[{"data":1,"prerenderedAt":108},["ShallowReactive",2],{"wiki-item-zh-car-t-therapy":3,"media-slots-zh":35},{"slug":4,"category":5,"categoryName":6,"title":7,"summary":8,"conditionName":9,"toc":10,"ymyl":27,"hasAlternate":34,"updatedAt":16},"car-t-therapy","technology","治疗技术","CAR-T细胞治疗","CAR-T细胞治疗全称为“嵌合抗原受体T细胞免疫疗法”，是通过提取患者的T淋巴细胞并加以改造,使它具有识别并杀死肿瘤细胞的能力,然后回输入患者体内达到治疗癌症的目的。","CAR-T治疗",[11,17,22],{"key":12,"title":13,"html":14,"icon":15,"updatedAt":16},"overview","概述","\u003Cp style=\"margin-top:0;margin-right:0;margin-bottom:8px;margin-left:0;text-indent:0;padding:0 0 0 0 ;text-align:justify;text-justify:inter-ideograph;background:rgb(255,255,255)\">\u003Cspan style=\"letter-spacing: 0px; font-size: 15px;\">CAR-T细胞治疗（Chimeric Antigen Receptor T-Cell Therapy，嵌合抗原受体T细胞治疗）是一项国际前沿的细胞免疫疗法。该技术通过基因工程改造患者自身或供者的淋巴细胞，使其能够精准识别并定向清除肿瘤细胞。\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"margin-top:0;margin-right:0;margin-bottom:8px;margin-left:0;text-indent:0;padding:0 0 0 0 ;text-align:justify;text-justify:inter-ideograph;background:rgb(255,255,255)\">\u003Cspan style=\"letter-spacing: 0px; font-size: 15px;\">这一疗法的出现，不仅为血液系统恶性肿瘤患者带来了新的治愈希望，也正在自身免疫性疾病与实体瘤的治疗探索中展现出广阔潜力，为更多缺乏有效治疗手段的患者打开了新的生命通道。\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","⚕️","2026-08-03",{"key":18,"title":19,"html":20,"icon":21,"updatedAt":16},"indication","应用","\u003Cp style=\"margin-top:0;margin-right:0;margin-bottom:8px;margin-left:0;text-indent:0;padding:0 0 0 0 ;text-align:justify;text-justify:inter-ideograph;background:rgb(255,255,255)\">\u003Cspan style=\"letter-spacing: 0px; font-size: 15px;\">目前，CAR-T细胞疗法已被证实在多种血液系统恶性肿瘤中具有显著疗效，包括急性淋巴细胞白血病、淋巴瘤、多发性骨髓瘤等。同时，CAR-T细胞疗法也正被用于探索治疗系统性红斑狼疮等自身免疫性疾病，以及消化系统肿瘤等实体瘤，为更多患者提供新的治疗可能。\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","🩹",{"key":23,"title":24,"html":25,"icon":26,"updatedAt":16},"complication","并发症","\u003Cdiv>\u003Cspan style=\"font-size: 15px;\">1.细胞因子释放综合征 (CRS)：CAR-T细胞在杀死肿瘤细胞时，可能会引发全身性炎症反应。 输注 CAR-T 细胞后，患者体内会出现一系列的免疫反应，从而出现高热、肌痛、乏力、恶心、低血压、心动过速、肾损害、肝衰竭,甚至呼吸困难等不良症状，严重者会有致死性风险。  CRS通常发生在 CAR-T治疗后的第一周内，且于 1 ~ 2 周内达到最高峰，其严重程度与癌细胞的数量、肿瘤的大小有关。  \u003C\u002Fspan>\u003C\u002Fdiv>\u003Cdiv>\u003Cbr\u002F>\u003C\u002Fdiv>\u003Cdiv>\u003Cspan style=\"font-size: 15px;\">2.神经毒性征：CAR-T细胞疗法的另一严重副反应就是神经毒性。大部分患者的神经毒性并发症是短暂和轻微的，只有小部分患者会有严重副反应，包括昏迷、头痛、意识水平下降、失语症、语言障碍、神经错乱、癫痫、局灶性神经功能缺损和颅内大出血等。 \u003C\u002Fspan>\u003C\u002Fdiv>\u003Cdiv>\u003Cbr\u002F>\u003C\u002Fdiv>\u003Cdiv>\u003Cspan style=\"font-size: 15px;\">3. 脱靶毒性：CAR-T细胞在杀伤肿瘤细胞的同时也可能会误伤正常组织细胞，这就产生了脱靶毒性。例如，碳酸酐酶IX( CAIX) -CAR-T细胞可以治疗肾透明细胞癌，但是也会攻击正常胆管上皮细胞，从而造成肝脏的损伤。\u003C\u002Fspan>\u003C\u002Fdiv>","🔬",{"author":28,"reviewedBy":28,"lastReviewed":28,"datePublished":28,"citations":29,"disclaimer":28},"",[30,32],{"title":31},"高博医疗集团官网https:\u002F\u002Fwww.gobroadhealthcare.com\u002Fdisease\u002F1710524777627680\u002Fcar-t-cell-therapy",{"title":33},"张宸瑜,陈柯远,贾雨婷,季少平.嵌合抗原受体T细胞免疫疗法在肿瘤治疗中的研究进展[J].中国免疫学杂志,2020,36(22):2791-2796,2801.DOI:10.3969\u002Fj.issn.1000-484X.2020.22.021. 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