[{"data":1,"prerenderedAt":424},["ShallowReactive",2],{"media-slots-zh":3,"guide-all-zh":76},{"about.gallery":4,"about.hero":21,"about.video":23,"about.video-cover":25,"charity.hero":27,"contact.hero":29,"footer.qr-blood":31,"footer.qr-mini":33,"footer.qr-official":35,"footer.qr-solid":37,"guide.hero":39,"home.hero":41,"home.news-featured":43,"home.story-featured":45,"news.hero":47,"news.lead":49,"news.thumb":51,"stories.cover":56,"stories.hero":63,"stories.lead":65,"wiki.cat":67,"wiki.detail-hero":72,"wiki.hero":74},[5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20],"https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fabout\u002F1.jpg?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fabout\u002F2.jpg?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fabout\u002F3.jpg?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fabout\u002F4.jpg?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fabout\u002F5.JPG?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fabout\u002F6.JPG?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fabout\u002F7.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fabout\u002F8.JPG?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fabout\u002F9.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fabout\u002F10.JPG?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fabout\u002F11.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F08\u002F5beecc557d469fab0ea942d5fc282dbf.jpg?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fabout\u002F13.jpg?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fabout\u002F14.JPG?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fabout\u002F15.jpg?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fabout\u002F16.JPG?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp",[22],"https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fpc_banner\u002F%E5%85%B3%E4%BA%8E%E5%8D%9A%E5%8C%BB%E5%90%8C%E8%A1%8C_cn.jpg?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp",[24],"https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fabout\u002F%E9%A3%9E%E4%B9%A620260729-233252_compressed.mp4",[26],"https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fabout\u002F%E5%BE%AE%E4%BF%A1%E5%9B%BE%E7%89%87_20260730145007_665_448.jpg?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp",[28],"https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fpc_banner\u002F%E5%85%AC%E7%9B%8A%E8%B5%84%E6%BA%90%E9%93%BE%E6%8E%A5_cn.jpg?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp",[30],"https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F08\u002F4bed89602307bb6484fc92308ed212cc.jpg?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp",[32],"https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fabout\u002Fqr-blood.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp",[34],"https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fabout\u002Fqr-mini.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp",[36],"https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fabout\u002Fqr-official.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp",[38],"https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fabout\u002Fqr-solid.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp",[40],"https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fpc_banner\u002F%E7%96%BE%E7%97%85%E7%9F%A5%E8%AF%86%E5%BA%93_cn.jpg?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp",[42],"https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fpc_banner\u002F%E9%A6%96%E9%A1%B5_cn.jpg?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp",[44],"\u002Fimages\u002Fhome\u002Fnews-featured.jpg",[46],"\u002Fimages\u002Fhome\u002Fstory-featured.jpg",[48],"https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fpc_banner\u002F%E6%82%A3%E5%8F%8B%E5%85%B3%E6%B3%A8_cn.jpg?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp",[50],"\u002Fimages\u002Fnews\u002Flead.jpg",[52,53,54,55],"\u002Fimages\u002Fnews\u002Fn1.jpg","\u002Fimages\u002Fnews\u002Fn2.jpg","\u002Fimages\u002Fnews\u002Fn3.jpg","\u002Fimages\u002Fnews\u002Fn4.jpg",[57,58,59,60,61,62],"\u002Fimages\u002Fstories\u002Fs1.jpg","\u002Fimages\u002Fstories\u002Fs2.jpg","\u002Fimages\u002Fstories\u002Fs3.jpg","\u002Fimages\u002Fstories\u002Fs4.jpg","\u002Fimages\u002Fstories\u002Fs5.jpg","\u002Fimages\u002Fstories\u002Fs6.jpg",[64],"https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fpc_banner\u002F%E6%82%A3%E8%80%85%E6%95%85%E4%BA%8B_cn.jpg?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp",[66],"\u002Fimages\u002Fstories\u002Flead.jpg",[68,69,70,71],"\u002Fimages\u002Fwiki\u002Fcat-1.jpg","\u002Fimages\u002Fwiki\u002Fcat-2.jpg","\u002Fimages\u002Fwiki\u002Fcat-3.jpg","\u002Fimages\u002Fwiki\u002Fcat-4.jpg",[73],"\u002Fimages\u002Fwiki\u002Fdetail-hero.jpg",[75],"https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fstatic\u002Fpc_banner\u002F%E6%8A%97%E7%99%8C%E7%99%BE%E7%A7%91_cn.jpg?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp",{"items":77,"hot":367},[78,107,131,145,197,207,234,264,290,304,337],{"slug":79,"kind":80,"title":81,"summary":82,"introTitle":83,"intro":84,"cover":85,"faqCount":86,"contentHtml":87,"toc":88,"relatedQuestions":89,"ymyl":90,"hasAlternate":105,"updatedAt":106},"cancer-psychological-support","manual","不懂就问科普手册心理篇","面向肿瘤患者及家属的心理支持科普手册，解答患病后的焦虑、恐惧、复发担忧、失眠，以及家属陪伴、自责和照护压力等常见问题。","患者篇","\u003Cp>\u003Cspan style=\"font-size: 15px;\">确诊、治疗和康复过程中，害怕、焦虑、愤怒、低落、失眠，甚至担心复发，都是很多病友会经历的情绪变化。这里想陪你一起看看这些感受从哪里来，什么时候可以自己慢慢调整，什么时候需要寻求帮助，也希望你在面对疾病时，不必一个人扛着。\u003C\u002Fspan>\u003C\u002Fp>","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F08\u002F07f2157290211adbdc8b5e43af1cb809.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp",13,"",[],[],{"author":91,"reviewedBy":92,"lastReviewed":93,"datePublished":94,"citations":95,"disclaimer":104},"刘亮茹、李桂花（新眼光心理服务部）","方玥立","2024-08-01","2024-08-31",[96,98,100,102],{"title":97},"曾值,邓窈窕.儿童心理社会肿瘤学临床研究进展[J].中国全科医学, 2019, 22(6):7.DOI:CNKI:SUN:QKYX.0.2019-06-005.",{"title":99},"方拥军,张姮.儿童恶性肿瘤幸存者健康相关生活质量研究进展[J].中华实用儿科临床杂志, 2020, 35(3):4.DOI:10.3760\u002Fc\u0002ma.j.cn101070-20200227-00275.",{"title":101},"唐丽丽.《中国肿瘤心理临床实践指南2020》",{"title":103},"赖小英,陈丽君.肿瘤相关性睡眠障碍的研究进展[J].世界睡眠医学杂志,2022,9(01):183-186.","本手册内容根据【博医同行】平台病友群提问、既往科普文章及直播活动整理，内容在平台发布时均由临床医生进行了专业审核。旨在传递科普知识，供患友及家属学\n习交流使用，不作为诊疗依据，对于具体的诊疗意见请咨询您的主管医生。",false,"2026-08-31",{"slug":108,"kind":80,"title":109,"summary":110,"cover":111,"faqCount":112,"contentHtml":87,"toc":113,"relatedQuestions":114,"ymyl":115,"hasAlternate":105,"updatedAt":130},"childhood-b-all","不懂就问儿童急性B淋巴细胞白血病科普手册","孩子确诊儿童B-ALL后，从怎么看危险度和治疗反应，到化疗、CAR-T、移植怎么选，这本手册帮家长把治疗过程中常见的问题一步步弄明白。","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F08\u002F0df57fc76428738e1eae8f8b3f8a9c46.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp",34,[],[],{"author":116,"reviewedBy":117,"lastReviewed":93,"datePublished":94,"citations":118,"disclaimer":129},"刘亮茹","刘嵘、刘双又、童春容",[119,121,123,125,127],{"title":120},"CSCO恶性血液病诊疗指南(2024)",{"title":122},"NCCN Guidelines Version 5.2024-- Pediatric Acute Lymphoblastic Leukemia.",{"title":124},"https:\u002F\u002Fwww.fda.gov\u002Fdrugs\u002Fresources-information-ap- proved-drugs\u002Ffda-approves-inotuzumab-ozogamicin-pediatric-patients-acute-lymphoblastic-leukemia",{"title":126},"解姣,刘素香,刘雨秋,等.贝林妥欧单抗治疗儿童难治\u002F复发前体B细胞急性淋巴细胞白血病的临床分析[.中华实用儿科 临床杂志,2023,38(9):707-712.",{"title":128},"博医同行·儿童B急淋系列科普答疑内容集锦","手册内容根据【博医同行】平台既往发布过的科普教育内容整理，这些内容在平台发布时均由临床医生进行了专业审核。手册内容仅供患友及家属学习交流使用，不作为诊疗依据，对于具体的诊疗意见请咨询您的主管医生。","2026-08-26",{"slug":132,"kind":80,"title":133,"summary":134,"cover":135,"faqCount":136,"contentHtml":87,"toc":137,"relatedQuestions":138,"ymyl":139,"hasAlternate":105,"updatedAt":144},"aplastic-anemia-guide","不懂就问再生障碍性贫血科普手册","确诊再生障碍性贫血后，这本手册会陪你一步步了解检查、治疗和日常管理，帮你更安心地面对每一个治疗阶段。","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F08\u002F8e7c8fadfd4ce92ce99592735eac53ed.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp",15,[],[],{"author":116,"reviewedBy":140,"lastReviewed":141,"datePublished":142,"citations":143,"disclaimer":129},"张凤奎","2025-08-01","2025-08-31",[],"2026-08-25",{"slug":146,"kind":80,"title":147,"summary":148,"cover":149,"faqCount":150,"contentHtml":87,"toc":151,"relatedQuestions":152,"ymyl":153,"hasAlternate":105,"updatedAt":196},"gastric-cancer-faq","不懂就问胃癌科普手册","围绕胃癌患者关心的检查、分期、治疗、复查及复发等问题，把看病过程中经常遇到的疑问一次讲清楚。","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F08\u002F175a25ac037c8aadff372a965ec56292.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp",26,[],[],{"author":116,"reviewedBy":116,"lastReviewed":93,"datePublished":94,"citations":154,"disclaimer":195},[155,157,159,161,163,165,167,169,171,173,175,177,179,181,183,185,187,189,191,193],{"title":156},"《胃癌诊疗指南（2024年版）》",{"title":158},"国家卫生健康委员会. 《胃癌诊疗规范（2022年版）》",{"title":160},"中国临床肿瘤学会（CSCO）. 《胃癌诊疗指南》",{"title":162},"《中国胃癌规范化诊疗指南（2023版）》",{"title":164},"日本胃癌学会. 《胃癌治疗指南（第6版）》",{"title":166},"National Comprehensive Cancer Network（NCCN）. Gastric Cancer Clinical Practice Guidelines",{"title":168},"European Society for Medical Oncology（ESMO）. Gastric Cancer Clinical Practice Guidelines",{"title":170},"中华医学会肿瘤学分会. 胃癌相关诊疗专家共识",{"title":172},"中国抗癌协会胃癌专业委员会. 胃癌综合治疗相关专家共识",{"title":174},"《胃癌外科治疗中国专家共识》",{"title":176},"《胃癌围手术期营养支持专家共识》",{"title":178},"《胃癌术后随访与复查相关指南》",{"title":180},"《肿瘤患者化疗相关恶心呕吐防治指南》",{"title":182},"《肿瘤患者化疗相关骨髓抑制管理专家共识》",{"title":184},"《胃癌靶向治疗专家共识》",{"title":186},"《HER2阳性胃癌诊疗专家共识》",{"title":188},"《胃癌免疫治疗专家共识》",{"title":190},"American Cancer Society. Stomach Cancer Treatment",{"title":192},"National Cancer Institute. Gastric Cancer Treatment",{"title":194},"Mayo Clinic. Stomach Cancer"," 手册内容根据【博医同行】平台既往发布过的科普教育内容整理，这些内容在平台发布时均由临床医生进行了专业审核。手册内容仅供患友及家属学习交流使用，不作为诊疗依据，对于具体的诊疗意见请咨询您的主管医生。","2026-08-20",{"slug":198,"kind":80,"title":199,"summary":200,"cover":201,"faqCount":202,"contentHtml":87,"toc":203,"relatedQuestions":204,"ymyl":205,"hasAlternate":105,"updatedAt":196},"gastrointestinal-cancer-faq","不懂就问消化肿瘤科普手册","围绕胃癌、结直肠癌及神经内分泌肿瘤，从治疗选择、术后复查到复发转移，解答不同治疗阶段病友经常遇到的问题。","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F08\u002F09ade03382ac8f5152b5f829301d1143.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp",11,[],[],{"author":116,"reviewedBy":116,"lastReviewed":93,"datePublished":106,"citations":206,"disclaimer":129},[],{"slug":208,"kind":80,"title":209,"summary":210,"intro":211,"cover":212,"faqCount":213,"contentHtml":87,"toc":214,"relatedQuestions":215,"ymyl":216,"hasAlternate":105,"updatedAt":196},"car-t-genetics","细胞免疫治疗科普手册-基因篇","看懂基因检测和基因变异意味着什么，帮助你更好地理解疾病风险、治疗选择和复查结果。","\u003Cp style=\"margin-bottom:0;text-indent:28px;text-autospace:ideograph-numeric;\">\u003Cspan style=\"font-size: 15px;\">造血干细胞分化为不同类型的成熟血细胞的一个高度受控的过程，任何调控环节中关键基因的异常，都可能打破这种平衡，导致细胞功能紊乱、过度增殖或失去应有的死亡机制，最终引发血液病或肿瘤。血液病及肿瘤发病原因及机制复杂，一般来说，与先天\u002F遗传因素、放射因素、化学因素、病毒等原因有关。这些原因导致染色体异常和\u002F或多种基因异常，后者引起造血细胞分化或凋亡异常，造血细胞不能分化为成熟细胞，大量幼稚细胞累积增加称为前体淋巴细胞肿瘤（包括急性淋巴细胞白血病或淋巴母细胞淋巴瘤）；染色体异常和\u002F或多种基因异常也可能减少正常细胞程序性死亡（凋亡）导致某一类或几类造血细胞累积增加引起白血病。\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-bottom:0;text-indent:28px;text-autospace:ideograph-numeric;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-bottom:0;text-indent:28px;text-autospace:ideograph-numeric;\">\u003Cspan style=\"font-size: 15px;\">随着分子生物学和高通量测序技术的进步，医学界对这些致病突变的识别能力不断提高。基因检测已经不仅仅是一种科研工具，它正快速进入临床实践，并成为血液肿瘤诊断和治疗的基础组成部分；某些特定突变甚至被纳入疾病命名和分类的标准，用以定义一个亚型白血病或淋巴瘤，这种在分子水平的精准分型，不仅帮助医生明确疾病本质，还能预测预后、评估复发风险、指导靶向治疗，甚至监测微小残留病灶，成为贯穿整个治疗周期的重要依据。\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-bottom:0;text-indent:28px;text-autospace:ideograph-numeric;\">\u003Cspan style=\"font-size: 15px;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-bottom:0;text-indent:28px;text-autospace:ideograph-numeric;\">\u003Cspan style=\"font-size: 15px;\">在不懂就问手册基因篇中，我们围绕多个关键基因突变展开科普——包括影响疾病起始的驱动突变、决定治疗反应的药物靶点突变、提示复发风险的耐药相关突变等。\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F08\u002Fb5963e602f42a1fc6c301bb5ce511a07.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp",22,[],[],{"author":116,"reviewedBy":116,"lastReviewed":141,"datePublished":106,"citations":217,"disclaimer":195},[218,220,222,224,226,228,230,232],{"title":219},"中华医学会血液学分会白血病淋巴瘤学组.《成人急性髓系白血病（非急性早幼粒细胞白血病）中国诊疗指南（2023年版）》. 中华血液学杂志，2023，44（9）：705-712 ",{"title":221},"中华医学会血液学分会白血病淋巴瘤学组.《中国复发难治性急性髓系白血病诊疗指南（2023年版）》. 中华血液学杂志，2023，44（9）：713-716 ",{"title":223},"中华医学会血液学分会实验诊断学组.《急性髓系白血病微小残留病检测与临床解读中国专家共识（2021年版）》. 中华血液学杂志，2021，42（11）：889-897",{"title":225},"中国临床肿瘤学会指南工作委员会.《中国临床肿瘤学会（CSCO）恶性血液病诊疗指南2024》. 人民卫生出版社，2024。",{"title":227},"Döhner H, Wei AH, Appelbaum FR, et al. Diagnosis and Management of AML in Adults: 2022 Recommendations from an International Expert Panel on Behalf of the European LeukemiaNet. Blood. 2022;140(12):1345-1377. ",{"title":229},"Heuser M, Freeman SD, Ossenkoppele GJ, et al. 2021 Update on MRD in Acute Myeloid Leukemia: A Consensus Document from the European LeukemiaNet MRD Working Party. Blood. 2021;138(26):2753-2767. ",{"title":231},"European Society for Medical Oncology. Acute Myeloid Leukaemia: ESMO Clinical Practice Guideline for Diagnosis, Treatment and Follow-up. ",{"title":233},"National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Acute Myeloid Leukemia.",{"slug":235,"kind":80,"title":236,"summary":237,"cover":238,"faqCount":86,"contentHtml":87,"toc":239,"relatedQuestions":240,"ymyl":241,"hasAlternate":105,"updatedAt":263},"car-t-cell-therapy","细胞免疫治疗科普手册CAR-T篇","了解CAR-T细胞治疗的基本原理、治疗流程、适用情况及常见不良反应，为接受治疗前后做好准备。","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F08\u002Fccf2414c4d09211e3560cbab9149ee21.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp",[],[],{"author":116,"reviewedBy":116,"lastReviewed":141,"datePublished":142,"citations":242,"disclaimer":195},[243,245,247,249,251,253,255,257,259,261],{"title":244},"中国医师协会血液科医师分会等. 《嵌合抗原受体T细胞治疗血液系统恶性肿瘤中国专家共识》.",{"title":246},"中国抗癌协会血液肿瘤专业委员会等. 《CAR-T细胞治疗成人急性B淋巴细胞白血病中国专家共识》.",{"title":248},"中华医学会血液学分会等. 《复发难治性B细胞非霍奇金淋巴瘤CAR-T细胞治疗中国专家共识》.",{"title":250},"中华医学会血液学分会浆细胞疾病学组等. 《多发性骨髓瘤CAR-T细胞治疗中国专家共识》.",{"title":252},"中国临床肿瘤学会指南工作委员会. 《中国临床肿瘤学会（CSCO）恶性血液病诊疗指南》.",{"title":254},"European Society for Blood and Marrow Transplantation and Joint Accreditation Committee of ISCT and EBMT. Management of adults and children undergoing chimeric antigen receptor T-cell therapy: best practice recommendations.",{"title":256},"European Hematology Association and European Society for Blood and Marrow Transplantation. Clinical practice recommendations for the use of CAR-T-cell therapies in hematological malignancies.",{"title":258},"National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Acute Lymphoblastic Leukemia.",{"title":260},"National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: B-Cell Lymphomas.",{"title":262},"National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Multiple Myeloma.","2026-08-19",{"slug":265,"kind":80,"title":266,"summary":267,"cover":268,"faqCount":269,"contentHtml":87,"toc":270,"relatedQuestions":271,"ymyl":272,"hasAlternate":105,"updatedAt":263},"hsct-gvhd","造血干细胞移植移植物抗宿主病篇","了解造血干细胞移植后移植物抗宿主病（GVHD）的发生原因、分类、高危因素、症状表现及治疗方法，做好移植后管理。","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F08\u002Fd7db1653e952050dee34e595d6ed4501.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp",7,[],[],{"author":273,"reviewedBy":274,"lastReviewed":275,"datePublished":276,"citations":277,"disclaimer":195},"郝钰","张二娟","2023-12-01","2023-12-31",[278,280,282,284,286,288],{"title":279}," 移植物抗宿主病百科 血液病治疗药物的安全应用 人民 卫生出版社 第四章第十节",{"title":281}," 《造血干细胞移植问与答》人民卫生出版社 第92问",{"title":283}," 甲泼尼龙片百科词条甲泼尼龙片_百度百科 (baidu.com)",{"title":285},"《实用造血干细胞移植》人民卫生出版社 第二版第四篇 第三节",{"title":287},"JagasiaMH, GreinixHT, AroraM, et al. National  institutes of health consensus development project on  criteria for clinical trials in chronic graft-versus-host  disease: Ⅰ. The 2014 Diagnosis and Staging Working Group  report[J]. Biol Blood Marrow Transplant, 2015,21(3): 389- 401. ",{"title":289},"B r a u n , L u k a s M , a n d R o b e r t Z e i s e r .  “Immunomodulatory Therapies for the Treatment of Graft\u0002versus-host Disease.” HemaSphere vol. 5,6 e581. 1 Jun.  2021.",{"slug":291,"kind":80,"title":292,"summary":293,"cover":294,"faqCount":295,"contentHtml":87,"toc":296,"relatedQuestions":297,"ymyl":298,"hasAlternate":105,"updatedAt":263},"hsct-conditioning","造血干细胞移植移植前预处理篇","了解造血干细胞移植前预处理的目的、方案类型、选择原则、常见不良反应及移植时机，帮助患者和家属更好地理解并做好移植前准备。","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F08\u002F5b0228150515d719bc201ee49c7c2118.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp",6,[],[],{"author":273,"reviewedBy":274,"lastReviewed":275,"datePublished":276,"citations":299,"disclaimer":195},[300,302],{"title":301},"实用造血干细胞移植 第二版；",{"title":303},"What to expect from Allogeneic Stem Cell Transplantation，Heidi Moawad,MD.et.2021,Oct 16.",{"slug":305,"kind":80,"title":306,"summary":307,"cover":308,"faqCount":295,"contentHtml":87,"toc":309,"relatedQuestions":310,"ymyl":311,"hasAlternate":105,"updatedAt":336},"hsct-donor-selection","造血干细胞移植供者选择篇","了解造血干细胞移植供者选择全过程，包括供者类型、匹配条件、检查评估、寻找流程及捐献相关知识，帮助病友和家属更好理解移植准备。","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F07\u002F73091562191dba92bd9bd88eecfe196b.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp",[],[],{"author":273,"reviewedBy":312,"lastReviewed":275,"datePublished":276,"citations":313,"disclaimer":129},"张二娟、高楠",[314,316,318,320,322,324,326,328,330,332,334],{"title":315},"造血干细胞移植问与答，第二版；",{"title":317},"单倍体造血干细胞移植供者选择研究进展；白血病•淋巴 瘤. 2020,29(06)。",{"title":319},"Donor pretreatment and machine perfusion: current  views;Stephen O'Neill.et.2020,Feb,25;",{"title":321},"黄晓军著，实用造血干细胞移植（第二版），第58-59页、 第61页",{"title":323},"Be the Match, Medical guidelines-who can join?",{"title":325},"中华骨髓库，加入中华骨髓库和造血干细胞捐献须知",{"title":327},"中华医学会，中华医学会根据“国家卫生计生委办公厅关 于实施有关病种临床路径的通知”要求发布临床路径",{"title":329},"潘妮，董磊．单倍体相合骨髓移植白血病患者造血重建的 I|缶床 分析和实践[J]．泰山医学院学报，2014，35(9)：895；",{"title":331},"王平，彭贤贵，陈幸华，等．单倍相合异基因外周血联合 骨髓造 血干细胞移植的干细胞采集及移植效果评价[J]．解放军 医学 杂志，2015，35(5)：585． E53",{"title":333},"文婷，陈世彪，赵为禄．骨髓移植供髓者骨髓移植供髓者 骨髓采集术1例麻醉体会EJ]．实用l临床医学，2010，1I(9)：54",{"title":335},"中国红十字会加入中华骨髓库和捐献造血干细胞简要说明。","2026-08-11",{"slug":338,"kind":80,"title":339,"summary":340,"cover":341,"faqCount":295,"contentHtml":87,"toc":342,"relatedQuestions":343,"ymyl":344,"hasAlternate":105,"updatedAt":366},"hematopoietic-stem-cell-transplant-basic-knowledge","造血干细胞移植基础知识手册","了解造血干细胞移植是什么、适合哪些人以及治疗流程，为治疗做好准备。","https:\u002F\u002Fgaobo-byh-h5.oss-cn-beijing.aliyuncs.com\u002Fbytx-pc-uploads\u002F2026\u002F07\u002F4ba87ed729ff12ae21f57a024600c323.png?x-oss-process=image\u002Fresize,limit_1,w_1600\u002Fquality,q_80\u002Fformat,webp",[],[],{"author":273,"reviewedBy":312,"lastReviewed":275,"datePublished":275,"citations":345,"disclaimer":129},[346,348,350,352,354,356,358,360,362,364],{"title":347},"造血干细胞移植问与答，P9-11，人民卫生出版社",{"title":349},"脐带血干细胞移植研究概述；生物学教学. 2021,46(06)",{"title":351},"HLA完全相合同胞骨髓移植与外周血造血干细胞移植治疗恶 性血液病临床疗效的Meta分析，2017年第02期",{"title":353},"《实用造血干细胞移植》人民卫生出版社",{"title":355},"Hamadani, M., Autologous hematopoietic cell  transplantation: an update for clinicians. Ann Med, 2014.  46(8): p. 619-32",{"title":357},"儿童髓母细胞瘤诊疗规范（2021年版）",{"title":359},"儿童神经母细胞瘤诊疗规范（2019年版）",{"title":361},"Be the Match.Transplant basics:understanding  transplant and how it works",{"title":363},"中高危骨髓增生异常综合征及其转化急性髓系白血病异基 因造血干细胞移植时机与疗效的临床研究；中国实用内科杂志.  2021,41(10)",{"title":365},"异基因造血干细胞移植在复发难治淋巴瘤中的应用；白血 病•淋巴瘤. 2021,30(07)","2026-08-18",[368,373,377,382,387,391,395,400,404,408,412,416,420],{"title":369,"handbookSlug":235,"sectionKey":370,"summary":371,"datePublished":372},"什么是CAR-T治疗？适用于哪些疾病？常见治疗靶点有哪些？","car-t-treatment-diseases-targets","准备做CAR-T？先了解适不适合、靶点检测、复发风险和常见不良反应。","2026-08-07",{"title":374,"handbookSlug":235,"sectionKey":375,"summary":376,"datePublished":372},"商业化CAR-T和研究型CAR-T有什么区别？CAR-T治疗前需要做哪些准备？","car-t-commercial-research-preparation","如果你正在考虑CAR-T治疗，先了解商业化和研究型CAR-T有什么不同，以及治疗前要做哪些检查、经历哪些步骤。",{"title":378,"handbookSlug":291,"sectionKey":379,"summary":380,"datePublished":381},"造血干细胞移植时机应该如何选择？","best-timing-for-hsct","对于需要接受移植的患者来说，抓住合适的治疗窗口，并做好移植前准备，是提高移植安全性和治疗效果的重要基础。","2026-08-04",{"title":383,"handbookSlug":338,"sectionKey":384,"summary":385,"datePublished":386},"什么是二次移植？哪些患者需要再次接受造血干细胞移植？","second-hematopoietic-stem-cell-transplantation","是否进行二次移植需要综合考虑疾病类型、复发情况、患者身体状态、前次移植效果以及再次治疗可能带来的获益和风险。","2026-07-31",{"title":388,"handbookSlug":338,"sectionKey":389,"summary":390,"datePublished":386},"造血干细胞移植有年龄限制吗？老年患者是否可以接受移植？","age-limit-for-hematopoietic-stem-cell-transplantation","随着移植技术、预处理方案和支持治疗的发展，部分年龄较大的患者也可以通过调整治疗方案接受造血干细胞移植。",{"title":392,"handbookSlug":338,"sectionKey":393,"summary":394,"datePublished":386},"造血干细胞移植可以治疗哪些疾病？哪些患者可能需要移植？","hematopoietic-stem-cell-transplantation-diseases-and-indications","是否需要进行造血干细胞移植，需要根据患者的疾病类型、危险分层、基因检测结果、治疗反应以及身体状态等因素综合判断。",{"title":396,"handbookSlug":208,"sectionKey":397,"summary":398,"datePublished":399},"都有TP53基因突变，治疗效果会一样吗？","tp53-mutation-prognosis-treatment","同样查出TP53突变，不同患者的治疗效果和复发风险也可能不同，需要结合突变类型、单等位或双等位状态、复杂核型以及治疗后MRD等综合判断。","2026-08-10",{"title":401,"handbookSlug":208,"sectionKey":402,"summary":403,"datePublished":399},"FLT3或NPM1突变阳性怎么办？需要靶向治疗或造血干细胞移植吗？","aml-flt3-npm1-targeted-therapy-transplant","查出FLT3或NPM1突变后，不要只看“阳性”判断风险，还要结合其他基因、MRD和治疗反应，进一步评估靶向治疗和造血干细胞移植。",{"title":405,"handbookSlug":235,"sectionKey":406,"summary":407,"datePublished":399},"CAR-T治疗后无效或复发怎么办？还能再次做CAR-T吗？","car-t-failure-relapse-retreatment","CAR-T后没有缓解或再次复发怎么办？先明确复发原因和靶点变化，再评估再次CAR-T、更换靶点或其他后续治疗。",{"title":409,"handbookSlug":235,"sectionKey":410,"summary":411,"datePublished":372},"完全缓解后多长时间不复发才算“治愈”？哪些因素会影响CAR-T疗效？","car-t-remission-cure-factors-affecting-outcomes","CAR-T后达到完全缓解，多久不复发才算真正稳定？了解“缓解”和“治愈”的区别，以及哪些因素会影响长期疗效。",{"title":413,"handbookSlug":235,"sectionKey":414,"summary":415,"datePublished":372},"CAR-T治疗会出现哪些不良反应？反应轻重会影响治疗效果吗？","car-t-side-effects-response-and-efficacy","CAR-T后发烧、感染或出现神经系统反应正常吗？了解常见不良反应，以及反应轻重和治疗效果之间到底有没有关系。",{"title":417,"handbookSlug":235,"sectionKey":418,"summary":419,"datePublished":372},"肿瘤负荷大，CAR-T治疗前为什么要先“减瘤”？减瘤时机如何把握？","car-t-tumor-debulking-bridging-treatment","肿瘤负荷高时，为什么CAR-T前常要先减瘤？了解什么时候该减、先采细胞还是先治疗，以及减到什么程度更合适。",{"title":421,"handbookSlug":235,"sectionKey":422,"summary":423,"datePublished":372},"人源化CAR-T、鼠源CAR-T、自体CAR-T、异体CAR-T和体内CAR-T有什么区别？","car-t-types-humanized-autologous-allogeneic-in-vivo","面对鼠源、人源化、自体、异体、体内CAR-T等不同说法，了解它们到底有什么区别，以及选择CAR-T时真正需要关注什么。",1789384078342]