have to shut yourself away from life. As your body recovers, you might try foods you enjoy or take a short walk somewhere nearby, just as I did. But everyone recovers differently, so always listen to your body, pace yourself, and put your health first.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002Fe5b92c6c9d73d97c8a1f5594c25a0db4_20260912223834.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"e5b92c6c9d73d97c8a1f5594c25a0db4_20260912223834.png\" alt=\"f5d863ea-7414-42d3-9e3c-cf656c58beeb.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">Ms. Zhang traveling more than one year after her transplant\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q5: What is life like for you now, and what do you hope for in the future?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: I am now approaching retirement, and life has returned to a simple, steady rhythm that I really value. I spend time with my elderly parents and try to be there for them in the small moments of everyday life. When I have time, I meet a few close friends for a meal and a chat. It is an ordinary life, but it feels peaceful and grounding.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Looking back, I want to say this to patients who are still going through the hardest part: do not be afraid. Be brave enough to face the disease, and place your trust in the medical team caring for you. The process can be very hard, but when you finally come through it, you may discover that you are much stronger than you ever imagined. There is tremendous strength inside us, and much of that strength comes from one simple belief: keep living. As long as you are here, you still have the chance to give back to the people who love you and the time to fulfill the hopes you once had for your life.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F72ee717e16ead6216282cddcbb7703c7_20260912224004.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"72ee717e16ead6216282cddcbb7703c7_20260912224004.png\" alt=\"72a9388f-da46-43a3-9bff-79ba4b7035d8.png\"\u002F>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">Ms. Zhang during a trip to Jiuhua Mountain in May 2026\u003C\u002Fspan>\u003C\u002Fp>","Dr. Shan Shao (Associate Chief Physician, MD; Medical Team Leader, GoBroad Shanghai Zhaxin Hospital):\n\nRefractory acute myeloid leukemia (AML) remains one of the major challenges in hematology. We are very pleased that, through the joint efforts of the entire team, Ms. Zhang was able to come through an extremely difficult period and move into a new chapter of life.\n\nMs. Zhang had high-risk AML that was FLT3-positive and NUP98-positive. Her disease had remained refractory to earlier treatment. After she came to our hospital, we used sorafenib as part of an induction strategy to achieve remission, followed by a related haploidentical allogeneic hematopoietic stem cell transplant. When she first arrived, she was understandably discouraged after so many setbacks in treatment, and our doctors and nurses spent time encouraging her every day.\n\nOnce she achieved her first remission after sorafenib-based treatment, her energy gradually returned. Throughout everything that followed, including transplant, she remained optimistic and actively engaged in her care. She became our team's \"little sun\" and would even try to comfort other patients when they were having a difficult time. In the end, three young women who became close friends while going through treatment around the same time all achieved complete remission (CR) after transplant and received their own milestone pins. (Read Ms. Yu's story) (Read Ms. Gu's story)\n\nSuccessful treatment for hematologic diseases depends on the work of doctors and nurses, but it is also closely tied to a patient's willingness to keep going and actively participate in care. To our \"little sun,\" I want to say: a new chapter has already begun. Keep embracing life with the same brightness and optimism - shining for yourself and bringing warmth to those around you.",{"slug":194,"title":195,"summary":196,"cover":197,"disease":198,"treatment":80,"patientType":67,"publishedAt":199,"contentHtml":200,"disclaimer":70,"hasAlternate":71,"updatedAt":126},"dlbcl-car-t-complete-remission","Relapsed Diffuse Large B-Cell Lymphoma: A 41-Year-Old Achieves Complete Remission After CAR-T Therapy","Just over six months after completing treatment, his lymphoma relapsed. After bridging therapy, CAR-T infusion, and subsequent maintenance treatment, his response deepened from partial remission to complete remission.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F3a9bc6103920e3df0aa11a1bf366befa.jpg?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","Diffuse Large B-Cell Lymphoma","2026-06-20","\u003Cp style=\"margin: 7px 0;\">\u003Cspan style=\"font-size: 15px;\">Summary: Li Xiang (pseudonym), 41, was diagnosed with diffuse large B-cell lymphoma (DLBCL) after developing a persistent dry cough and night sweats. He initially achieved complete remission after systemic chemotherapy and local radiotherapy, but new hypermetabolic lesions were found just over six months after treatment ended, indicating an early relapse. After transferring to Beijing GoBroad Hospital, Dr. Kai Hu and his team assessed his overall condition, tumor burden, target expression, and the absence of central nervous system involvement, and developed an individualized treatment plan consisting of bridging therapy followed by CD19 CAR-T cell therapy. After infusion, he developed Grade 1 cytokine release syndrome (CRS), which resolved with timely management, and he experienced no immune effector cell-associated neurotoxicity syndrome (ICANS). One month after CAR-T therapy, he achieved a partial response. He then received maintenance therapy, and approximately three months after infusion, the lesions had completely disappeared, indicating complete remission. He has since returned to his normal daily life and continues regular follow-up. His experience illustrates the full treatment journey for early-relapsed DLBCL, from reassessment and bridging therapy to CAR-T infusion and deepening response, and highlights the importance of comprehensive care throughout cell therapy.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">If the first lymphoma diagnosis felt like a storm that came without warning, for 41-year-old Li Xiang, having the disease return only six months after complete remission was an even greater test.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">It all began in August 2024 with what seemed like an ordinary irritating dry cough. What followed was a prolonged battle between his immune system and lymphoma.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>A Long Road to a Clear Diagnosis\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At first, Li Xiang simply felt tired, with night sweats and a dry cough that worsened at night. At a hospital outside his home region, a mediastinal needle biopsy performed during bronchoscopy produced an inconclusive result: “reactive hyperplasia of fragmented lymphoid tissue.” Oral steroid treatment did not improve his condition, and the enlarged lymph nodes persisted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After seeking care at several hospitals, an outside pathology review finally provided a clearer diagnosis: a lymphoproliferative lesion consistent with B-cell lymphoma, possibly nodal marginal zone lymphoma with transformation toward large B-cell lymphoma, or Grade 3A follicular lymphoma. Genetic testing identified a CD79B mutation, and PET-CT showed a Deauville score of 5. Li Xiang was ultimately diagnosed with diffuse large B-cell lymphoma (DLBCL), non-GCB subtype, Stage IVB, with an IPI score of 2 and an ECOG performance status of 1.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">He then received six cycles of R2-CHOP together with local mediastinal radiotherapy. At the end of treatment, PET-CT showed complete disappearance of the lesions and a Deauville score of 1, confirming complete remission.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">But the remission lasted only six months.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Relapse: What Comes Next?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In January 2026, just over six months after completing treatment, ultrasound detected abnormal lymph nodes in the left supraclavicular and axillary regions. A subsequent PET-CT confirmed a new hypermetabolic retroperitoneal lesion, and the Deauville score had returned to 5. The lymphoma had relapsed.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Li Xiang and his family did not give in to panic. They began researching the latest lymphoma treatments in China and abroad, and through both their own research and recommendations from other patients, one name came up repeatedly: Dr. Kai Hu, Director of the Department of Lymphoma and Myeloma at Beijing GoBroad Hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Dr. Hu and his team were among the earlier groups in China to systematically incorporate CAR-T cell therapy into clinical practice and have accumulated extensive experience in individualized treatment for relapsed or refractory lymphoma.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Li Xiang's family brought his complete medical records to Dr. Hu. After carefully reviewing his diagnosis and treatment history, Dr. Hu identified several key points: although the disease had relapsed, Li Xiang remained in relatively good overall condition and his tumor burden was still manageable; biopsy after relapse showed high expression of CD19, CD20, CD22, and CD79b; and there was no central nervous system involvement.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Taken together, these features made CAR-T therapy a particularly suitable treatment option.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">During detailed discussions with the family, Dr. Hu explained who may benefit from CAR-T therapy, its potential risks and benefits, and the careful management required at each stage of treatment. After fully understanding the treatment plan, the family chose ranicabtagene autoleucel (HICARA®), a CD19-directed CAR-T therapy approved in China.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Bridging, Lymphodepletion, and Infusion: Each Step Matters\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Once the decision to proceed with CAR-T therapy was made, Dr. Hu's team first used cytoreductive treatment to bring the disease burden down. In February 2026, Li Xiang received a second-line regimen centered on POLA plus platinum-based chemotherapy, together with targeted therapy. This “bridging therapy” was intended to reduce tumor burden as much as possible before CAR-T infusion and create a more favorable setting for the infused immune cells to work.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">On March 6, 2026, Li Xiang began FC lymphodepleting conditioning. On March 11, ranicabtagene autoleucel was infused.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">On Day 4 after infusion, Li Xiang developed recurrent high fever and headache. The team promptly assessed this as Grade 1 cytokine release syndrome (CRS). He had no hypotension or hypoxemia, his ICE score was 10, and there were no signs of ICANS.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Following the team's pre-established, risk-stratified management plan, an IL-6 antagonist was administered promptly to control the immune reaction. His temperature gradually normalized, and the CAR-T cells expanded well in his body. He did not develop higher-grade CRS or ICANS at any point.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>After the Initial Response: Moving into Maintenance Therapy\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">About one month after CAR-T infusion, Li Xiang underwent his first response assessment. PET-CT showed a marked decrease in metabolic activity in both the original and newly developed lesions, with the Deauville score falling to 3. He had achieved a partial response.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The result gave both the care team and the family renewed confidence. After evaluation, Dr. Hu's team believed the response could deepen further as the CAR-T cells continued to exert their effect.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Li Xiang then moved into maintenance treatment. Under the plan developed by Dr. Hu's team, he received lenalidomide plus a BTK inhibitor to consolidate the response to CAR-T therapy and reduce the longer-term risk of relapse.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In June 2026, approximately three months after infusion, Li Xiang underwent another PET-CT. This time, the lesions had completely disappeared and the Deauville score had fallen to 1 — confirming complete remission.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">From a Deauville score of 5 at relapse to a score of 1 three months after CAR-T therapy, Li Xiang had made remarkable progress in just three months.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Today, Li Xiang is back to his normal life. He exercises moderately, follows a regular diet, and returns to the hospital for scheduled follow-up. “After going through this twice, I understand the value of good health more than ever,” he said. “I am grateful to Dr. Hu and his team, and to my family for always being there for me.”\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Dr. Kai Hu said: “Li Xiang's treatment course again demonstrates the value of CAR-T cell therapy in relapsed or refractory diffuse large B-cell lymphoma. For patients with early relapse, high target expression, and no central nervous system involvement, CAR-T therapy can be an important potentially curative option. CAR-T therapy is not the end of treatment, however. Maintenance therapy and long-term follow-up remain equally important.”\u003C\u002Fspan>\u003C\u002Fp>",{"slug":202,"title":203,"summary":204,"cover":205,"disease":206,"treatment":99,"patientType":67,"publishedAt":207,"contentHtml":208,"expertView":209,"disclaimer":70,"hasAlternate":71,"updatedAt":126},"hlh-unrelated-donor-hsct-recovery","Diagnosed with HLH at 28, an Unrelated Donor Gave Him a Second Chance at Life","After a sudden HLH diagnosis and no suitable donor match within his family, a fully HLA-matched unrelated donor found through the China Marrow Donor Program helped make an allogeneic stem cell transplant possible - and gave him a new beginning.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002Fec62e8f5f1c7a543ac74ba082bea3412.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","Hemophagocytic Lymphohistiocytosis","2026-06-12","\u003Cp style=\"margin: 7px 0;\">\u003Cspan style=\"font-size: 15px;\">Summary: At 28, Xiao Wei (pseudonym) sought medical care for persistent fever, severe fatigue, and yellowing of his skin and eyes, and was ultimately diagnosed with hemophagocytic lymphohistiocytosis (HLH). Because the disease was progressing rapidly and his condition was critical, Dr. Jun Zhu's team at GoBroad Shanghai Liquan Hospital developed a treatment plan to first bring the disease under control and then proceed to allogeneic hematopoietic stem cell transplantation. When no family member was a suitable donor match, the team promptly initiated an unrelated donor search through the China Marrow Donor Program (CMDP) and found a fully HLA-matched donor. In March 2026, Xiao Wei underwent an allogeneic stem cell transplant and left the transplant unit after more than 20 days of treatment. Now more than two months post-transplant, his strength and ability to manage everyday activities are gradually returning. He has also begun sharing his treatment experience online, hoping to encourage others living with blood disorders. His story traces the journey from an acute, life-threatening diagnosis and the search for a donor to transplantation and early recovery - and shows how an unrelated stem cell donor can offer a patient a vital second chance.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F990d9b621342a7d9dcf539ef678b7002_20260912220500.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"990d9b621342a7d9dcf539ef678b7002_20260912220500.png\" alt=\"10216bcd-641f-49cd-a3c6-4c8785885814.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Xiao Wei never imagined that life would force him to stop so suddenly.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At 18, he packed his bags and left home for an unfamiliar city. Over the next decade, he built a career in mobile phone sales and became a consistent top performer. He was always on the move, filling every day with work and measuring his progress by results. Illness barely crossed his mind - he had hardly even caught a cold in the previous nine years. He assumed life would keep moving at the same relentless pace.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Then, in December 2025, everything stopped. It began with a fever and an overwhelming heaviness in his arms and legs. He thought it was an ordinary cold and expected it to pass. But the fever persisted, and then his eyes and skin began to turn yellow. His older brother drove him overnight from Ningbo to Shanghai, where doctors gave him a diagnosis he had never heard of before: hemophagocytic lymphohistiocytosis (HLH).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">It felt as if someone had suddenly pressed pause on his life. The days that followed were spent beneath the white ceiling of a hospital room. The young man who had once thrived in the fast-moving world of sales was now lying in a hospital bed, watching every number on every lab report.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F16da8b238a50f391e5833fc8b8dd0339_20260912220522.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"16da8b238a50f391e5833fc8b8dd0339_20260912220522.png\" alt=\"040fee58-b1d5-41e9-a351-44eca56a37d0.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003Cspan style=\"font-size: 15px; color: rgb(127, 127, 127);\">January 2026\u003C\u002Fspan>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Yet even in the middle of that uncertainty, a turning point came. When no one in his family proved to be a suitable donor match, GoBroad Shanghai Liquan Hospital quickly initiated an unrelated donor search through the China Marrow Donor Program (CMDP). Fortunately, a stranger he had never met was found to be a fully HLA-matched donor - and was willing to donate hematopoietic stem cells. In March 2026, Xiao Wei successfully underwent an allogeneic hematopoietic stem cell transplant. After more than 20 days in the transplant unit, he was able to leave and begin the next stage of recovery. More than two months later, his hair is growing back, his strength and sense of control over his body are returning, and the facial swelling caused by steroids has subsided.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">He can now drive himself to the hospital for follow-up appointments.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Only half a year has passed, yet to Xiao Wei it feels like half a lifetime. Illness disrupted the pace of his old life, but it also opened a new chapter. Throughout treatment, he continued sharing his experience online and livestreaming to encourage people to pay more attention to their health. He also connected with many other patients and exchanged words of support. “I received so much kindness from people I had never met,” he said. “Now I want to be a light for someone else.”\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F58a4c47ab984dea7912c01304b3c561c_20260912220549.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"58a4c47ab984dea7912c01304b3c561c_20260912220549.png\" alt=\"21042319-8a09-422e-8c03-151b18df0b1c.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003Cspan style=\"font-size: 15px; color: rgb(127, 127, 127); text-align: center;\">June 2026: Xiao Wei with Dr. Bo Lü, a member of Dr. Jun Zhu's team\u003C\u002Fspan>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>Patient Q&A\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q1: At first you thought it was just a cold. What went through your mind as you learned you actually had HLH?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: At first, I really thought it was just a minor cold. I had a fever and felt weak all over, and I assumed I could just push through it. But the fever went on for days. Then my eyes started turning yellow, and so did my skin.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I was still forcing myself to go to work. Eventually I just couldn't keep going, so I went to a nearby hospital for a blood test. When the results came back, I was stunned. Hemophagocytic lymphohistiocytosis - I had never even heard of it.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The local doctor told me this was not something that could wait and advised me to get to a hospital in Shanghai as soon as possible so I wouldn't miss the best window for treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">That same night, my brother drove me from Ningbo to Shanghai. My mind was completely blank on the way. I kept thinking about how healthy I had always been - I hardly ever even caught a cold. How could I suddenly have something this serious? Part of me kept wondering whether the doctors had made a mistake, whether it could be a misdiagnosis. I just didn't want to believe it was real.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">It wasn't until all the test results were back and the hematologist sat down with me to explain the diagnosis and the treatment plan that it really sank in. I had no choice but to face what was happening.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q2: How did you feel when your family members were not suitable matches, and then a fully matched unrelated donor was found?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: HLH can progress very quickly and become life-threatening. In January 2026, I was transferred to GoBroad Shanghai Liquan Hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Dr. Jun Zhu was leading my care. He explained the plan clearly: first use chemotherapy to get the disease into the best possible remission, and then move ahead with an allogeneic hematopoietic stem cell transplant at the right time, with the goal of achieving durable complete remission.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The medical team was highly experienced. I was still afraid of the unknown, of course, but once I started treatment there, I felt much more settled.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">As soon as chemotherapy began, my family members were tested as potential donors. When the results came back, none of them was a suitable match.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Dr. Zhu told me that because my disease had come on so quickly and was so severe, an allogeneic transplant offered the best path forward. He recommended that, while I continued treatment, we immediately contact the China Marrow Donor Program to search for an unrelated donor.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The waiting was the hardest part. Every day brought a little more anxiety. What if there was no match? And even if there was, what if the person didn't want to donate? Those thoughts kept circling in my head, though I tried not to let myself dwell on them.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Then, a few days later, Dr. Zhu brought me the news I had been hoping for: there was a fully HLA-matched donor in the registry - and the donor was willing to help.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At that moment, a huge part of the weight on my mind lifted. I knew there were still many challenges ahead - the transplant unit, the risk of graft-versus-host disease, and everything else that comes with transplant - but the most important piece was finally in place.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q3: Once you learned that a fully matched donor had been found, how did you prepare for transplant? Were you nervous before entering the transplant unit?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: Finding a donor made me feel much more secure, but I also knew the hardest part was still ahead.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Before I went into the transplant unit, Dr. Zhu and the medical team walked me through the entire process again and again. They explained what side effects I might experience and how they would manage them. By turning the unknown into something I could understand, they made me feel much more prepared.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Of course I was nervous. But by then I had accepted that fear wasn't going to change what needed to be done. Instead of spending every day imagining what might go wrong, I decided to get myself into the best condition I could and face the transplant head-on.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In March 2026, I entered the transplant unit.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F8f4a94c17ec1c96eab3c59b4b1c0d896_20260912220640.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"8f4a94c17ec1c96eab3c59b4b1c0d896_20260912220640.png\" alt=\"0ab3062d-9e9a-4fdf-bfd3-7e1f6503b377.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">March 2026, inside the transplant unit at Shanghai Liquan Hospital\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q4: How did you get through those more than 20 days in the transplant unit?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: Once I entered the unit, I first received high-dose conditioning chemotherapy to prepare my body for the transplant. Those days were difficult. I had almost no appetite and felt groggy and exhausted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">But the hardest part was actually waiting for my blood counts to recover. Every day, I looked at my blood test results and hoped the numbers would rise even a little. The waiting felt like counting the hours in the dark without knowing when morning would come.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The nurses and care staff in the unit were incredibly attentive. They would talk with me and help ease my anxiety. My family couldn't come inside, but they encouraged me every day by video call.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Around the second week after the stem cell infusion, my counts finally began to come up. When I saw that upward arrow on the report, something in me lit up. I knew I had made it through the hardest part.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q5: How has recovery been since you left the transplant unit? What is everyday life like now?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: Leaving the transplant unit was only the first step. Recovery afterward is a much longer process.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At first I was still very weak and would get out of breath after walking only a few steps. But I could genuinely feel myself getting a little better every day. My hair started growing back, and my strength slowly returned.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Now, more than two months after transplant, I can drive myself to the hospital for follow-up visits. I'm still recovering, but compared with how I felt when I first became ill, I'm doing so much better.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">This illness taught me something very simple: health is the “1,” and everything else is just the zeros that come after it. I used to think I was young and healthy and had nothing to worry about. Now I understand that without your health, everything else becomes harder.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q6: After everything you've been through, what do you hope for in the future?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: Before I got sick, all I thought about was work, targets, and pushing forward. I always felt that slowing down meant wasting time. Looking back now, I was like a machine that never stopped running.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Getting sick taught me what it really means to slow down. It doesn't mean giving up. It means understanding what matters - every breath, time with my family, and all those ordinary moments I used to overlook.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Now I share my experience online and livestream to encourage people to take their health seriously. I've received so many messages of support from strangers, and many patients have written to tell me that my story gave them courage.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">That has made me feel that, although this illness knocked me down hard, it also gave me a new purpose: to use what I've been through to help people who are still trying to find their way through the dark.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In the future, I want to live well, work well, and keep being someone who can offer a little light to others.\u003C\u002Fspan>\u003C\u002Fp>","Dr. Jun Zhu (Chief Physician; Medical Director, GoBroad Shanghai Zhaxin Hospital \u002F Shanghai Liquan Hospital):\n\nAs Xiao Wei's primary physician, I witnessed every step of his journey, from his HLH diagnosis through transplantation and into recovery.\n\nHLH can be extremely aggressive. In a patient like Xiao Wei, allogeneic hematopoietic stem cell transplantation offered the best chance of achieving durable remission.\n\nTreating a serious blood disorder requires a true partnership between the patient, family, and medical team. Xiao Wei and his family's trust allowed us to make the transplant decision decisively and move forward at the right time. Their constant support throughout treatment was equally important.\n\nDischarge after transplant is only the beginning of a long recovery. Rehabilitation, prevention and management of graft-versus-host disease, infection prevention, and relapse monitoring all require time and patience. We will continue to walk alongside Xiao Wei throughout this next stage.\n\nWe are also grateful that Xiao Wei chose to share his experience. His story can offer hope and strength to other patients who may be facing some of the darkest moments of their own treatment journey.",{"slug":211,"title":212,"summary":213,"cover":214,"disease":89,"treatment":80,"patientType":91,"publishedAt":207,"contentHtml":215,"disclaimer":70,"hasAlternate":71,"updatedAt":126},"b-all-car-t-relapse","Leukemia Returned After Five Years: A 9-Year-Old Girl's CAR-T Journey Despite Severely Low Blood Counts","After initial treatment, completing therapy, relapse, and chemotherapy resistance, she achieved remission again with CAR-T therapy, creating a new opportunity for the next stage of treatment.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F9dd29357512d4eb20a4011e2baabaa0d.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","\u003Cp style=\"margin: 7px 0;\">\u003Cspan style=\"font-size: 15px;\">Summary: Xinxin (pseudonym), now 9, was diagnosed with B-cell acute lymphoblastic leukemia (B-ALL) at age 5. She completed standard treatment and was able to stop therapy, but the leukemia relapsed nearly three years later. Conventional re-induction chemotherapy did not achieve remission, and lymphoblasts remained at very high levels in her bone marrow, placing her disease in the relapsed\u002Frefractory setting. After she was transferred to Beijing GoBroad Hospital, Dr. Jing Pan's team comprehensively assessed her disease burden, treatment history, and overall condition and developed a CAR-T treatment plan. Despite profoundly low blood counts, the team successfully completed autologous lymphocyte collection, bridging therapy, CAR-T cell infusion, and comprehensive management of treatment-related complications. Xinxin developed only mild cytokine release syndrome (CRS) and no immune effector cell-associated neurotoxicity syndrome (ICANS). Bone marrow assessment after infusion showed remission, and she has now moved into recovery and follow-up. Her experience offers a look at the full CAR-T treatment journey for a child with relapsed\u002Frefractory B-ALL and highlights the value of careful assessment, end-to-end management, and multidisciplinary collaboration in cellular therapy.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">For children with relapsed\u002Frefractory B-cell acute lymphoblastic leukemia, approved CAR-T therapies have opened up an additional treatment option for some patients. This story follows one child who received CAR-T therapy despite profoundly low blood counts and achieved remission, while also showing the full clinical pathway delivered by Dr. Jing Pan's team - from disease assessment, cell collection and manufacturing to infusion management and follow-up.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>What Looked Like an Ordinary Cold Turned Out to Be a Sign of Relapse\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In December 2025, 9-year-old Xinxin went to a local hospital with a respiratory infection. Fever, throat discomfort, and nasal congestion made it look like an ordinary cold.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">But her complete blood count immediately raised concern: she had neutropenia along with anemia. Further testing confirmed what no family wanted to hear - Xinxin's leukemia had relapsed.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">For the family, the news came as a devastating shock.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Xinxin's first encounter with leukemia dated back to October 2020. She was 5 years old when a bone marrow abnormality was discovered after an accidental fall, leading to a diagnosis of B-cell acute lymphoblastic leukemia in the low-risk group. Over the next two and a half years, she completed standard induction, consolidation, re-induction, and maintenance therapy, enduring the many challenges of chemotherapy along the way. In March 2023, she finally completed treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">For nearly three years after treatment ended, Xinxin's bone marrow examinations remained normal and life seemed to be back on track. Then the relapse came without warning.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>A Critical Turn: Chemotherapy Fails as Lymphoblasts Fill the Bone Marrow\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In January 2026, Xinxin's parents took her to a local hematology hospital. The bone marrow results were alarming: lymphoblasts accounted for 98.5%, and measurable residual disease (MRD) was as high as 90.5%. Immunophenotyping showed a common B-ALL phenotype, consistent with relapsed\u002Frefractory B-cell acute lymphoblastic leukemia.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Doctors urgently started induction chemotherapy with venetoclax plus a VDP regimen. However, bone marrow assessments in mid-February and again at the end of February 2026 showed persistently high lymphoblast levels of 93.5% and 88%, respectively, while MRD remained above 87%.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The leukemia had become refractory to chemotherapy, conventional treatment was no longer controlling it, and the disease continued to progress.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Choosing the Next Treatment: Helping Their Daughter Get Better With Less Suffering\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Faced with their daughter's rapidly worsening condition, Xinxin's parents were desperate to find another way forward. Their wish was simple: for her to get better as quickly as possible and endure as little additional treatment-related suffering as possible. After researching extensively, they eventually found Dr. Jing Pan's team.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Dr. Pan's team carried out a comprehensive assessment of Xinxin's treatment history, current disease burden, and overall condition and determined that CAR-T cell therapy offered the most promising option at that point. After detailed discussions with Xinxin and her family, the team decided to proceed with Puzolcabtagene Autoleucel Injection, an autologous humanized CD19 CAR-T therapy.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The family had also previously purchased commercial health insurance for Xinxin that included coverage for approved CAR-T treatment, providing important financial support during the course of therapy.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>The Most Demanding Part of CAR-T Treatment Is Not the Infusion Day Alone\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">CAR-T therapy is sometimes thought of as a single cell infusion. In reality, the infusion itself is only one step in a much longer treatment process.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">From the initial assessment, physicians need to evaluate the patient's current condition, disease course, and prior treatment to determine whether CAR-T is appropriate. The team then develops and continuously adjusts the treatment plan while moving through key steps such as cell collection, manufacturing, and infusion.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After infusion, patients may experience fever, cytokine release syndrome (CRS), neurological toxicities such as ICANS, infection, and challenges related to immune recovery. Follow-up then continues to monitor treatment response and recovery over time.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">These stages are closely connected and influence one another; they rarely exist in isolation. For patients, CAR-T is better understood as an ongoing treatment journey rather than a one-time procedure. What often matters most is not the infusion day alone, but the care delivered before and after it.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Xinxin's experience illustrates exactly why the entire process matters.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Collecting Enough Autologous Cells Despite Profoundly Low Blood Counts\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In early March 2026, Xinxin was admitted to the Department of Hemato-Oncology & Immunotherapy at Beijing GoBroad Hospital. Her blood counts were severely suppressed on admission, with very low white blood cells, neutrophils, and platelets - an expected consequence of her previous chemotherapy, but one that made the next stage of treatment more challenging.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Even so, Dr. Pan's team quickly put a detailed treatment plan in place. Bone marrow testing showed that lymphoblasts still accounted for nearly 90%, making time critical. The team decided to move ahead with lymphocyte collection as quickly as possible so CAR-T manufacturing could begin without delay.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Before her blood counts had recovered, the team successfully collected peripheral blood lymphocytes from Xinxin. To ensure that enough backup cells were available, a second collection was performed several days later.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">This was one of the most technically demanding steps in the treatment: despite Xinxin's profound cytopenias, the team was able to collect an adequate number of autologous lymphocytes for CAR-T manufacturing. It required not only clinical and procedural expertise, but also careful control of timing across the entire treatment pathway.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">While the CAR-T cells were being manufactured, Xinxin received bridging chemotherapy to keep the leukemia burden under control and create the best possible conditions for infusion.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>After Infusion: Rapid CAR-T Expansion With Mild Toxicity\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In mid-April 2026, Xinxin received her infusion of Puzolcabtagene Autoleucel. Within just a few days, monitoring showed that the CAR-T cells had begun to expand, indicating that the manufactured cells were active and proliferating in her body as they targeted the leukemia cells.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Encouragingly, Xinxin's cytokine release syndrome remained mild. Her main symptom was intermittent fever, which improved quickly with prompt supportive treatment and one bedside plasma exchange procedure, with both the frequency and peak of the fevers decreasing soon afterward.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">CRS is a common complication of CAR-T therapy that requires close monitoring, and severe cases can be life-threatening. Xinxin's CRS remained Grade 1 throughout treatment, presenting mainly as intermittent fever and improving quickly with timely supportive care.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At the same time, the team remained highly alert for another potentially serious complication: immune effector cell-associated neurotoxicity syndrome (ICANS). According to the product label, in the PB07 clinical trial (N=56), ICANS occurred in 50.00% of patients and Grade 3 or higher ICANS occurred in 37.50%. The median time to onset was 7.0 days after infusion (range, 5-13 days), with a median duration of 3.5 days (range, 1-14 days); Grade 3 or higher ICANS had a median duration of 3 days (range, 1-17 days). Reported manifestations and neurological toxicities included tremor (19.64%), convulsive seizures (17.86%), epilepsy (14.29%), decreased level of consciousness (12.50%), increased intracranial pressure (10.71%), cerebral edema (5.36%), and delirium (5.36%).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Given these risks, Dr. Pan's team took no chances. Neurological monitoring began from the first day after infusion, together with a graded plan for early intervention if symptoms emerged. Fortunately, Xinxin developed no ICANS-related symptoms throughout treatment and remained at ICANS Grade 0.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">About two weeks after infusion, Xinxin underwent her first response assessment. The bone marrow results brought welcome news: her leukemia was in remission. Her inflammatory markers continued to fall, medications were gradually reduced and discontinued as appropriate, and her blood counts began to recover steadily. In early May 2026, on Day 23 after infusion, Xinxin was discharged home to continue her recovery. Her total hospital stay was 60 days, and the overall CAR-T treatment course went smoothly.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Choosing Cellular Therapy Also Means Choosing a Complete Care System\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Looking at the full treatment pathway makes one point especially clear: patients are not simply choosing a single technology. They are choosing a healthcare system capable of supporting that treatment safely and consistently from beginning to end.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">That capability includes systematic risk assessment and stratification, reliable execution of each stage of the treatment pathway, experience managing complex complications, and the ability to continuously adjust treatment through multidisciplinary collaboration.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">These strengths are rarely visible at just one moment; they run through the entire course of care. For complex diseases such as hematologic malignancies, the decision is therefore not only about selecting a technology, but also about selecting a clinical team that can deliver it reliably and take responsibility for the whole treatment journey.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Xinxin's course is a clear example. From disease assessment and treatment planning to cell collection during profound cytopenias, bridging chemotherapy, CRS management after infusion, response assessment, discharge, and follow-up, every step depends on experience, anticipation, and execution.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Afterword\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">From her diagnosis in 2020 to completing treatment in 2023 and then relapsing at the end of 2025, Xinxin's journey with leukemia had already lasted more than five years. This time, with support from Dr. Jing Pan's team, she was able to complete CAR-T therapy despite profoundly low blood counts and achieve remission.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">For Xinxin and her family, treatment is not over. Follow-up and long-term recovery are still ahead. But this time, they have been given a new reason to hope.\u003C\u002Fspan>\u003C\u002Fp>",{"slug":217,"title":218,"summary":219,"cover":220,"disease":115,"treatment":221,"patientType":91,"publishedAt":207,"contentHtml":222,"expertView":223,"disclaimer":70,"hasAlternate":71,"updatedAt":126},"burkitt-lymphoma-targeted-immunotherapy"," 5-Year-Old with High-Risk Burkitt Lymphoma Achieves Complete Remission with Chemotherapy and Targeted Immunotherapy","After multiple rounds of chemotherapy failed to achieve complete remission, a fresh assessment and personalized combination treatment opened up a new path forward.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F6f48ad1a611db8477d0a5e30992c5dd2.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","Chemotherapy, Targeted therapy","\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Summary: Five-year-old Dingding (pseudonym) was diagnosed with high-risk stage III Burkitt lymphoma after developing a persistent fever. Genetic testing identified several tumor-related abnormalities, including TP53, MYC, ID3, and GNA13. He received multiple courses of first- and second-line chemotherapy at another hospital. Although the lesions became smaller, he did not achieve complete remission. In January 2026, Dingding was transferred to the Department of Pediatric Hematology & Oncology at Beijing GoBroad Boren Hospital. Prof. Yonghong Zhang's team repeated the pathology and imaging review and completed additional target-expression testing. Based on his previous response to treatment and strong CD79b expression, the team developed a personalized regimen combining chemotherapy with targeted immunotherapy. After several courses of treatment and consolidation therapy, Dingding achieved complete remission and has continued to maintain it. He is now steadily recovering and looking forward to returning to school. His experience shows how comprehensive reassessment and individualized combination therapy can create new possibilities for children with high-risk Burkitt lymphoma when multiple rounds of chemotherapy have not achieved remission.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In October 2025, five-year-old Dingding (pseudonym) was diagnosed with high-risk stage III Burkitt lymphoma after seeking care for a persistent low-grade fever. Genetic testing showed a TP53 mutation as well as abnormalities involving MYC, ID3, GNA13, and other tumor-related genes. After four courses of chemotherapy at a hospital in Tianjin, he still had not achieved complete remission. His family refused to give up. In January 2026, his parents brought him to Beijing GoBroad Boren Hospital to see pediatric hematology-oncology specialist Prof. Yonghong Zhang. Soon after admission, Prof. Zhang and her team carried out a new pathology review and developed a risk-adapted, individualized plan combining chemotherapy with targeted immunotherapy. After just over three months of structured treatment, Dingding achieved complete remission (CR) and was discharged to continue his recovery at home. Today, he is getting stronger day by day and looking forward to the moment he can return to school.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002Fd3ba1fbaf3c4eb890844e2c5c9a4ee30_20260912212404.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"d3ba1fbaf3c4eb890844e2c5c9a4ee30_20260912212404.png\" alt=\"9be106c9-fce5-4b05-b105-a24d039058e7.png\"\u002F>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">Group photo at discharge\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Persistent Fever Leads to a Diagnosis of High-Risk Lymphoma at Age Five\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Before Dingding became ill, our family life was calm and ordinary. Then, on the evening of September 25, 2025, he suddenly developed a fever of 39.4°C. The fever came down after medicine, but for more than a week afterward he kept running a low-grade fever during the day that would settle at night.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">On October 4, we took him to our county hospital. Based on his blood test and chest X-ray, the doctor initially thought it was pneumonia. But after three days of IV treatment, he was no better at all. I kept thinking, if this really is pneumonia, why is the treatment not helping? I did not want to wait any longer, so that same day I decided to take him to a major hospital in Tianjin.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">That afternoon, Dingding had an ultrasound, blood tests, and other examinations. The results came back quickly. His attending doctor did not give us a diagnosis right away, but his expression was serious. He told us lymphoma was suspected and arranged a biopsy and further pathology testing.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A few days later, after review by a higher-level pathology center, Dingding was diagnosed with high-risk stage III Burkitt lymphoma. Genetic testing also showed a TP53 mutation and abnormalities involving MYC, ID3, GNA13, and several other tumor-related genes.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At the time, I knew almost nothing about the disease. I only understood that it could take my son away from us very quickly. I had one thought in my mind: save my child.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>After Multiple Rounds of Chemotherapy, Complete Remission Remained Out of Reach\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Burkitt lymphoma can progress extremely quickly, so Dingding started chemotherapy soon after diagnosis. He received R-AA, R-BB, and R-CC regimens. At the interim assessment, PET-CT showed that the lesions had improved but remained metabolically active, while ultrasound showed that the thickest part of the bowel wall was still 6 mm. Because Dingding had a TP53 mutation and other genetic features associated with an unfavorable prognosis, his doctors switched the fourth course to second-line R-ICE chemotherapy.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Each round of chemotherapy brought side effects to some degree - nausea, vomiting, and loss of appetite became common. Yet Dingding handled everything with a maturity that was hard to watch in such a young child. He endured bone marrow aspirations and injections without crying.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Once, after we had taken him home for a few days, I asked, "Do you still want to go back to the hospital?" He said, "Yes." When I asked why, he replied, "I want to get better soon so I can go home and go back to school."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Hearing that from a child who was not yet six was heartbreaking and comforting at the same time. As his father, all I wanted was for him to get better as soon as possible and not have to suffer anymore.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After the R-ICE course, Dingding had another ultrasound. The thickened area of bowel wall was almost unchanged. When I saw the result, I made a firm decision. In fact, from the day he was diagnosed, I had been reading everything I could find and, on the recommendation of other parents, started following Prof. Yonghong Zhang's WeChat account. I remember clearly that there were already more than 920 posts at the time. I read every new update - case discussions, educational articles, and answers to parents' questions. The more I read, the more confidence I had in Prof. Zhang's expertise in pediatric lymphoma.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">As soon as the interim assessment results came out, I booked a consultation with Prof. Zhang. After learning about Dingding's situation, she advised us that if he showed a response after the fourth course, he could continue treatment where he was; if not, we should come to Boren as soon as possible. So when the assessment showed no meaningful improvement, I immediately decided to bring Dingding to see her.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>A Fresh Assessment and Personalized Combination Therapy Lead to Complete Remission\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In January 2026, Dingding was transferred to Beijing GoBroad Boren Hospital. Prof. Yonghong Zhang's team immediately arranged a repeat pathology review and additional target-expression testing. Because Dingding had a TP53 mutation, multiple germinal-center-related gene abnormalities, and resistance-associated mutations, the team also collected his autologous peripheral blood lymphocytes in advance to keep future treatment options open.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After a comprehensive review of Dingding's disease course, Prof. Zhang's team decided to continue treatment based on the CNCL-NHL-2017 protocol for mature B-cell lymphoma, while tailoring the regimen more precisely to his individual situation:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">1. First course: Dingding received R + COPADM1. At the end of the course, follow-up imaging showed that the bowel wall thickness had decreased from 6 mm to 4 mm. After treatment had appeared to stall at the previous hospital, this was the first time we had seen the lesion continue to shrink. It gave me hope again.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">2. Second course: Because immunohistochemistry showed strong CD79b expression, the team adjusted treatment to an anti-CD79b antibody + CYVE2 regimen. The residual lesion became smaller again, and the response continued to improve.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">3. Third course: Based on the changes in the lesion, the team switched to an anti-CD79b antibody + M1 regimen. In March 2026, a comprehensive imaging assessment brought the news we had been waiting for: the lesion had completely disappeared, indicating an initial complete remission (CR). I was so overwhelmed that I could not speak. Nearly six months of worry, travel, fear, and uncertainty suddenly felt worth it.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">4. Consolidation therapy: To strengthen the response and reduce the risk of relapse, Dingding then completed one course each of anti-CD79b antibody + M2 and anti-CD79b antibody + M3 as consolidation. Imaging at the end of treatment continued to show CR.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">During treatment, Dingding experienced common chemotherapy-related complications, including neutropenia, thrombocytopenia, and diarrhea. With close nursing care and supportive treatment, each was managed successfully. At the end of all planned therapy, his results looked good and he was discharged to continue recovering at home.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Recovering Well and Looking Forward to Going Back to School\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Dingding is now recovering steadily and feeling better day by day. We are hoping he can return to school next September, and he cannot wait to be back with his teachers and classmates.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Looking back on the past several months, the people I most want to thank are Prof. Yonghong Zhang and her entire team. To me, Prof. Zhang was the person who helped turn things around for my son. She brought him back from an extremely difficult situation and gave him another chance at life. When we felt most helpless, her expertise and sense of responsibility showed us a way forward.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I am also deeply grateful to Beijing GoBroad Boren Hospital. The hospital made it possible for us to meet such a strong team and for so many children to move toward recovery. I was especially touched by the efficiency of the care, the service philosophy, and the compassion shown here - above all, the professional and attentive support provided to children with blood disorders and cancer.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Finally, I want to say to every parent going through something similar: please do not give up easily. I know how hard this road can be. I have felt the helplessness of watching your child suffer when there is nothing you can do, and the fear of not knowing what tomorrow will bring. But children are often stronger than we imagine, and as parents, we sometimes have to find more strength in ourselves than we thought we had. I hope every child can grow up healthy, safe, and surrounded by kindness.\u003C\u002Fspan>\u003C\u002Fp>","Clinical Commentary (Dr. Ying Liu, Ward Director, Department of Pediatric Hematology & Oncology, on Prof. Yonghong Zhang's team): \nThe patient was diagnosed with Burkitt lymphoma in October 2025. At presentation, the disease involved the small-bowel wall in the mid and lower abdomen and multiple lymph nodes anterior to the right kidney. No tumor cells were detected in the bone marrow or cerebrospinal fluid. At the referring hospital, he was classified as high-risk stage III according to the 2025 guideline for the diagnosis and treatment of lymphoma in children and adolescents. He received cytoreductive therapy followed by R-AA, R-BB, and R-CC chemotherapy. Interim PET-CT showed reduced small-bowel wall thickening but persistent hypermetabolism (Deauville score 5), while ultrasound continued to show thickening of the right abdominal bowel wall, suggesting residual active disease without remission. He was then switched to second-line R-ICE chemotherapy. The residual bowel wall thickening remained unchanged, indicating no disease progression but failure to achieve complete remission (CR), and he was therefore referred to our hospital.\n\nAfter admission, the diagnosis was reviewed using pathology consultation, expert review of all prior PET\u002FCT scans, MRI performed at our hospital, and gastrointestinal ultrasound by Dr. Liqun Jia of Beijing Children's Hospital. The final diagnosis was high-risk stage III, CNS1 Burkitt lymphoma with bulky disease. After four courses of first- and second-line chemotherapy at the referring hospital, CR had not been achieved, and a small amount of residual tumor could not be excluded at the thickened terminal ileum. The patient had several adverse prognostic factors: 1) extensive small-bowel wall involvement at diagnosis with bulky disease measuring more than 10 cm; 2) a TP53 variant associated with treatment resistance; and 3) failure to achieve remission at interim assessment, an independent adverse prognostic factor.\n\nBecause there was no disease progression, we recommended switching to the CNCL-2017 frontline chemotherapy protocol for mature B-cell lymphoma. Taking into account his cumulative prior chemotherapy exposure, the planned sequence was COPADM, CYVE2, M1, M2, and M3 chemotherapy combined with monoclonal antibody therapy. Before chemotherapy began, autologous peripheral blood lymphocytes were collected and cryopreserved in case CAR-T cell therapy was needed later. The pathology workup at the referring hospital had not included target markers such as CD19, CD22, and CD79b, so these were added after admission. Rituximab was combined with COPADM during the first course, with subsequent treatment to be adjusted according to target-expression results and tumor response.\n\nAfter the first course of rituximab + COPADM, assessment still showed irregular thickening of the terminal ileum, with residual tumor mixed with scar tissue, but the overall appearance had improved and areas of complete scarring were present. Because tumor response was clearly delayed and the tumor tissue showed strong CD79b expression, an anti-CD79b antibody was added to subsequent chemotherapy to reduce relapse risk. After the second course of anti-CD79b antibody + CYVE2 and the third course of anti-CD79b antibody + M1, gastrointestinal ultrasound showed no obvious residual bowel wall thickening at the original terminal ileal lesion, suggesting an initial CR. He then completed a fourth course of anti-CD79b antibody + M2 and a fifth course of anti-CD79b antibody + M3. End-of-treatment imaging continued to show CR.\n\nA key factor in the success of this case was the individualized combination strategy. The TP53 mutation and markedly delayed response suggested possible primary resistance to chemotherapy, so frontline chemotherapy was combined with second-line targeted immunotherapy.",{"slug":225,"title":226,"summary":227,"cover":228,"disease":190,"treatment":99,"patientType":67,"publishedAt":229,"contentHtml":230,"expertView":231,"disclaimer":70,"hasAlternate":71,"updatedAt":72},"76-year-old-patient-allogeneic-hematopoietic-stem-cell-transplantation","At 76, She Underwent Allogeneic Stem Cell Transplantation and Remains Stable at Six-Month Follow-Up","At 76, Mrs. Xiao (pseudonym) faced progression of leukemia and increasingly limited treatment options. After a comprehensive evaluation, she underwent allogeneic hematopoietic stem cell transplantation and is now steadily regaining her strength.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002Fa1ad00a947818903f18b9aa742543768.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","2026-06-05","\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Summary: \u003C\u002Fspan>\u003Cspan style=\"font-size: 15px;\">Mrs. Xiao (pseudonym), 76, had been enjoying a quiet retirement when chronic myelomonocytic leukemia (CMML) progressed to acute myeloid leukemia (AML), leaving her with increasingly limited treatment options. Her age added another layer of complexity to the possibility of hematopoietic stem cell transplantation. After a comprehensive assessment by Dr. Tong Wu, Dr. Yanzhi Song, and the transplant team at Beijing GoBroad Boren Hospital, she underwent allogeneic hematopoietic stem cell transplantation. After 36 challenging days in the transplant unit, she was able to leave protective isolation. At her six-month follow-up, her laboratory results were stable and her overall condition was continuing to improve.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">On December 5, 2025, after 36 days in the transplant unit, 76-year-old Mrs. Xiao (pseudonym) from Xi'an, Shaanxi, was wheeled out of protective isolation by the medical team. Her son, Mr. Li (pseudonym), had been waiting outside for her. Mrs. Xiao had seen her chronic myelomonocytic leukemia (CMML) transform into acute myeloid leukemia (AML). With the care of Dr. Tong Wu, Dr. Yanzhi Song, and the transplant team at Beijing GoBroad Boren Hospital, she successfully completed an allogeneic hematopoietic stem cell transplant, setting a new age record for transplantation within GoBroad Healthcare Group. On May 10, 2026, six months after transplant, follow-up testing showed stable results and continued recovery. Her son shared the family's experience of navigating this difficult treatment journey with an elderly parent.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002F98d85b2c1f7c65ee07098275c226349d_20260913001023.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"98d85b2c1f7c65ee07098275c226349d_20260913001023.png\" alt=\"e432d62d-ddf5-4811-b2c6-1024b0786d12.png\"\u002F>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px; text-align: center;\">Photo taken when she left the transplant unit\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>A Leukemia Diagnosis in Her Seventies - and an Age Barrier to Transplant\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">My mother had always kept up with regular health checks. Because she also had underlying conditions such as diabetes, we were especially attentive to her health. In July 2024, routine testing showed several abnormalities in her blood counts, including a white blood cell count above 40,000\u002FμL. A subsequent bone marrow aspiration confirmed chronic myelomonocytic leukemia (CMML), with DNMT3A, FLT3, IDH2, and NPM1 mutations. For someone in her seventies who should have been enjoying retirement, the diagnosis came as a profound shock.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">My mother soon began treatment at a hospital in Xi'an. She initially received cytoreductive chemotherapy and intermittent azacitidine plus venetoclax, which kept the disease relatively stable for nearly six months. In January 2025, however, her condition worsened sharply, and bone marrow testing showed transformation to acute myeloid leukemia (AML). Her doctors adjusted the regimen and added the targeted agent gilteritinib. Her blood counts stabilized for a time, but only for a few months. By June 2025, the disease was progressing again.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">As the disease worsened, my mother had to begin chemotherapy, but she reacted very strongly. Her blood counts fell rapidly and she needed daily supportive care, including platelet transfusions, while the chemotherapy itself was not producing the response we had hoped for. When the doctors began considering another chemotherapy adjustment, we hesitated. At her age, we worried that her body could no longer withstand repeated rounds of intensive treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">We contacted several hospitals in Xi'an to ask whether hematopoietic stem cell transplantation might still be possible. The answers were almost always the same: "She is too old, the disease is too complicated, and the transplant risk is too high. We would recommend continuing conservative treatment."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>When Options Were Running Out, Beijing Offered a New Possibility\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Just when we felt we had almost run out of options, one specialist suggested that we take my mother to Beijing for another opinion and recommended three hospitals, including Beijing GoBroad Boren Hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In early August 2025, I took time off work and traveled to Beijing. Over two days, I visited the hospitals and spoke with specialists in detail. At Boren, I met Dr. Yanzhi Song. He carefully reviewed all of my mother's medical records and patiently discussed her condition with me. Most importantly, he addressed the question that had been weighing on me: age alone is not an absolute contraindication to hematopoietic stem cell transplantation. What matters is a systematic assessment of the patient's overall condition, including organ function, as well as the wishes of the patient and family. His candid and professional explanation was the first thing that gave me real hope after days of anxious searching. Another important factor was an article I had read about Boren successfully performing transplantation for a 74-year-old patient with AML. That experience strengthened our decision to bring my mother here.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Going Beyond the Usual Age Limits: Working Together for a Second Chance\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">On August 18, 2025, my mother was admitted to Ward 5 of the transplant department at Beijing GoBroad Boren Hospital. Dr. Tong Wu, Dr. Yanzhi Song, and their team carried out a comprehensive evaluation. Bone marrow testing showed 18.69% abnormal myeloid blasts by flow cytometry, an NPM1 quantitative level of 52.84%, and FLT3-ITD and IDH2 mutations.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">My mother had leukemia as well as several chronic conditions, including diabetes, hypertension, hypertrophic cardiomyopathy, and Hashimoto's thyroiditis. The hospital quickly organized a multidisciplinary consultation. After a detailed assessment, the team determined that her overall condition met the requirements for transplantation. After weeks of uncertainty, that conclusion finally gave us some relief.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Because my mother's leukemia burden was still high, the transplant team first designed an individualized chemotherapy regimen to reduce the disease burden and create the best possible conditions for transplant. The treatment was difficult, and she also developed allergic purpura during chemotherapy, but the complication was brought under control. By late September, abnormal cells in her bone marrow had fallen from 12% to 0.1%, and the window for transplantation had opened.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Then we encountered an unexpected problem. I had originally planned to be my mother's stem cell donor, but a key test showed that she had strongly positive HLA antibodies directed against me. Using me as the donor would therefore have increased the risk of graft failure, so we had to turn to the donor registry and search for an unrelated donor.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">My mother's disease was moving faster than we had expected, and the leukemia cells were beginning to rise again. The longer we waited, the less favorable the situation became. Those were some of the most anxious days for me. Fortunately, we soon received good news from the China Marrow Donor Program: a matching volunteer donor had been found. What moved us even more was how quickly and generously the donor cooperated. From confirmation of the match, through the medical examination and collection preparations, to the successful infusion of the stem cells into my mother, the entire process took only 25 days.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002F8b58d1c86a71754d383ff0337b175e1d_20260913001056.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"8b58d1c86a71754d383ff0337b175e1d_20260913001056.png\" alt=\"febbb840-6895-4cea-a4d1-2b4f3d97c139.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I remain deeply grateful to this donor, someone we have never met. Without hesitation, they gave my mother something priceless: the treatment time she urgently needed.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Because of my mother's age, engraftment was somewhat slower. Even so, the transplant course was more stable than we had expected. She did not develop any severe infections, and although each step of recovery took time, she kept working with the medical team with remarkable determination. Day by day, she continued moving forward at her own pace.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">On December 5, 2025, after 36 days in the transplant unit, my mother safely left protective isolation. While I was waiting outside, I also saw a 15-year-old girl walk briskly out of the unit. My mother, by contrast, was wheeled out slowly and still looked frail. But I knew that for a 76-year-old woman, making it through this stage and reaching the other side was an extraordinary and deeply meaningful victory.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Age Is Not the End of the Road: Recovery Brings New Hope\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">My mother is now six months post-transplant. Her follow-up results remain stable, and she is gradually regaining her strength. Looking back on everything our family went through, there are a few things I would like to share with other patients and families.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Information and choices matter. When we consulted hospitals in Xi'an, one of the responses we heard most often was, "Seventy-five is too old. We only transplant patients under 65." I am very grateful to the doctor who encouraged us to seek another opinion, and I am glad I did not hesitate to come to Beijing and speak with specialists in person. That decision helped us find another possibility at a time when we thought there were none left.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Trust expertise and communicate openly. At Boren, we experienced the transplant team's professionalism and depth of experience, particularly in caring for older adults undergoing hematopoietic stem cell transplantation. From designing the conditioning regimen, to round-the-clock monitoring in the transplant unit, to preventing and managing post-transplant complications and providing day-to-day care guidance, every step was handled carefully. I am deeply grateful to the Boren team for giving an elderly patient like my mother a chance to move forward.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Details matter, and caregiving is an important part of treatment. My mother had always been very frugal and would even hesitate to throw away leftovers. But after transplant, anything she ate could affect her infection risk. I explained it to her in practical terms: "Food is less than 1% of what we spend on treatment. But if unsafe food causes an infection, the cost could be tens of thousands of yuan - and more importantly, you would suffer and face additional risk." That helped her understand why following the medical team's instructions so carefully mattered. For older transplant patients in particular, attentive day-to-day care can make a meaningful difference.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">As medicine continues to advance, I hope more patients and families are able to find their own door to hope. May every effort to keep going find an answer, and may every life placed in the hands of a medical team be treated with the care it deserves.\u003C\u002Fspan>\u003C\u002Fp>","Clinical Commentary (Dr. Zhanxiang Liu, on behalf of the team led by Dr. Tong Wu and Dr. Yanzhi Song): \n\nScientific understanding is never built in a single step, and medicine is no different. At 76, Mrs. Xiao successfully underwent an allogeneic hematopoietic stem cell transplant from an unrelated donor at our hospital. For our transplant center, this represented both a new age milestone and another example of how mature transplant techniques can be applied to carefully selected older patients. Hematopoietic stem cell transplantation is a complex and time-intensive process. Before proceeding with Mrs. Xiao's transplant, we carried out extensive preparation, repeatedly reviewing her pre-existing conditions and the complications she might face. With careful treatment and nursing from the medical team, close coordination from patient services and the unrelated donor registry, and strong support from her family, the donor stem cells were finally infused and successfully began to engraft. Mrs. Xiao's optimism and determination helped her work through the discomfort of treatment, leave the transplant unit, and eventually leave the hospital. Completing the early post-transplant period was the first critical step; she is now continuing with the second, third, and many steps that follow.\n\nMrs. Xiao remained in Beijing for follow-up for six months after transplant. During that period, she experienced nausea, diarrhea, poor appetite, and substantial weight loss compared with before transplant. Even so, her resilience and optimism gradually carried her out of the darkest part of the illness. When the six-month bone marrow assessment came back with very encouraging results, she immediately got into the family car to begin the journey home. It was clear how much she had missed being there.\n\nNow that she is back home, the long distance means that routine tests are usually done at a local hospital. If a test is not available locally, samples can be sent to Beijing. We share results by phone and provide remote guidance on diet, medication, and other aspects of follow-up care. Mrs. Xiao is still recovering little by little - something we can see both in her laboratory results and in the photos she sends us.\n\nWe wish Mrs. Xiao continued progress throughout her follow-up and recovery, and we hope her treatment journey offers encouragement to other patients and families. Science has no fixed borders, and neither should the possibilities of medicine. Our team will continue to approach transplantation with commitment, rigor, and evidence-based care, working to help more patients gain another chance at life.",{"slug":233,"title":234,"summary":235,"cover":236,"disease":237,"treatment":238,"patientType":67,"publishedAt":239,"contentHtml":240,"expertView":241,"disclaimer":70,"hasAlternate":71,"updatedAt":126},"multiple-myeloma-car-t-retirement-life","A New Lease on Life After CAR-T: Reflections from a Patient with Relapsed\u002FRefractory Multiple Myeloma","After multiple rounds of treatment, an autologous stem cell transplant, and another relapse, CAR-T therapy brought him sustained complete remission - and helped him return to a peaceful life with his family.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F0c8054daedfdcc89f43b26d4252539b1.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","Multiple Myeloma","CAR-T, Autologous Hematopoietic Stem Cell Transplantation","2026-05-21","\u003Cp style=\"margin: 7px 0;\">\u003Cspan style=\"font-size: 15px;\">Summary: Soon after retirement, Mr. He developed recurrent fever, fatigue, and bone pain and was diagnosed with IgG lambda multiple myeloma. He underwent chemotherapy followed by autologous hematopoietic stem cell transplantation, but the disease did not achieve the hoped-for response. He later came to GoBroad Shanghai Zhaxin Hospital, where targeted and immunotherapy-based treatment combined with chemotherapy kept his disease under control for several years. In 2025, follow-up testing again raised concern for relapse, at a time when several previous drugs and treatment approaches were no longer providing sufficient control. After comprehensive evaluation and detailed discussions with the medical team, Mr. He received CAR-T cell therapy with zevorcabtagene autoleucel (zevor-cel) in September 2025. His myeloma remains in complete remission, his strength is gradually returning, and he has resumed traveling with his wife and enjoying retirement. His story reflects the long treatment journey that many patients with relapsed or refractory multiple myeloma may face - from chemotherapy and autologous transplant to CAR-T - and the difference that advances in medicine, family support, and access to healthcare can make in everyday life.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002Fbf38a6f83ffc36792adc6e378fe3ba71_20260912214822.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"bf38a6f83ffc36792adc6e378fe3ba71_20260912214822.png\" alt=\"575ba3d1-4bd9-4443-b039-cc86e523a273.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Six years ago, soon after retiring, Mr. He (pseudonym) signed up for a piano class at a university for older adults. He was ready to enjoy a colorful new chapter of retirement. Then recurrent fevers, fatigue, and persistent bone pain began to worry his family. A comprehensive health check showed several abnormalities, and further hematology testing ultimately confirmed the diagnosis: IgG lambda multiple myeloma.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">With his family by his side, Mr. He began treatment. In November 2020, he underwent an autologous hematopoietic stem cell transplant, but the disease did not go into remission. He then received a combination of targeted therapy, immunotherapy, and chemotherapy, which kept the disease stable for several years. By May 2025, however, myeloma-related markers that had long been controlled began to rise again, suggesting another relapse. By then, several drugs and treatment approaches had already provided limited benefit.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Just when options seemed to be running out, CAR-T cell therapy offered a new possibility. In September 2025, the medical team at GoBroad Shanghai Zhaxin Hospital treated Mr. He with CAR-T cell therapy using zevorcabtagene autoleucel (zevor-cel).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Now, more than eight months after treatment, his multiple myeloma remains in complete remission.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At last, he can enjoy the retirement he had once imagined - traveling with his wife, Mrs. Yang, visiting new places, and living a calm and fulfilling everyday life.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F329d3b941c4b5accb1fa93151db0ca7d_20260912214837.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"329d3b941c4b5accb1fa93151db0ca7d_20260912214837.png\" alt=\"b60bb128-54e9-4767-acb5-546cbe87d033.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">Mr. He and Mrs. Yang traveling together in late 2025\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">As both his longtime caregiver and a healthcare professional herself, Mrs. Yang has many reflections on the journey:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">"My father was diagnosed with multiple myeloma in 1993, before he had even turned 70. Medical options were much more limited then, and he was unable to receive sufficiently effective treatment. His quality of life was very poor, and he suffered greatly from the disease.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">So much has changed since then. With rapid advances in medicine in China, new drugs and treatment approaches continue to become available. Today, patients like my husband can not only receive standardized, effective treatment, but can also maintain a good quality of life during treatment - something that would have been difficult to imagine in the past.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">That is why I want other people living with myeloma to keep believing that there is hope.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">It is also worth mentioning that GoBroad Shanghai Zhaxin Hospital is one of the designated hospitals for CAR-T treatment under Shanghai's 'Huhuibao' supplementary health insurance program. This coverage greatly reduced the financial pressure on our family and made an otherwise very costly advanced therapy much more accessible and affordable.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">We are deeply grateful for the progress in medical care, the support provided through healthcare policy, and the dedication of every member of the medical team at Zhaxin Hospital."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F2ec7c64c5e7ac69df3b4f789ec5c37a4_20260912214851.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"2ec7c64c5e7ac69df3b4f789ec5c37a4_20260912214851.png\" alt=\"9f3a6237-3454-47c5-86e1-5b8bb56a9dce.png\"\u002F>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px; text-align: center;\">October 2025: Mr. and Mrs. He with Dr. Ying Jiang and Nurse Manager Xia Yan\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>- Patient Q&A -\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q1: Mrs. Yang, how was Mr. He's multiple myeloma first diagnosed?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Mrs. Yang: In April 2020, he suddenly began having recurrent fevers, usually a little above 38°C. At first, we thought it was a cold. The symptoms improved after a few days, but then the fever came back. He also began to feel some discomfort in his lower back. We did not know what was causing it or even which specialty to see, so we decided to start with a full health check.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">That same day, the hospital called to tell me that several test results were abnormal and recommended that we see a hematologist for further evaluation. We were very worried and arranged for him to be admitted right away. The next morning, after PET-CT and other tests, he was diagnosed with multiple myeloma. Fortunately, it was identified relatively early. If we had waited another week or two, his disease markers might have worsened further.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q2: Mr. He, what ultimately led you to choose GoBroad Shanghai Zhaxin Hospital?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Mr. He: After the diagnosis, I started chemotherapy. That year was extremely difficult. I spent more than half of each month either in the hospital or traveling back and forth for treatment. I was particularly sensitive to some chemotherapy drugs, and one side effect followed another - fever, diarrhea, rashes, and more. I felt miserable, yet the treatment response was still not what we had hoped for.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In November 2020, because the standard chemotherapy regimen had not worked well enough, I followed my doctor's recommendation and underwent an autologous hematopoietic stem cell transplant. My disease was not in complete remission before the transplant, and afterward the result was still not as expected. More discouragingly, within one or two months, the disease-related markers began to rise again. That period was very hard, both physically and emotionally.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">When treatment seemed to have reached a dead end, we learned that Professor Chun Wang had extensive experience in relapsed and refractory hematologic diseases.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">So in January 2022, we came to GoBroad Shanghai Zhaxin Hospital for further treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After I arrived, Professor Wang adjusted my treatment based on my condition. He introduced targeted therapy combined with chemotherapy and also modified some of the medications I had not tolerated well before. Gradually, the disease stabilized, and symptoms such as fever and diarrhea became much less troublesome. Although some markers fluctuated again about a year later, the doctors adjusted my medications promptly based on each follow-up result, so overall the disease remained under control. I kept up with regular follow-up, monitored my results closely, and adjusted treatment when needed. That allowed me to maintain a reasonably good quality of life.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Then, at a follow-up visit in May 2025, the markers began to rise again, suggesting that the myeloma might be returning.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q3: Mr. He, when the disease began to relapse again, how did you decide to proceed with CAR-T therapy using zevorcabtagene autoleucel (zevor-cel)?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Mr. He: Based on my condition, the medical team at Zhaxin Hospital recommended CAR-T as the most appropriate treatment option for me at that point. We had always trusted the team's decisions, but I still hesitated before making this one.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">We had learned a little about CAR-T before. In my mind, it felt like the 'ultimate weapon.' Part of me wanted to wait and see whether medication could keep things under control a little longer. I hoped the markers might not rise too quickly.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">But during the two months I hesitated, the abnormal markers climbed rapidly. My attending physician, Dr. Ying Jiang, understood my concerns and explained patiently: "You have already tried several previous treatment approaches, and repeating them may not work well. If we wait until the myeloma burden rises further before proceeding with CAR-T, the outcome may not be any better than treating earlier, and the side effects could also be greater."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The cost of CAR-T was another major reason we hesitated. Later, we learned that GoBroad Shanghai Zhaxin Hospital is a designated CAR-T treatment hospital under 'Huhuibao,' and that I met the reimbursement criteria for adults with relapsed or refractory multiple myeloma whose disease had progressed after at least three prior lines of therapy.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">That coverage greatly reduced the financial burden of treatment and removed one of our biggest concerns.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong> \u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q4: Mr. He, you have experienced both an autologous stem cell transplant and CAR-T therapy. How did the two treatments feel different to you?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Mr. He: As another patient once shared, the overall experience of CAR-T felt much easier for me than the autologous transplant. I did not need to stay in a transplant isolation room. Instead, a protective laminar-flow canopy was placed over my hospital bed, and my family could remain nearby to care for me. That made a big difference psychologically.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After the CAR-T infusion, I had a high fever for two or three days, with the temperature rising above 39°C. But Dr. Jiang had prepared us for that in advance. She explained that the engineered T cells would enter the body and 'fight' the myeloma cells, so some discomfort could be expected along the way. Because I knew what might happen, the whole process felt relatively manageable and I was not frightened.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I was discharged successfully after about two weeks and only needed to return for regular follow-up. About three months after CAR-T, my strength had improved a great deal, and my wife and I even traveled to Guangzhou together.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q5: Mrs. Yang, you have been by Mr. He's side throughout these years. What do you think matters most when caring for someone with multiple myeloma?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong> \u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Mrs. Yang: Caring for someone with myeloma is a long-term commitment. Family caregivers first need to take care of their own mindset so they can better support the patient. Test results will inevitably go up and down from one follow-up to the next. I used to become very anxious whenever his results were not ideal. Once, a nurse manager saw how worried I was and came over to reassure me: "Let the doctors worry about the numbers. What you need to focus on is his meals, daily routine, and day-to-day care. Leave the medical decisions to the professionals." Those words lifted a huge weight from me.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">As family caregivers, we should try not to exhaust ourselves by worrying constantly about every medical number. It is often better to put our energy into the parts of care that we can actually do well.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q6: Mr. He, after everything you have been through, how has this illness changed the way you think about life?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Mr. He: Before I became ill, I had planned to sign up for a piano class at a university for older adults and finally pursue a dream I had carried since I was young. But before I ever got the chance to touch the keys, the illness arrived first. Life does not always follow our plans. Instead of always thinking about 'someday,' I would rather live each day in front of me as fully as I can.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I am especially grateful to my wife. Through all these years, she has stayed beside me, caring for me with patience and gentleness. What I want now is very simple: she loves traveling, so I go with her whenever I can. Even if we are in the same city and she goes out sightseeing while I rest at the hotel and wait for her to come back, I still feel at peace.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I do not spend much time thinking about the distant future anymore. If I can eat well today, walk around today, and the two of us can still sit together and talk, that is enough.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">This illness taught me something important: life does not have to be perfect to feel complete. Sometimes, having 'just enough' is its own kind of happiness.\u003C\u002Fspan>\u003C\u002Fp>","Dr. Ying Jiang (Associate Chief Physician, MD; Medical Team Leader, GoBroad Shanghai Zhaxin Hospital):\n\nMultiple myeloma requires long-term monitoring, with treatment adjusted over time according to changes in laboratory and disease-related markers. In recent years, the continued introduction of new drugs and immunotherapies such as CAR-T has significantly extended survival for many patients. At the same time, quality of life has also improved meaningfully during what can be a long course of treatment and follow-up.\n\nWe wish Mr. He and Mrs. Yang many more years of traveling side by side, seeing beautiful places together, and sharing the simple joys of everyday life.",{"slug":243,"title":244,"summary":245,"cover":246,"disease":89,"treatment":181,"patientType":91,"publishedAt":247,"contentHtml":248,"expertView":249,"disclaimer":70,"hasAlternate":71,"updatedAt":72},"b-all-cart-hsct-five-year-survival","Relapse After Chemotherapy, Then Again After CAR-T: A Young Man Reaches Five Years in Remission After CD22 CAR-T and Transplant","After multiple rounds of treatment and relapse, Yangyang (pseudonym) is now back at university and hopes his experience can encourage others to keep going.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002Fe5fb2a5f1b295916a1e43dd71e229626.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","2026-05-18","\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Summary: \u003C\u002Fspan>\u003Cspan style=\"font-size: 15px;\">At 17, Yangyang (pseudonym) should have been focused on school and the future. Instead, he was diagnosed with B-cell acute lymphoblastic leukemia (B-ALL). He achieved remission with chemotherapy but later relapsed, and then relapsed again after CD19 CAR-T therapy. In 2021, he and his mother traveled to Beijing GoBroad Boren Hospital. Given his high-risk disease, including an E2A-PBX1 fusion and multiple relapses, the teams led by Dr. Tong WU and Dr. Yanzhi SONG developed an integrated treatment plan using CD22 CAR-T therapy as a bridge to a related-donor haploidentical hematopoietic stem cell transplant. Yangyang ultimately achieved long-term remission. Now, five years after transplant, his bone marrow remains in complete remission, donor chimerism remains fully donor-derived, and he has returned to university to continue the life that illness once interrupted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At 17, Yangyang, from Sichuan, should have been studying in the classroom and running across the school field. Instead, he was diagnosed with B-cell acute lymphoblastic leukemia. He relapsed after achieving remission with chemotherapy and then relapsed again after CAR-T immunotherapy, leaving his family with few options. In early 2021, after searching widely for help, Yangyang and his mother traveled to Beijing GoBroad Boren Hospital. Taking into account his E2A-PBX1 fusion-positive disease and history of multiple relapses, the teams led by Dr. Tong WU and Dr. Yanzhi SONG developed a personalized plan using CAR-T therapy as a bridge to a related-donor haploidentical hematopoietic stem cell transplant, with his father as the donor.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Today, at 22, Yangyang has reached the important five-year post-transplant milestone. His bone marrow remains in complete remission, donor chimerism remains fully donor-derived, and his overall results are stable. The teenager who stayed optimistic even at the hardest moments is now a second-year university student. He still has the same warm smile, but with a calmness that comes from everything he has been through. His story carries a simple message: when you choose not to give up, a way forward can still appear.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260913\u002F35aea199126eb192da3585837185d266_20260913000808.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"35aea199126eb192da3585837185d266_20260913000808.png\" alt=\"ed02475a-883f-47ec-989d-56926fa29243.png\"\u002F>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px; text-align: center;\">Photo from Yangyang's five-year post-transplant follow-up\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>From Over 75 kg to 54 kg: An Unexpected Health Crisis at 17\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At the beginning of 2020, I was in my first year of high school. At some point, I started feeling exhausted all the time and lost my appetite. My weight dropped from more than 75 kg to about 54 kg. I became so thin that even my pajamas hung loosely on me. I went to the hospital twice because of weakness and joint swelling after eating seafood. But I had always been healthy, had never been hospitalized, and did not even know what an IV infusion felt like, so I did not think much of it.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Then one morning in February 2020, I was getting ready for breakfast when my nose started itching. I scratched it casually and suddenly began bleeding. The blood looked unusually thin and watery rather than the normal thick, bright red. My mother's expression changed immediately, and she rushed me to the emergency department.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I underwent a full evaluation at a local hospital in Sichuan. My blood count showed a hemoglobin level of just 53 g\u002FL and a platelet count of only 15 x 10^9\u002FL. A bone marrow examination found that blasts accounted for 65% of the cells. I was diagnosed with acute lymphoblastic leukemia, common B-ALL, with an E2A-PBX1 fusion.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">My family worried that I would not be able to handle the truth, so they did not tell me exactly what the diagnosis was. I did not ask many questions either. All I wanted was to get better and go back to school. Looking back now, I had no idea how difficult the road ahead would become.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Relapse After Relapse: Running Out of Options\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After diagnosis, I began a long course of treatment. I first received VDCLP induction chemotherapy. At the end of treatment, my bone marrow showed morphologic remission, flow cytometry was negative, and the E2A-PBX1 fusion became undetectable. I then completed Hyper-CVAD A consolidation chemotherapy and went home to recover as instructed. I was so happy at the time and thought the illness was finally behind me.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Only about two weeks later, a repeat bone marrow examination showed that blasts had risen to 94%. My mother wanted to take me to a major tertiary hospital in Sichuan, but there were no beds available and we could not afford to wait. We transferred to a hospital in Xi'an for further treatment. After FC chemotherapy, my bone marrow morphology improved, but flow-cytometric MRD remained positive, the E2A-PBX1 fusion remained detectable, and a new PAX5 mutation was also identified.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In July 2020, another bone marrow examination showed that blasts had risen again to 81.5%. My treating physician promptly arranged an infusion of CD19 CAR-T cells. Assessments on days 17 and 30 after CAR-T showed sustained bone marrow remission, and both E2A-PBX1 and PAX5 became undetectable. Once my condition stabilized, I even returned to school briefly and completed part of a semester.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Around that time, on the way to a follow-up visit, my mother carefully asked me, "Have you ever wondered what illness you actually have?" When she saw that I was calm, she told me the truth. Strangely, knowing the diagnosis made me feel less burdened. I have always been someone who does not swing too far between highs and lows. I also feel that the better your mindset, the easier it is to focus on recovery. The more you avoid talking about the illness, the more it can feel like a weight pressing down on you.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Unfortunately, the remission did not last. In January 2021, PET-CT showed extramedullary disease. After repeated relapses and increasingly difficult-to-control leukemia, the local hospital had no effective options left to offer. Once again, we had to look elsewhere for a way forward.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Traveling to Beijing: CD22 CAR-T as a Bridge to Transplant\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Even then, my mother refused to give up. She kept asking around and learned that Beijing GoBroad Boren Hospital had extensive experience treating refractory and relapsed leukemia. Chinese New Year was approaching, but she did not want treatment to be delayed, so she took me to Beijing as soon as possible.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">We arrived at Beijing GoBroad Boren Hospital on January 28, 2021. A comprehensive evaluation showed morphologic bone marrow remission and negative flow cytometry, but the E2A-PBX1 fusion was still detectable at 0.022%. The teams led by Dr. Tong WU and Dr. Yanzhi SONG quickly developed a treatment plan. Given my young age and history of multiple relapses, they recommended CAR-T therapy followed by transplantation as the best next step.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">On February 10, I received CD22 CAR-T cells. Follow-up evaluations at two weeks and one month showed remission by both bone marrow assessment and flow cytometry, and the fusion gene finally became undetectable. PET-CT also showed that the lesions had shrunk substantially and their metabolic activity had fallen markedly. After reviewing everything together, however, the team felt that a small risk of residual disease remained. Dr. Yanzhi SONG spoke with my mother in detail about the next phase of treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The transplant teams led by Dr. Tong WU and Dr. Yanzhi SONG then designed an individualized transplant plan for me. On March 24, 2021, I began an intensified conditioning regimen with TBI\u002FAra-C\u002FVP-16\u002FFLU\u002FATG. On April 6, I received my father's bone marrow, followed by peripheral blood stem cell infusions over the next two days.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Before I entered the transplant unit, I really had no idea what transplantation would be like. I have always thought of myself as an optimistic person, but being alone in a closed protective-isolation room could still make me feel low and irritable. Eventually I developed a routine: every afternoon at around two or three, I would take a nap. When I woke up, I usually felt calmer again.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">When I had free time, I would play online games with friends. But they still had school and their own lives, so they could not always be there. The loneliness could be intense. I knew, though, that this was one part of the journey I had to get through myself.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">During transplant, I developed severe mouth ulcers, my platelet count was slow to recover, and steroids caused noticeable facial swelling. It was a difficult period. Fortunately, engraftment went relatively smoothly: my platelets engrafted on day +11 and my white blood cells on day +16. Compared with what some other patients went through, I felt I had been fortunate. The day I left protective isolation and breathed the air outside again, I felt as though I had finally come back to life.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At my one-month post-transplant evaluation, the results were reassuring: both bone marrow and cerebrospinal fluid were in complete remission, and chimerism had become fully donor-derived. I soon met the criteria for discharge and went home to continue recovering.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">As my health steadily improved, I finally returned to school a little over a year after transplant. I went on to finish high school and was admitted to university, where I wanted to learn a practical skill and build my future step by step.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The five years after transplant were not completely smooth. My white blood cell and platelet counts sometimes dropped again, and my blood pressure fluctuated frequently. Fortunately, Dr. Tong WU and Dr. Yanzhi SONG continued to follow me closely. With their clinical experience, they evaluated each new problem carefully and adjusted my care as needed, helping me through one recovery challenge after another. The hardest setback for me came about two years after transplant, when I developed avascular necrosis of the right femoral head. Before I became ill, I loved playing table tennis and could move quickly around the table. Afterward, walking too much made my leg feel so heavy that it was hard to lift. By following the medical team's advice, resting when needed, and taking care of the joint over the long term, the discomfort gradually improved. I now have very little pain and can manage normal daily activities without difficulty.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Since becoming ill, I have never felt an overwhelming emotional burden about the diagnosis. When friends ask, I do not try to hide it. They know I am generally optimistic and they treat it matter-of-factly, which actually makes me feel more comfortable.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Going through all of this also helped me change some careless habits from when I was younger. My parents used to run a restaurant, and I would help out. As a reward, they let me have one bottle of soda a day. I remember lying in bed at night happily wondering whether I would choose Coke or Sprite the next day. I still buy a bottle once in a while as a treat, and I still enjoy it, but now I automatically remind myself not to overdo things the way I used to.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Gratitude and a New Beginning: The Things I Never Said Out Loud\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Looking back over these five years, there is so much I could say. But the first thing I want to tell my mother is simply: Mom, I'm sorry.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">There was a period during treatment when I became very irritable and would lose my temper for no reason. I did not really notice how much I had changed, but my mother did. I have always felt that I owed her that apology.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I also want to thank my father. While my mother stayed with me in Beijing for treatment, he remained back home, working from early morning until late at night to earn money for my care, while carrying the worry about my condition largely on his own. It is hard to imagine how much pressure he was under.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">And of course, I want to thank the medical team at Beijing GoBroad Boren Hospital. Dr. Tong WU, Dr. Yanzhi SONG, and all the nurses who looked after me every day gave me hope through their expertise, patience, and constant care. I still remember the day I finished my five-year follow-up. My attending physician, Dr. Erhui YUAN, smiled and said, "You won't need to keep coming back like this anymore." In that moment, all the difficult days and all the persistence suddenly felt worth it. I felt relieved, fortunate, and deeply grateful all at once.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">If someone asks me how I got through all of this, I would say that mindset really matters. I knew another patient who became completely discouraged after learning about the diagnosis, stopped following medical advice, secretly ordered takeout, and ignored dietary precautions. The disease later relapsed, which was heartbreaking. I have always felt that we cannot choose whether illness happens to us, but we can choose how we respond to it. If we give up on ourselves, even the best doctors and the best treatment plans can only do so much.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Five years have passed since my transplant almost before I realized it. At this latest follow-up, my results remained stable and the leukemia was still in complete remission. I am now back at university, studying steadily and trying to make the most of each day. For me, an ordinary, peaceful life like this is the best kind of life. I hope my story can offer even a small amount of light and strength to someone who is still trying to find a way through the dark. Do not give up. The night can feel darkest just before dawn, but if you keep going, morning will come.\u003C\u002Fspan>\u003C\u002Fp>","Clinical Commentary (Dr. Erhui YUAN, from the teams of Prof. Tong WU and Dr. Yanzhi SONG): \n\nYangyang had B-cell acute lymphoblastic leukemia (B-ALL) with an E2A-PBX1 fusion, a high-risk subtype associated with a tendency toward extramedullary involvement and refractory or relapsed disease. He relapsed only six months after his first CD19 CAR-T treatment, raising concern for CD19 antigen escape or insufficient persistence of CAR-T cells in vivo. Promptly switching targets and giving sequential CD22 CAR-T therapy was therefore a critical salvage strategy. CD22 CAR-T could target residual leukemic clones that may have lost CD19 expression while also achieving another deep response at extramedullary sites, creating a valuable window for subsequent therapy. This was followed by allogeneic hematopoietic stem cell transplantation, ultimately resulting in a five-year clinical cure after transplant. The case demonstrates the integrated value of sequential dual-target CAR-T therapy bridging to allogeneic transplantation in refractory\u002Frelapsed B-ALL, combining precision immunotherapy with established transplant strategies to overcome high-risk disease.\n\nLong-term complications also require close attention. During extended survival, the patient developed avascular necrosis of the femoral head as well as hypertension requiring combination antihypertensive therapy. Although the avascular necrosis is currently not causing significant symptoms, regular imaging follow-up remains important, excessive weight-bearing should be avoided, and progression should be monitored. For hypertension, combination treatment should aim to maintain blood pressure within target range, with close monitoring of renal function and electrolytes.\n\nOverall, this case achieved long-term control of high-risk, refractory B-ALL. However, managing late complications is just as important as controlling the leukemia itself. Long-term multidisciplinary follow-up involving hematology, orthopedics, cardiology, endocrinology, and other specialties is needed to help patients move from simply surviving to living well.\n\nThroughout years of treatment and recovery, Yangyang remained remarkably cheerful and optimistic. For this patient, reaching the five-year milestone represents what we call a \"clinical cure\" in oncology. It is not only a victory of treatment, but also a reflection of his resilience and inner strength. Yangyang has shown how a positive outlook can help turn medical possibilities into real life. We are delighted to see him reach this new beginning. There is still a long road ahead, so keep that smile. \"You are your own hero, and you are also one of the reasons we, as doctors, keep moving forward.\"",{"slug":251,"title":252,"summary":253,"cover":254,"disease":237,"treatment":255,"patientType":67,"publishedAt":256,"contentHtml":257,"expertView":258,"disclaimer":70,"hasAlternate":71,"updatedAt":126},"multiple-myeloma-car-t-remission","After CAR-T Therapy, I Got My Quality of Life Back","After multiple rounds of chemotherapy, an autologous transplant, and a relapse, she achieved complete remission with CAR-T therapy—and gradually found her way back to a life with rhythm, purpose, and quality.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F2f474be97daf8bba2f93472a5351176d.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp"," CAR-T, Autologous Hematopoietic Stem Cell Transplantation","2026-05-09","\u003Cp style=\"margin: 7px 0;\">\u003Cspan style=\"font-size: 15px;\">Summary: Ms. Zhang, 55, was diagnosed with IgD-λ multiple myeloma after developing lower-back discomfort and widespread bone pain. After several courses of treatment, she achieved only a partial response. In 2023, she came to GoBroad Shanghai Liquan Hospital for further treatment and underwent an autologous hematopoietic stem cell transplant, achieving complete remission for a period of time. Two years after the transplant, follow-up tests showed signs that the disease might be returning. By then, she had reached fourth-line treatment and was struggling to tolerate long-term drug therapy. After a comprehensive assessment, Dr. Su Li’s team recommended CAR-T cell therapy with FUCASO® (equecabtagene autoleucel). More than six months after CAR-T therapy, she achieved MRD-negative complete remission. As her physical and emotional well-being improved, she returned to painting, embroidery, travel, and other things she loves. Her story traces the journey of a patient with relapsed\u002Frefractory multiple myeloma from chemotherapy and autologous transplantation to CAR-T therapy—and shows why quality of life matters just as much as the goal of living longer.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cbr\u002F>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F94ec5e05e659d289c2f356636e10b6a2_20260912213651.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"94ec5e05e659d289c2f356636e10b6a2_20260912213651.png\" alt=\"9d5f19d4-baeb-4c7c-9fca-b4be66863b8f.png\"\u002F> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In July 2025, nearly two years after her autologous transplant, Ms. Zhang (pseudonym) had been keeping up with regular follow-up visits when tests began to show signs that her multiple myeloma might be returning. The shadow of repeated chemotherapy—something she had hoped was finally behind her—seemed to be closing in again. “I don’t want to go through chemotherapy anymore,” she said. “I want to live well, not just stay alive.”\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">With the goals of long-term disease control and a better quality of life, the medical team at GoBroad Shanghai Liquan Hospital carried out a comprehensive assessment. After detailed discussions with Ms. Zhang and her family, the team proceeded with CAR-T cell therapy using FUCASO® (equecabtagene autoleucel) in September 2025. More than six months later, her multiple myeloma is in complete remission.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F508c68874e5d72d7da37c919ff38668b_20260912213707.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"508c68874e5d72d7da37c919ff38668b_20260912213707.png\" alt=\"5d8d39e0-a1fc-4f7a-a898-fde14a17ac06.png\"\u002F>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px; text-align: center;\">Ms. Zhang teaching her students in the classroom in 2021\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Now 55, Ms. Zhang spent more than 30 years as a devoted schoolteacher. In the second half of 2022, as a new school year approached, she was preparing for her classes just as she always had. Then a nagging ache appeared in her lower back and gradually developed into bone pain throughout her body. At first, she did not think much of it. But one evening after work, she suddenly became very unwell and vomited through the night. Further tests at the hospital eventually led to a diagnosis of IgD-λ multiple myeloma.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">“At the time, I was worried about my students. I was afraid my absence would disrupt their learning,” Ms. Zhang recalled, still emotional when speaking about her diagnosis. She never imagined that once she stepped away from the classroom she loved, she would not be able to return.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After that, whenever she passed by the school and saw the familiar playground, she would often tear up, missing the life she had left behind.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Treatment turned out to be far more difficult than she had expected. After several courses of standard chemotherapy, she achieved only a partial response (PR). In February 2023, Ms. Zhang came to GoBroad Shanghai Liquan Hospital for further treatment and underwent an autologous hematopoietic stem cell transplant that June. She then moved into maintenance treatment, and for a while everything seemed to be improving. But two years later, her IgD level began to rise again during follow-up, suggesting that the myeloma might be returning.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Ms. Zhang had relapsed\u002Frefractory multiple myeloma, with several episodes of disease progression in less than three years. By this point, she had reached fourth-line treatment, and CAR-T cell therapy offered a new option. GoBroad Shanghai Liquan Hospital is also a designated CAR-T treatment center under Shanghai Hu Hui Bao, a supplemental health insurance program, which substantially reduced the financial burden of treatment for her family.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">She had been through chemotherapy, an autologous transplant, and then CAR-T therapy. Along the way, she endured the physical toll of repeated disease progression and fell into a deep depression during especially difficult periods of chemotherapy. Step by step, she worked through both the physical and emotional challenges. Today, she has returned to a quieter, fuller life shaped by painting, embroidery, travel, and the things that bring her joy—and her smile has returned with it.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Ms. Zhang says she is sharing her experience in the hope that her treatment journey can be a source of light for other people with blood disorders who may still be going through their darkest days.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">For anyone living through illness right now, we hope her story offers a little more hope and courage—and reminds you that it is possible to find your way back to the life, places, and moments that matter to you.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002Fe02babdc6a8373fdf5ceb7112578de0d_20260912213728.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"e02babdc6a8373fdf5ceb7112578de0d_20260912213728.png\" alt=\"3b8ab996-731b-40d4-bc75-f3fd5bbd9cc6.png\"\u002F>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">Ms. Zhang with Dr. Su Li in April 2026\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q1: What symptoms did you first notice in 2022, and how were you eventually diagnosed with multiple myeloma?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: It started when I hurt my lower back while doing yoga. I thought it was just a muscle strain, so I tried massage therapy, but it never got better. Not long after that, I started having bone pain all over my body. Then one day after work, I couldn’t eat and spent the entire night vomiting. The next day, I went to an internal medicine clinic. My blood tests were abnormal—both my calcium and creatinine were significantly elevated.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A doctor I knew looked at the results and called me that evening because he was concerned. He explained that the combination of these findings fit the “CRAB” features commonly associated with myeloma and urged me to see a hematologist as soon as possible.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I then had a bone marrow aspiration in the hematology department, which confirmed multiple myeloma. I burst into tears. I thought having a blood cancer meant I was going to die. I even asked my husband to take me to hospice. I had completely lost hope.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Later, a hematologist sat down with me and explained very patiently that although multiple myeloma is not currently considered curable, standardized treatment can help people live longer.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">So I began chemotherapy. But that was only the beginning. The road ahead was much harder than I had imagined.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q2: What brought you to GoBroad Shanghai Liquan Hospital, and why did you choose to have an autologous hematopoietic stem cell transplant there?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: After several courses of standard treatment for myeloma, I had achieved only a partial response. At the same time, chemotherapy was extremely hard on me. I needed an injection every week, and by the next day I would feel terrible. Going through the same cycle week after week wore me down physically and emotionally.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">That was when I came to GoBroad Shanghai Liquan Hospital to look for another option. As part of the treatment plan, I went on to have an autologous hematopoietic stem cell transplant.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Before I became ill, I was a teacher and I loved my job. If this disease had not appeared so suddenly, I would have stayed in the classroom until retirement. Even after I started chemotherapy, I still imagined that one day I might go back to teaching. But weekly treatment and constant hospital visits slowly made that hope feel less realistic. Spending all day at home, I often felt useless, as though I no longer had a place or purpose.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">What made things even harder was that my M-protein level was still high before the autologous transplant, so I had to continue taking chemotherapy drugs to bring it down. Emotionally, I was at my limit.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I don’t know how much of it was related to the medication, but I couldn’t sleep, I was extremely anxious, and there were times when I wanted to stop treatment altogether because death felt like an escape.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F84c958a35e0e401c430f2ef26a541232_20260912214348.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"84c958a35e0e401c430f2ef26a541232_20260912214348.png\" alt=\"cd68da01-af00-413b-b156-f18a0a6be5fd.png\"\u002F>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px; text-align: center;\">Ms. Zhang receiving further treatment at GoBroad Shanghai Liquan Hospital in February 2023\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">On my doctor’s advice, I went to the neurology department at another hospital and started medication to help with my anxiety and sleep. During that time, my family stayed close and encouraged me every day. My doctors also checked in often and helped me keep going. Before every dose of chemotherapy, I had to talk myself through it. No matter how difficult it felt, I forced myself to take the medication. Eventually, my M-protein level came under control.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Next, I received targeted therapy to reduce the remaining myeloma cells further and prepare for the autologous transplant.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I was very afraid of entering the transplant isolation unit, but once I was actually there, it was not as frightening as I had imagined. The nurses and care staff were very professional and often chatted with me. Dr. Su Li also came in every day to see how I was doing. I spent more than 20 days in the unit, and eventually I was able to leave it successfully.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The transplant worked well, and I achieved complete remission.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">During follow-up, Dr. Su Li recommended consolidation treatment every two months. As I became stronger, the interval between visits gradually became longer and my emotional state also improved. I slowly tapered off the medication I had been taking for my mental health symptoms, and little by little, life began to feel normal again.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q3: After the transplant, things seemed to be settling down—until your IgD level started rising again during maintenance treatment. How did you learn about CAR-T therapy, and what ultimately led you to choose it?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong> \u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: Things had been improving, and I was approaching the two-year mark after my transplant when one follow-up test showed that my IgD level had started to rise. That suggested the disease might be coming back.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I had learned that IgD multiple myeloma tends to relapse more easily. I also did a lot of reading on my own and understood that myeloma cannot yet be completely cured. One reason I had chosen an autologous transplant was to reduce how often I needed chemotherapy and improve my quality of life. I simply did not want to spend the rest of my life going through chemotherapy. It was too hard for me.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Given my situation, Dr. Su Li recommended CAR-T therapy for myeloma. He told me that approved CAR-T therapies were already well established in clinical practice in China and that Liquan Hospital had treated many patients with commercial CAR-T products and seen good outcomes.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At first, I was very hesitant. I searched online and found so many different opinions that I didn’t know what to believe. Then one day, another patient with myeloma told me he had undergone CAR-T therapy and had responded very well. I asked him, “Did you still need chemotherapy afterward?” He said no. Seeing him living just like anyone else—and knowing he no longer needed chemotherapy—finally helped me make up my mind.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Another important factor was that Shanghai Liquan Hospital is a designated CAR-T treatment center under Shanghai Hu Hui Bao. Commercial CAR-T therapy is expensive, but I met the coverage criteria for adults with relapsed or refractory multiple myeloma whose disease had progressed after three prior lines of therapy. The insurance coverage reduced a substantial portion of our out-of-pocket cost and greatly eased the financial pressure on my family.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q4: Many patients worry about side effects from CAR-T therapy, including cytokine release syndrome (CRS). Did you experience fever, fatigue, or other reactions after the CAR-T cell infusion?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: For me personally, CAR-T therapy was much easier to tolerate than the autologous transplant. To begin with, I didn’t have to stay in a transplant isolation unit. I only needed a bedside laminar-airflow canopy, which already made the experience feel much less stressful.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">For the first few days, I received lymphodepleting chemotherapy, and that part was uncomfortable. But after the CAR-T cells were infused, I felt much better. I wasn’t vomiting much, and I didn’t lose my hair—the way I had during the autologous transplant, when I had to shave my head. I stayed under the laminar-airflow canopy for about 20 days. My highest fever was around 38°C and it resolved within two or three days. The main issue was a poor appetite. Compared with the autologous transplant, when I was vomiting constantly and my fever reached 39°C, this experience was much easier for me.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Of course, everyone responds differently, but in my own case, the overall discomfort was much less.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q5: It has been more than six months since your CAR-T therapy. How has your recovery been in terms of energy, appetite, and sleep? What feels most different compared with the time when you were ill?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: CAR-T is not a magic injection that cures everything overnight. Recovery still takes time, and you have to rebuild your strength gradually.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After discharge, I went home to recover and returned to the hospital regularly for follow-up. About three months later, my appetite started to come back and I was gradually able to go outside for short walks. I could genuinely feel myself getting a little better every day.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">For me, the happiest thing is not having to go through chemotherapy anymore. I can eat, I can sleep, and I feel so much lighter emotionally.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">This April, when I went to Zhejiang during the Qingming holiday to visit family graves, I spent a day sightseeing as well. Seeing spring everywhere—the green grass, birds, peach blossoms, and fresh willow leaves—I felt the joy of simply being alive in a way I hadn’t for a long time.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F853d2c7fe0982045cbeba39a118ecce3_20260912214414.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"853d2c7fe0982045cbeba39a118ecce3_20260912214414.png\" alt=\"27fa832b-68a8-4634-8fe0-facc5851bbd0.png\"\u002F>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px; text-align: center;\">Spring scenery photographed by Ms. Zhang in April 2026\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q6: After such a difficult treatment journey and gradually finding your way back to everyday life, has your perspective on life changed?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A serious illness completely disrupted the life I had planned and forced me to leave the classroom I loved. The repeated setbacks and the pain of treatment pushed me into a deep depression for a time. Looking back on those darkest days, it was my family’s unwavering support and encouragement, together with the professional treatment and thoughtful care I received from every healthcare professional I met, that helped me reach this important milestone in my recovery and gradually find my way out of that emotional darkness.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Today, I am more open-minded and at peace than I used to be. Before I became ill, work left me little time for many of the things I enjoyed. Now I can return to them slowly—practicing calligraphy, painting, and embroidery. Each one helps me settle my mind and notice the small, beautiful details of everyday life. I also have opportunities to visit cities I had always wanted to see and experience places I once knew only from books.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">If I ever have the chance to stand in a classroom again, I would like to tell my students what this experience taught me about life after facing mortality: strength does not mean never breaking down. It means that even after your defenses have given way, you can still find a way to climb back up.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Life is unpredictable, but that uncertainty has also taught me how to value what I have and live with greater calm.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F7cd6791b9dae2f6af504ec02cf8659cb_20260912214456.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"7cd6791b9dae2f6af504ec02cf8659cb_20260912214456.png\" alt=\"67d253cf-15c7-4cc1-8fd1-b90b432bd0f8.png\"\u002F>\u003C\u002Fspan>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px; text-align: center;\">Ms. Zhang’s life through painting and calligraphy\u003C\u002Fspan>\u003C\u002Fp>","Dr. Su Li (Associate Chief Physician, MD; Director of Hematology and Myeloma Center, GoBroad Shanghai Liquan Hospital):\n\nMs. Zhang has IgD multiple myeloma and has poor tolerance to myeloma medications. She was unable to tolerate immunomodulatory drugs such as lenalidomide and pomalidomide because of significant adverse effects, which limited the intensity of treatment. As a result, her myeloma progressed several times in less than three years, bringing her to fourth-line therapy.\n\nAt that point, CAR-T therapy was an appropriate option. We had already identified CAR-T as the treatment strategy early in the relapse. There was one additional challenge: a bone marrow sample from the posterior superior iliac spine did not detect myeloma cells, so we could not confirm the BCMA target. Guided by MRI, we then sampled an abnormal area in the sternum, successfully obtained myeloma cells, and were able to confirm the target.\n\nDuring CAR-T treatment, Ms. Zhang experienced only mild cytokine release syndrome (CRS), while the response was very encouraging. She achieved MRD-negative complete remission (CR). She continues regular follow-up and receives periodic immunoglobulin infusions to help prevent infection, and her quality of life has improved significantly. We will continue to monitor her response and manage any treatment-related effects over the long term.",{"slug":61,"title":62,"summary":63,"cover":64,"disease":65,"treatment":66,"patientType":67,"publishedAt":68,"contentHtml":69,"disclaimer":70,"hasAlternate":71,"updatedAt":72},{"slug":261,"title":262,"summary":263,"cover":264,"disease":198,"treatment":80,"patientType":67,"publishedAt":265,"contentHtml":266,"expertView":267,"disclaimer":70,"hasAlternate":71,"updatedAt":126},"dlbcl-patient-car-t-autologous-transplant-five-year-remission"," After Relapsed\u002FRefractory Lymphoma and a Long Search for Care, Autologous Transplant Combined with CAR-T Brings Five Years of Sustained Remission","Diagnosed with diffuse large B-cell lymphoma at 19, she later faced relapse and limited treatment options. At Beijing GoBroad Boren Hospital, she received autologous hematopoietic stem cell transplantation combined with CAR-T cell therapy. Five years later, she remains in complete remission and has returned to everyday life.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F52f2548fe0c0e171eb4b471280262953.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","2026-04-30","\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Article Summary: Yanyan (pseudonym) was 19 and had just started university when a persistent cough led to a diagnosis of diffuse large B-cell lymphoma. Her disease initially responded to treatment, but relapsed only three months later, and subsequent therapy provided limited benefit. At one point, she felt close to giving up. In 2020, after her family searched widely for another treatment option, Yanyan came to Beijing GoBroad Boren Hospital. The specialist team developed an individualized strategy to reduce her tumor burden, followed by autologous hematopoietic stem cell transplantation combined with CAR-T cell therapy to give her the best chance of durable remission. Now, five years after treatment, Yanyan remains in complete remission. She has returned to an ordinary, fulfilling life and hopes her experience can encourage others who are still going through treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cbr\u002F>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Youth is supposed to be full of possibilities: enjoying life, chasing dreams, and imagining the future. But sometimes it also means facing a life-threatening illness head-on and fighting with everything you have.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In 2019, 19-year-old Yanyan (pseudonym), a university student from Inner Mongolia, was diagnosed with diffuse large B-cell lymphoma. Chemotherapy at another hospital initially brought the disease under control, but only three months later it relapsed. Further chemotherapy had little effect. Again and again, Yanyan and her family allowed themselves to hope, only to be met with disappointment. Just as she was close to giving up, they heard about Beijing GoBroad Boren Hospital through other patients and began looking there for another chance. With an individualized combination of chemotherapy, autologous hematopoietic stem cell transplantation, and CAR-T cell immunotherapy, Yanyan eventually achieved complete remission (CR). Today, she has passed the five-year milestone with reassuring follow-up results. The young woman who once cried from her hospital bed that she wanted to stop treatment has moved beyond that chapter and stepped into a new life of her own.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002Fda20f210dd943e86341d45b674f710b4_20260912235847.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"da20f210dd943e86341d45b674f710b4_20260912235847.png\" alt=\"7ec565c7-7420-452b-abbf-675a8753acd6.png\"\u002F>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px; text-align: center;\">Photo from her five-year complete remission follow-up\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>A Cancer Diagnosis Put My Life on Pause\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In 2019, I had just started my second year of university. If life had gone as expected, I would have been doing what other people my age were doing: going to class, shopping, traveling with friends, taking photos, and trying different foods. Instead, life suddenly took a very different turn.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At first, I only had a cough and assumed it was a common cold. I did not think much of it until the shortness of breath became worse and even climbing stairs left me breathless. A CT scan led to devastating news. Pathology ultimately confirmed diffuse large B-cell lymphoma. This type is more common in adults. My disease was in the mediastinum and accompanied by fibrous connective tissue proliferation, almost like a layer of 'armor' around the tumor cells, which made conventional chemotherapy more difficult to penetrate and the disease more challenging to treat.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At first, I did not know the full truth about my condition. My parents were afraid the diagnosis would be too much for me, so they tried to protect me with a well-intentioned explanation. I had always been healthy growing up, and even while lying in an ICU bed, I was still relatively calm.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">That changed when I watched a patient in the bed next to mine being covered with a yellow sheet and wheeled away. Then I heard heart-wrenching crying outside the room. In that moment, it suddenly hit me: death was much closer than I had realized.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Eventually, my attending doctor told me the truth. She looked at me seriously and asked, 'Do you understand how serious this disease is?' I said I did not, but I was not afraid. Looking back, I suppose I simply did not yet understand enough to be afraid.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Caught Between Hope and Despair: Remission Lasted Only Three Months Before Relapse\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Once treatment really began, I understood just how hard it could be.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">My first chemotherapy regimen was standard R-CHOP. The nausea, vomiting, and hair loss were overwhelming. Vomiting was the hardest part. Other patients might feel sick for two or three days, but I would vomit for half a month, sometimes until there was only bile left, and I became so weak I could barely manage a spoonful of porridge. Standing or walking for long periods was exhausting. I looked in the mirror at my bald head, hunched posture, and steroid-related 'moon face' and could hardly recognize the person looking back at me.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Meanwhile, people my age were still living the life that had once felt completely normal to me - going to class, traveling, meeting friends, taking pictures. I felt as if everyone else was moving forward while I had been forced to stay still.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">But was I going to let that defeat me? No. If chemotherapy made me vomit, I would still try to eat. If I felt low, I would find something to distract myself. My life could not stay on pause forever.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">So I pushed through eight cycles of chemotherapy. By the end of 2019, PET\u002FCT showed complete metabolic response (CMR). I was overjoyed. I thought the chemotherapy was finally over and I could go back to normal life.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">That happiness lasted only three months. In April 2020, follow-up testing showed a new FDG-avid lesion in the mediastinum, raising concern for relapse. I completely broke down when I saw the result. How could it come back so quickly? Hadn't I already been told I was in remission?\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">My doctors recommended another needle biopsy to confirm the diagnosis, but because of the tumor's location and the procedural risk, I declined. I then received R-DHAP chemotherapy. I forced myself through another full course, only to find at follow-up that the tumor had not shrunk - it had grown.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Each new hope seemed to end in another disappointment. I felt completely powerless, as if no matter how hard I tried, I could not escape the disease. I kept crying to my family, 'Why me? I'm exhausted. I want to give up.'\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Fortunately, my parents refused to give up on me. My mother said, 'You're only in your early twenties. There are still so many beautiful things in life you haven't experienced. Your dad and I don't want you to give up so young. We helped you through this once - let us help you again. Don't give up. You are what keeps us going.'\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">My father kept searching for lymphoma specialists. Through another patient, he learned about Dr. Shaomei Feng and the lymphoma team at Beijing GoBroad Boren Hospital. That patient had a similar situation and had achieved complete remission after treatment at Boren.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Precision Treatment: Autologous Transplant Combined with CAR-T Brings a New Beginning\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In November 2020, with what felt like our last remaining hope, my family and I came to Beijing GoBroad Boren Hospital. I was emotionally overwhelmed that day and cried, 'I don't want any more treatment.' Instead of becoming frustrated, the doctor patiently encouraged me to try one more time. When she learned how severe my chemotherapy-related nausea and vomiting had been, she reassured me, 'We'll find a way to make it easier on you.'\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After admission, the specialist team reassessed my condition from the beginning. To clarify the diagnosis, they arranged a needle biopsy of the mediastinal mass and sent the specimen for expert pathology review by Professor Zifen Gao. I later learned that Professor Gao is a leading lymphoma pathologist in China. The review confirmed diffuse large B-cell lymphoma, with features favoring primary mediastinal large B-cell lymphoma.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Based on that detailed reassessment, the team developed a comprehensive, individualized treatment plan. To reduce my tumor burden, I received antitumor immunotherapy combined with multi-agent chemotherapy. After the first course, contrast-enhanced chest CT showed that the tumor had shrunk by more than two-thirds, giving our whole family renewed hope. After the second course, PET\u002FCT showed complete remission. I was so happy I could hardly hold back tears.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The team then moved to the most important stage of treatment: autologous stem cell transplantation combined with CAR-T cell therapy. There was one small episode before I entered the transplant unit. I tried to bargain with the doctors, saying, 'I'll do CAR-T, but I don't want the transplant!' In the end, with a lot of reassurance and persuasion, I went into the transplant unit. On February 5, 2021, I underwent autologous hematopoietic stem cell transplantation. On February 8, I received an infusion of murine CD19-directed CAR-T cells. Both procedures went smoothly.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Looking back now, the transplant itself was not as frightening as I had imagined, and the stem cell infusion was actually quite straightforward. The hardest part was the high-dose conditioning chemotherapy beforehand. I felt constantly nauseated without being able to vomit, and the mouth ulcers were even worse - my entire mouth was covered with them and I could not eat. I weighed about 60 kilograms before treatment and just over 40 kilograms when I left the transplant unit.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">But I made it through. PET\u002FCT after leaving the transplant unit showed complete remission. I had won that round.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Throughout treatment, the specialist team closely monitored my condition and treated side effects promptly. At my previous hospital, every chemotherapy cycle left me vomiting for half a month. At Boren, with careful symptom management, I usually had only a couple of days of nausea and could still manage to eat a little. The overall treatment experience was much more manageable. Dr. Shaomei Feng was like an older sister. She would smile and ask how I was doing on every ward round, and she was always patient. My mother later said, 'At Boren, we never felt that same fear or tension. The doctors and nurses felt like friends and family. They always answered our questions and were incredibly patient.'\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Turning Toward the Sun: Five Years in Complete Remission, and Back to Everyday Life\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Today, I have been in complete remission for five years. I still remember one follow-up visit when Dr. Feng was delighted for me and said, 'You finally don't need to keep coming back. You're free.'\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Looking back, I understand more deeply how fragile and precious life can be. In the darkest period, the thing that carried me through was simply refusing to give up. My parents were a huge part of that, but so was the medical team at Boren. I want to say thank you to Dr. Feng and to every doctor and nurse who helped me. If I had not met you when I did, I might truly have stopped treatment. You encouraged me with extraordinary patience, almost as if you were coaxing a frightened child, and helped me press the restart button on my life. I will never forget that.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Now I have finally returned to an ordinary life: working, shopping and eating out with friends, and using my camera to capture the small, beautiful moments that make everyday life worth remembering.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I once wrote in an essay, 'A few hundred words can never capture everything we go through during treatment, but I want to tell people facing something similar: nothing has the right to put our lives on permanent pause. The restart button is still in our hands.' I still want to say the same thing today. I understand the discomfort, despair, and helplessness that treatment can bring. But even if life has been forced onto pause, it can start again. Keep going. There is still a road ahead.\u003C\u002Fspan>\u003C\u002Fp>","Clinical Commentary (Dr. Shaomei Feng, on behalf of Dr. Chunrong Tong's team): \n\nThe patient had received guideline-based treatment at another hospital, yet the disease did not achieve adequate remission and instead continued to progress, while the burden of treatment remained substantial. Clinical guidelines provide standardized recommendations for most patients, but every patient also has individual disease features. Applying a standard regimen without adapting it to those differences may limit benefit for some people. By taking into account each patient's immunophenotype, genetic alterations, lesion location, and surrounding tissue environment, and by flexibly combining targeted agents with cytotoxic drugs, treatment can be better individualized and more patients may benefit.\n\nCAR-T cell therapy has distinct advantages because it can selectively target tumor cells. For young patients with relapsed or refractory disease, however, autologous transplantation can also be an important consolidation strategy. When tumor burden has been reduced, integrating autologous transplantation with CAR-T therapy can make use of the period after transplant conditioning and before full immune reconstitution, allowing CAR-T cells to target residual tumor cells that conditioning may not have eliminated completely. This may improve the chance of durable remission.\n\nTraditional cytotoxic chemotherapy, monoclonal or bispecific antibodies, CAR-T cell immunotherapy, autologous transplantation, local radiotherapy, and targeted therapies are not mutually exclusive treatment approaches. For an individual patient, carefully integrating several of these modalities can attack the disease from different directions and may make sustained, long-term remission more achievable. This patient has now remained in remission for five years, and her current risk of relapse is considered very low.\n\nAs the saying goes, the sun comes out after the storm. The young woman whose life was once forced onto pause has now started again. The road behind her was difficult; we hope the road ahead will be much smoother.",{"slug":269,"title":270,"summary":271,"cover":272,"disease":198,"treatment":273,"patientType":67,"publishedAt":265,"contentHtml":274,"expertView":275,"disclaimer":70,"hasAlternate":71,"updatedAt":126},"diffuse-large-b-cell-lymphoma-stem-cell-transplantation","After Two Transplants, He Finally Found His Way Back to Everyday Life","After a liver transplant and treatment for lymphoma, he spent five years rebuilding his health and returning to work and family life.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F605bdbc303f368fec724ccd899e23150.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","Hematopoietic Stem Cell Transplantation, Chemotherapy","\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">Summary: Mr. Wang, 45, had already been through a liver transplant and made his way back to everyday life when sudden abdominal pain led to a diagnosis of diffuse large B-cell lymphoma (DLBCL). When chemotherapy failed to control the disease and it continued to progress, he went through an extremely difficult period. After seeking other treatment options, he came to GoBroad Shanghai Zhaxin Hospital \u002F Shanghai Liquan Hospital. Following an adjustment to his treatment plan, he achieved complete remission and underwent an autologous hematopoietic stem cell transplant in 2021. Five years later, he is doing well and has returned to work and family life. From a liver transplant to a stem cell transplant, Mr. Wang has faced two major health crises. He hopes his story can give strength and confidence to others going through treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F28fc0371b699c9273f4cd3ad3ac94fd8_20260912205102.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"28fc0371b699c9273f4cd3ad3ac94fd8_20260912205102.png\" alt=\"61e98944-c3a7-4410-a31d-d295ff82b60c.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Recently, GoBroad Shanghai Liquan Hospital welcomed back a very special “graduate.” Now 45, Mr. Wang (pseudonym) walked in with a steady stride and an easy smile, speaking openly about everything he had been through. “Looking at me now, no one would guess I’ve had two major procedures,” he said. “One was a liver transplant, and the other was a hematopoietic stem cell transplant.”\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">He still remembers the sudden abdominal pain that changed his life five years ago. At first, he thought it was acute gastroenteritis. But the pain kept getting worse. While he was in hospital waiting for the pathology results, even morphine could not bring the pain under control—an experience he has never forgotten. It was only after he was diagnosed with diffuse large B-cell lymphoma and started chemotherapy that the pain finally eased.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">His treatment journey, however, was far from straightforward. He went through the shock of diagnosis, the disappointment of chemotherapy not working as hoped, the stress of poor stem cell collection, and the anxiety of entering the transplant ward. Now, five years later, Mr. Wang chose this milestone to return to Liquan Hospital for a follow-up. For him, it was a way to close one difficult chapter and begin the next.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">When asked about the future, he smiled and said, “Three meals a day, simple food on the table, and my family by my side—that’s happiness.”\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">From a liver transplant to a hematopoietic stem cell transplant, from life-threatening illness back to the rhythms of ordinary life, Mr. Wang has spent five years rebuilding his life. His message to others going through treatment is simple: even the hardest road can be finished one step at a time, and even the longest night eventually gives way to morning.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F889cdad12f0d3481801bb8170d849d59_20260912205130.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"889cdad12f0d3481801bb8170d849d59_20260912205130.png\" alt=\"5a4b1509-2752-4392-959d-ffc329c7359d.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">Today, Mr. Wang is back on the badminton court, enjoying an active life.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q1: Looking back, what symptoms did you first notice, and how did you feel when you received the diagnosis?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: In September 2019, I went to hospital because of sudden abdominal pain. At first, I thought it was acute gastroenteritis, and the symptoms improved somewhat after IV treatment. But soon after the National Day holiday, the severe abdominal pain came back. A contrast-enhanced CT scan showed enlarged lymph nodes in my neck and multiple enlarged retroperitoneal lymph nodes, so I was transferred to hepatobiliary surgery. A biopsy and pathology report ultimately confirmed diffuse large B-cell lymphoma.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I had already undergone a liver transplant in 2011. It had taken so much to come through that experience and return to a normal life. Being diagnosed with lymphoma after all that was another huge blow, both emotionally and financially.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I kept asking myself, “Why me again?” The nightmares I thought I had put behind me seemed to come rushing back overnight. The emotional pressure and financial worries fed into each other, and there were many nights when I lay awake until morning.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">But my family never gave up on me. Their support, encouragement, and constant presence became the light that slowly pulled me out of that dark place. I began telling myself: I made it through once before, so I had to give it everything I had one more time.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Even then, treatment was difficult. After four cycles of first-line chemotherapy, the disease was still progressing. I then had four cycles of second-line chemotherapy, but the lymphoma still did not go into remission. Every follow-up felt like a roller coaster—hope, disappointment, then finding the strength to keep going again. My body and emotions were both being pushed to the limit, but I wasn’t ready to give up.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q2: What brought you to GoBroad Shanghai Zhaxin Hospital \u002F Shanghai Liquan Hospital?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: I had my liver transplant at Shanghai General Hospital, so I had known for years about Prof. Chun Wang, then Director of Hematology there, and his reputation for treating complex hematologic diseases. When lymphoma treatment kept failing and I felt I was running out of options, his name stayed in my mind.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At that point, I saw two main options: join a clinical trial, or go to GoBroad Shanghai Zhaxin Hospital to see Prof. Chun Wang and look for another chance. I thought it over again and again, asked around, and discussed it with my family many times. In the end, I decided to put my trust in a specialist whose expertise and reputation I had known for years. In October 2020, I went to Zhaxin Hospital for further treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Prof. Chun Wang’s team developed a new chemotherapy plan for me. I had mixed feelings at the time—I was hopeful, but also afraid of being disappointed again. Then, finally, things began to turn around. The new regimen worked very well, and my assessment showed that I had achieved complete remission.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Prof. Chun Wang and my attending physician, Dr. Su Li, recommended consolidating that remission with an autologous hematopoietic stem cell transplant, with the goal of achieving a deeper and more durable response.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I later learned that the Department of Hematology at GoBroad Shanghai Liquan Hospital had just opened. As someone coming from outside Shanghai, whether I was treated at Zhaxin or Liquan made little difference medically. What stood out at Liquan was the practical support for families: rooms were available for accompanying family members, and the hospital provided complimentary transportation for patients on the day of admission and discharge. Those thoughtful details made the travel and logistics much easier for all of us. In March 2021, I successfully underwent an autologous hematopoietic stem cell transplant at Liquan Hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q3: What was the hardest part of treatment for you?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: For me, the hardest part was often the anxiety—the mental strain more than anything else.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">During stem cell mobilization and collection, things did not go as smoothly as we hoped because I had been taking immunosuppressive medication long-term after my liver transplant. The first collection produced only a very small number of stem cells—nowhere near enough. We tried mobilization a second time, and only after combining the two collections did we barely reach the amount needed. I’ll admit I was very nervous before entering the transplant ward. I kept worrying that something might go wrong and was afraid of what I didn’t know.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">But once I was actually in the transplant ward, the experience was much smoother than I had imagined. I did feel weak and lost my appetite, but compared with my liver transplant in 2011, both the physical discomfort and the fear were much more manageable. The care and attention from the medical team also gave me a great deal of confidence.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I had very little appetite in the transplant ward, but I made myself eat every day. I kept thinking: I’ve already come this far—I can’t stop at the final hurdle. One bite at a time, one day at a time. Before I knew it, more than 20 days in the transplant ward had passed.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Looking back now, I feel very fortunate. I made it through two major hurdles: a liver transplant and an autologous hematopoietic stem cell transplant.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Life has thrown plenty of challenges my way, but each time things were at their hardest, there was still a path forward.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q4: Has going through these serious illnesses changed the way you look at life?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: I would never have made it this far without my family standing behind me.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Going through two major illnesses placed a huge financial burden on our family. The liver transplant alone cost more than we could cover even after selling a property. I’m especially grateful to my younger brother, my wife, my aunt, and my uncle. None of them had money to spare, but they each found a way to help—some contributed 50,000 yuan, some 40,000, and some more than 10,000. I still haven’t been able to repay all of it.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">My mother passed away around 2000. When I became ill, my aunt and uncle looked after me as if I were their own child, and I will always be grateful for that. I also have two children. My wife had to carry the weight of the household while caring for them, so she could not always be with me in hospital. My younger brother was the family member who stayed with me most during my hospitalizations.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Today, I’m back to a normal working and family life. I work as a driving instructor. I keep a regular routine, eat three meals a day, and most importantly, I have my family around me.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I’m still paying back some of the debt from my treatment, little by little, but I’m content with where I am.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">What I want now is simple: to live each day well. Waking up to sunlight, being free from pain, being able to eat and sleep normally—that is a good day to me.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong> \u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q5: What would you like to say to other patients who are still going through treatment?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong> \u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: I know how hard this road can be. I’ve had to work my way through setback after setback too.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">That’s why, looking back on everything I’ve been through, I want to say this: keep believing in yourself, keep trusting your doctors, and believe that after the difficult stretches and the storms, there can still be a new beginning.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Today may be hard. Tomorrow may be hard too. But the day after that, the light may finally start to come through.\u003C\u002Fspan>\u003C\u002Fp>","Dr. Su Li (Associate Chief Physician, MD; Director, Department of Hematology, and Director, Myeloma Center, GoBroad Shanghai Liquan Hospital):\n\nThis patient had an exceptionally difficult treatment course. He developed diffuse large B-cell lymphoma after a liver transplant, and the disease continued to progress despite both first- and second-line treatment. At the time, he was also under significant financial pressure.\n\nAfter he came to our hospital, we adjusted his treatment plan. We used a regimen combining rituximab, a BTK inhibitor, and lenalidomide, together with ESHAP chemotherapy. He successfully achieved complete remission (CR), and we were then able to complete stem cell collection.\n\nThroughout chemotherapy and transplantation, we also took his history of hepatitis B into account and continued hepatitis B immunoglobulin prophylaxis to reduce the risk of HBV reactivation and support the safe completion of treatment. Five years have now passed, and it is deeply rewarding to see him continuing to do well and back to his normal work and family life.",{"slug":277,"title":278,"summary":279,"cover":280,"disease":190,"treatment":99,"patientType":67,"publishedAt":281,"contentHtml":282,"expertView":283,"disclaimer":70,"hasAlternate":71,"updatedAt":126},"elderly-aml-patient-five-year-survival-after-transplant","At 62, His Leukemia Did Not Respond to Chemotherapy. Five Years After Transplant, He Reached a Major Recovery Milestone","Diagnosed with acute myeloid leukemia at 62, he went through chemotherapy without remission and even an ICU stay before receiving a haploidentical hematopoietic stem cell transplant at Beijing GoBroad Boren Hospital. Five years later, he remains disease-free and is once again enjoying retirement.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F05adfba22db456472916956b7fdb55f8.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","2026-04-17","\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Summary: In 2020, 62-year-old Mr. Liu (pseudonym) was preparing for surgery for varicose veins when abnormal blood test results led to an unexpected diagnosis of acute myeloid leukemia. Older age, failure to achieve remission with chemotherapy, and serious complications during treatment left him feeling hopeless at times. With his family’s support, he came to Beijing GoBroad Boren Hospital, where Dr. Tong Wu’s team evaluated him and proceeded with a haploidentical hematopoietic stem cell transplant. After making it through the transplant unit, management of graft-versus-host disease, and years of follow-up, he has now passed the important five-year post-transplant milestone with stable blood counts and has returned to everyday life. His experience shows that age alone does not determine what treatment is possible, and that appropriate treatment, close medical care, and a strong partnership between patients, families, and clinicians can open new possibilities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cbr\u002F>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In hematologic care, five years of disease-free survival is often regarded as an important milestone toward clinical cure. For a 62-year-old patient with acute myeloid leukemia (AML) whose disease had not gone into remission with chemotherapy and who had once required ICU care, reaching that milestone was especially hard-won. After undergoing a haploidentical hematopoietic stem cell transplant at Beijing GoBroad Boren Hospital, he made it through those five years and recorded his own story of recovery - one shaped by perseverance and trust.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002Faddb6912e09734b3c48cde6d223cbfa8_20260912233937.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"addb6912e09734b3c48cde6d223cbfa8_20260912233937.png\" alt=\"3684402c-f9cf-40a4-beb5-d34daf00780c.png\"\u002F>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">Photo from his five-year post-transplant follow-up\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>My Recovery Story - Facing Leukemia in My 60s and Reaching the Five-Year Milestone\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In September 2020, I was 62. I had imagined retirement would mean spending time with my grandchildren and traveling with my family. Then one diagnosis suddenly put everything on hold: acute myeloid leukemia.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At the time, I was at a hospital in Beijing preparing for surgery for varicose veins that had bothered me for years. My preoperative blood tests showed a high white blood cell count and low platelets, and the doctor suggested a bone marrow test. I felt as though the ground had fallen away beneath me. At my age, chemotherapy was not only risky - it was exhausting. I did not achieve remission after either the first or second cycle. I even had a brief loss of consciousness and was admitted to the ICU. Once I stabilized, I was transferred back to the hematology chemotherapy unit, but I could no longer tolerate standard-dose chemotherapy, and the leukemia cells were still there. Lying in the laminar-flow ward and watching birds outside the window, I kept thinking: this cannot be how my life ends.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">My wife and daughter actively searched for other treatment options. They asked around and eventually found Dr. Tong Wu’s team at Beijing GoBroad Boren Hospital. They came back and told me the hospital could take my case and that a haploidentical hematopoietic stem cell transplant was possible. My daughter held my hand and said, “Dad, let’s give it a chance.”\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After one cycle of treatment at Boren Hospital, my bone marrow was MRD-negative. Then came donor matching, conditioning, and the stem cell infusion - a long process. I still remember the smell of disinfectant, all the tubes attached to my body, and the rash and diarrhea caused by graft-versus-host disease. I got through each of them. The hardest part was the month in the transplant unit. I was so weak that even taking a sip of water felt like a struggle. But I kept telling myself: now that I’ve chosen treatment, I cannot let my family’s tears or the medical team’s efforts be in vain.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The day I left the transplant unit, the sunlight felt especially bright. Dr. Yongqiang Zhao told me that the donor stem cells had successfully engrafted and my blood counts were beginning to recover. To me, it felt as though a new blood-forming system had been planted inside my body.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Over the five years since transplant, I have never taken recovery for granted. Regular follow-ups, a consistent routine, a balanced diet, and rehabilitation exercise became non-negotiable parts of my life. For the first three years, I would lose sleep before almost every checkup, terrified that the word “relapse” might return to my life. But with one reassuring test after another, my confidence gradually came back.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Today, I am 67. I can walk with my wife - often around 15,000 steps a day - take my granddaughter to and from school, and even play chess with neighbors in our community. Looking back on these five years, there is one thing I want to tell other patients: age is never, by itself, a reason to give up. Leukemia once brought me to the lowest point of my life, but modern medicine and my family’s love helped pull me back. I am grateful to the part of me that kept going, to the medical team for their expertise, and to my family for never leaving my side.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I have crossed the five-year milestone that, clinically, marks an important threshold toward cure.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">To everyone who is still on this road, I hope you too will one day look up and see your own clear sky after five years.\u003C\u002Fspan>\u003C\u002Fp>","A Message from the Medical Team: Age Is Not a Barrier - Patients and Clinicians Can Create New Possibilities Together.\n\nWhen we first met this patient, he was 62 and had been diagnosed with acute myeloid leukemia (AML). Older age, high-risk disease, and underlying health conditions all made his treatment particularly challenging.\n\nOlder patients with AML often tolerate conventional chemotherapy less well and face a higher risk of relapse, with less favorable long-term outcomes. After repeated discussions with the patient and his family, we decided to pursue a more demanding but potentially more promising path: allogeneic hematopoietic stem cell transplantation.\n\nThe transplant was not easy. Mucosal injury from conditioning, infection risk, and repeated fevers during bone marrow suppression tested both his resilience and our clinical judgment every day. Yet his engagement with treatment exceeded our expectations. He never complained. Even at the hardest moments, he would simply say quietly, “Doctor, I trust you. Thank you.”\n\nBy day 14 after the stem cell infusion, his peripheral blood counts began to recover. By day 28, donor chimerism had reached full-donor status - evidence that the new hematopoietic system had successfully engrafted.\n\nBut successful engraftment was only the first step. Managing graft-versus-host disease, preventing infection, and monitoring for relapse are all part of the long-term work after transplant. Over the past five years, he has followed medical advice closely and returned for every scheduled follow-up. His blood counts, bone marrow findings, donor chimerism, and viral load measurements have remained stable and within the expected range.\n\nToday marks a full five years since his transplant. In hematology, five years of disease-free survival is regarded as an important marker of clinical cure. For this patient, it means the leukemia has remained controlled over the long term and the donor-derived hematopoietic system has continued to function successfully.\n\nMedically, this is an excellent transplant outcome. But as a doctor, I see something more: a recovery made possible by patients, families, and clinicians working together with the same goal.\n\nTo all patients living with a blood disorder, we would like to say:\n\nAge is not an absolute barrier, and courage can create possibilities. Advances in modern medicine - particularly in transplantation - are making treatment possible for more patients who might once have had very limited options.\n\nCongratulations to Mr. Liu, and thank you for the trust he placed in us.\n\nFive years is a milestone, not an endpoint. We hope the next five and ten years bring him continued health and peace of mind.",{"slug":285,"title":286,"summary":287,"cover":288,"disease":89,"treatment":289,"patientType":67,"publishedAt":290,"contentHtml":291,"expertView":292,"disclaimer":70,"hasAlternate":71,"updatedAt":126},"ph-positive-all-transplant-recovery","Diagnosed with B-ALL at 62, She Returns to Everyday Life After a Stem Cell Transplant","An unexpected health check changed the course of her life, but optimism and perseverance carried her through leukemia treatment and back to everyday living.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002Fce402178ecfac1d3a5ab14560ccc594f.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp"," Hematopoietic Stem Cell Transplantation","2026-04-10","\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">Summary: At 62, Ms. Chen (pseudonym) joined a friend for a hospital visit and decided to have a health check of her own. Unexpectedly, her blood tests were abnormal, and she was later diagnosed with Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia (Ph+ B-ALL). The sudden diagnosis left her and her family frightened and unsure where to turn, but they soon began searching for treatment options. After coming to GoBroad Shanghai Zhaxin Hospital, the medical team developed an individualized treatment plan, and she underwent autologous hematopoietic stem cell transplantation, achieving complete remission. In the years since transplant, Ms. Chen has gradually returned to normal life. She now manages household chores, gets around independently, travels with friends, and once again enjoys ordinary moments with family and loved ones. By sharing her story, she hopes to encourage other patients to hold on to hope, trust their medical team, and stay actively engaged in treatment and recovery.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F5eab334e3ca31f5b3667a6a569e5f267_20260912204744.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"5eab334e3ca31f5b3667a6a569e5f267_20260912204744.png\" alt=\"22cfb1b4-728c-4d3b-9e30-a1ee9172fe44.png\"\u002F> \u003C\u002Fspan>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Ms. Chen (pseudonym), now 62, was accompanying a friend to the hospital in the spring of 2021 when she decided to have a health check herself. That casual decision changed everything. Her blood test results were abnormal, and before she had even completed the rest of the routine checkup, she received an urgent call from the doctor asking her to be admitted to the hospital immediately.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In May 2021, after further testing, Ms. Chen was diagnosed with Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia (Ph+ B-ALL). The news felt devastating, as though life had suddenly been put on a countdown. She and her family were shocked, frightened, and unsure what to do next. Still, they did not give up. They quickly began asking around and looking for treatment options. Their search eventually brought them to GoBroad Shanghai Zhaxin Hospital. After a comprehensive assessment, the medical team developed a treatment plan tailored to her condition. In February 2022, Ms. Chen underwent an autologous hematopoietic stem cell transplant and recovered smoothly through the transplant phase. Her leukemia went into complete remission. More than four years later, she is back to doing household chores, riding her e-bike independently, and going out with friends. Most days, she hardly feels like someone who once had a serious blood cancer. At this follow-up visit, accompanied by her younger sister, Ms. Chen completed all her scheduled tests and shared her treatment experience with other patients. Her message to them is simple: believe in yourself, stay hopeful, and keep moving forward through treatment and recovery.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Ms. Chen's sister also shared advice for families: stay close, offer reassurance, pay attention to the patient's emotional needs, and do what you can to make everyday life more comfortable — including helping with food and meals when appetite is difficult. Small acts of care can help patients feel supported and less alone.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>\u003Cbr\u002F>\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q1: When you think back to the moment Ms. Chen was first diagnosed, what was going through your mind as her sister?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Ms. Chen's sister: I still remember getting a phone call from my niece. She was crying and said, 'Auntie, Mom has leukemia.' Just hearing the word 'leukemia' was terrifying. Before that, it was something I had only heard about on television. I never imagined it could happen to someone in our own family. While my sister was in the local hospital, the doctors gave us devastating news — they said she might have as little as one month to live. We simply could not accept it. She had seemed perfectly well and had only gone for a checkup. How could she suddenly be so seriously ill? When we first heard the diagnosis, it felt as if the sky had fallen in. The whole family was crying, and none of us knew what to do. We kept asking people where we should go and what treatment might help. It was an incredibly frightening and painful time.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong> \u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q2: Ms. Chen, what helped you regain confidence and decide to go ahead with an autologous stem cell transplant? What was the transplant-unit experience like for you, both physically and emotionally?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Ms. Chen: I really feel that coming to GoBroad Shanghai Zhaxin Hospital was meant to be. Before we arrived, my family and I had no sense of direction. We were ordinary people facing something completely unfamiliar, and we were deeply afraid. But after speaking with the medical team here and understanding the treatment plan, we realized that leukemia was not necessarily a hopeless diagnosis. With appropriate treatment, there was a real possibility of recovery and returning to normal life. The doctors and nurses were patient and attentive. My Mandarin is not very good, but they never made me feel rushed. They explained things again and again, and sometimes spoke through my daughter to make sure I understood what was happening at every step. The atmosphere here felt warm and reassuring, and everyone around us was kind. Slowly, our whole family began to relax after the fear and panic we had felt at the beginning. Before I entered the transplant unit, my family was very worried because I was already close to 60. But once I was there, the 20-plus days passed faster than I expected. My two daughters rented a place near the hospital and brought me food every day. Things went smoothly throughout. I was definitely scared before the transplant, but looking back now, it was not nearly as frightening as I had imagined.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After I was discharged, I went home to recover. Whenever I felt unwell or had questions after follow-up tests at my local hospital, I would contact Dr. Chuxian Zhao. She always responded promptly, answered my questions, and reassured me. That helped me feel much more at ease.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q3: More than four years after your transplant, how is life different from before you became ill? How have you recovered, and is there anything you pay particular attention to now?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Ms. Chen: I have never been very good at sitting still, and I tend to worry about everything. But during the first year after transplant, I wanted to focus completely on recovery, so I bought a small place out in the countryside — what I jokingly called the 'middle of nowhere.' The air was fresh, and my daughters would not let me do any housework at all. After about a year, I could feel my strength gradually coming back, and I started taking care of things around the house again, just as I used to. When I first came home after the transplant, I had lost all my hair, and that affected my confidence. Now it has all grown back. Today I can ride my e-bike to buy groceries and go out on my own. If I do not tell people, they would never know I once had leukemia. For me, mindset matters a lot. During treatment, trust your doctors and believe that you can get through the difficult days. During recovery, do not rush — take it one step at a time and listen to your body. Once you are well again, try not to think of yourself only as a patient. Go back to living your life and enjoy it.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002Fad77b51fa307a54d733239c009c04250_20260912204807.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"ad77b51fa307a54d733239c009c04250_20260912204807.png\" alt=\"ac7a9179-3994-4c4e-9680-a56eae0cfbd5.png\"\u002F>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px; text-align: center;\">Photo taken in April 2026 during a self-drive trip with a friend.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Q4: Recovery from a blood disorder often depends on the quiet, day-to-day support of family. From a caregiver’s perspective, what advice would you give families going through a similar experience?\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Ms. Chen's sister: Her two daughters were her main caregivers. To me, they were still 'kids' themselves, but when their mother became seriously ill, they stepped up and carried an enormous responsibility. They gave her strength and confidence, both in practical ways and emotionally. They learned how to care for her and often asked other caregivers on the ward for advice. Their attentive care played an important part in my sister's recovery. For this follow-up, I insisted on coming with her. I wanted to witness this important milestone and hoped that, after passing this latest 'exam,' she might finally be able to 'graduate' from the hospital. When someone in the family becomes seriously ill, caregivers also go through tremendous emotional strain. The most important thing is to look after your own emotional wellbeing so you can keep supporting the patient. If the patient becomes upset or discouraged, try to be patient and understanding. When the whole family pulls together, it becomes much easier to get through the hardest parts of treatment and recovery.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002Fdd998aff1e71c82c49117eb968e7c2f6_20260912204826.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"dd998aff1e71c82c49117eb968e7c2f6_20260912204826.png\" alt=\"07bda77f-3a3f-4410-b347-f7bbceffeee2.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">Photo taken in March 2026 during Ms. Chen’s follow-up visit at GoBroad Shanghai Zhaxin Hospital.\u003C\u002Fspan>\u003C\u002Fp>","Dr. Chuxian ZHAO (Associate Chief Physician, MD; Director, Hematopoietic Stem Cell Transplantation Center, GoBroad Shanghai Zhaxin Hospital):\n\nMs. Chen's bright, infectious laughter has stayed with us. As the gentle spring breeze returns and blossoms appear on the branches, we hope this new season brings her continued health and recovery.\n\nTreatment for Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) has advanced significantly in recent years. As non-transplant approaches have become more effective, the role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) has become more individualized. For some patients who achieve a deep molecular response with a tyrosine kinase inhibitor (TKI) plus immunotherapy, allo-HSCT may not be necessary.\n\nLooking ahead, treatment for Ph+ ALL is moving toward more individualized and less toxic strategies. For selected patients, combinations of immunotherapy and molecularly targeted therapy may even make it possible to avoid both chemotherapy and transplantation, creating more treatment possibilities for patients.",{"slug":294,"title":295,"summary":296,"cover":297,"disease":89,"treatment":181,"patientType":91,"publishedAt":298,"contentHtml":299,"expertView":300,"disclaimer":70,"hasAlternate":71,"updatedAt":126},"b-all-child-car-t-transplant-five-year-remission","A New Start After Leukemia Relapse: CAR-T Followed by Transplant, and Five Years Later, Back to a Bright Teenage Life","Diagnosed with leukemia at age 6, Xixi relapsed and went on to receive CAR-T therapy followed by hematopoietic stem cell transplantation. Now 15, she has reached her five-year post-transplant milestone in sustained remission and is embracing teenage life again.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F27a0589bbcade659e0bd71c7a274d284.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","2026-04-03","\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Article summary: Xixi (pseudonym) was diagnosed with B-cell acute lymphoblastic leukemia at age 6 in 2017 and was able to return to everyday life after treatment. Three years later, however, the leukemia relapsed with central nervous system (CNS) involvement. In 2020, after a recommendation from another patient family, Xixi and her parents traveled to Beijing GoBroad Boren Hospital. Under the close care of the teams led by Dr. Tong WU and Dr. Yanzhi SONG, she achieved remission with CD19 CAR-T cell therapy and then underwent a related-donor haploidentical hematopoietic stem cell transplant. Over the five years that followed, she faced infections, graft-versus-host disease (GVHD), and other challenges, gradually recovering with the support of her medical team and family. Today, at 15, she has successfully completed her five-year post-transplant evaluation. Her bone marrow remains in remission and donor chimerism remains at 100%. The little girl who once battled leukemia has grown into a quiet, confident teenager looking ahead with hope.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In 2017, when Xixi was only 6, she was diagnosed with B-cell acute lymphoblastic leukemia. After treatment at another hospital, she briefly returned to normal life, only for the disease to relapse three years later. In November 2020, on the recommendation of another family from their hometown, Xixi and her parents came to Beijing GoBroad Boren Hospital. With treatment from the teams led by Dr. Tong WU and Dr. Yanzhi SONG, she successfully underwent a related-donor haploidentical hematopoietic stem cell transplant. Now, five years after transplant, her comprehensive follow-up results are reassuring: her bone marrow remains in remission and donor chimerism is still 100%. Over a nine-year leukemia journey, the little girl who once had bleeding spots all over her legs has grown into a calm, cheerful, and hopeful teenager.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F46cd706eeb35368cbedac377d1199a0b_20260912230551.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"46cd706eeb35368cbedac377d1199a0b_20260912230551.png\" alt=\"2bec3ecc-f08f-4ea0-94c4-a205758643a4.png\"\u002F>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px; text-align: center;\">Photo from Xixi's five-year post-transplant follow-up\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>A Few Tiny Red Spots Marked the Start of a Life-Changing Journey\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In 2017, my daughter Xixi was 6 years old and still in kindergarten. One day, I noticed a few small red spots on her legs. They didn't hurt or itch, so I assumed it was a simple skin allergy and took her to a dermatologist for some ointment. The spots faded after a few days, and I felt relieved. I had no idea that this was the beginning of something much more serious.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">That March, a few days after we took her to a hot spring, the red spots appeared again - this time with nosebleeds. My heart sank, and I took her to see a doctor right away. As soon as the blood test results came back, the doctor became very serious and told us to take her to a major hospital as soon as possible.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At a hospital in Kunming, MICM testing soon confirmed that Xixi had B-cell acute lymphoblastic leukemia, classified as intermediate risk. Hearing the diagnosis felt like being struck by lightning. Leukemia was something I had only ever heard about on television. I couldn't understand how it had suddenly happened to my little girl.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Chemotherapy was incredibly hard on her. Xixi had severe nausea and vomiting and could barely eat. But she was far more resilient than I had imagined. She quietly endured each treatment without crying or complaining and cooperated with everything the doctors asked of her. Watching such a young child be so brave broke my heart, but I kept telling myself that the hardest days would eventually pass.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">She made it through 12 courses of chemotherapy, one after another. During the next three years of maintenance therapy, she was eating and sleeping well and remained stable. For a while, I truly believed the storm had passed and our lives were finally getting back on track.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Relapse Changes Everything: Traveling to Beijing for Another Chance\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">But the disease returned. In May 2020, a routine bone marrow examination brought devastating news: MRD was 25.63%. My daughter's leukemia had relapsed.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I didn't want to believe it. We held on until another evaluation that October, but the result was even harder to hear: hematologic relapse. Her treating doctor told us that conventional chemotherapy was unlikely to offer much benefit at that point and recommended CAR-T therapy. But CAR-T was not yet well established at the hospital where she was being treated, and we had no idea what to do next.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">When our family felt completely lost, a phone call from another patient family from our hometown gave us a new direction. Their child also had B-ALL and had successfully undergone transplantation at Beijing GoBroad Boren Hospital. They told us the specialists there had extensive experience and encouraged us to go and seek another opinion.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In November 2020, carrying all of our hope and anxiety with us, we boarded a flight to Beijing to look for another chance for our daughter.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>CAR-T Followed by Transplant: A New Path Forward\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After arriving at Beijing GoBroad Boren Hospital, the immunotherapy team carried out a comprehensive assessment. The results were difficult to take in: Xixi had an overt leukemia relapse, a high disease burden, and CNS involvement. With concurrent leukoencephalopathy, she needed repeated lumbar punctures every other day for a period of time. She gritted her teeth and cooperated each time. Standing beside her, I could only wish I could take some of that pain for her.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">On November 17, 2020, Xixi received an infusion of CD19 CAR-T cells and achieved sustained bone marrow remission. Before we could fully relax, the medical team explained that because her leukemia burden had been so high, proceeding to transplantation promptly would offer the best chance of consolidating the response and reducing the risk of the disease returning.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">We had originally come to Boren for CAR-T and had never expected transplantation to be the next step. But at that point, we didn't hesitate. We had chosen to trust the team. I told the doctor, "We're not going anywhere else. We want to continue her treatment here."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Dr. Tong WU's transplant team soon developed an individualized plan for Xixi, using a TBI-based myeloablative conditioning regimen and selecting her father as the related haploidentical donor. In mid-to-late December 2020, she began pre-transplant conditioning. I still remember watching her small figure enter the transplant unit. She wasn't even 10 years old and had to face so much on her own. In early January 2021, she received her father's hematopoietic stem cells in two infusions. With close care from the transplant team, platelet engraftment was achieved on day +13 and white blood cell engraftment on day +15. She had made it through another major milestone.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After leaving protective isolation, skin GVHD, diarrhea, and a pulmonary infection followed one after another. Dr. WU's team adjusted treatment carefully and managed each complication as it arose. Eventually, Xixi's clinical indicators stabilized and she was discharged, continuing regular medications and scheduled follow-up visits.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">For the most part, Xixi remained stable afterward. The most frightening episode came at the end of 2022, when a viral infection left her with profound weakness in her arms and legs and her condition became critical. Once again, the medical team treated her intensively and helped her through the crisis. Each time she recovered from a setback, our trust in the team grew stronger.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">When we were treated in Yunnan, we rarely had much opportunity to communicate directly with the doctors, let alone stay in touch after leaving the hospital. At Boren, the experience felt very different. Dr. Tong WU was thorough during every ward round and patient whenever we asked questions. Dr. Yanzhi SONG was equally attentive; even after we went home, she would message us to ask how Xixi was doing and remind us about follow-up visits and medications. Once, after returning from a business trip, Dr. Qi Wang brought Xixi a Frozen doll. She was so happy and still treasures it today.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Xixi often says, "Dr. Wu, Dr. Song, and everyone here are so gentle." Whenever she felt frightened during treatment, the doctors and nurses would speak softly to her, encourage her, and tell her what a brave little fighter she was.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Ms. Xinxin, a teacher at the ward school, organized crafts and activities for the children every week. Xixi loved going while she was in the hospital and still remembers those classes fondly.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Treating our daughter had used up nearly all of our family's savings. The hospital proactively helped us apply for financial assistance for major illness, which came at a time when we desperately needed it. Xiaobai Chuntian, a patient-family support charity, also provided practical help and a warm community for families going through treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Those small acts of kindness and steady support meant that our nine-year leukemia journey was not defined only by pain and uncertainty. They also gave us the strength and hope to keep going.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Five Years After Transplant: A Milestone Worth Celebrating\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Xixi is 15 now, almost as tall as I am. The fragile little girl I remember has grown into a calm, bright teenager. She loves quietly working on crafts and sometimes shares small moments from her everyday life on social media, one post at a time. Things that once felt impossibly far away have now become ordinary parts of her life - and that makes them all the more precious.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Her five-year post-transplant evaluation brought the news we had been hoping for: all of her results met the expected targets. She had passed this major five-year milestone. I asked what she wanted to say to her doctors. She didn't use many words. She simply looked at me and said sincerely, "Thank you for taking care of me all these years - and most of all, thank you for giving me a second chance at life."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">From 2017 to 2026, nine full years and more than 3,000 days have passed. Only our family truly knows how much fear, exhaustion, disappointment, and hope were packed into that time. But if I could pass one thing on to families who are still going through leukemia treatment, it would be this: please keep going. The nights that feel endless and the challenges that seem impossible will eventually pass, and there can still be light ahead.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">My greatest wish for the years ahead is that Xixi can finally set aside the identity of a "leukemia fighter" and simply live like other girls her age - return to school, make friends who share her interests, pursue the things she loves, and experience all the ordinary joys of being a teenager. I hope life is gentler with her from here on, and that she can keep growing toward the light.\u003C\u002Fspan>\u003C\u002Fp>","Clinical Commentary (Dr. Qi Wang, from the teams of Dr. Tong WU and Dr. Yanzhi SONG): \n\nThis patient had refractory\u002Frelapsed B-ALL with CNS involvement, for which conventional chemotherapy was unlikely to eradicate the disease. CD19 CAR-T therapy was used as a bridge to transplantation, rapidly achieving a deep bone marrow remission and creating an optimal window for HSCT. Transplantation was initiated approximately 1.5 months after CAR-T, providing close treatment continuity and helping reduce the risk of immune escape and disease rebound. A TBI-based myeloablative conditioning regimen was selected for its tissue penetration and ability to address residual CNS disease, with the aim of reducing post-transplant CNS relapse. After transplantation, the patient developed gastrointestinal, pulmonary, and neurologic GVHD. Neurologic GVHD manifested as severe myasthenia gravis, with an inability to lift her limbs or head - a rare and serious form of GVHD. Her eventual return to normal function reflects precise adjustment of immunosuppressive therapy and effective multidisciplinary care. She also developed a secondary renal tumor after transplant and underwent surgical resection, underscoring the importance of monitoring for second malignancies during long-term follow-up. Structured surveillance enabled early detection and intervention.\n\nFrom a clinical perspective, five years of disease-free survival after transplant is considered a clinical cure. Xixi has reached that milestone. Behind it are her own resilience, her parents' unwavering support, and the trust built between the family and the medical team. Xixi's mother said she hopes her daughter can finally take off the armor of a \"leukemia fighter\" and live like any other girl. That is also what we, as doctors, hope for most. After nine years, this leukemia journey has finally reached its end. We wish Xixi a healthy, peaceful life ahead, always moving toward the light.",{"slug":302,"title":303,"summary":304,"cover":305,"disease":306,"treatment":307,"patientType":91,"publishedAt":308,"contentHtml":309,"expertView":310,"disclaimer":70,"hasAlternate":71,"updatedAt":126},"t-lymphoblastic-lymphoma-teenager-treatment","At 15, He Was Diagnosed with T-Lymphoblastic Lymphoma. His Father Kept Learning, Searching, and Standing Beside Him on the Road to Sustained Deep Remission","After 15-year-old Xiaohao was diagnosed with T-lymphoblastic lymphoma (T-LBL), his family sought care in different cities to find a treatment plan better suited to him. With careful, risk-adapted management by Professor Yonghong Zhang's team, nearly a year of standardized treatment brought Xiaohao into sustained deep remission, and he is now steadily moving toward recovery.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F394543c0abb9753b4ad3da1a7c7b399d.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","T-Lymphoblastic Lymphoma","Chemotherapy‌","2026-03-27","\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Summary: Fifteen-year-old Xiaohao had been enjoying high school life when a lump in his neck led to an unexpected diagnosis of T-lymphoblastic lymphoma. As treatment became more complex, his father began reading extensively, searching for a more standardized approach that could offer his son the best chance of long-term benefit. In 2025, Xiaohao came to the Department of Pediatric Hematology & Oncology at Beijing GoBroad Boren Hospital. Professor Yonghong Zhang's team conducted a comprehensive reassessment and carefully planned his subsequent treatment based on the disease characteristics, treatment response, and risk factors. After nearly a year of guideline-aligned, systematic treatment, Xiaohao achieved sustained deep remission and has now entered maintenance therapy. His father, whom other families came to call a 'research-minded parent,' shares what he learned along the way in the hope that their experience can offer practical reference and encouragement to other families facing adolescent hematologic cancers.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In January 2025, 15-year-old Xiaohao (pseudonym), from Jiangsu, was diagnosed with T-lymphoblastic lymphoma. After completing four initial cycles of chemotherapy at another hospital, his family traveled to Beijing in search of more standardized and precise follow-up treatment that could give him the best chance of long-term disease control. They came to the Department of Pediatric Hematology & Oncology at Beijing GoBroad Boren Hospital. Based on Xiaohao's disease features, Professor Yonghong Zhang's team developed an individualized treatment plan and managed every stage closely. After nearly a year of systematic treatment, Xiaohao achieved sustained deep remission and successfully transitioned to maintenance therapy. He is now moving steadily toward recovery.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F4d0359593b08ebbb943efe66d4f6cafa_20260912230138.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"4d0359593b08ebbb943efe66d4f6cafa_20260912230138.png\" alt=\"39827cec-4ed4-4310-8b80-c04d5e0a8d07.png\"\u002F>\u003C\u002Fspan>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px; text-align: center;\">Photo at Discharge\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>A Lump Appears in a 15-Year-Old's Neck - and Leads to an Unexpected Cancer Diagnosis\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Just after the 2025 New Year holiday, we received a call from our son's high school. His teacher said she had felt a fairly large lump on Xiaohao's neck and suggested that we take him to a hospital as soon as possible. We did not dare delay. We took him to a local hospital immediately, where ultrasound and CT scans showed enlarged lymph nodes in his neck and in several other areas of his body. The doctor advised us to transfer him to a higher-level hospital for further evaluation.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">We took Xiaohao to a provincial hospital right away. The days waiting for the pathology result felt endless; I barely slept, and every minute seemed to drag. Then the pathology report finally came back: T-lymphoblastic lymphoma, Stage II, Group A.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At 15, Xiaohao's life was only just beginning to unfold, yet suddenly he had been handed a challenge none of us had ever imagined. From the moment we received that report, the calm, ordinary life our family had known was completely changed.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Chemotherapy Starts to Work, but the Family Travels to Beijing for More Standardized Care\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At the provincial hospital, Xiaohao quickly started chemotherapy. The first two cycles worked well, shrinking the mediastinal tumor by 65%. But we could not relax. T-LBL is an aggressive disease, long-term outcomes can vary, and relapse is always a concern. What worried us most was that Xiaohao had not been treated with a pediatric protocol; instead, he was receiving a modified adult regimen. That left us uncertain about whether the treatment was truly standardized for someone his age and what it might mean for his long-term outcome.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">During that period, I began reading everything I could find about T-LBL: Chinese medical papers, English-language guidelines, clinical studies, patient forums - anything related to the disease. I went through the information carefully, trying to work out which direction might be most appropriate for my son. That was how I first learned about Professor Yonghong Zhang. She is a leading specialist in pediatric lymphoma in China and founded the China National Childhood Lymphoma Cooperative Group (CNCL). Her team has extensive clinical experience in standardized treatment and the management of difficult pediatric T-LBL cases.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">My wife and I also learned a great deal from other families and from published clinical cases. We kept hearing that for T-LBL, families often sought specialist care in either Shanghai or Beijing. In the end, we decided to go to Beijing to see Professor Zhang's team. We felt that her expertise and clinical experience in T-LBL gave us the greatest confidence and made her team the one we most trusted with our son's care.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In April 2025, as soon as Xiaohao completed his fourth cycle of chemotherapy at the provincial hospital, we took him to Beijing and began the next stage of treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Switching to a Pediatric Protocol: Precision Treatment for a Stronger Path to Long-Term Recovery\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In May 2025, we brought Xiaohao to Beijing GoBroad Boren Hospital. The team promptly completed additional evaluations and invited Professor Chunju Zhou to review his recent outside PET\u002FCT imaging. The review showed residual disease in the mediastinum but no evidence of progression. Because Xiaohao was an adolescent, Professor Zhang's team reassessed his stage using the International Pediatric Non-Hodgkin Lymphoma Staging System (IPNHSS). Given the bulky mediastinal disease, he was reclassified as Stage III, CNS2.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Continuing the modified adult regimen would have meant a lower likelihood of durable remission and a higher risk of relapse. After a comprehensive review, Professor Zhang's team quickly optimized the treatment strategy. They switched Xiaohao from the modified adult regimen to the CNCL-NHL-2017-LBL high-risk protocol, which is better suited to children and adolescents. Treatment restarted from the induction phase with VDLP chemotherapy, with bortezomib added to improve steroid sensitivity and strengthen the foundation for the stages that followed.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">As I stayed beside my son and continued learning, I gradually came to understand how different pediatric lymphoma care can be from adult lymphoma treatment. Accurate staging, a standardized protocol, and a plan that reflects the physiology of children and adolescents can all have a direct impact on long-term outcomes and relapse risk.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Two weeks after starting induction chemotherapy, MRI showed that the residual mediastinal lesion had shrunk further, and there was no progression through discharge. That result made us even more confident that coming to Beijing had been the right decision. Taking into account the initially bulky disease, the possibility that residual tumor was still active when he arrived in Beijing, and several potentially adverse mutations identified on genetic testing, Professor Zhang's team ultimately chose a high-risk treatment protocol to maximize his chance of durable disease control.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Chemotherapy brought one challenge after another: bone marrow suppression, infections and fever, mouth ulcers, drug-induced liver injury, and coagulation abnormalities. Each episode was frightening for us as parents. Fortunately, Professor Zhang's team responded calmly and promptly every time, helping Xiaohao safely through one complication after another.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">By early February 2026, after precise risk stratification and standardized treatment by the specialist team, Xiaohao had achieved sustained deep remission and smoothly entered the maintenance phase. On the day he was discharged, seeing how happy and excited he was made all the travel, worry, and difficult days feel worthwhile. Now, I simply look forward to staying beside him as he takes one steady step after another toward recovery.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F439fe7bd88e368acbf930e1fd645d48e_20260912230212.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"439fe7bd88e368acbf930e1fd645d48e_20260912230212.png\" alt=\"b0df148e-d157-4ac9-ae37-4ea9b7977ff8.png\"\u002F>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Becoming a 'Research-Minded Parent': What One Father Learned Along the Way\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Over the year I spent accompanying Xiaohao through treatment, I gradually changed from an anxious, overwhelmed parent into what other families jokingly called a 'research-minded parent.' That probably has something to do with my own work in data analysis. In my spare time, I also run an online account with more than 50,000 followers where I share analysis and observations. I am used to organizing information in a rational, structured way, so I approached the details of my son's treatment the same way. It helped make this complicated medical journey feel clearer and more manageable. I want to share some of the lessons I learned in the hope that our real experience can help other families facing similar uncertainty.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">1. The Right Specialist Team Can Matter Even More Than the Name of the Hospital\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Xiaohao's initial treatment at the provincial hospital produced a reasonable response, but I still insisted on bringing him to Beijing because I wanted a team with deep expertise in pediatric T-LBL. At Boren, Professor Zhang's team used precise risk stratification, individualized treatment, and tightly coordinated scheduling. Whenever Xiaohao's clinical condition and blood counts allowed, the next stage of treatment moved forward promptly, without unnecessary delay.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Through nationwide patient and parent groups, I met many families and heard about children whose treatment was interrupted or delayed before the disease had been adequately controlled. In some cases, treatment gaps can give tumor cells an opportunity to become resistant, which is heartbreaking. For an aggressive hematologic cancer such as T-LBL, timely and standardized treatment is critically important. An experienced team can make the right judgment at key moments. The team also uses molecular testing to refine disease classification, guide treatment choices, and assess risk, making treatment more evidence-based and more individualized.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">2. Infection Is Never a Small Issue - Prevention Matters More Than Rescue\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Before coming to Beijing, Xiaohao had two significant infections at the provincial hospital: influenza A and influenza B. The crowded ward environment made infection prevention particularly difficult. During chemotherapy-induced bone marrow suppression, a child's immune defenses can be extremely low. A serious infection can interrupt chemotherapy, worsen the overall condition, add financial burden, and in severe cases become life-threatening. From my perspective, reducing the risk of cross-infection is an important part of safely delivering intensive chemotherapy.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">3. Nutrition Is the Foundation: Eating Well Helps the Body Get Through Treatment\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">During chemotherapy, Xiaohao often had poor appetite, nausea, bloating, and periods when he needed a low-fat diet. I spent a lot of time working out foods he might actually want to eat - for example, making braised chicken with minimally processed seasonings or a mild, non-spicy version of dishes he normally liked. I also found that plain sparkling water sometimes helped his bloating after medication. Ultimately, recovery requires adequate nutrition. White blood cell recovery and hematopoietic recovery both depend on sufficient protein and overall nutritional support. With the medical team's approval, and only when it would not interfere with treatment or add unnecessary liver or kidney burden, I also used appropriate nutritional supplements. These cannot replace medical treatment, but they may help address nutritional gaps when dietary intake is limited.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">4. A Positive Mindset Is Not Just a Slogan - It Is Part of Getting Through Treatment\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At the provincial hospital, most of the patients around Xiaohao were middle-aged or older adults, and the ward often felt quiet and heavy. After transferring to Boren, he was surrounded mostly by children and teenagers, and the atmosphere immediately felt more lively. The hospital also regularly organized activities such as birthday celebrations, craft sessions, and charity events. Xiaohao received several small gifts as well. He may no longer think of himself as a little child, but the happiness on his face whenever he received one was impossible to hide. A positive, hopeful state of mind may be invisible, but for us it clearly helped him get through one cycle of treatment after another.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Looking back on this past year, it was undeniably difficult, but it also changed the way our whole family sees life. We adjusted our diet and daily routines alongside Xiaohao, and we learned how to find a sense of certainty even when so much felt uncertain. As I gradually began sharing the things I had learned, I discovered that helping other people can also be a way of healing yourself.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">There is still a long road ahead, but at least for now, sunlight has returned to our lives. Xiaohao is feeling better day by day, and our family is filled with renewed hope. We are deeply grateful to Professor Yonghong Zhang's team for their expertise and attentive care, and to every person who reached out to help us along the way. We also hope that our experience can offer even a small measure of reassurance and confidence to families who are still going through their own difficult season.\u003C\u002Fspan>\u003C\u002Fp>","Clinical Commentary (Dr. Ying Liu, on behalf of Professor Yonghong Zhang's team): \n\nXiaohao initially presented with a bulky mediastinal mass. At a local adult hematology department, he was diagnosed with T-lymphoblastic lymphoma and classified as Stage II, Group A. He received two cycles of an adult regimen consisting of Hyper-CVAD plus pegaspargase. No lumbar puncture with intrathecal therapy was performed at the start of chemotherapy, and only one intrathecal treatment was given later. After the final treatment cycle, therapy was interrupted for 37 days because of a pulmonary infection. Repeat PET\u002FCT continued to show residual disease in the mediastinum.\n\nAfter admission to our hospital, pathology review by Professor Chunju Zhou confirmed T-lymphoblastic lymphoma and excluded an early T-cell precursor immunophenotype. Because the patient was an adolescent, we reassessed him using the International Pediatric Non-Hodgkin Lymphoma Staging System (IPNHSS). Given the bulky mediastinal disease, he was classified as Stage III, CNS2. Outside MRI, CT, and PET\u002FCT images were reviewed together with MRI performed at our hospital. The lesions were continuing to shrink without progression, with only a small amount of low-activity residual disease in the mediastinum. Archived diagnostic tumor tissue from the outside hospital was submitted for RNA sequencing and tumor-related mutation testing to identify adverse prognostic molecular features.\n\nTaken together, Xiaohao had several high-risk features. First, as a child\u002Fadolescent with T-LBL, he should have been treated using a pediatric\u002Fadolescent protocol, but he had initially received an adult regimen. Intrathecal therapy was not given at the start of chemotherapy and was clearly insufficient afterward, increasing the risk of central nervous system relapse. Second, there was a substantial treatment delay after the last chemotherapy cycle, increasing the risk of progression or relapse. Third, the tumor carried adverse genetic alterations, including JAK3 and TP53 variants.\n\nIn view of these adverse prognostic factors, treatment was changed to the BFM-modified CNCL-NHL-2017-LBL high-risk protocol. Bortezomib, a proteasome inhibitor, was added during VDLP induction to reduce the risk of treatment resistance. At interim assessment, the patient achieved complete remission. There was no indication for allogeneic hematopoietic stem cell transplantation in first remission, so sequential chemotherapy was continued. He has now entered maintenance therapy.\n\nPrecise risk stratification based on multidimensional prognostic assessment is critical to improving cure rates in T-LBL and can raise cure rates to above 80%. This approach is appropriate not only for children and adolescents, but also for young adults under 25. Through this case, we hope to remind families that adolescents older than 14 who develop lymphoblastic lymphoma should seek early, standardized care in a pediatric hematology-oncology setting to maximize the chance of cure.",{"slug":312,"title":313,"summary":314,"cover":315,"disease":316,"treatment":99,"patientType":67,"publishedAt":317,"contentHtml":318,"expertView":319,"disclaimer":70,"hasAlternate":71,"updatedAt":320},"myelodysplastic-syndrome-transplant-recovery","Diagnosed with Myelodysplastic Syndrome at Nearly 60, Five Years After Transplant He Celebrates a \"Second Birthday\"","In the five years spanning from his MDS diagnosis to his recovery following the transplant, Uncle Ji has come to regard the day of the procedure as his \"second birthday,\" while also channeling his own experiences into a source of encouragement for fellow patients.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F865b932e95d7fda0d8d11e96982f9ee8.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","Myelodysplastic Syndrome,","2026-03-25","\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Summary: In 2019, Mr. Ji learned he was anemic during a routine workplace health check. As fatigue and a persistent cough worsened, he sought further medical care and was diagnosed with myelodysplastic syndrome (MDS) in April 2020. As his blood counts continued to fall and his condition deteriorated, he underwent a thorough evaluation and, in December of that year, received a related haploidentical allogeneic hematopoietic stem cell transplant from his younger brother. The transplant journey was difficult, with bleeding and painful ulcers in his mouth and esophagus, but he kept eating, stayed engaged in his care, and gradually recovered with the support of his family and medical team. More than five years later, Mr. Ji is back to everyday life and now considers the day of his transplant his "second birthday." His story follows an MDS patient approaching 60 from diagnosis through transplant and long-term stability, and shows how hope, perseverance, and supporting others can become a source of strength.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"letter-spacing: 0px; font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Now 64, Mr. Ji (pseudonym) first learned that he was anemic during a routine workplace health check in November 2019. Because he felt well at the time, he did not think much of it. As his fatigue gradually worsened and a persistent cough failed to improve, he sought further medical care. In April 2020, he was diagnosed with myelodysplastic syndrome (MDS).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">That December, Mr. Ji successfully underwent a related haploidentical allogeneic hematopoietic stem cell transplant at GoBroad Shanghai Zhaxin Hospital. The road was far from easy, but with his own determination, the steady support of his family, and dedicated care from the medical team, he made it through transplantation and began a new chapter of life.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">More than five years later, Mr. Ji remains clinically stable and has returned to his normal routine. He sees transplantation as a new beginning and marks the transplant date as his second birthday. Over time, he has also become more open and at peace. One idea he often shares is that strength comes from looking beyond oneself, treating others with kindness, and thinking of their needs as well. During his recovery, he has repeatedly offered encouragement and practical advice to other patients, hoping his own experience can help them through difficult moments.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">As he reaches the five-year milestone after transplant, Mr. Ji hopes that sharing his experience - especially his decision to undergo transplantation when he was close to 60 - can offer hope and encouragement to others still going through treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q1: When you were first diagnosed with myelodysplastic syndrome (MDS) in April 2020, what symptoms were you experiencing?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: My blood test results had already shown some mild abnormalities during my workplace health check in 2019. But because I did not feel unwell at the time, I did not pay much attention to it.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">During the 2020 Spring Festival period, I spent more than a month helping with community COVID-19 response shifts as a Communist Party member. After that, I began to feel unusually tired and weak, and I had a cough that just would not go away. I went to the hospital, and a complete blood count showed that several of my blood counts had dropped significantly. That was when I realized something was wrong. I was referred to hematology and was eventually diagnosed with MDS.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">When I was first diagnosed, my thinking was actually very simple: if my body was not making enough blood cells, couldn't I just go to the hospital for regular transfusions? I later realized it was nowhere near that simple. A colleague working in Shanghai helped me make connections, and I eventually came to GoBroad Shanghai Zhaxin Hospital to see Professor Chun Wang. Over the next few months, I was losing almost half a kilogram a day. I kept getting thinner and weaker. At one point, my platelet count fell to around 7 or 8, and even a small cut could keep bleeding. The situation became very difficult.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q2: When your doctors recommended an allogeneic hematopoietic stem cell transplant, you were already close to 60. Many people worry that transplantation at an older age carries substantial risk. What helped you decide to move forward?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: At first, I was afraid of transplantation because I did not understand much about it. Professor Chun Wang reviewed my condition and felt that going directly to an allogeneic hematopoietic stem cell transplant would offer me greater potential benefit. Through conversations with other patients and by learning more about my disease, I gradually came to understand that MDS is different from leukemia. In my own way of thinking about it, it was not simply a matter of "bad cells attacking"; the blood-forming stem cells themselves were abnormal and could no longer produce healthy blood cells properly. I also came to understand that prolonged chemotherapy was unlikely to be the best approach for my situation, so transplantation seemed like the better option. To me, a stem cell transplant was like replacing the body's "blood-making factory" with a new, healthy one - one of the best ways to aim for long-term control of MDS and reduce the risk of progression to leukemia.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I had read online that people over 55 were often advised against transplant and treated more conservatively because of the risks. Then I followed the hospital's WeChat account and learned that, in 2017, Professor Chun Wang's team had been the first in China to successfully perform a haploidentical allogeneic stem cell transplant in a 67-year-old patient. While I was receiving treatment, I also heard about a 71-year-old man from Guangdong who had successfully undergone an allogeneic transplant. Those cases showed me how experienced Professor Wang's team was and gave me more confidence in my decision.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">My family fully supported my decision, especially my younger brother. He is an incredibly generous person. Not only did he donate hematopoietic stem cells for me, he had already registered with the China Marrow Donor Program (CMDP). He kept encouraging me to stay confident in the decision to proceed with transplantation.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Looking back, I feel I did not lose time going down the wrong path. For me, choosing transplantation directly was the right decision.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q3: Which part of the treatment journey was the hardest for you?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: For me, the hardest time was actually before I decided to have the transplant. Twice, I had bleeding from both my nose and mouth. Blood was dripping from my nose, and when I pinched it, blood started coming out of my mouth as well. I was terrified because it just would not stop. That was the most frightening part of the whole experience.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Once the transplant actually started, I was not as afraid anymore. I was in Transplant Room 5. The patient in the next room could barely get out of bed, but I kept getting up to use the bathroom on my own and sat up to eat. My mouth and esophagus were covered in painful ulcers, but I still made myself eat. Sometimes it took me two hours to finish one bowl of food. No matter how much it hurt, I swallowed one bite at a time. I even asked the nurses for ice and numbed my mouth before trying to eat again. At my weakest, I could barely get up from bed, but I still pushed myself to sit up and eat because I knew my body needed calories and nutrition to keep going.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I believe that once you have a goal and something to hope for, you have a reason to keep going. When the fear and uncertainty about what lies ahead begin to fade, what remains is the determination to hold on and get through it.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q4: After going through such a serious illness, has the experience changed the way you see life?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: Even now, when I think back on that period, I still feel a little tense. Some things are impossible to fully understand unless you have lived through them yourself.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After transplant, many of us felt the same way: it was like being given another life, like coming back from the edge. When I talked with other patients, some said they had changed their birthday to the day of their transplant; one person even renamed his company because he wanted to mark the start of a new life. Back then, when we talked, we did not ask, "How old are you?" We asked, "How many days or months has it been since your transplant?" - almost like asking the age of a newborn. I will never forget that time.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I am a Communist Party member, and in Party lectures and in my own regular study I often came across the idea of "selflessness" - not thinking only about yourself, but considering others as well. I believe that if you treat people with kindness, even when life is difficult, you can still find something good and a way forward.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q5: What would you like to say to other patients who are still in treatment and fighting their illness?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: I remember a woman in her 50s who could not decide whether to go ahead with a transplant. Patients in the hospital often talk with one another and ask who is recovering well or responding well to treatment. She heard that I was doing well and came to ask about my experience, so I shared what I had been through and tried to encourage her.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I told her three things. First, trust the clinical expertise of the team at GoBroad Shanghai Zhaxin Hospital. Second, trust that the team genuinely cares about its patients. Third, trust in how far medicine has come - conditions that once felt untreatable now have more treatment options. Most importantly, have confidence in yourself.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">If fear or indecision takes over and keeps you from moving forward, you may end up missing an important window for treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">That is what I most want to say to others still going through treatment: stay confident and keep believing.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260910\u002F619832dbd36660aa547ba9a61bd1161c_20260910155032.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"619832dbd36660aa547ba9a61bd1161c_20260910155032.png\" alt=\"045de88a-609c-4769-8c01-9b5010f574a0.png\"\u002F>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">Mr. Ji during a spring outing in a park, March 2026\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>A Message of Thanks from Mr. Ji\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I am deeply grateful to the medical team led by Professor Chun Wang. Their expertise, dedication, and compassion gave me a second chance at life. I am especially grateful to Dr. Chuxian Zhao for the thoughtful care and support she has provided throughout my long-term follow-up after transplant. At GoBroad Shanghai Zhaxin Hospital, everyone - from doctors and nurses to patient services and support staff - made me feel genuinely cared for. You are all people with great compassion. For the rest of my life, I will always speak warmly of Zhaxin Hospital. Words can hardly express how thankful I am.\u003C\u002Fspan>\u003C\u002Fp>","Dr. Chuxian Zhao (Associate Chief Physician, MD; Director, Hematopoietic Stem Cell Transplantation Center, GoBroad Shanghai Zhaxin Hospital):\n\nMr. Ji is optimistic, determined, and always willing to help others. By sharing his recovery journey and what he has learned along the way, I hope he can give encouragement, confidence, and strength to many patients who are still in treatment.\n\nAs transplantation medicine continues to advance, age alone is no longer an absolute barrier to hematopoietic stem cell transplantation, giving more patients with blood disorders the opportunity to pursue long-term remission and, in selected cases, cure.\n\nEven in the darkest moments, there can be a way forward. We hope our team's work can help patients facing difficult treatment decisions find a breakthrough and move toward brighter days ahead.","2026-09-10",{"slug":322,"title":323,"summary":324,"cover":325,"disease":190,"treatment":99,"patientType":67,"publishedAt":326,"contentHtml":327,"expertView":328,"disclaimer":70,"hasAlternate":71,"updatedAt":329},"acute-myeloid-leukemia-haploidentical-transplant-recovery","Diagnosed with Acute Myeloid Leukemia at 60, She Found a Second Chance at Life with Stem Cells Donated by Her Son","After her diagnosis, she underwent a hematopoietic stem cell transplant with her son as the donor. Today, she is back to enjoying life with her family.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F1b7cd578491ad72461e7370fe2fde5f6.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","2026-03-11","\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">Summary: At 60, Ms. Chao sought medical care for persistent fatigue and pain in both legs. She was ultimately diagnosed with acute myeloid leukemia (AML) that had transformed from myelofibrosis. Her disease was high-risk and difficult to treat, and multiple rounds of chemotherapy failed to bring it into remission. Worried about the risks of treatment - and about asking her son to become her stem cell donor - she once considered giving up on transplant. With encouragement from her family, however, she came to GoBroad Shanghai Zhaxin Hospital, where she underwent a haploidentical allogeneic hematopoietic stem cell transplant using stem cells donated by her son. Her leukemia went into complete remission after transplant, and her health gradually returned. Today, she is once again enjoying everyday family life. Her story follows a 60-year-old patient from a difficult diagnosis to renewed hope, and reflects the strength that can come from family support, compassionate medical care, and the determination to keep going.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260911\u002Fd52d4e7722edcab31ed396c6fef5c172_20260911221420.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"d52d4e7722edcab31ed396c6fef5c172_20260911221420.png\" alt=\"677d9d0b-1939-4494-9123-71962843bbea.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At 60, Ms. Chao (a pseudonym) had a happy family and was looking forward to a peaceful retirement. Instead, persistent fatigue and pain in her legs led her to seek medical care, where she was diagnosed with acute myeloid leukemia. Further testing showed a markedly enlarged spleen, and a bone marrow biopsy revealed myelofibrosis, suggesting transformation from a myeloproliferative neoplasm and an overall poor prognosis.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Ms. Chao has always been cheerful and optimistic. But when she first learned that her disease was difficult to treat and that therapy could carry significant risks - and then learned that her son might need to donate stem cells - she considered giving up. Her family, however, never gave up on her. They kept searching for another path forward.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">With her family beside her, Ms. Chao came to GoBroad Shanghai Zhaxin Hospital. The medical team’s careful assessment and extensive experience in hematopoietic stem cell transplantation gave her renewed confidence. In January 2024, she successfully underwent an allogeneic hematopoietic stem cell transplant with her son as the donor. The new stem cells successfully engrafted and began to grow.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After transplant, her leukemia achieved complete remission and her recovery went well. Recently, she returned to GoBroad Shanghai Zhaxin Hospital for her two-year post-transplant follow-up. She hopes that sharing both the setbacks she encountered and the practical lessons she learned during recovery can encourage other patients on the same journey.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260911\u002F1f7f101883a107fe0c6d677c63980a0c_20260911221455.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"1f7f101883a107fe0c6d677c63980a0c_20260911221455.png\" alt=\"ccf09208-18cd-4f55-843d-d83f30f6fd26.png\"\u002F>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">January 2026: Ms. Chao with Nurse Manager Bo Wang\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>- Patient Q&A -\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q1: Looking back, what were the first warning signs that something was wrong?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: At the end of 2022, I had a viral cold. The cold itself cleared up within a few days, but from then until February 2023 I constantly felt weak and exhausted. Even walking felt difficult. At first I assumed I was just taking a long time to recover from the cold, so I rested at home and did not think too much of it. Then the pain in both legs became so severe that I could not sleep at night, and that was when I finally went to the hematology department at a local hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">My blood test came back abnormal. The doctor told me to be admitted right away because my blood cell counts were very low. After I was hospitalized, I had a bone marrow aspiration and a series of further tests. The final diagnosis was acute myeloid leukemia transformed from myelofibrosis.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">That was the beginning of a long and difficult course of treatment. I went through several rounds of chemotherapy, but the disease never went into remission. The doctors told me that mine was a high-risk, refractory case and that an allogeneic hematopoietic stem cell transplant was the only treatment that could potentially offer long-term survival.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Looking back now, my body had actually been sending warning signs about six months earlier. I had developed many small bleeding spots on both legs, but I did not pay much attention. I thought they were like ordinary bruises from bumps and would disappear after a few days, but they never did. It was only when the weakness and leg pain became obvious that I realized something more serious was going on.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q2: What led you to choose GoBroad Shanghai Zhaxin Hospital for your transplant?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: The doctors had recommended an allogeneic hematopoietic stem cell transplant. We could not find a fully matched donor in the registry, so both my son and my younger brother were tested. My brother was 57 and was a half match, and my son was also a half match. After an overall assessment, my son was considered the better stem cell donor for me.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I asked the doctor what my chances would be if I had the transplant at the local hospital. Based on my age and condition, I was told it was around 30%. Hearing that number, my heart sank and I immediately thought about giving up. I was already 60, and I did not feel that a 30% chance was worth such a gamble. As a mother, I also could not bear the thought of my son donating stem cells for me. I did not understand the donation process at the time and assumed it would harm his health. So I thought I should just continue with conservative treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The doctor told me that giving up on transplant would essentially mean giving up on treatment, but I still chose to go home. I had several more rounds of chemotherapy, yet the disease still did not respond. My platelet count fell into the single digits. Every week I had to go to the hospital for a transfusion. It might rise into the teens or twenties afterward, only to fall back into the single digits a few days later. It was no longer helping.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I may have been ready to give up, but my family never stopped looking for hope. They asked around to find out which hospitals had the most experience treating a disease like mine. After speaking with many people, we learned about Professor Chun Wang and his team at GoBroad Shanghai Zhaxin Hospital. With nothing to lose, we made an appointment with him.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Professor Wang was impressive. He reviewed my previous medical records and described my condition very precisely. The question that mattered most to me was still the chance of success, so I gathered my courage and asked again. Professor Wang answered calmly, “Based on your condition, there is a good chance that transplant could lead to a cure.” His confidence made me feel that he truly knew what he was doing.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">During the consultation, we also raised our biggest concern: would donating stem cells harm my son? Professor Wang patiently explained that the current approach uses medication to mobilize stem cells from the bone marrow into the peripheral blood. The cells can then be collected in a process similar to giving blood; a machine separates out the stem cells and returns the remaining blood components to the donor. His explanation put our whole family at ease.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Professor Wang also used a simple analogy. He said my disease was like a field overgrown with weeds: first you clear away the weeds, then plant healthy seeds from my son so that good crops can grow. That made everything much easier to understand, and much of our fear about transplant disappeared. I remember taking his hand and saying again and again, “That’s wonderful.”\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After the appointment, my son and I sat in the hospital lobby and talked it over. He said, “Mom, let’s do the transplant here. Other people have made it through, and so can we. If there’s a chance for a cure, we should go for it.” I said, “All right. We’ll do it here.”\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In December 2023, I was admitted to GoBroad Shanghai Zhaxin Hospital and began the pre-transplant preparations. In January 2024, I entered the transplant unit.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260911\u002F8e56e75844acb35dcfb851dbcf254110_20260911221622.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"8e56e75844acb35dcfb851dbcf254110_20260911221622.png\" alt=\"68c61719-38e9-4125-ae26-90e694d50676.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q3: What was it like in the transplant unit? Were you nervous or afraid?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: Before I went in, I was definitely worried and scared. I had read stories online saying that some transplant units felt cold, clinical, and depressing.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">But on the day I entered the unit, the nurse manager, my husband, and my son walked me in together. The moment I got there, I realized it was nothing like I had imagined. The room had soft, warm off-white tones, and even the flooring and blinds made the space feel comfortable. It was not a large room, but I actually slept very well that first day. Most of my worries disappeared almost immediately.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Things also moved quickly. Before long, the doctors and nurses were starting my high-dose conditioning chemotherapy. Everyone was very kind. They checked on me often and would stop to chat, which helped me gradually relax.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">What touched me most was that Dr. Huixia Liu came to see me early every morning. I was in Room 1, and every time she came in she would greet me warmly and ask how I was doing. I could not make sense of my blood test results, so she would point to the numbers on her phone and say, “Your blood counts have started to come up today!” The numbers were still only just beginning to rise, but she was so happy and told me it meant “the seeds have started to sprout.” She encouraged me every single day, and that gave me something to look forward to.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">During my time in the transplant unit, I did not have many major problems apart from a fever, and I did not have diarrhea. Near the time I was ready to leave the unit, however, I developed some mouth ulcers. I have to admit I was partly to blame. The unit provided a medicated mouth rinse, and the nurses had explained exactly how to use it, including holding it in the mouth long enough for it to reach the back of the throat. I disliked the taste and did not follow the instructions as carefully as I should have, and then the ulcers appeared.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The mouth ulcers had already started a little while I was still in the unit, but the week after I came out was the hardest. I could barely drink or eat because it hurt so much. Fortunately, Dr. Chuxian Zhao’s team responded quickly and provided daily oral care. After about a week, as my blood counts continued to recover, the inflammation settled and the ulcers healed.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I left the transplant unit in the second half of January. I then stayed in the hospital for nearly two more months for recovery and observation, and finally went home in mid-March. Overall, the process went quite smoothly.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q4: You once thought about giving up. What changed your mind and helped you keep going?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: At the local hospital, I had three rounds of chemotherapy without achieving remission, and my condition had become very serious. I remember lying in bed drenched in sweat, staring out the window and thinking, “It’s all right. If this is what fate has decided, then I’ll accept it.”\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Before I got sick, my son and I would occasionally argue. I have a quick temper, and so does he, so sometimes we would talk back to each other. But after I became ill, he changed completely. When I wanted to give up on transplant, he would not allow it. He held my hand and said, “Mom, I’ll donate my stem cells. I’ll find a way to handle the money - even if I have to sell the house.” He simply refused to give up on me.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">My family was the biggest reason I kept going. My husband and son were incredibly attentive. If I showed even a little anxiety or started saying, “How did I end up with such a serious illness?”, they would stop me from dwelling on it. When I felt physically miserable, my son would send me videos of my little grandson. Seeing his sweet face always cheered me up. I told myself I had to stay alive and fight for more time with my family.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Thank you to my son for giving me a second chance at life. Thank you to my family for never giving up on me. And thank you to the doctors and nurses at the hospital for caring for me so attentively. I would not be where I am today without all of you.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q5: Are there any lessons from your post-transplant recovery that you would like to share with other patients?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: One experience really stayed with me. It was May 2024, about half a year after my transplant, and I had been eating a very light diet. I am from Changzhou, and one day I casually mentioned that I was craving the local pickled radish. My daughter-in-law kindly went out and bought some for me. It was homemade-style pickled radish from a market stall. I ate just one piece, and by that evening I had diarrhea.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I immediately messaged Dr. Chuxian Zhao, and she told me to come to the hospital right away. Fortunately, we treated it promptly and the diarrhea was quickly brought under control. Since then, I have stayed away from pickled foods.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">We also paid a lot of attention to hygiene at home. My son bought an air purifier specifically for my bedroom. Whenever I was resting in bed, he would turn it on to keep the air fresh. I wore a mask whenever I went out, and if anyone in the family had a cold or cough, I took extra precautions.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">There was also one small care tip I learned in the transplant unit: using a cotton swab to apply a small amount of chlortetracycline eye ointment just inside the nostrils to help prevent bleeding from fragile nasal capillaries. I sometimes did this in dry weather to reduce nosebleeds. (*Please note: This is based on one patient’s personal care experience and may not be appropriate for everyone. Always follow the treatment and medication guidance of your own medical team.)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q6: After everything you have been through, what are you hoping for in the years ahead?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: It has been two years since my transplant, and I feel that I have recovered very well. At home, I like trying out recipes, and when I have time I knit little sweaters for my grandson. Sometimes my husband and I take a walk together in the evening as the sun sets. Life is quiet and peaceful now, and that is enough for me.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I do not have any grand plans for the future. My biggest wish is simply to watch my grandson grow up healthy and happy. Being at home, safe and well, with my family close by - that is the kind of happiness that means the most to me.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260911\u002F61c31b0bd8fb7e6f29d1a396f0009605_20260911221915.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"61c31b0bd8fb7e6f29d1a396f0009605_20260911221915.png\" alt=\"d973ad1b-9637-4250-b6b5-988b1bfa5a5c.png\"\u002F>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">Everyday moments from Ms. Chao’s life after recovery\u003C\u002Fspan>\u003C\u002Fp>","Dr. Chuxian ZHAO (Associate Chief Physician, MD; Director, Hematopoietic Stem Cell Transplantation Center, GoBroad Shanghai Zhaxin Hospital):\n\nFor patients with acute myeloid leukemia (AML) transformed from myelofibrosis (MF), allogeneic hematopoietic stem cell transplantation is currently the only treatment with the potential to achieve long-term survival and, in some cases, cure.\n\nMs. Chao underwent a related haploidentical transplant. Her underlying disease is now in complete remission, and both her blood counts and physical condition have recovered well.\n\nIt has been deeply moving to see Ms. Chao’s optimism and the love and support shared within her family. We hope these peaceful, happy days continue for many years to come.","2026-09-11",{"slug":331,"title":332,"summary":333,"cover":334,"disease":335,"treatment":336,"patientType":91,"publishedAt":337,"contentHtml":338,"expertView":339,"disclaimer":70,"hasAlternate":71,"updatedAt":126},"t-lymphoblastic-lymphoma-targeted-therapy","At 9, She Faced High-Risk T-Lymphoblastic Lymphoma\u002FLeukemia. Precision Care in Beijing Brought Complete Remission - and a New Beginning","From traveling to Beijing just days after diagnosis to completing high-risk chemotherapy and moving into maintenance treatment, this resilient young girl is gradually getting back to the childhood she loves.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F95f8d7d641055105d3e97975d434ae29.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp"," T-Lymphoblastic Lymphoma\u002FLeukemia","Chemotherapy, Targeted Therapy, Pediatric","2026-03-06","\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Summary: Nine-year-old Mango developed a lump below her collarbone and was diagnosed with T-lymphoblastic lymphoma\u002Fleukemia (T-LBL\u002FT-ALL). Five days after the diagnosis, her parents brought her to the Department of Pediatric Hematology & Oncology at Beijing GoBroad Boren Hospital for further care. Taking into account high-risk features including a bulky mediastinal mass, central nervous system involvement, and an NUP214-ABL1 fusion, Professor Yonghong Zhang's team carried out a comprehensive assessment and developed an individualized plan combining a pediatric high-risk chemotherapy protocol with targeted therapy. Treatment was adjusted dynamically according to her response, with close management throughout. After intensive therapy, her tumor achieved complete remission and bone marrow measurable residual disease (MRD) became negative. She remains in deep remission and has now entered maintenance treatment. Her family's journey reflects the importance of timely diagnosis, risk-adapted treatment, and careful long-term management for children with high-risk T-lymphoblastic lymphoma\u002Fleukemia, as well as the strength that family support and a positive outlook can bring during a long course of treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">During the Lunar New Year of the Year of the Horse, while families across China were heading home to reunite, Mango (pseudonym) and her family from Henan spent this meaningful holiday in Beijing. In April 2025, 9-year-old Mango was diagnosed with T-lymphoblastic lymphoma\u002Fleukemia at another hospital. After careful consideration, her family decided to travel to Beijing GoBroad Boren Hospital to seek care from Professor Yonghong Zhang's team. After admission, the team completed a comprehensive assessment based on Mango's disease characteristics and developed a personalized treatment plan combining a pediatric high-risk chemotherapy protocol with targeted therapy. Her treatment was adjusted throughout according to her condition and response. Following systematic treatment, Mango achieved sustained deep remission and has now entered the maintenance phase. Recovering at home after discharge, she is gradually regaining her strength and rediscovering the colorful childhood that belongs to her.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F40ede07260ff1a1fcb6183ab565f7112_20260912213228.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"40ede07260ff1a1fcb6183ab565f7112_20260912213228.png\" alt=\"e52eefa7-ad06-4d86-bcb9-efdcc4e70ec9.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px; text-align: center;\">A Photo at Discharge\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>A Happy Family Suddenly Faced the Unexpected: Their 9-Year-Old Daughter Was Diagnosed with Lymphoma\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Like any parent, I never imagined the word "lymphoma" would have anything to do with my daughter, Mango. She had always been healthy and was tall for her age, and we had rarely had to worry about her health while she was growing up. Then, in early April 2025, a small lump suddenly appeared below her left collarbone. It improved slightly after she took anti-inflammatory medication, but something still did not feel right, so we took her to a local hospital for a thorough evaluation. That visit changed everything. Her blood test showed an abnormally high white blood cell count, and the doctor recommended immediate admission for further tests. Bone marrow aspiration, lumbar puncture, pathology - one test followed another, and it all felt overwhelming.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">When the diagnosis of "T-lymphoblastic lymphoma\u002Fleukemia" was finally confirmed, it felt as if my whole world stopped. The shock was almost impossible to process, and fear, denial, and helplessness came all at once. Mango was in third grade at the time. When she saw the sign for the hematology-oncology department, she quietly asked me, "Mom, do I have a tumor?" I fought back tears and tried to reassure her while hiding my own fear. We were also afraid to tell the elderly grandparents at home because we worried the news would be too much for them, so we only said Mango needed to stay in the hospital for a few days of observation. Her father and I carried all the fear, anxiety, and pressure between us.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Heading to Beijing Without Delay: Making the Most of a Critical Treatment Window\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Because there was no time to lose, Mango began chemotherapy at the local hospital. At the same time, we faced one of the hardest decisions we had ever made as parents: where should we take our daughter for the best possible care?\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Just when we felt completely lost, a phone call from a friend gave us hope. Her child had been diagnosed with lymphoma back in 2017 and had been treated successfully at Beijing GoBroad Boren Hospital. She strongly recommended Professor Yonghong Zhang, telling us that Professor Zhang was a leading expert in pediatric lymphoma with extensive clinical experience. We later learned that our local hospital was also a member of the China Net Childhood Lymphoma (CNCL), a national collaborative network led by Professor Zhang. While we were still hesitating, our friend said something that finally made the decision clear: "Your child is different from everything else in life. She has her whole future ahead of her. Put everything else aside - saving her life comes first."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">On April 16, 2025, just five days after Mango's diagnosis, we completed her discharge from the local hospital that morning and traveled to Beijing GoBroad Boren Hospital that afternoon. With no other choice, we left our younger child - barely one year old and only just learning to say "Mom" and "Dad" - in the care of the grandparents. We felt terribly guilty as parents, but there was no alternative. For Mango, we had to do everything we could.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Looking back, it was without question one of the most decisive and important choices we made for our daughter. Mango was newly diagnosed, received a timely diagnosis, and was able to reach an experienced specialist team quickly, without losing valuable time along the way. For lymphoma, timely and standardized treatment can be critical to outcomes. Mango was unlucky to become ill, but we also feel fortunate that, when we were most uncertain, we found clear guidance.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>An Individualized Treatment Plan - and a Brave Girl Facing Every Challenge with Optimism\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Once we arrived at Beijing GoBroad Boren Hospital, the medical team moved quickly and methodically. Professor Yonghong Zhang's team completed a comprehensive reassessment and disease evaluation, and genetic testing results soon became available. Mango was found to have several adverse molecular features, including an NUP214-ABL1 fusion, as well as a NOTCH1-related mutation, which has been associated with more favorable outcomes in some studies. Taking into account her disease subtype, bulky tumor, and central nervous system involvement, the team promptly developed a personalized treatment plan combining chemotherapy with targeted therapy.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The treatment that followed felt like a series of difficult hurdles, each bringing a new challenge. Chemotherapy-related bone marrow suppression, recurrent infections, persistent high fevers, and oral and perianal ulcers all took a toll on Mango and weighed heavily on our entire family. As her mother, I went from being a parent who only had a vague fear of the disease to someone trying to learn everything I could about daily care - how to look after her mouth, recognize signs of infection, and prepare nutritious meals. I kept telling myself that I had to be the person she could rely on most, her safest and warmest source of support.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Fortunately, the hard work began to bring good news. After the first intensive chemotherapy course using the VDLP regimen, follow-up showed that Mango's mediastinal tumor had shrunk by 75%, while abnormal cells in the bone marrow had also decreased substantially. At the interim assessment, imaging showed complete remission, and bone marrow measurable residual disease (MRD) had become negative. It was an important milestone - a sign that Mango had won a meaningful early victory in her treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Even now, when I think back on everything she endured - especially the way she tried to hold back her tears during bone marrow aspirations and lumbar punctures - my heart still aches. As her mother, I do not want her memories of this period to be only white hospital rooms and painful procedures. I tell her that illness is one unusual chapter in life. It can teach us how precious health is and how much it matters to have family beside us. I also hope she will understand that life brings both easy and difficult seasons; what matters is how we choose to face them.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">What comforts me most is that Mango turned out to be even stronger than I imagined. She quickly created her own little world in the hospital - playing games, editing short videos, folding paper stars, drawing, and finding ways to make each day interesting. She especially loved taking part in activities at the hospital's "Ward School." Even Professor Yonghong Zhang praised the remarkable sense of ease and composure Mango had for a child her age. That optimism and calm helped carry her through the hardest part of the journey.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Expert Care for the Disease, Compassionate Support for the Child\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">During our time at Beijing GoBroad Boren Hospital, what we experienced was not only highly professional medical care, but also warmth and compassion woven into the everyday details of treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">No matter how busy she was, Professor Yonghong Zhang never missed her weekly rounds. She carefully reviewed Mango's records, followed every detail of her condition, and patiently answered every question we had. Her expertise and calm confidence gave us enormous reassurance when things felt difficult. Dr. Ying Liu made rounds almost twice a day, and we often saw her working on the ward even on weekends. Dr. Yang Liu, Dr. Yali Peng, and other members of the team were always willing to answer questions. They closely followed Mango's treatment while also paying attention to how she was feeling emotionally. Nurse Manager Rong Zhang and her nursing team were skilled and gentle, doing everything they could to minimize discomfort during procedures while offering encouragement and companionship. That human warmth, alongside professional care, became a steady source of strength that helped us keep moving forward.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Remission Continues: Grateful for Every Step, Hopeful for What Comes Next\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Today, Mango has completed all intensive chemotherapy and remains in sustained remission. She has now entered an 18-month maintenance phase. On the day she was discharged, we took a group photo with the medical team and wrote a thank-you letter. The words were simple, but every line came from the heart. To express our gratitude to Professor Yonghong Zhang and the entire team, we also had a small trophy made to thank them for giving Mango renewed hope through both expertise and compassion. Mango herself made Lunar New Year gifts by hand for the doctors and nurses who had cared for and stayed beside her over the past year.\u003C\u002Fspan>\u003Cspan style=\"font-size: 15px; text-align: center;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F737d3c98c5ed0632f9246352f5e1095f_20260912213302.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"737d3c98c5ed0632f9246352f5e1095f_20260912213302.png\" alt=\"1918fd0c-f387-4ef2-8dcd-a246fd78a86d.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Looking back on nearly a year of cancer treatment brings so many emotions. Like many parents, I used to worry about my child's school performance. Now, our one wish is simply that she stays safe and healthy. This experience has stayed with me deeply, and I would like to share a few thoughts with other parents going through something similar:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">1. Trust expertise and seek the right team early. When a child faces a serious illness, finding an experienced, specialized medical team is an important first step toward effective treatment. When we first learned that Beijing GoBroad Boren Hospital is a privately run hospital, we had some reservations - a bias that many families may share. Our experience changed that view. The hospital brings together nationally recognized pediatric lymphoma specialists, including Professor Yonghong Zhang and her team, with internationally aligned treatment approaches, standardized clinical processes, efficient care, and a strong emphasis on the patient and family experience.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">2. Take care of your own emotions. A parent's emotional state can affect a child directly. No matter how frightened or overwhelmed you may feel, try to offer your child steadiness, encouragement, and a calm presence as you face treatment together.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">3. Be attentive to daily care and work closely with the medical team. Treatment is not only the responsibility of doctors. Family caregiving matters too. Nutrition, hygiene, infection prevention, and many other small details can all play a role in a child's recovery.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">4. Face practical challenges realistically and ask for support. The financial pressure of a serious illness is real. Families can proactively learn about national medical insurance policies for major illnesses and available charitable assistance programs, and apply for any support for which they are eligible. Family members also need to support one another through difficult times. While we were in Beijing, Mango's father registered as a food-delivery rider and took on deliveries when he could to help ease some of the financial burden.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Today, Mango is gradually regaining her strength, and the lively, energetic girl we remember is coming back. This journey through cancer has been extraordinarily difficult, but it has also taught our family more deeply what life means and made us more grateful for every act of kindness and every person who has helped protect her along the way. We believe that, after everything she has weathered, Mango will keep moving forward into a bright future of her own.\u003C\u002Fspan>\u003C\u002Fp>","Clinical Commentary (Dr. Ying Liu, on behalf of Professor Yonghong Zhang's team): \n\nAmong pediatric non-Hodgkin lymphomas, lymphoblastic lymphoma is the second most common subtype, and approximately 70%-80% of cases are T-lymphoblastic lymphoma (T-LBL). Children with T-LBL commonly present with a bulky mediastinal mass, sometimes with airway compression, and many also have bone marrow involvement. At present, international collaborative groups report 5-year disease-free survival rates above 80% for pediatric T-LBL. The average long-term disease-free survival rate in China is approximately 60%-70%, while the 5-year disease-free survival rate for newly diagnosed pediatric T-LBL at the Department of Pediatric Hematology & Oncology at Beijing GoBroad Boren Hospital is 83%.\n\nA key reason for this improvement is the use of precise risk-stratified treatment based on adverse prognostic factors. Assessing these factors in T-LBL requires dynamic and comprehensive evaluation across multiple dimensions, including immunophenotype, high-risk genetic features, clinical stage and risk group, and early treatment response. Specific factors include the presence of a bulky mediastinal mass; myeloid antigen expression or an early T-cell precursor phenotype on immunophenotyping; high-risk molecular abnormalities such as MLL rearrangement, C-MYC rearrangement, SIL\u002FTAL1 fusion, PTEN mutation, loss of heterozygosity on the long arm of chromosome 6, and NOTCH fusion; delayed remission at interim assessment; substantially prolonged chemotherapy courses; and inadequate dosing of key chemotherapy agents.\n\nLooking back at children with relapsed or refractory T-LBL treated at our center, some had previously received incomplete assessment of adverse prognostic factors. In some cases, immunophenotyping had not identified an early T-cell precursor phenotype in time; in others, limitations in genetic testing meant high-risk alterations such as PTEN mutations were missed. In still others, interim assessments relied only on bone marrow testing while overlooking tumor evaluation, or focused only on imaging while omitting bone marrow MRD testing, leading to an inaccurate assessment of remission status. These gaps may prevent some patients from being escalated to a high-risk treatment protocol when needed, or even cause them to miss the optimal window for transplant when transplantation is indicated. Complications such as infection can also delay chemotherapy, while pancreatitis and other adverse events may affect the use of key drugs such as asparaginase. For newly diagnosed T-LBL, systematic, standardized management throughout the entire treatment course is therefore essential.\n\nIn Mango's case, she was diagnosed at our hospital with stage IV T-lymphoblastic lymphoma, CNS3, with a bulky mediastinal mass at presentation and an NUP214-ABL1 fusion detected in the tumor cells. These features placed her in the high-risk group, and she received a high-risk treatment protocol. Interim assessment showed complete remission. At key points during consolidation and delayed intensification, both imaging and bone marrow MRD monitoring confirmed ongoing remission. She has now successfully entered maintenance therapy combined with a tyrosine kinase inhibitor. We wish Mango a smooth treatment journey and a happy, healthy childhood.\n\nThis case highlights how risk-stratified treatment based on multidimensional prognostic assessment, together with careful management at every stage of therapy, can be critical to improving cure rates in children with T-LBL. We hope this story helps more families understand the disease, seek timely diagnosis and treatment, and follow standardized care so that more children can have the opportunity for cure.",{"slug":341,"title":342,"summary":343,"cover":344,"disease":173,"treatment":273,"patientType":67,"publishedAt":345,"contentHtml":346,"expertView":347,"disclaimer":70,"hasAlternate":71,"updatedAt":320},"primary-mediastinal-b-cell-lymphoma-transplant-recovery","Diagnosed with Primary Mediastinal Large B-Cell Lymphoma, She Studied for Graduate School from Her Hospital Bed — Today, She Has Graduated and Started Her Career","After being diagnosed with primary mediastinal large B-cell lymphoma during her senior year of college, Xiao Min underwent an autologous hematopoietic stem cell transplant; she was admitted to graduate school while recovering and has since returned to a normal work and personal life.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F69c6aa4201de62945fb981e916797358.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","2026-02-28","\u003Cp style=\"margin: 7px 0;\">\u003Cspan style=\"font-size: 15px;\">Summary: Shortly after starting her senior year of college, Xiaomin sought medical care for a persistent cough, chest pressure, and fever. She was diagnosed with primary mediastinal large B-cell lymphoma. After coming to GoBroad Shanghai Zhaxin Hospital, she received chemotherapy and underwent an autologous hematopoietic stem cell transplant in March 2020. Treatment brought loss of appetite and other physical challenges, but Xiaomin did not let life stop at the hospital bed. Whenever she felt well enough, she began preparing for graduate school entrance exams. After discharge, she continued studying while recovering at home and was admitted to graduate school the following year. She has since completed her master’s degree and started her career. Today, Xiaomin is back to a stable work and daily routine and has completed her long-term follow-up. Her story follows a young patient from diagnosis and treatment back to campus and into the workplace — a reminder that life can keep moving forward beyond illness.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260910\u002F5191b52818fc8231cf00c659c2f8af15_20260910153138.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"5191b52818fc8231cf00c659c2f8af15_20260910153138.png\" alt=\"b6039c99-4338-4a22-8d8e-3df8feb2563c.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In September 2019, shortly after the start of her senior year of college, Xiaomin (a pseudonym) had been coughing on and off for more than a month. She thought it was just a common cold and did not pay much attention to it. A hospital visit, however, brought an unexpected diagnosis: primary mediastinal large B-cell lymphoma. Suddenly, the future she had carefully planned seemed to come to a halt.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">With her family by her side, Xiaomin came to GoBroad Shanghai Zhaxin Hospital for treatment. Her medical team developed a treatment plan tailored to her condition. In March 2020, she successfully underwent an autologous hematopoietic stem cell transplant.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Days in the hospital could feel long and difficult, and Xiaomin did not want to spend them focused only on the pain of treatment. During the periods when she felt a little better, she gave herself a new goal: preparing for graduate school. From then on, it became common to see her quietly reading and working through practice questions in her hospital room. After she was discharged home, she kept going — recovering physically while continuing to study. The following year, she was admitted to graduate school.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Today, Xiaomin has completed her master’s degree and has been working for more than two years. Like many other young adults, she keeps a regular nine-to-six schedule, works hard, and enjoys everyday life. She carries an upbeat energy with her, and when she smiles, her eyes still have the same bright spark.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Not long ago, Xiaomin took time out from work to return to the hospital for follow-up. After successfully completing this important long-term checkup, she smiled and said, “I’ve graduated from the hospital too!”\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Looking back, Xiaomin hopes her experience can encourage other young patients facing a similar journey: “No matter what happens, don’t give up. There is still so much life ahead of us. Hold on to hope, and keep moving forward one step at a time.”\u003C\u002Fspan>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260910\u002F2f11b31465caf8b4428212e9bfcdafea_20260910153158.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"2f11b31465caf8b4428212e9bfcdafea_20260910153158.png\" alt=\"2f994a65-572f-4c55-8bc0-ad6d2ea91ce2.png\"\u002F>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">January 2026: Xiaomin with Dr. Chuxian Zhao and Nurse Manager Bo Wang\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q1: Looking back to 2019, what symptoms did you first notice, and how were you eventually diagnosed with lymphoma?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: My lymphoma was in the mediastinum. At first, I only had a cough. When I lay down, it felt as though something was pressing on my chest, which was very uncomfortable. Since coughing was my only symptom at the beginning, I did not think much of it. I assumed it was a cold and tried cough and cold medicines, but nothing really helped.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Later, I went to a hospital near my university. The doctor suspected pneumonia, so I was admitted right away. I continued to have a fever that would not come down. After two or three days of tests, I was diagnosed with lymphoma. As soon as we received the diagnosis, my family and I transferred to Shanghai that same day. My family had heard that Professor Wang Chun was highly experienced in treating blood disorders, so the next day we went directly to GoBroad Shanghai Zhaxin Hospital for consultation.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q2: Do you remember the moment the doctors told you that you had primary mediastinal diffuse large B-cell lymphoma?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: I actually did not have much of an emotional reaction that day. Maybe the shock was so great that my mind could not process it right away. Looking back now, it does scare me a little, but I am also glad I went to the hospital as soon as I felt something was wrong and did not delay getting checked.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I later searched online for information about the disease, and of course I was frightened. But I was fortunate to have come to GoBroad Shanghai Zhaxin Hospital right from the start of treatment, and the medical team stepped in quickly. Knowing I was surrounded by experienced doctors gradually helped me feel more settled.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The doctors explained the plan to me: four to five cycles of chemotherapy, followed by an autologous hematopoietic stem cell transplant. I had already read a little about transplantation, and the doctors also discussed the possible risks in detail with my family. I agreed almost immediately. Partly, it was because I was young and the doctors felt the risks were relatively manageable. More importantly, the team had given me confidence from the very first cycle of chemotherapy, and I had responded very well to the initial treatment. I trusted them.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The transplant went smoothly, and I was able to leave the transplant unit after about 20 days. I am very grateful that I found the right hospital from the beginning. Treatment was not easy, but I felt reassured at every step.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q3: Is there a moment from your treatment that still stands out vividly in your memory?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: There were definitely periods that were very difficult. The chemotherapy used for an autologous transplant is high-dose, and it made me feel extremely unwell. I had almost no appetite during that time, and every day felt hard to get through.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">There are so many moments I still remember. During an earlier round of chemotherapy, my veins were difficult to access and an IV could not be placed in the usual way, so one of the nurses had to place the line in my thigh. I had never experienced anything like that before and was quite scared. But she was incredibly gentle and paid close attention to how I was feeling throughout the procedure. The doctors also came to see me every day, explained how treatment was going, and reassured me not to be afraid. From the very beginning, the whole team helped me build confidence in facing the illness.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I was also deeply touched by the caregiver who looked after me in the transplant unit. During the first few days, I felt so unwell that I barely wanted to speak. She would help me wash every day and quietly tell me, “You’ll feel better soon.” Those simple words meant a lot. At this hospital, I felt that everyone — doctors, nurses, and other staff — cared about how patients were feeling emotionally, not just physically. They kept giving us encouragement when we needed it most.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I was never afraid of injections. What I dreaded most was taking medicine, especially steroids, because they tasted so bitter. Every dose required a lot of mental preparation. The doctors and nurses would gently coax me along, saying, “It’s okay, take it — you’ll be through this soon.” They comforted me almost like they were reassuring a child. Even now, remembering those moments still feels very warm.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q4: You were preparing for graduate school while going through treatment. Was that difficult, and what helped you keep going?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: I had my transplant in March 2020, when I was still in my senior year of college. By the time treatment ended and I returned home, graduation was coming up. I knew that after a serious illness, I probably would not be ready to jump straight into a job. I thought this might be a good opportunity to continue my education and give myself a clearer direction for the future. That was when I decided to apply to graduate school.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">While I was in treatment, I only studied now and then. Chemotherapy made me feel awful, and I needed something to take my mind off it. At first I watched videos or played games, but after a while I felt I was simply passing time. So I started studying for ten or fifteen minutes a day whenever I could. It was not intense studying — it was more a way to give my days some structure and shift my focus. I only began studying seriously after I returned home.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I graduated from college in 2020. While recovering at home, I studied for the entrance exam, and in 2021 I was admitted to the Japanese Translation program at my own university.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Looking back, my mindset definitely changed depending on how I felt physically. On good days, I could focus and study. On difficult days, all I could do was lie down and get through them. But I kept doing a little whenever I could, and slowly I made my way forward.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I went on to complete three years of graduate school and found a job I really wanted after graduation. I have now been working for more than two years, usually nine to six, and my daily life is really no different from anyone else’s.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q5: Did your experience with illness change how you think about your education, your goals, or life in general?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: It changed me in many ways. The biggest change is that I learned to take better care of myself. Before, I barely paid attention to minor illnesses. Now, whenever I feel even slightly unwell, I take it seriously. Getting enough rest and protecting my health have become some of my highest priorities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">It also changed my relationship with my parents. I think a lot of people become less expressive with their parents as they grow up. This illness made me truly understand how important they are to me, and it taught me to be more open about how I feel. In the end, I learned both to care for myself more and to show more love to the people around me.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">If a young patient asked me today whether treatment will derail their life or future plans, I would say: you do not have to feel lost, and you do not have to be afraid. This may be one difficult — even painful — chapter in your life, but it does not have to define everything that comes after. Trust your doctors, trust medical science, and work closely with your care team. After recovery, keep looking after your health. You can still return to everyday life and keep pursuing the future you want.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q6: What does reaching this five-year “graduation” milestone mean to you, and what do you hope for the future?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: I graduated from college, then graduate school — and now I’ve graduated from the hospital too!\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Actually, I have been doing well for almost six years. I was so busy with work that I did not have time to come back for my five-year follow-up earlier. For me, this visit feels more like a chance to close one chapter. I have finally passed an important “exam” and handed in an answer I can be proud of. I can tell myself: I finished this chapter. I did it.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">As for the future, there will always be unknowns. I do not have any grand plan. I just want to stay grounded and take care of the life in front of me. The future can unfold in its own time.\u003C\u002Fspan>\u003C\u002Fp>","Dr. Chuxian ZHAO (Associate Chief Physician, MD; Director, Hematopoietic Stem Cell Transplantation Center, GoBroad Shanghai Zhaxin Hospital):\n\nPrimary mediastinal large B-cell lymphoma is an aggressive B-cell lymphoma that most commonly affects young women. A typical presentation is a rapidly enlarging mass in the anterior mediastinum. For patients who respond well to first-line high-dose chemotherapy, consolidation with autologous hematopoietic stem cell transplantation may offer the possibility of cure.\n\nI remember Xiaomin as the quiet, hardworking student everyone has known in a classroom — the kind of person you suddenly think of years after graduation. She kept a notebook with a cute cartoon cover beside her, filled her textbooks with color-coded highlights, and would sometimes quietly watch anime at the little bedside table while enjoying one of her favorite snacks.\n\nSeeing Xiaomin again, she is still every bit as gentle and warm, but now with an added sense of calm. She is more talkative than before, too. To me, she is a quietly strong young woman, carrying warmth within her and a bright road ahead.",{"slug":349,"title":350,"summary":351,"cover":352,"disease":65,"treatment":99,"patientType":67,"publishedAt":353,"contentHtml":354,"expertView":355,"disclaimer":70,"hasAlternate":71,"updatedAt":126},"aplastic-anemia-transplant-recovery","After 16 Years with Aplastic Anemia, a Sudden Deterioration: At 62, He Found a New Beginning Through Transplant","After living with aplastic anemia and PNH for 16 years, Mr. Zhang faced a sudden deterioration and a serious infection. At 62, he underwent hematopoietic stem cell transplantation and successfully left protective isolation, beginning a new stage of recovery.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F52d2c4b47874e92012183a3b5c1f830f.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","2026-02-13","\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Summary: Mr. Zhang (pseudonym) was diagnosed with aplastic anemia accompanied by paroxysmal nocturnal hemoglobinuria (PNH) in 2009. For more than a decade, regular treatment and follow-up kept his condition stable. In 2025, however, his disease suddenly worsened and could no longer be controlled with conventional treatment, making hematopoietic stem cell transplantation an important option for long-term remission. After arriving at Beijing GoBroad Boren Hospital at age 62, he was evaluated by Dr. Tong WU's team. Given his age, underlying health conditions, and severe pulmonary infection, the team developed an individualized plan and first focused on controlling the infection to make transplantation possible. In December 2025, he underwent a related-donor haploidentical hematopoietic stem cell transplant and successfully left protective isolation in January 2026. He is now recovering well, with gradual hematopoietic recovery and improvement in PNH-related findings. His 16-year journey reflects both the progress of medicine and the perseverance that can carry patients through difficult turning points.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In 2009, Beijing resident Mr. Zhang (pseudonym) was unexpectedly diagnosed with aplastic anemia accompanied by PNH (paroxysmal nocturnal hemoglobinuria). For years afterward, he attended regular follow-up visits at a hospital in Beijing, took his medications as prescribed, and remained relatively stable. Then, in August 2025, his condition deteriorated rapidly. His doctors told him that hematopoietic stem cell transplantation had become his only potentially curative option. At 62, Mr. Zhang came to Beijing GoBroad Boren Hospital in search of that possibility. After overcoming several major challenges around transplantation, he successfully left protective isolation in early January 2026 - closing one chapter of a 16-year illness journey and beginning another.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F97c1c7e8cece4b7baafbf7598591b083_20260912225624.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"97c1c7e8cece4b7baafbf7598591b083_20260912225624.png\" alt=\"13ba5670-41ad-4e09-8d04-a05de9ce38cf.png\"\u002F>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px; text-align: center;\">Successfully Leaving Protective Isolation After Transplant\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Sixteen Stable Years, Then a Sudden Turn for the Worse\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In 2009, Mr. Zhang began experiencing intermittent fatigue, poor appetite, and weight loss. After strenuous activity, his urine would sometimes turn a dark tea color. A bone marrow examination at a major tertiary hospital in Beijing led to the diagnosis of aplastic anemia with PNH, bringing sudden uncertainty into what had been an otherwise ordinary family life. Fortunately, with appropriate treatment and oral medications, his condition was brought under stable control.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">"For more than ten years, we followed the doctor's advice, took the medications, and went back for regular checkups. He couldn't do heavy physical work like other people, but overall life was stable. We thought we could keep going like that," recalled his wife, Ms. Zhu (pseudonym).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">But in August 2025, things changed without warning. Mr. Zhang became increasingly fatigued and dizzy, and his usual medications were no longer able to keep the disease under control. "They tried all the medications available at the hospital, but his numbers just kept falling. Our whole family panicked," Ms. Zhu recalled, still remembering how anxious that period felt.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">As the family struggled to see a way forward, Mr. Zhang's treating physician offered a crucial recommendation: "At this point, hematopoietic stem cell transplantation is the only potentially curative option. Dr. Tong WU at Beijing GoBroad Boren Hospital has extensive experience in this field. You could go and speak with her." For the family, that recommendation offered a clear direction at a time when they desperately needed one.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>At 62, a Serious Infection Becomes the First Hurdle Before Transplant\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In November 2025, Mr. Zhang and his family arrived at Beijing GoBroad Boren Hospital and met Dr. Tong WU. What they had not expected was that the first major challenge would not be the transplant itself, but a difficult pulmonary infection. "When he was first admitted, he was coughing badly, with chest tightness and shortness of breath. The lung infection just wasn't coming under control, and we were very worried he might miss the right window for transplant," Ms. Zhu said. Watching him struggle during those days was extremely difficult for the family.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The medical team responded quickly. Taking into account Mr. Zhang's age, overall condition, and the severity of his pulmonary infection, Dr. WU and her team developed an individualized plan with one immediate priority: bring the infection under control and create a safer foundation for transplantation. His vital signs were closely monitored around the clock, the lung infection was assessed every day, anti-infective therapy was adjusted as his condition changed, and the nursing team provided careful supportive care throughout. After more than 20 days of intensive treatment, the infection was effectively controlled and his clinical indicators gradually stabilized, allowing him to proceed to transplantation. "Once the infection was under control, we finally felt we could breathe again. It also made us even more confident that coming to Boren was the right decision," Ms. Zhu said.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Through Transplant: Care, Determination, and a New Beginning\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In mid-December 2025, Mr. Zhang entered the transplant unit and began hematopoietic stem cell transplantation. To stay close and support him, Ms. Zhu rented a room near the hospital and settled into a daily routine of traveling between the apartment and the hospital, preparing all three meals herself. "The doctors specifically reminded us that infection can sometimes be linked to unsafe food during this period. We didn't want to take any chances. I bought fresh ingredients every morning, paid close attention to hygiene when cooking, and disinfected the tableware after every use." Preparing and delivering meals every day was exhausting, but for Ms. Zhu, knowing that he could eat safely made it worthwhile.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The nearly month-long stay in the transplant unit tested both Mr. Zhang's body and his resolve. Side effects from the conditioning regimen were difficult to endure. Whenever he felt discouraged, however, the medical team was there. The doctors checked on how he was feeling each day and adjusted treatment as his condition changed. The nurses not only managed infusions and daily care, but also talked with him, reassured him, and kept encouraging him. That combination of clinical expertise and compassionate support helped him find the strength to keep going.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Leaving Protective Isolation and Starting a New Chapter\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">On January 12, 2026, after nearly a month of waiting and treatment, Mr. Zhang successfully left protective isolation. He had lost about 10 kilograms since admission, but he was in good spirits and smiling again. "The moment he came out, we saw how relieved the doctors and nurses looked. Our whole family was overwhelmed with emotion. It felt as though a huge weight had finally been lifted," Ms. Zhu said.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Mr. Zhang continued to recover well after leaving the transplant unit. His blood cell counts steadily increased, his appetite improved, and he felt stronger day by day. Looking back on their experience at Beijing GoBroad Boren Hospital, Mr. Zhang and Ms. Zhu said they were especially grateful for both the medical care and the way the team communicated with them. "From the admission assessment and infection treatment to the transplant and post-transplant care, we felt supported at every step. Whenever we had questions, the doctors and nurses took the time to explain things carefully and patiently."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">During the hospital stay, the family also met patients who had traveled from many parts of China - Shanxi, Gansu, Guangzhou, Hainan - as well as patients from overseas. Many told them they had come after recommendations from other patients or physicians. For Ms. Zhu, meeting so many families on similar journeys was reassuring. "We also want to share our experience with other people living with aplastic anemia, so that those going through a difficult time can see that there may still be options. Even for an older patient, transplant can sometimes offer a new chance at life."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Today, Mr. Zhang continues to regain his strength and is moving closer to returning to everyday life. Looking back over 16 years, the journey has included the challenge of living with a chronic illness, the fear of a sudden deterioration, and the relief of reaching a new beginning after transplant. His experience is a story shaped by both medical care and the resilience to keep moving forward.\u003C\u002Fspan>\u003C\u002Fp>","Clinical Commentary (Dr. Fang Fang, from the teams of Dr. Tong WU and Dr. Yongqiang ZHAO): \n\nThe patient is a 62-year-old man with a 16-year history of aplastic anemia accompanied by PNH. He had moderate anemia and thrombocytopenia and had been treated with androgen therapy, including stanozolol, as well as prednisolone. His transfusion requirements were relatively low and his condition remained generally stable. In October 2025, he developed fever, cough with sputum, and blood-streaked sputum, together with a severe pulmonary infection, severe anemia, and profound thrombocytopenia. Pathogen screening after admission, including targeted testing of respiratory specimens, identified Aspergillus fumigatus, Ralstonia mannitolilytica, and human herpesvirus 7 (HHV-7). The pulmonary infection improved after active anti-infective treatment. A suitable related donor was available and passed the donor evaluation, and the patient proceeded to a related-donor haploidentical hematopoietic stem cell transplant. Given his age, impaired cardiac and renal function, and limited treatment tolerance, a reduced-intensity conditioning regimen was selected. Conditioning and stem cell infusion were completed without major difficulty. Leukocyte engraftment and platelet engraftment were both achieved on day +11. At the one-month post-transplant assessment, PNH-FLAER testing showed normal CD55 and CD59 expression on red blood cells and normal CD55, CD59, and FLAER findings in granulocytes. Bone marrow morphology, cytogenetics, and chimerism studies showed no abnormalities. The patient was in generally stable condition and was expected to be discharged soon.",{"slug":357,"title":358,"summary":359,"cover":360,"disease":89,"treatment":273,"patientType":67,"publishedAt":353,"contentHtml":361,"expertView":362,"disclaimer":70,"hasAlternate":71,"updatedAt":320},"ph-positive-all-transplant-recover","Five Years After Leukemia Relapse and Stem Cell Transplant, He Gives Flowers to the Wife Who Cared for Him for Seven Years","After being diagnosed with Ph-positive acute lymphoblastic leukemia, Mr. Xu endured a relapse and underwent an allogeneic hematopoietic stem cell transplant; supported by his wife throughout the past seven years, he has now reached the five-year mark of recovery—a moment of \"graduation.\"","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F24e646c1b05ae3f3f2f6689c6f580978.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">Summary: In 2019, Mr. Xu was diagnosed with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-positive ALL) after persistent headaches and a low-grade fever. His treatment journey included a severe fungal lung infection, relapse, and several difficult treatment decisions. In February 2021, he ultimately underwent an allogeneic hematopoietic stem cell transplant from an unrelated donor. After transplant, he faced severe oral mucositis, diarrhea, infections, and ischemic strokes. With treatment from his medical team and seven years of steadfast care from his wife, Mrs. Dai, he made it through one challenge after another and, five years after transplant, reached his recovery "graduation" milestone. Their story follows not only one leukemia patient's path from relapse and transplant to long-term stability, but also the devotion, responsibility, and love of a partner who never left his side.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cbr\u002F>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260910\u002Fe36eccf37659b66c8a818a9b46684920_20260910151833.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"e36eccf37659b66c8a818a9b46684920_20260910151833.png\" alt=\"f770fb68-ae69-47ec-af5f-6869ec1ea5f6.png\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Blood disorders can involve long and intensive treatment journeys, and patients often need tremendous support from their families. In countless homes, the person who takes on much of that responsibility is the patient's spouse.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At GoBroad Shanghai Zhaxin Hospital \u002F Shanghai Liquan Hospital, there are many couples like this. Some are newly married, while others have shared decades together. When serious illness enters their lives, they become each other's strongest source of support.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Love is not always spoken aloud. More often, it is seen in the day-to-day care, the sleepless nights, and simply being there. Mr. Xu and Mrs. Dai are one such couple.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Recently, 63-year-old Mr. Xu marked five years of recovery with a special "graduation" ceremony at GoBroad Shanghai Zhaxin Hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At this meaningful moment, he turned and handed the flowers he was holding to Mrs. Dai, who had cared for him for seven years. The bouquet said what words could not: thank you for never leaving my side.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Mr. Xu and Mrs. Dai also sat down with us to look back on the difficult road they had traveled together.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260910\u002Fd9dabea1b4a6523cac7da0e451e6bfa9_20260910151848.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"d9dabea1b4a6523cac7da0e451e6bfa9_20260910151848.png\" alt=\"f7ae437e-bf57-4d7a-a394-27bf15f8b350.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px; text-align: center;\">February 2026: Mr. Xu with members of his care team\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>- Patient Q&A -\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q1: From an unexpected diagnosis to the first turning point, can you take us back to how the illness was discovered, how the diagnosis was confirmed, and how treatment began?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Mr. Xu: In mid-to-late March 2019, I went to the hospital after several days of headaches and an unexplained low-grade fever. In early April, the results came back: Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia (Ph-positive B-ALL). A hard fight had begun without warning.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After my third round of chemotherapy, I developed a severe fungal infection in my lungs with a large pleural effusion. The doctors performed a drainage procedure and removed more than 2 liters of fluid, so chemotherapy had to be paused. By late September, after going from hospital to hospital, I arrived at the Department of Hematology at Shanghai General Hospital. Professor Chun Wang carefully reviewed my case. Because a repeat genetic test was negative, he recommended moving quickly to an autologous hematopoietic stem cell transplant, which generally allows faster immune recovery, but only if three consecutive fusion-gene tests were negative.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In early 2020, I followed Professor Wang to the newly opened GoBroad Shanghai Zhaxin Hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">As soon as I was admitted, we repeated the genetic test for the third time. Unfortunately, because pneumonia had delayed my chemotherapy earlier, the leukemia cells had started to return. At that point, if we wanted to clear the disease and still aim for a cure, we needed a more intensive approach. Allogeneic hematopoietic stem cell transplantation became the only option.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The thought of an allogeneic transplant was frightening. We knew there could be severe infections and unpredictable graft-versus-host complications, so the whole family hesitated. Just when we felt we were running out of options, a new treatment plan gave us a way forward. We first got the fusion-gene test back to negative, then went through six alternating cycles of chemotherapy at different intensities, followed by a third-generation targeted therapy to keep the disease under control. By June of the following year, I had finished all the chemotherapy and went home to recover, full of hope.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q2: When the disease came back and you were facing another major decision, what ultimately made you choose allogeneic hematopoietic stem cell transplantation?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Mrs. Dai: One day in August 2020, he suddenly felt a pain near his right cheek and ear, almost like an insect bite. Dermatology treatment did not help, and soon the entire right side of his face was swollen and he had a fever. At one point, we even wondered if it was mumps. Dr. Jun Zhu treated him and the symptoms improved with medication, but they came back quickly after the medication was stopped. We told Dr. Zhu what had happened, and he immediately became concerned and told us to come into the hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The leukemia had fully relapsed, and this time the symptoms were more aggressive than ever. The doctors were preparing him for cell therapy, which meant his regular medication had to be stopped beforehand. As soon as the medication was discontinued, an ulcerated lesion appeared in the middle of his chin and became so deep that the bone could be seen. Overnight, his scalp was covered in tiny raised spots, almost like heat rash. On top of that, he had severe bone pain all over his body, especially around the joints. It hurt so much that he could not even step over the small threshold into our bathroom at home.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At that point, we had nowhere else to turn. An allogeneic stem cell transplant was our only hope.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">It was during the COVID-19 pandemic, and our daughter was away at school and could not come home. We therefore started a donor search through the China Marrow Donor Program while he received a new bispecific antibody therapy. Before long, we received good news: a matched donor had been found, and the volunteer was willing to donate. Our whole family is still deeply grateful to this stranger we have never met.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In February 2021, he underwent an allogeneic hematopoietic stem cell transplant and successfully left the transplant unit. But we soon realized that getting through the transplant itself was only the first step.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">For the first three years, one problem seemed to follow another. It felt like fighting monsters: as soon as we beat one, another appeared. So we faced them one at a time, and got through them one at a time.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q3: Looking back on the entire treatment journey, what was the hardest period for you?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Mrs. Dai: The most difficult time was right after the transplant. His mouth was covered in severe ulcers, so painful that he could not eat anything. The diarrhea was just as bad - five or six times a day, sometimes six or seven. He was so weak that he could barely make the few steps from the bed to the bathroom, and often did not get there in time. I would finish cleaning up, turn around, and it would happen again. It went on all day, and the room could become chaotic.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I especially want to thank Dr. Chuxian Zhao. She was incredibly responsible and attentive. She asked me to let her know every time he had a bowel movement so she could assess it herself. At first I called her each time, but there were so many that I felt bad asking her to come over again and again. So I started taking photos and sending them to her instead - six or seven times a day. I felt embarrassed, but Dr. Zhao never showed any impatience. She carefully reviewed every single photo.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The doctors explained that his gut function was essentially having to rebuild and readapt. At that stage, almost everything he ate passed straight through, so food had to be added back slowly and carefully.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">We started with the clearest rice porridge water, one spoonful at a time, almost like feeding a newborn. When he improved a little, I minced Chinese yam very finely and added tiny amounts to the porridge. Every meal felt like an experiment, and every day felt like walking a tightrope.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q4: Mrs. Dai, you have been the person standing behind Mr. Xu throughout this journey. What have you learned from caring for him over the years that you would like to share with other families?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Mrs. Dai: Leaving the transplant unit was really only the first step in a very long recovery.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">By then, his body had been through so much that he seemed even more fragile than a newborn, and his risk of infection was far higher than that of a healthy person. From that day on, I did not dare let my guard down. I handled everything myself. We had a medical-grade sterilizing device at home, and every day I cleaned the floors and tables with Dettol disinfectant. I removed as much clutter as I could so there were fewer places for germs to collect. Even with all that, he still developed pneumonia repeatedly. Sometimes all it took was one cough or a slightly different sound in his breathing for my heart to drop. We would go to the hospital, and sure enough, it would be pneumonia. Over the years, I developed my own internal "alarm" - just hearing his cough was enough to tell me something was wrong.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">For a patient recovering from a stem cell transplant, food safety became one of the biggest things I watched. From the day he left the transplant unit, every meal mattered. I cooked food fresh for every meal, never served leftovers, and avoided raw, cold, or externally prepared foods. One thing a doctor told me stayed with me: "If hygiene is done properly, the patient has a better chance of going the distance. Once an infection happens, no one can predict the consequences." I was not willing to take that risk.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I was also extremely careful with fruit. For apples and pears, I washed them under running water first, then wiped the outside with a disinfecting wipe or rinsed them with boiling water. The knife was disinfected, my hands were washed, and once I started peeling, I peeled straight through without touching the flesh with my fingers. The fruit went directly into a disinfected bowl, and he picked it up himself with chopsticks. Bananas and oranges were easier because they could be peeled. Blueberries and strawberries were hard to clean thoroughly, so I simply did not buy them. Over the past two years, his blood counts have stabilized and his immunity has improved, so I no longer disinfect the outer skin, but I still keep the rule of not touching the peeled fruit with my hands.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">What scared me was the thought that one unsafe bite could undo years of hard work. I cannot speak for everything, but when it came to what he ate, I watched it as carefully as I could, and thankfully we never had a major problem from food.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">It was not until last year that I finally felt comfortable taking him on a trip. We drove to a hotel with friends. Before we left, I packed a disinfection lamp, along with our own sheets, duvet cover, and pillowcases. When we reached the hotel, I went straight to our room, made the bed with everything we had brought, set up the disinfection lamp, and only let him come in after the room had been disinfected. Our friends said I was too nervous. But after everything we had been through, taking a chance was one thing I just could not bring myself to do.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q5: Mr. Xu, it has now been five years since your transplant, and today you received a commemorative pin marking this milestone. How are you feeling?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Mr. Xu: Before I got sick, I was constantly busy with work and traveled often, so I did not spend much time with my family. Around the time I was diagnosed, I once thought about taking a trip to the grasslands and seeing China's vast landscapes one more time, then coming home and simply letting nature take its course, even if that meant stopping treatment. But then I thought about my daughter and my wife. How could I bear to leave them? No matter how hard things became, I kept going. I did not ask for much - I just wanted one more day with them, then another. As long as I am still here, there is hope. As long as I can keep going, our family is still whole.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">So to have reached today, the people I most want to thank are the medical team at GoBroad Shanghai Zhaxin Hospital for being with me every step of the way.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Your expertise pulled me back from the edge and carried me through one stage after another. After all these years together, the doctors and nurses here feel like family.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Today, I am "graduating" here. This pin is not only a reminder of my recovery. It belongs to everyone at Zhaxin and to our family - a medal for the battle we fought and won together.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260910\u002Fe0c0cebb5109388fa312f7284d13e7a6_20260910152045.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"e0c0cebb5109388fa312f7284d13e7a6_20260910152045.png\" alt=\"1131c9b2-a962-41a9-a238-07fed560872c.png\"\u002F>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q6: With Valentine's Day just around the corner, is there anything the two of you would like to say to each other?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Mrs. Dai: I was busy with work before I retired too, leaving early and coming home late every day. I had imagined that after retirement I would finally have time to slow down, travel, and enjoy life. Instead, he fell ill in April, one month before I retired in May. From then on, the two of us became inseparable - and that has lasted for more than seven years.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">From the day he became ill, I never really relaxed. My whole life revolved around taking care of him. Only in the past two years, once his condition became stable, did I start occasionally meeting up with old friends again.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After 30 years of marriage, romantic love grows into something deeper - family, responsibility, and commitment. And after living that responsibility day after day, it simply becomes instinct.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">If he coughs once, my heart skips. If he walks across the room, my eyes follow him. After seven years, caring for him has become part of everyday life. As long as he is here, our family is still here. And my responsibility is still right here too.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Mr. Xu: My wife and I have really made it through one difficult hurdle after another. The transplant brought my blood disease under control, but then life gave us another challenge. In 2023, I had three ischemic strokes. Every time, she noticed the warning signs quickly and got me to the hospital right away. Again and again, her decisiveness helped pull me through a dangerous moment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I am incredibly lucky to have her in my life. She jokes that she must have owed me something in a past life, which is why she has had to work so hard for me in this one. But what I have never said out loud is this: I must have saved the world in a past life to be lucky enough to marry you in this one.\u003C\u002Fspan>\u003C\u002Fp>","Dr. Chuxian Zhao (Associate Chief Physician, MD; Director, Hematopoietic Stem Cell Transplantation Center, GoBroad Shanghai Zhaxin Hospital):\n\nOn a February afternoon, news of Mr. Xu's five-year \"graduation\" quickly spread through every floor of the inpatient wards. Everyone who had cared for him was delighted.\n\nMrs. Dai has been an exemplary family caregiver. Her attentive care helped Mr. Xu through one challenge after another, and the home-care experience she has built over the years can also offer useful perspective to other families.\n\nTime and experience have given this commemorative pin its special weight. It carries the love and devotion that Mr. Xu and Mrs. Dai have shared throughout the years.\n\nAs the New Year begins, I wish Mr. Xu and Mrs. Dai continued health, many smiles, lasting happiness, and peaceful days ahead.",{"slug":364,"title":365,"summary":366,"cover":367,"disease":65,"treatment":99,"patientType":91,"publishedAt":368,"contentHtml":369,"expertView":370,"disclaimer":70,"hasAlternate":71,"updatedAt":320},"severe-aplastic-anemia-transplant-recovery","Five Years After Transplant for Severe Aplastic Anemia: Back to School and Now at University","Diagnosed with severe aplastic anemia at the age of 16, the individual returned to school after undergoing allogeneic hematopoietic stem cell transplantation and has now embarked on university life.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F660a00304a3aca46213fdef11fe951bf.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","2026-02-06","\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">Summary: At 16, Xiaojie was diagnosed with severe aplastic anemia (SAA) after developing bleeding gums and severe abdominal pain. With his condition critical, he underwent an allogeneic hematopoietic stem cell transplant from his father in February 2021. During treatment, he faced persistent pain and skin graft-versus-host disease (GVHD), but gradually recovered with the support of his medical team and family. Two years later, he returned to school, completed high school, and earned a place at his dream university. Now, five years after transplant, he is back to everyday life. His story is one of perseverance, return, and growing forward - and a source of hope for others living with aplastic anemia.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260910\u002F49bb6bb1fefed39c7ae727015ee27994_20260910151026.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"49bb6bb1fefed39c7ae727015ee27994_20260910151026.png\" alt=\"3605b141-f4a6-466e-b142-b8c340c89c04.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In January 2021, during winter break in his first year of high school, 16-year-old Xiaojie noticed that his gums had been bleeding for several days. At first, he did not think much of it. Then one night, he woke from sleep with severe abdominal pain. An emergency hospital visit led to a diagnosis of severe aplastic anemia (SAA). The illness came on suddenly, confronting a teenager with a life-threatening challenge he had never imagined. The following month, Xiaojie underwent an allogeneic hematopoietic stem cell transplant at GoBroad Shanghai Zhaxin Hospital, with his father as the donor.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After more than 20 difficult days in the transplant unit, Xiaojie was finally able to leave protective isolation. That day felt brighter than usual. But an unexpected challenge followed: intense pain shot through his body from head to toe, almost like an electric current. Around the clock, the medical team cared for him with both expertise and compassion, helping him through one painful day at a time. Gradually, the pain eased and his strength returned, and he was eventually discharged. Even then, a lingering ache stayed with him on and off for nearly a year.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">For the next two years, Xiaojie returned to the hospital regularly for follow-up visits, always accompanied by his family. As his health steadily improved, he was finally able to put on his backpack again, return to school, and pick up the studies that illness had interrupted. More than two years of life may have been put on hold, but his determination had not faded.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">He went on to finish high school, perform well in China's national college entrance examination, and earn a place at the university he had hoped to attend.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Today, Xiaojie is a second-year university student. At the five-year milestone after transplant, his doctor presented him with a commemorative pin recognizing that he had reached the milestone of clinical cure. It honors everything he has come through and carries a wish for many healthy years ahead.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Xiaojie also chose to share his story - a journey shaped by pain and hope, support and growth - with other patients still finding their way forward. He believes every difficult journey deserves to be seen, and one person's story may become a light for someone else in a dark moment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260910\u002F9b7af499c393df0bf11c06059e4d48b9_20260910151048.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"9b7af499c393df0bf11c06059e4d48b9_20260910151048.png\" alt=\"e1963d0c-7274-49bf-b68e-ad0e4c104a4a.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px; text-align: center;\">February 2026: Xiaojie with Dr. Ying Jiang and Nurse Manager Xia Yan\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>- Patient Q&A -\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q1: Can you take us back to when you were diagnosed? What symptoms were you having?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: It was winter break during my first year of high school. My gums had been bleeding for several days, but I did not think much of it. Then one night, I suddenly developed severe abdominal pain. I went to the hospital and was diagnosed with aplastic anemia.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Looking back, I was in shock. I mainly remember how anxious my family was and how urgently they were trying to find the right hospital. My platelet count was already extremely low, so the situation was actually very dangerous.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">With my family beside me, we first went to Professor Wang Chun's clinic, and I was admitted that same day. Dr. Ying Jiang was my attending physician. She was very clear that I should undergo an allogeneic hematopoietic stem cell transplant as soon as possible. Treatment moved quickly. HLA matching was done with my father, and before long I entered the transplant unit.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At that point, we really did not have many options. Transplant was essentially the only treatment that offered a way forward.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q2: How did you get through your time in the transplant unit? Did it feel lonely without your parents by your side?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: Before I went in, I thought it would simply be a different place to rest and that nothing would be too unusual. Once treatment started, the physical reactions made me realize it was much harder than I had expected. My family could not stay with me, and when I felt unwell, I sometimes felt lonely too.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I did not want my parents to worry, and I often felt too unwell to reply to my mother's messages right away. But during the brief visiting time each day, she would always come and see me through the glass. We did not need to say anything. I could see the concern and encouragement in her eyes, and that quiet support gave me strength to keep going.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I am not very good at expressing my feelings, but I always knew how much my parents loved and supported me. When things were hard, I would tell myself: I have to get through this.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In some ways, the days in the transplant unit passed quickly. The doctors, nurses, and caregivers were always there, looking after me and helping me make it through the hardest period one day at a time.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q3: What was the hardest part of treatment for you?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: During recovery after transplant, my skin became darker and was repeatedly itchy, and I also had severe pain throughout my body. For a while, I needed pain-relief injections almost every day just to get some relief. The doctors explained that the donor cells from my father and my body were learning to coexist, and that the graft-versus-host reaction was part of this 'conversation' inside my body.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The pain often made it hard to eat or sleep, but I kept telling myself: hold on, get through this, and things will get better. After leaving the transplant unit, I remained in the hospital for more than three months. As the pain gradually eased, I was finally able to go home and return for regular follow-up visits.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The pain did not disappear completely right away. It was more like a slowly receding tide that would still come back from time to time. It took almost a year after transplant before it finally went away for good.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q4: When were you able to return to school?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: About two years after transplant, I had mostly recovered. At follow-up, my doctors felt I was ready to go back to class, and I felt I could keep up too. So I returned to the first year of high school and continued the studies I had had to put on hold.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Walking back onto campus after more than two years brought up so many emotions. There was a deep sense of relief, and the joy of seeing sunlight again after a long storm. Eventually, all of those feelings settled into a sense of calm.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Before I got sick, I put a lot of pressure on myself academically and always wanted to do my best. After returning to school, I became much more balanced. I realized that health comes first, and grades were no longer my number-one priority. That did not mean I stopped working hard.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I have always believed that illness is only one chapter in a life. If it could not break me, then it would make me stronger. I graduated two years later than my classmates, but I still earned a place at the university I wanted to attend.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Now I am a second-year university student. I go to class, take part in activities, and eat out with friends just like everyone else. I am fairly disciplined in daily life. I do not have strict food restrictions, but I usually choose clean, healthy food. Every now and then I might have a skewer or two of barbecue, but I keep it moderate.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q5: What does reaching the five-year 'graduation' milestone mean to you, and what do you hope for next?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">A: Looking back on these years, I feel deeply grateful. My mother was always there, taking care of every detail. My father donated the stem cells that helped give me my life back. My grandparents did everything they could to prepare food I was able to eat at the time. I remember what each of them did for me.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">During my time in the transplant unit, one of the caregivers also gave me a lot of warmth and support. She patiently passed messages back and forth between my mother and me and carefully handled the food my family brought. I am also deeply grateful to Dr. Ying Jiang and her team. Their expertise and attentive medical care helped me regain my health.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">It has not been an easy road. I could only make it to where I am today because so many people stood by me and supported me along the way. And now, I have finally passed this five-year 'final exam'!\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">It closes one chapter and opens the next.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cbr\u002F>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">For the rest of my life, I will remember that I have already been through a life-or-death experience. Whatever comes next, I will face it with more courage and more calm.\u003C\u002Fspan>\u003C\u002Fp>","Dr. Ying Jiang (Associate Chief Physician, MD; Medical Team Leader, GoBroad Shanghai Zhaxin Hospital):\n\nXiaojie came to GoBroad Shanghai Zhaxin Hospital in late January 2021 and was diagnosed with severe aplastic anemia, together with an intra-abdominal infection and gingival bleeding. It was only two weeks before the Spring Festival, a period when blood donation often falls and blood supplies can become tight. In that setting, restoring his blood counts as quickly as possible became a key treatment priority.\n\nWe promptly initiated an allogeneic hematopoietic stem cell transplantation plan. By February 23, his platelet count had returned to normal and neutrophil engraftment had been achieved. After transplant, he developed immune-mediated pain and cutaneous graft-versus-host disease. His symptoms gradually improved after adjustments to immunosuppressive therapy and other supportive treatment.\n\nToday, Xiaojie has returned to everyday life, gone back to school, and continued his education. His recovery reflects not only his own perseverance, but also the steady support and companionship of his family throughout treatment.\n\nWishing you health, happiness, and many good days ahead.",{"slug":372,"title":373,"summary":374,"cover":375,"disease":376,"treatment":273,"patientType":91,"publishedAt":377,"contentHtml":378,"expertView":379,"disclaimer":70,"hasAlternate":71,"updatedAt":126},"mpal-hsct-recovery","A 7-Year-Old Boy with Rare Mixed Phenotype Leukemia Finds a New Beginning","After multiple rounds of chemotherapy failed to bring his disease into remission, an accurate diagnosis and individualized treatment helped him successfully undergo hematopoietic stem cell transplantation and get back to being a child again.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F24f4dcb244034ac66321607e19d3840f.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","Mixed Phenotype Acute Leukemia\u002FLymphoma","2026-01-30","\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Summary: Seven-year-old Xiaole developed persistent fever, thrombocytopenia, and other symptoms and was initially diagnosed with T-lymphoblastic lymphoma\u002Fleukemia with myeloid expression. Despite multiple rounds of standard chemotherapy, his disease continued to progress. After he was transferred to Beijing GoBroad Boren Hospital, Prof. Yonghong Zhang’s team brought together multidisciplinary expertise, genetic testing, and precision diagnostics to identify the underlying disease as mixed phenotype acute leukemia\u002Flymphoma (T\u002FB\u002Fmyeloid) driven by an NRAS somatic mosaic mutation. The team then developed an individualized treatment strategy combining targeted therapy with allogeneic hematopoietic stem cell transplantation. In March 2025, Xiaole successfully underwent a related haploidentical transplant. He remains in complete remission and is steadily recovering. His story shows how an accurate diagnosis and tailored treatment can open a path forward for a child with a rare and complex blood cancer, while also highlighting the value of multidisciplinary care.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In May 2024, seven-year-old Xiaole (pseudonym) was diagnosed at another hospital with stage IV T-lymphoblastic lymphoma\u002Fleukemia with myeloid expression (CNS1). Yet after multiple rounds of standard chemotherapy, his disease still did not go into remission, and treatment seemed to have reached an impasse. In November 2024, after his local doctor invited Prof. Yonghong Zhang for a consultation, Xiaole was transferred to the Department of Pediatric Hematology & Oncology at Beijing GoBroad Boren Hospital to understand why the disease was proving so difficult to treat. The team first carried out a comprehensive review of his case, then quickly convened a multidisciplinary consultation and incorporated genetic testing and other precision diagnostic tools. This ultimately revealed the key driver of his disease: mixed phenotype acute leukemia (MPAL) driven by an NRAS somatic mosaic mutation. The team designed an individualized plan using pathway-directed targeted therapy together with chemotherapy to bring the disease under control and create the right conditions for transplantation. In March 2025, Xiaole successfully underwent a related haploidentical hematopoietic stem cell transplant. With close supportive care from the medical team, he made it through critical post-transplant challenges including infection and graft-versus-host disease (GVHD).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Today, more than 10 months after transplantation, Xiaole remains in complete remission (CR). His strength is returning, his familiar smile is back, and childhood is once again filling his days with color.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F3be2728e5d56d4dff003653f399958c7_20260912211602.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"3be2728e5d56d4dff003653f399958c7_20260912211602.png\" alt=\"c890892b-a3af-45b2-be8f-81618cc453ae.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">Xiaole after treatment and discharge\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>From Common Symptoms to a Rare Diagnosis\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The story began in early 2024, when Xiaole developed a cough and fever. At first, his family thought it was simply a common cold and took him to a local hospital for symptomatic treatment. A month or two later, however, small red spots appeared on his skin, raising new concerns. His family took him from their home in Anhui to a hematology department at a hospital in Zhejiang. The initial test results were worrying: his platelet count was low, and his liver, spleen, and lymph nodes were enlarged. After a series of detailed examinations, the family received a diagnosis they had never expected: T-lymphoblastic lymphoma with myeloid expression (stage IV, CNS1), with NRAS and DDX3X mutations also identified.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">“I was completely stunned. It felt like a dream. I had never even heard of lymphoma before...” Xiaole’s mother still remembers the shock and helplessness she felt when she first heard the diagnosis.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Determined to save their son, Xiaole’s family went through several courses of chemotherapy at the local hospital. But instead of improving as hoped, the disease repeatedly pushed back, leaving the family feeling that they were running out of options. At a time when they were anxious, confused, and close to despair, a message in a patient support group gave them a new lead: Prof. Yonghong Zhang’s team at Beijing GoBroad Boren Hospital was known for extensive experience in pediatric lymphoma, particularly relapsed and refractory disease. After Xiaole’s local doctor invited Prof. Zhang for a consultation, the family made the trip to Beijing in November 2024, determined to pursue every possible option.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Precision Diagnosis: Finding the Driver and a Path Forward\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Faced with this unusually complex case, Prof. Yonghong Zhang’s team immediately began a comprehensive review. The new evaluation revealed a more complicated picture: in addition to hepatosplenomegaly, Xiaole’s bone marrow contained three populations of tumor cells with abnormal T-cell, B-cell, and myeloid phenotypes, consistent with a mixed-lineage leukemia. NGS screening for susceptibility genes related to hematologic and immune disorders also showed an NRAS variant allele frequency of 93.36%, yet the variant was not inherited from either parent. Through a joint molecular and clinical review, the team determined that the NRAS change was a somatic mosaic mutation arising early in embryonic development. Because it was neither an inherited germline variant nor a tumor-specific mutation, it helped explain the highly unusual clinical presentation.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">That precise diagnosis became the turning point. Early in treatment, the team tried several combinations of chemotherapy and targeted agents, but the disease continued to progress. In February 2025, as the tumor burden remained difficult to control, Prof. Zhang’s team rapidly convened another multidisciplinary consultation. After repeated review and discussion, they reached the integrated diagnosis of mixed phenotype acute leukemia\u002Flymphoma. The NRAS somatic mosaic mutation was driving a malignant hematopoietic stem-cell clone capable of differentiating along multiple lineages, helping explain why several lines of chemotherapy had failed to achieve a meaningful response.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The experts agreed that allogeneic hematopoietic stem cell transplantation offered the only realistic path toward rebuilding Xiaole’s blood-forming and immune systems and pursuing a potential cure. Before transplantation, however, the disease first had to be controlled. Prof. Zhang’s team therefore developed a bridging regimen combining two targeted agents. Encouragingly, after only four days of targeted therapy, Xiaole’s enlarged spleen had already shrunk noticeably. That early response gave both the family and the medical team renewed confidence that transplantation might now be within reach.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Through the Darkest Days: A Vigil in the Transplant Unit\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">On February 19, 2025, Xiaole entered the transplant unit and began conditioning. His hematopoietic stem cells were infused over two days, March 5 and 6. For his family, these “seeds of life” carried their deepest hopes, as well as the medical team’s careful preparation for what came next.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The conditioning regimen took a heavy toll on Xiaole. The wait for blood-cell recovery was filled with uncertainty, and the fear of infection weighed constantly on the family. His mother later described that period as “the darkest time of our lives,” when every day seemed to bring a new worry.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">But Xiaole was not facing it alone. The medical team stayed close throughout the transplant journey. With careful monitoring and supportive care, his neutrophils engrafted on day 16 and his platelets on day 25. He then faced one challenge after another, including infection and intestinal GVHD. Each time, the team responded promptly and precisely, helping him safely through the complications.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The signs of a new beginning became clearer with each follow-up. At one month after transplantation, imaging showed no obvious tumor lesions, bone marrow testing showed complete donor chimerism, and the NRAS mutation was no longer detected in either bone marrow or peripheral blood. At the two-month assessment, Xiaole had achieved complete remission, confirming that the disease was under effective control.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002Ff76791f054f8c67719415d39021f3e47_20260912211632.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"f76791f054f8c67719415d39021f3e47_20260912211632.png\" alt=\"09ac912d-40ad-4150-9110-8cce7106c647.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">Xiaole returned to the general ward after leaving the transplant unit\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>A New Beginning: Gratitude for the Return of Everyday Happiness\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Today, more than 10 months after his transplant, Xiaole remains in complete remission and continues to regain his strength. The child who once spent his days consumed by illness is now laughing and playing with friends again, just like other children his age. “The best decision I made was bringing him to Boren,” his mother said. Her voice still trembled as she looked back on the journey - with memories of how difficult it had been, but also with gratitude for where her son is today.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In a thank-you letter to the hospital, Xiaole’s mother wrote: “Looking back on this journey, I know clearly that the expertise of the Boren medical team paved the way for his recovery... What you protected was not only his health, but the ordinary days and future that every family treasures most.” She also shared how much Xiaole enjoyed the hospital’s regular arts-and-crafts classes and holiday activities. These seemingly simple moments helped preserve the fun, interaction, and sense of childhood he deserved, bringing warmth and color to an otherwise difficult treatment journey.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">“To families facing something similar, I want to say this: no matter how complicated or rare the disease is, keep looking for answers and don’t give up on finding a way forward for your child. Trust an experienced medical team.” These are the words Xiaole’s mother most hopes other families in difficult situations can hear.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002Fdfabaac6e5713c84c5d2722f400cb666_20260912211730.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"dfabaac6e5713c84c5d2722f400cb666_20260912211730.png\" alt=\"45d8fe55-4262-48f0-98bf-c0394d7ba023.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">Thank-you letter from Xiaole’s mother\u003C\u002Fspan>\u003C\u002Fp>","Case Commentary from Prof. Yonghong Zhang’s Team: \nXiaole, a seven-year-old boy, first presented in late February 2024 with thrombocytopenia and enlargement of the liver, spleen, and lymph nodes. In May 2024, he underwent bone marrow aspiration and excisional biopsy of a left axillary lymph node at another hospital. Based on lymph-node histopathology and immunohistochemistry, flow-cytometric immunophenotyping, hematologic malignancy-related gene mutation testing, and whole-transcriptome sequencing, he was diagnosed with stage IV T-lymphoblastic lymphoma\u002Fleukemia with myeloid expression (CNS1). Beginning June 20, 2024, he received treatment according to the CNCL-NHL-2017-LBL high-risk protocol, including VDLP, CAM1, CAM2, and HR-1. During treatment, however, lesions in the lymph nodes, bone marrow, and spleen all progressed. He was therefore transferred to the Department of Pediatric Hematology & Oncology at Beijing GoBroad Boren Hospital under Prof. Yonghong Zhang for further evaluation and treatment.\n\nWe integrated the patient’s MICM findings - morphology, immunology, cytogenetics, and molecular biology - from the lymph nodes, bone marrow, and peripheral blood and diagnosed progressive mixed phenotype acute leukemia\u002Flymphoma involving T-cell, B-cell, and myeloid lineages. He subsequently received four second-line chemotherapy courses designed to cover both lymphoid and myeloid components, together with several targeted agents. Although the lymph-node disease improved, the proportions of the three abnormal T-, B-, and myeloid cell populations in the bone marrow fluctuated and showed no clear overall decline, while the spleen repeatedly enlarged. This heterogeneous response suggested that chemotherapy directed at both lymphoid and myeloid disease was addressing the manifestations without fully treating the underlying driver.\n\nTo identify what was driving the disease, we re-examined the patient’s molecular and immunophenotypic features. The NRAS mutation was detected in bone marrow, lymph-node tissue, and peripheral blood. It was neither germline nor tumor-specific, but rather a somatic mosaic mutation. Such RAS somatic mosaicism can produce different immunophenotypes across tissues within the lymphohematopoietic system. In addition to mixed phenotype leukemia\u002Flymphoma, the patient also had RAS-associated autoimmune leukoproliferative disorder (RALD), creating an overlap of malignancy, clonal hematopoiesis, and immune dysregulation. This helped explain the inconsistent responses to chemotherapy.\n\nBecause the NRAS somatic mosaic mutation was identified as the key disease driver, we discontinued chemotherapy and switched to a multi-agent targeted approach to control tumor progression. The hepatosplenomegaly improved after targeted treatment, while preparations were made for allogeneic hematopoietic stem cell transplantation to rebuild hematopoietic and immune function.\n\nA related haploidentical hematopoietic stem cell transplant was initiated on February 19, 2025. At the one-month assessment on April 14, 2025, ultrasound showed no obvious tumor lesions and the spleen was no longer palpable below the costal margin. Bone marrow chimerism was 100% donor-derived, and both bone marrow flow cytometry and testing for the NRAS mutation were negative. Quantitative NGS for the NRAS mutation in peripheral blood was negative, while quantitative NGS of peripheral-blood cell-free nucleic acid showed an NRAS level of 0.42%. At the two-month assessment on May 6, 2025, imaging again showed no tumor lesions and no palpable splenomegaly. Bone marrow flow cytometry and NRAS mutation testing remained negative; quantitative peripheral-blood NGS remained negative, and the NRAS mutation in peripheral-blood cell-free nucleic acid also became undetectable, indicating deep molecular remission. The patient has now maintained remission for eight months.\n\nTo our knowledge, this is the first reported case worldwide of a mosaic RASopathy presenting as mixed phenotype leukemia\u002Flymphoma together with RAS-associated autoimmune leukoproliferative disorder. Targeted therapy with a MEK inhibitor and an mTOR inhibitor, followed by allogeneic hematopoietic stem cell transplantation, achieved sustained remission.",{"slug":381,"title":382,"summary":383,"cover":384,"disease":385,"treatment":99,"patientType":67,"publishedAt":377,"contentHtml":386,"expertView":387,"disclaimer":70,"hasAlternate":71,"updatedAt":320},"angioimmunoblastic-t-cell-lymphoma-recovery","A 76-Year-Old \"Graduate\" Marks a Five-Year Milestone","Diagnosed with angioimmunoblastic T-cell lymphoma at age 71, the patient underwent hematopoietic stem cell transplantation after facing the challenges of chemotherapy, and five years later, returned to a life shared with family.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002Fabdeedbac8984562f87563ca0a0f2e38.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","Angioimmunoblastic T-Cell Lymphoma","\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">Summary: At 71, Mr. Chen was diagnosed with angioimmunoblastic T-cell lymphoma (AITL). After several rounds of chemotherapy, he had still not achieved a complete remission. Despite the challenges of his age and hard-to-control disease, Mr. Chen and his family kept looking for another option. In December 2020, after evaluation by Professor Chun Wang's team at GoBroad Shanghai Zhaxin Hospital, he underwent a related-donor haploidentical allogeneic hematopoietic stem cell transplant (allo-HSCT). Five years later, he remains in long-term remission and is back to enjoying everyday life with his family. His story is about an older patient who kept moving forward through a difficult diagnosis - and about the hope his journey may offer others facing cancer.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260910\u002F35252919cd75794ce6b8cb5556ffbab0_20260910141545.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"35252919cd75794ce6b8cb5556ffbab0_20260910141545.png\" alt=\"23c41c91-c188-449e-8a7a-7e47e1063aae.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">In July 2020, 71-year-old Mr. Chen went to the hospital with a widespread rash and fever. The diagnosis - angioimmunoblastic T-cell lymphoma - came out of nowhere and suddenly disrupted the quiet life he had known. He and his family chose to face it together. But after several rounds of chemotherapy, he achieved only a partial response, and the future began to feel much less certain.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">Being 71 and still not in complete remission made the road ahead especially difficult. At the time, only a small number of centers in China would consider allogeneic hematopoietic stem cell transplantation for a patient of his age. Even as their options narrowed, Mr. Chen and his family kept calling, asking and searching for a possible path forward.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">A turning point came when they reached Professor Chun Wang's team at GoBroad Shanghai Zhaxin Hospital. In December 2020, at age 71 and with the full support of his family, Mr. Chen underwent a related-donor haploidentical allogeneic hematopoietic stem cell transplant. It was a demanding decision, both medically and personally - one made by a patient and a family who understood the risks but chose to pursue a chance for long-term survival.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">Five years on, that decision has led to the outcome they had hoped for. Mr. Chen achieved complete remission and is considered clinically cured. Just as importantly, he has returned to the ordinary moments he once feared he might lose: meals at home, time with his children and grandchildren, and the quiet rhythm of everyday family life. What once felt far away is now part of his daily life again.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">At this five-year milestone, Mr. Chen hopes his experience can encourage other older patients still making their way through treatment. He says: "No matter how small an instruction from your doctor may seem, follow it. Even when it is hard, keep going. During treatment, we need to trust our medical team, but we also need to hold on to our own determination. Do not give up hope. A better tomorrow is worth holding on for."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260910\u002F9f6386b62bef3fbf3f284d35bef89742_20260910141607.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"9f6386b62bef3fbf3f284d35bef89742_20260910141607.png\" alt=\"e88a461f-781f-459d-901a-bca0f492e2c1.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">December 2020\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260910\u002F22b6fc93e764f86a5c06829984758d4c_20260910141624.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"22b6fc93e764f86a5c06829984758d4c_20260910141624.png\" alt=\"0e5f81dc-7370-4914-847e-af4908997537.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"color: rgb(127, 127, 127); font-size: 15px;\">January 2026\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong> \u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 16px;\">\u003Cstrong>- In Conversation with Mr. Chen -\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q1: When you were diagnosed, how did you and your family react? What did the doctors tell you at the time?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">A: In July 2020, I was diagnosed with lymphoma at a hospital in Guangzhou. It was the first time I had ever heard of the disease. My Mandarin is not very good, so I had trouble following everything the doctors were saying. My son was worried the news would be too much for me. He only told me that the doctors said it was treatable, but treatment would take time and come with some risks.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">After the diagnosis, I had four months of chemotherapy at the local hospital, but the lymphoma never went into complete remission. I knew the situation was probably serious, so I insisted that my son tell me the truth. He finally told me that the doctors felt a complete cure would be very difficult and that even with active treatment, my outlook might not be good. I was devastated. It took me a long time to come to terms with it.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q2: Why did you ultimately decide to seek treatment at GoBroad Shanghai Zhaxin Hospital?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">A: As a family, we still were not ready to give up. My son kept looking for information and learned that allogeneic hematopoietic stem cell transplantation might offer a chance of cure for angioimmunoblastic T-cell lymphoma. But I was already 71. He contacted several hospitals, and none were willing to take me on for transplant because of my age.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">Eventually, we were referred to Professor Chun Wang, a specialist in hematopoietic stem cell transplantation. We had three in-depth discussions with his team. At first, Professor Wang had reservations: I was older, and I still had not reached complete remission after several rounds of chemotherapy, so transplant would be very challenging. But my family and I strongly wanted to pursue treatment, and I was otherwise in relatively stable condition. After careful evaluation, he agreed to take my case.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">In December 2020, I underwent an allogeneic hematopoietic stem cell transplant at GoBroad Shanghai Zhaxin Hospital, using stem cells donated by my son.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q3: As an older transplant patient, what worried you and your family most about the risks? What ultimately led you to go ahead?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">A: Before the transplant, all of us understood there were real risks. But without transplant, chemotherapy alone was unlikely to give me either a good quality of life or much time. I thought: if there is still a chance of a cure, why not take it?\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">My family gave me tremendous support. My sons told me: "Do not worry about the cost or caregiving. As long as you have the confidence and determination to do this, we will be behind you all the way." With them behind me, I wanted even more to gain more time and be there with my family.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">The care team at Zhaxin also gave me a lot of confidence. My attending physician, Dr. Chuxian Zhao, checked on me every day and paid attention to every detail. The doctors and nurses were always there, almost like family. That made me feel safe and strengthened my resolve to continue treatment.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q4: What was the hardest or most memorable period during transplant, and what helped you get through it?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">A: Once I entered the transplant isolation unit, I had to stay there for about a month. It was very difficult. After the transplant, I had a high fever for 12 days. I felt terrible physically. The food in Shanghai was sweeter than I was used to, so I barely had any appetite, and I also had diarrhea every day. I felt exhausted and anxious.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">During that period, the caregiver who looked after me was a huge support. She kept telling me, "Do not be afraid. Just keep going." She also reassured me that my condition was actually not too bad and that the diarrhea was not severe. Maybe she was simply trying to comfort me, but it helped more than she probably knew.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">What reassured me most was Dr. Zhao. She came to see me every day, checked how I was doing, and encouraged me not to get too anxious because things would improve step by step. She told me: "Keep hope and confidence. Once your blood counts start to recover, your body will get stronger day by day. When the cells grow back, it is like new energy returning to your body."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">And she was right. Once I got through the hardest stretch, my blood counts gradually recovered and I felt stronger each day. Eventually, I was well enough to leave the transplant isolation unit.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q5: What would you like to share with other patients about recovery after transplant?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">A: For me, the hardest part was the time in the transplant unit. Once I was out, recovery went fairly smoothly and I did not have much discomfort. As soon as I felt a little stronger, I started walking up and down the ward corridor every day for about an hour. Sometimes a nurse on duty would see me and ask, "You are already up and walking this early?" I would say, "Yes - I want to keep moving and build my strength back up."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">After I went home, I was very careful about daily life. Apart from my morning walk, I mostly stayed home and avoided crowded places. One habit helped me a lot: unless it was raining, I walked for an hour every day, about five kilometers.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">I also paid close attention to nutrition. I am allergic to milk and eggs, and for a while after transplant I was eating a very limited diet. When I got home, a local doctor told me I was a little malnourished. So my advice is: food safety matters, but so does variety. Try to eat a balanced diet and keep regular meal times.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cstrong>\u003Cspan style=\"font-size: 15px;\">Q6: What does reaching the five-year "graduation" milestone mean to you and your family? What are you hoping for next?\u003C\u002Fspan>\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">A: "Graduating" at five years means that life has given my family and me more time - and more warmth. Being able to return to ordinary life and spend each peaceful day with my family is already the greatest gift.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">We are a big family. After the children finish work, they come home and we eat together and chat. My oldest grandson is in college now. During school holidays, we often travel as a family, and I have been to quite a few places with them. Having this time with the people I love makes me very happy and grateful.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cspan style=\"font-size: 15px;\">Looking ahead, I hope life can stay this simple and warm: to watch my grandchildren grow up, and to share many more seasons and trips with my family. Every day feels like a gift.\u003C\u002Fspan>\u003C\u002Fp>","Dr. Chuxian Zhao (Director, Hematopoietic Stem Cell Transplantation Center, GoBroad Shanghai Zhaxin Hospital):\n\nUnder Professor Chun Wang's leadership, our team has continued to explore better treatment approaches for difficult-to-treat T-cell lymphomas. At our center, patients with relapsed\u002Frefractory T-cell non-Hodgkin lymphoma (R\u002FR T-NHL) have achieved a long-term disease-free survival rate of 58%.\n\nWith advances in transplant medicine, age alone is no longer an absolute barrier to allogeneic hematopoietic stem cell transplantation. Patients over 70 who are otherwise physically fit may still be candidates for allogeneic transplantation with curative intent.\n\nThat said, older patients still face multiple challenges during treatment, including organ function and physical recovery. Every patient who recovers and returns to life after treatment is a tremendous source of encouragement for our team.\n\nMr. Chen's bright smile is the best gift our care team could receive.",{"slug":389,"title":390,"summary":391,"cover":392,"disease":393,"treatment":99,"patientType":91,"publishedAt":394,"contentHtml":395,"expertView":396,"disclaimer":70,"hasAlternate":71,"updatedAt":126},"severe-beta-thalassemia-hsct-recovery","From Lifelong Transfusions to a New Beginning: An 18-Year-Old with Thalassemia Steps into a New Chapter","After years of waiting and finally undergoing a transplant, he now has the chance to pursue his dreams like any other young person.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002F081394ca31fe27a69fb513f0728804af.webp?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","Severe Beta-Thalassemia","2026-01-23","\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Summary: Eighteen-year-old Aguang (pseudonym) was diagnosed with severe beta-thalassemia shortly after birth. For years, regular blood transfusions and iron chelation therapy were essential to keeping him well. Over 15 years of living with the disease, he waited for a fully matched donor and once lost a transplant opportunity when a donor withdrew. After finishing the college entrance examination, Aguang came with his family to GoBroad Chunfu Institute of Hematology & Oncology for evaluation. As haploidentical hematopoietic stem cell transplantation (HSCT) became increasingly established, he ultimately chose a PTCy-based haploidentical transplant. In July 2025, the transplant was successfully completed. He is now recovering well, with stable blood counts, and is gradually leaving long-term transfusions and iron chelation behind. His story reflects the journey from being constrained by thalassemia to reclaiming everyday young adulthood — made possible by advances in medicine, the support of his family, and his own determination.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After the college entrance examination, while his classmates were planning graduation trips, 18-year-old Aguang (pseudonym) and his mother, Ms. Chun (pseudonym), were preparing for a far more important journey: hematopoietic stem cell transplantation, a treatment that could free him from the lifelong burden of severe thalassemia. In the summer of 2025, Aguang and his mother came to GoBroad Chunfu Institute of Hematology & Oncology, where he was treated by Dr. Jianyun Liao and underwent a PTCy-based haploidentical transplant. Five months after transplantation, his follow-up results remain stable. He plans to begin university next September, ready to start this new chapter with a healthier body.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>01 Diagnosed with Severe Thalassemia: The Weight of “Lifelong” Treatment\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In 2008, before Aguang was seven months old, his parents took him to a local hospital because he looked pale and had little appetite. The diagnosis — severe beta-thalassemia — came as a devastating blow to the family.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">“Severe beta-thalassemia means lifelong blood transfusions and iron chelation therapy...” Ms. Chun understood every word on the report, but together they felt unbearably heavy. The idea of “lifelong” suddenly carried a weight she could hardly describe.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">On the advice of a local doctor, Ms. Chun took her baby to see Prof. Chunfu Li, who was then practicing at Nanfang Hospital. Prof. Li told her, “Thalassemia can achieve deep remission. If the hematopoietic stem cell transplant is successful, your child can live like other children.” As parents, giving up was never really an option. But that reassuring answer gave Ms. Chun the courage to keep going.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>02 Searching for a Fully Matched Donor: Hope, Lost and Found\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At the time, transplantation from a fully HLA-matched donor was the more established option. After no one in the family proved to be a match, Ms. Chun turned to the China Marrow Donor Program (CMDP), hoping to find what felt like a genetic needle in a haystack. Two years — more than 700 days — passed between hope and disappointment. Then, when Aguang was three, the call finally came: “We found one. There is a fully matched donor.”\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The day the match was confirmed, Ms. Chun held both of her children and cried, believing the hardest part was finally over. But the transplant plan was abruptly halted. Shortly before stem cell collection, the donor decided not to proceed and cut off contact. To see hope burn so brightly and then disappear was, for the family, even harder than never having found it at all. Ms. Chun asked Prof. Li, “If a fully matched transplant is no longer possible, is there another way to treat this disease?” Prof. Li explained that a haploidentical transplant could also be considered, but the approach was not yet mature at the time. If the family was willing, they could wait, because medicine would continue to advance. Ms. Chun kept searching, but another fully matched donor never came.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Waiting became something the whole family learned to live with — waiting for transplant technology to mature, and waiting for another chance.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>03 Longing to Break Free from Thalassemia: 15 Years Tied to Transfusions\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At 173 cm tall, lean but not frail, Aguang looked much like any other teenager thanks to the careful support of his mother and older sister. But he always knew his life was different.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">As Aguang grew older and gained weight, his transfusion needs steadily increased — from one unit of red blood cells every 40 days to 4.5 units every 20 days, just to keep his hemoglobin at around 60 g\u002FL. What does 60 g\u002FL feel like? Aguang compared it to a phone that is always stuck at 15% battery, with just enough power for the most basic functions. “Even sitting up in bed, I had to wait about 30 seconds or my vision would go dark. I couldn’t run or jump. In PE class, I was always the one watching from the sidelines.” Long-term transfusions brought another concern: his ferritin levels remained around 2,000–3,000 ng\u002FmL. Excess iron could build up in organs such as the liver and heart, creating another threat to his health. To manage it, he needed long-term oral iron chelation therapy as well as deferoxamine injections.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">To make sure Aguang could continue receiving transfusions and iron chelation, the family cut back on every nonessential expense. Ms. Chun saved wherever she could. She ate the simplest meals at her workplace cafeteria, avoided extra spending, and volunteered for holiday shifts whenever others preferred to take time off, simply to earn a little more overtime pay.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">But there was one thing hard work alone could not solve: blood shortages. For many people, a notice about low blood supplies might be just another headline. For Aguang’s family, it could directly affect whether he could maintain his everyday health. That uncertainty was frightening.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>04 Expert Support: Turning Fear of the Unknown into Risks That Could Be Managed\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The possibility of transplantation came up again after Aguang finished the college entrance examination and received his university admission letter. Still unsure whether they should keep waiting for a fully matched donor, Ms. Chun returned to GoBroad Chunfu Institute of Hematology & Oncology to speak with Prof. Li and Dr. Liao. Dr. Jianyun Liao gave the family a clear answer: “There is no need to keep waiting for a full match. Haploidentical transplantation is now a well-established approach, with strong success rates.” Hope returned, but so did a new set of very real concerns. The family held countless discussions, and this time the final decision rested with Aguang, who had just turned 18. “I was afraid. I worried that if the transplant failed, I might lose even the life I had then. Would donating stem cells harm my sister? Could the transplant affect my fertility? Would I still be able to have a family one day?” Dr. Liao’s team addressed each concern carefully and patiently. They shared detailed transplant data and examples of successful adult cases to help the family understand that haploidentical transplantation had become a mature and safe option. Aguang’s sister also underwent a thorough donor evaluation, helping ease the family’s concerns. Before transplantation, the team coordinated with a reproductive medicine center to preserve Aguang’s fertility, keeping more possibilities open for his future.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Every conversation with Dr. Liao gave Aguang greater confidence, turning unknown fears into risks he could understand and prepare for. In the end, he made the decision himself to move forward with transplantation. In July 2025, with his mother by his side, Aguang was admitted to the transplant isolation unit.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>05 Leaving the Transplant Unit: Taking the Future Back into His Own Hands\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">When the isolation-room door closed, it separated Aguang from the outside world — but it also marked the beginning of a new chapter. Dr. Liao, the physicians, and the nursing team became the closest partners Aguang and his mother had through the transplant. Ms. Chun still remembers those days vividly.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">“Before we went in, I was so scared that I couldn’t sleep at night. But once we were there, I realized Dr. Liao and the nurses were even more attentive than I had imagined.” When Aguang developed a fever during chemotherapy, the nurses stayed by his bedside through the night to monitor him and guide his care. When he lost his appetite and refused to eat, Dr. Liao patiently encouraged him: “Think of food as part of your medicine. You need the strength to get through this.”\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">These small acts of care became a source of warmth during a difficult time. Aguang’s cooperation, his family’s trust, and the medical team’s expertise and compassion helped the transplant move forward smoothly. After leaving protective isolation, signs of recovery showed up in everyday details: his hemoglobin stabilized at around 120 g\u002FL, he gained about 10 kg, color returned to his face, and the transfusion bags and chelation pump that had been part of his life for years were finally gone.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Before transplantation, Aguang had already received his university admission letter. He chose to take a year off so he could focus on follow-up care and recovery. His hope is simple: to begin university in good health — to run, jump, join clubs he enjoys, and take part in internships with his classmates. For most people, these are ordinary parts of student life. For Aguang, they represent something far more meaningful: the freedom to move forward.\u003C\u002Fspan>\u003C\u002Fp>","Dr. Jianyun Liao (Chief Physician, GoBroad Chunfu Institute of Hematology & Oncology):\n\nHematopoietic stem cell transplantation is an important curative treatment for severe thalassemia. In the past, transplantation was often limited by the difficulty of finding a fully matched donor.\n\nToday, as transplant techniques have become more mature, haploidentical transplant strategies have also continued to improve. Parents and siblings can serve as donors, greatly expanding donor availability. Transplant safety has improved substantially, and age-related limitations have become less restrictive, giving more older adolescent and adult patients like Aguang an opportunity for long-term recovery.\n\nComprehensive pre-transplant evaluation — including fertility preservation when appropriate — together with high-quality post-transplant management can help protect patients’ long-term quality of life. Patients and families are encouraged to stay hopeful and seek evaluation and treatment at experienced medical centers.",{"slug":398,"title":399,"summary":400,"cover":401,"disease":190,"treatment":402,"patientType":67,"publishedAt":403,"contentHtml":404,"expertView":405,"disclaimer":70,"hasAlternate":71,"updatedAt":126},"aml-cik-treatment","After Her Fusion Gene Stayed Positive Through Multiple Rounds of Chemotherapy, CIK-Based Treatment Brought Deep Remission","Diagnosed with acute myeloid leukemia at 49, she went through multiple rounds of chemotherapy, yet her fusion gene remained detectable. After coming to Beijing GoBroad Boren Hospital for individualized treatment including CIK cell immunotherapy, she achieved deep remission. She has now stopped all anti-cancer medications and has remained in remission for more than three years.","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F09\u002Fee64fdb4a2341584de4c88b6c478d565.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","CIK Cell Immunotherapy, Targeted Therapy","2026-01-16","\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Summary: At 49, Ms. Yu was diagnosed with AML-M2 with a positive CBFβ-MYH11 fusion. She underwent multiple rounds of chemotherapy. Although her bone marrow morphology showed remission, the fusion gene remained detectable, leaving treatment at an impasse. On the recommendation of another patient, she came to Beijing GoBroad Boren Hospital, where Dr. Chunrong Tong, Dr. Defeng Zhao, and their team developed an individualized treatment plan. In addition to chemotherapy and targeted therapy, CIK cell immunotherapy was incorporated into her treatment, and the CBFβ-MYH11 fusion eventually became undetectable, marking deep remission. Her journey later included another setback when leukemia involved the central nervous system. The team promptly adjusted the treatment strategy with intrathecal therapy, radiotherapy, and long-term maintenance treatment, helping her regain and sustain remission. In November 2025, she successfully stopped all anti-cancer medications, including targeted therapy. She now only needs follow-up every six months and has remained in remission for more than three years. Her experience highlights the value of individualized precision treatment, cellular immunotherapy, and consistent long-term management for AML, and offers hope to patients whose treatment has reached a difficult crossroads.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In September 2021, 49-year-old Ms. Yu (pseudonym), a full-time mother, was focused on supporting her son through his final year of high school and preparation for the gaokao, China's national college entrance examination. Then an AML-M2 diagnosis, with a positive CBFβ-MYH11 fusion, suddenly disrupted the family's life. She underwent multiple rounds of chemotherapy at a local hospital, but the key fusion gene remained detectable and treatment reached an impasse. In March 2022, encouraged by another patient, Ms. Yu traveled to Beijing GoBroad Boren Hospital. Dr. Chunrong Tong, Dr. Defeng Zhao, and their team quickly carried out a comprehensive assessment and designed an individualized treatment plan combining chemotherapy, targeted therapy, and CIK cell immunotherapy. With treatment tailored closely to her disease, the fusion gene finally became undetectable and she achieved deep remission. In November 2025, she stopped all anti-cancer medications, including targeted therapy, and now only needs follow-up every six months.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Today, Ms. Yu has remained in remission for more than three years and continues to regain her strength. Her son has also gone on to attend a top university. From having their lives suddenly thrown off course by leukemia to finding stability and hope again, the family has finally entered a new chapter.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";\">\u003Cimg src=\"https:\u002F\u002Fgaobo-byh-h5.oss-accelerate.aliyuncs.com\u002Fimages\u002F20260912\u002F07135c7bd6558a0544e6f35ea402e83d_20260912225228.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp\" title=\"07135c7bd6558a0544e6f35ea402e83d_20260912225228.png\" alt=\"412e86b2-af2a-4ff5-a3da-798cb1cb09db.png\"\u002F>\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>The Diagnosis: Leukemia Arrived During Her Son's Final Year of High School\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">In August 2021, I began having unexplained pain in my right leg. I went to the hospital several times, but no clear cause was found. Then in September, a bone marrow aspiration finally gave us the diagnosis: AML-M2 with a positive CBFβ-MYH11 fusion.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The first thing I asked after the diagnosis was, "Do I still have a year? Will I be able to stay with my son until he finishes his final year of high school?"\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">My husband stayed with me in the hospital, while our son was trying to cope with both schoolwork and the changes at home. I know he must have cried many times when I could not see him, but whenever he was with me, he stayed positive and upbeat. That gave me enormous comfort.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>A Treatment Roadblock: Multiple Courses of Chemotherapy, but the Fusion Gene Remained Detectable\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After five months of treatment, my bone marrow showed morphologic remission, but the CBFβ-MYH11 fusion fell only from 26.76% to 0.03% and never became undetectable. We felt completely stuck. A family member of another patient in the same ward suggested that we seek further care at a specialized hematology hospital. My husband consulted several hematology specialists online, and the professionalism, sincerity, and clear treatment approach of Dr. Chunrong Tong at Beijing GoBroad Boren Hospital gave us hope. We decided to come to Boren.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Seeking Care in Beijing: CIK Cell Immunotherapy Brings a Breakthrough\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Four years later, I still remember the first time I met Dr. Chunrong Tong. After carefully explaining the treatment plan, she gently patted my shoulder and said with confidence, "I've successfully treated patients like you before. Give me two months - let me help you beat this." I burst into tears. In that moment, her calm confidence gave me a sense that there was finally a way through.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">I knew Dr. Tong was not making a casual promise. Her confidence came from decades of clinical experience and from having treated many patients with difficult blood cancers.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">After a detailed review of my disease, Dr. Tong and the team developed a step-by-step individualized plan. In the first phase, I received a combination of several anti-cancer medications while the team closely monitored my results. After treatment, the fusion-gene level decreased slightly, but not enough. In April 2022, the team adjusted the plan and moved into a second phase, optimizing the medications and combining a CD38 monoclonal antibody, epigenetic therapy, and multiple targeted agents. Unfortunately, the fusion gene was still detectable.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The real turning point came after CIK cell immunotherapy. My CIK cells were collected on May 21, 2022, and I received two infusions on May 31 and June 1. By then, I was trying not to expect too much. Because earlier treatments had not worked as well as we hoped, the transplant team had already discussed transplantation with me. After the second infusion, I even returned home before the test results came back, carrying a mix of emotions.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">On June 14, 2022, my attending doctor called me, clearly excited: "Your fusion gene is negative!" I opened the hospital app on my phone and saw the result I had waited so long for: "Fusion gene: 0.00%." Nearly a year of struggle, uncertainty, pain, and disappointment suddenly gave way to hope. Dr. Defeng Zhao called soon afterward to congratulate me. I will never forget the joy in his voice.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>A Second Setback: CNS Leukemia Relapse, Followed by Another Carefully Tailored Treatment Plan\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Just when I thought the hardest part was behind me and was looking forward to fewer follow-up visits, another challenge arrived. In October 2022, a routine lumbar puncture showed a cerebrospinal fluid CBFβ-MYH11 fusion level of 6.78%, and I was diagnosed with central nervous system leukemia. In addition to intrathecal therapy, I needed radiotherapy at another hospital. During the cold Beijing winter, my son, who was on school break, accompanied me every day as we carried the heavy radiotherapy positioning mold back and forth between two hospitals. Before I went into the treatment room, we would look at each other without saying much - but that look seemed to say everything.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Radiotherapy made the hair that had finally grown back fall out again. I dealt with nausea, fatigue, dizziness, and vomiting, but with careful medical management and my family's support, I completed the full course of treatment. By March 2023, follow-up testing showed that the fusion gene in my cerebrospinal fluid remained undetectable. I had made it through another major hurdle.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Dr. Chunrong Tong and Dr. Defeng Zhao then developed a long-term treatment plan for me, with regular return visits to maintain remission, reduce the risk of relapse, and consolidate the response. As my condition became more stable, the interval between follow-up visits gradually became longer. In November 2025, I returned to Beijing GoBroad Boren Hospital for another review. The results were reassuring: my disease remained in remission. After that visit, I was finally able to stop all anti-cancer medications, including targeted therapy. From now on, I only need a follow-up every six months.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>Care Beyond Treatment: The Small Moments That Helped Me Through\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Looking back on this long and winding leukemia journey, I realize that the moments of kindness along the way were far more numerous than I ever noticed at the time.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">At Boren, I received not only expert medical care, but also thoughtful support in the smallest details. While I was anxiously waiting for bone marrow results, my attending doctor would call the laboratory in advance just so I could hear the result half an hour sooner. When chemotherapy affected my appetite, one of the doctors caring for me took a detour in the rain on the way to work to buy me freshly baked bread. Dr. Defeng Zhao made time to chat with me every day, helping ease my anxiety during treatment. When I was too weak to walk, the nurses pushed me in a wheelchair to different departments for tests. A member of the cleaning staff would sometimes bring me homemade snacks. The mother of another patient in my room carefully helped arrange my meals as if I were her own daughter. I was cared for by so many people along the way. Sometimes medicine can cure; often it can help; and always, compassion can comfort.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: center;\">\u003Cspan style=\"font-size: 15px;\">\u003Cstrong>A New Chapter: Seeing Life Differently and Passing the Kindness On\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">This illness changed the way I see life. I often hear other patients ask, "Why me? Why did this happen to me?" One line from a film has stayed with me: "Some of life's sweetest joys grow out of sorrow, and some of its most beautiful things are born from hardship. We go through difficult times ourselves, and only then learn how to comfort others."\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">The summer breeze, autumn leaves, and winter snow once felt ordinary. Now they are some of the most beautiful things in the world to me. Walking through the hospital corridors, I would see the names of doctors and nurses who had volunteered to donate blood. Their faces and smiles comforted me more than once. I do not know them personally, but I will always remember their kindness. I came to feel that faith does not need a shrine; compassion can be found in ordinary people all around us.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\";text-align: justify;\">\u003Cspan style=\"font-size: 15px;\">Thank you, Boren. If there were a book of angels on earth, your names would be written in gold on the very first page.\u003C\u002Fspan>\u003C\u002Fp>","Case Commentary from Dr. Defeng Zhao: \nThe patient was diagnosed with AML-M2 with a CBFβ-MYH11 fusion. Despite multiple rounds of chemotherapy at another hospital, the fusion gene remained detectable and she had not achieved deep remission. We used targeted therapy, including CIK cell therapy, and her bone marrow fusion-gene level subsequently fell to zero, indicating deep remission of the leukemia. At Beijing GoBroad Boren Hospital, our strategy is to continue targeted therapy together with immunomodulatory treatment for three years, with the goal of maintaining deep remission, preventing relapse, and working toward clinical cure. For patients with relapsed or refractory AML, selecting an appropriate targeted agent, combining it with immunomodulatory therapy, and using cellular therapy when appropriate can be an effective way to achieve another remission. These approaches can also be relatively well tolerated and may have a limited impact on quality of life.",1789384073199]